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Newswise Special Wire
Tuesday, February 18, 2020

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Newswise Cancer Research Wire for 18-Feb-2020
 

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.


Cancer Research


New Computational Tools Identify Alternative Splicing Changes in Aggressive Cancers

A multi-institutional group of researchers led by Children’s Hospital of Philadelphia (CHOP) has linked a strong cancer driver gene to changes in proteins that regulate alternative splicing. The researchers created new computational tools and biolo...

– Children's Hospital of Philadelphia

Proceedings of the National Academy of Sciences

Embargo expired on 17-Feb-2020 at 15:00 ET


Intratumoral heterogeneity may be responsible for chemotherapy resistance in patients with small cell lung cancer

A study at The University of Texas MD Anderson Cancer Center found that chemotherapy results in increased heterogeneity within small cell lung cancer, leading to the evolution of multiple resistance mechanisms.

– University of Texas M. D. Anderson Cancer Center

Nature Cancer

Embargo expired on 17-Feb-2020 at 11:00 ET


Cancer Immunotherapy Target Helps Fight Solid Tumors

Yvonne Chen engineers immune cells to target their most evasive enemy: cancer. New cancer immunotherapies generate immune cells that are effective killers of blood cancers, but they have a hard time with solid tumors.

– Biophysical Society

BPS Annual Meeting, Feb-2020

Embargo expired on 15-Feb-2020 at 07:00 ET


A New Way to Monitor Cancer Radiation Therapy Doses

More than half of all cancer patients undergo radiation therapy and the dose is critical. Too much and the surrounding tissue gets damaged, too little and the cancer cells survive.

– Biophysical Society

BPS Annual Meeting, Feb-2020

Embargo expired on 15-Feb-2020 at 07:00 ET


New High-Throughput Method to Study Gene Splicing at an Unprecedented Scale Reveals New Details About the Process

Genes are like instructions, but with options for building more than one thing. Daniel Larson, senior investigator at the National Cancer Institute, studies this gene “splicing” process, which happens in normal cells and goes awry in blood cancer...

– Biophysical Society

BPS Annual Meeting, Feb-2020

Embargo expired on 15-Feb-2020 at 07:00 ET


Researchers Validate Link Between Genetic Variant and Poor Outcomes in Men with Advanced Prostate Cancer

In a new Cleveland Clinic-led study published in JAMA Oncology, researchers show that a testosterone-related genetic variant – HSD3B1(1245C) – is associated with more aggressive disease and shorter survival in men with metastatic prostate cancer....

– Cleveland Clinic

JAMA Oncology - Feb. 13, 2020

Embargo expired on 13-Feb-2020 at 11:00 ET


New, Detailed Molecular Roadmap Boosts Fight Against Endometrial Cancer

Scientists have taken an unprecedented look at proteins involved in endometrial cancer, commonly known as uterine cancer. The study offers insights about which patients will need aggressive treatment and which won’t, and offers clues about why a co...

– Pacific Northwest National Laboratory

Cell, Feb. 13, 2020; U24CA210955 National Cancer Institute; U24CA210954 National Cancer Institute; U24CA210972 National Cancer Institute; U24CA210979 National Cancer Institute...

Embargo expired on 13-Feb-2020 at 11:00 ET


Absent p53, oral cancers recruit and reprogram nerves to fuel tumor growth

Loss of an important tumor-suppressing gene allows head and neck cancer to spin off signals to nearby nerves, changing their function and recruiting them to the tumor, where they fuel growth and cancer progress.

– University of Texas M. D. Anderson Cancer Center

Nature

Embargo expired on 12-Feb-2020 at 13:00 ET


Combination Drug Therapy For Childhood Brain Tumors Shows Promise In Laboratory Models

In experiments with human cells and mice, researchers at the Johns Hopkins Kimmel Cancer Center report evidence that combining the experimental cancer medication TAK228 (also called sapanisertib) with an existing anti-cancer drug called trametinib ma...

– Johns Hopkins Medicine

Neuro-oncology


Targeting Turncoat Immune Cells to Treat Cancer

A Ludwig Cancer Research study has identified a mechanism by which regulatory T cells, which suppress immune responses, adapt their metabolism to thrive in the harsh microenvironment of the tumor.

– Ludwig Cancer Research

Nature Immunology, Feb-2020


Study identifies states with highest rates of melanoma due to ultraviolet radiation

A new study finds a wide state-by-state variation in rates of melanoma caused by ultraviolet (UV) exposure with highest rates in several states on the East and West Coast including Hawaii, but also a few landlocked states, including Utah, Vermont, an...

– American Cancer Society (ACS)

IJC International Journal of Cancer


Moffitt Researchers Say Multiple Drug Adaptive Therapy is Possible

In a new article published online ahead of print in Cancer Research, members of Moffitt’s Center of Excellence for Evolutionary Therapy present a case study of an adaptive treatment approach based on evolutionary principles in prostate cancer and s...

– Moffitt Cancer Center

Cancer Research, Jan-2020


Novel targeted drug shows promise in advanced kidney cancer

Scientists report promising activity of a novel drug that targets a key molecular driver of clear cell renal cell carcinoma (ccRCC) in patients with metastatic disease.

– Dana-Farber Cancer Institute

J Clin Oncol 38, 2020 (suppl 6; abstr 611); 2020 Genitourinary Cancers Symposium


Much shorter radiation treatment found to be safe, effective for people with soft tissue sarcoma

A new study led by researchers UCLA found that treating soft tissue sarcoma with radiation over a significantly shorter period of time is safe, and likely just as effective, as a much longer conventional course of treatment.

– University of California, Los Angeles (UCLA), Health Sciences

Clinical Cancer Research


Gay and bisexual men have higher rate of skin cancer

In the largest study of skin cancer rates among gay, lesbian or bisexual individuals, investigators from Brigham and Women's Hospital report important differences in skin cancer prevalence among sexual minorities.

– Brigham and Women’s Hospital

JAMA Dermatology


CDI Lab Explores Pathway to Open up Blood Cancer Treatments

The CDI team’s findings could ultimately improve cancer treatments for people of advanced age, like that of adult acute myeloid leukemia (AML)

– Hackensack Meridian Health

Nature Communications


ORNL researchers develop ‘multitasking’ AI tool to extract cancer data in record time

To better leverage cancer data for research, scientists at ORNL are developing an artificial intelligence (AI)-based natural language processing tool to improve information extraction from textual pathology reports. In a first for cancer pathology re...

– Oak Ridge National Laboratory

Journal of the American Medical Informatics Association, Jan-2020


FSU Researchers Look to Natural Products to Shed Light on Protein Interactions in Cancer, Neurological Diseases

A team of Florida State University researchers from the Department of Chemistry and Biochemistry found that a natural product from the fungus Fusicoccum amygdali stabilizes a family of proteins in the cell that mediate important signaling pathways in...

– Florida State University

ACS Chemical Biology


Utah Researchers Discover a Key Protein in Endometrial Cancer Growth

New research, published today in the journal Cancer Research, outlines findings scientists hope will advance our understanding of endometrial cancer and lead to more effective treatments.

– Huntsman Cancer Institute at the University of Utah

Cancer Research


Replacing Animal Testing with Synthetic Cell Scaffolds

Electrospun synthetic cell scaffolds are not only more consistent than animal cells for cancer research, they hold the potential to replace animal testing.

– Michigan Technological University

IEEE Open Journal of Engineering in Medicine and Biology; Royal Chemistry Society Advances


From breast cupcakes to breast surgery

Angela used her experience with breast cancer treatment at Beaumont to help her family, friends and surgeons see the benefits of infusing treatment with humor.

– Beaumont Health


Cancer Announcements


Wills Eye Hospital Announces Clinician-Scientist Jose S. Pulido, MD, MS, MBA, MPH to Hold Prestigious Endowed Chair

Wills Eye Hospital is pleased to announce Jose S. Pulido, MD, MS, MBA, MPH, a world-renowned retina and ocular oncology clinician-scientist, has been named the Larry A. Donoso Endowed Chair and Director of the Henry and Corrine Bower Memorial Laborat...

– Wills Eye Hospital


ASTRO awarded contract from Department of Veterans Affairs to develop measures on quality of radiation therapy services

The American Society for Radiation Oncology (ASTRO) has been awarded a new one-year contract from the U.S. Department of Veterans Affairs (VA) to develop quality indicators (QI) for radiation treatments provided to veterans with head and neck, breast...

– American Society for Radiation Oncology (ASTRO)


Rush Earns National Center of Excellence for Pancreatic Cancer Designation

The National Pancreatic Foundation’s National Center of Excellence for Pancreatic Cancer designation is earned by hospitals that demonstrate the multi-disciplinary approach, social support and advanced research resources needed to treat this devast...

– Rush University Medical Center


New website powered by St. Jude informs families facing childhood cancer no matter where the patient receives treatment

The Together website by St. Jude offers information about diseases, diagnosis and treatment options, as well as supportive care resources and shared stories of hope, healing and experience.

– St. Jude Children's Research Hospital

Together


Hackensack Meridian John Theurer Cancer Center Announces Affiliation with ProCure NJ to Offer Advanced Proton Therapy for Cancer

Through our new clinical affiliation with ProCure Proton Therapy Center (ProCure NJ) in Somerset, NJ, Hackensack Meridian Health patients now have access to all available forms of radiation therapy.

– Hackensack Meridian Health


Cancer Experts and Features


New Graphic Tobacco Warnings and the First Amendment

– George Washington University

JAMA Oncology

Embargo expired on 13-Feb-2020 at 11:00 ET

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