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Newswise Special Wire
Tuesday, April 21, 2020

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Newswise Cancer Research Wire for 21-Apr-2020

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Cancer Research

Turning On the ‘Off Switch’ in Cancer Cells

A team of scientists has identified the binding site where drug compounds could activate a key braking mechanism against the runaway growth of many types of cancer. The discovery marks a critical step toward developing a potential new class of an...

– Michigan Medicine - University of Michigan


Embargo expired on 20-Apr-2020 at 11:00 ET

NCCN Prostate Cancer Patient Guidelines Listed among Top Global Sources for Trustworthy Online Information

A recently-published, independent, peer-reviewed, international study in Current Urology measured reliability and transparency of online medical information for people with prostate cancer and their caregivers, and found the NCCN Guidelines for Patie...

– National Comprehensive Cancer Network® (NCCN®)

Current Urology

Embargo expired on 20-Apr-2020 at 08:35 ET

Study points to obesity as driver of pancreatic cancer

A new study led by Yale Cancer Center (YCC) researchers has demonstrated in mice that hormones released from the pancreas itself can advance pancreatic cancer — and that weight loss can stop this process in its early stages. The research was publis...

– Yale Cancer Center


Embargo expired on 17-Apr-2020 at 11:00 ET

Finding Leukemia’s Weakness Using Genome-Wide CRISPR Technology

Researchers at University of California San Diego School of Medicine and Moores Cancer Center used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia.

– University of California San Diego Health

Nature Cancer

What’s old is new again

Drug resistance is a major obstacle in cancer treatment—leading to relapse for many patients. In a new study, published online April 20, 2020, in Nature Cell Biology, researchers from the Stowers Institute for Medical Research, Children’s Mercy K...

– Stowers Institute for Medical Research

Nature Cell Biology

Signal Switch Gives MDS Cells a Competitive Advantage that Supports Disease Progression

A study published online April 20, 2020, in Nature Immunology, led by researchers at Cincinnati Children's reports a possible new approach for treating myelodysplastic syndrome (MDS), which often can lead to leukemia.

– Cincinnati Children's Hospital Medical Center

Nature Immunology, Apr-2020

Kawate lab unveils structure of major membrane protein

In a paper published on Feb 12 in the journal eLife, Dr. Toshimitsu Kawate, associate professor in the Department of Molecular Medicine and his team reveal the form of pannexin1, a cellular membrane protein present in all vertebrates. With the size, ...

– Cornell University


Ludwig MSK Study Reveals Bile Metabolite of Gut Microbes Boosts Immune Cells

A Ludwig Cancer Research study has discovered a novel means by which bacterial colonies in the small intestine support the generation of regulatory T cells—immune cells that suppress autoimmune reactions and inflammation.

– Ludwig Cancer Research


Drug prevents cognitive impairment in mice after radiation treatment for brain tumors

UCLA researchers identify a possible new drug that could help prevent cognitive decline in people who undergo radiation therapy for brain tumors.

– University of California, Los Angeles (UCLA), Health Sciences


Massive study reveals how “hypermutated” malignant brain tumors with many mutations escape chemotherapy and immunotherapy

An analysis of more than 10,000 gliomas and clinical outcomes reported in Nature by scientists in Boston and Paris found that glioma patients whose tumors were hypermutated actually had no significant benefit when treated with checkpoint blockers.

– Dana-Farber Cancer Institute


Discovering the secrets of the enigmatic caspase-6

Researchers identified the mechanisms underlying the innate immune function of the enzyme caspase-6, offering ways to combat viral infection, inflammatory diseases and cancer.

– St. Jude Children's Research Hospital

Cell, Published Apr. 15, 2020

Depression, anxiety may be side effects as nation grapples with COVID-19

Millions of Americans are being impacted by the psychological fallout from the COVID-19 pandemic and its economic aftermath

– UT Southwestern Medical Center

New England Journal of Medicine

Therapies show knockout potential for rare, deadly liver cancer

A new study identifies some of the most critical genes that may drive a rare but deadly liver cancer, providing a road map for developing drugs that target those genes.

– Cornell University

Cell Reports

Big variability in blood pressure readings between anatomical sites

Blood pressure readings taken from neuroscience intensive care unit (NSICU) patients had marked differences between opposite sides of the body and different anatomical sites in each individual

– UT Southwestern Medical Center

Scientific Reports

Diagnostic Biomarkers Uncovered for Rare Kidney Cancer

Using next-generation RNA sequencing techniques, a team of scientists from the University of Michigan Rogel Cancer Center has uncovered the gene signature of chromophobe renal cell carcinoma (ChRCC) and have extensively tested the expression of three...

– Michigan Medicine - University of Michigan

European Urology

Chronic Stress Can Impact Response to Radiation Therapy for Cancer, Roswell Park Study Suggests

Radiation is one of the oldest and most common therapies for cancer, and typically is delivered locally, or to specific targeted sites in the body. While it has long been thought that locally-delivered radiation therapy typically does not help to shr...

– Roswell Park Comprehensive Cancer Center

Nature Communications; R01CA236390; R01CA099326; R01CA205246; P30CA016056; S10OD16450

Research News Tip Sheet: Story Ideas From Johns Hopkins

During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas ...

– Johns Hopkins Medicine

journal Science Advances; journal BMJ ; PLOS Biology; American Heart Association

Cancer Experts and Features

Finding Credible Cancer Education Resources during the COVID-19 Pandemic

While most public, hospital and academic libraries are closed to visitors due to the COVID-19 pandemic, there is a wealth of information available online, especially for cancer patients seeking disease specific information. Rutgers Cancer Institute o...

– Rutgers Cancer Institute of New Jersey

Cancer Announcements

Yale Cancer Center Announces Hematology Leadership Appointments

Yale Cancer Center announces the appointments of Thomas Prebet, M.D., Ph.D., as Disease Aligned Research Team (DART) Leader for Myeloid Malignancies and Amer Zeidan, MBBS, as Director of the Hematology Early Therapeutics Program.

– Yale Cancer Center

NYU Dentistry Awarded $2.2 Million NIH Grant to Investigate How Oral Cancer Causes Pain

The National Institute of Dental and Craniofacial Research has awarded NYU College of Dentistry’s Yi Ye, PhD, a $2.2 million, five-year grant to study the role of Schwann cells, the most prevalent type of cell supporting neurons in the peripheral n...

– New York University


Global COVID-19 Observatory and Resource Center for Childhood Cancer to serve as hub for sharing information on treating pediatric cancer patients infected by the virus

St. Jude Children’s Research Hospital, in partnership with the International Society of Paediatric Oncology (SIOP), today launched the Global COVID-19 Observatory and Resource Center for Childhood Cancer.

– St. Jude Children's Research Hospital





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