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Newswise Special Wire
Tuesday, May 19, 2020

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Newswise Cancer Research Wire for 19-May-2020

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Cancer Research

Scientists identify promising immunotherapy combination for pediatric brain cancer

Scientists at Sanford Burnham Prebys have discovered that combining immunotherapy with a drug called tumor necrosis factor (TNF) eradicated a deadly type of pediatric brain tumor in mice. The discovery, published in Nature Neuroscience, is expected t...

– Sanford Burnham Prebys Medical Discovery Institute

Nature Neuroscience; R01CA148699; R01CA159859; 2R01CA159859-06; P30CA30199; P01CA177322; K22CDACA229613; R01AI048073; SU2C; SU2C-AACR-DT1113...

Embargo expired on 18-May-2020 at 11:00 ET

Genome-wide pattern found in tumors from brain cancer patients predicts life expectancy

For the past 70 years, the best indicator of life expectancy for a patient with glioblastoma — the most common and the most aggressive brain cancer — has simply been age at diagnosis. Now, an international team of scientists has experimentally va...

– University of Utah Health

APL Bioengineering; CA-230150; OD-021644

Embargo expired on 15-May-2020 at 09:00 ET

Study Demonstrates Impact of Both Inherited and Acquired Mutations on Cancer

The common belief that tumors arise via activation of a few genes that “drive” cancer development is unsupported by a widespread investigation into those genes and others in three large patient genetic databases, according to a study led by Yale ...

– Yale Cancer Center

Nature Communications

Embargo expired on 15-May-2020 at 05:00 ET

ASCO 2020: First National-Scale Study on the Impact of Medicaid Expansion on Cancer Mortality Rates Highlighted in Press Program

New data from researchers at Memorial Sloan Kettering Cancer Center (MSK) revealed the effects of Medicaid expansion on cancer death rates on a national scale. The landmark study found that states that adopted Medicaid expansion following the passage...

– Memorial Sloan Kettering Cancer Center

American Society of Clinical Oncology

Embargo expired on 13-May-2020 at 17:00 ET

New analytic tool designed to help guide precision oncology discovery and treatments

How can researchers and oncologists glean meaningful information from mounds of data to help guide cancer research and patient care? A new analytic tool developed by University of Michigan Rogel Cancer Center researchers combines multiple data sets t...

– Michigan Medicine - University of Michigan

Journal of Clinical Oncology Clinical Cancer Informatics; CA220299-01A1; CA224065; CA070907-20S1; CA160736; CA194391; CA46592; CA1745486; CA209851...

New Study Confirms Important Clues to Fight Ovarian Cancer

A new study comparing cancerous tissue with normal fallopian tube samples advances important insights about the rogue cellular machinery that drives a majority of ovarian cancers.

– Pacific Northwest National Laboratory

Cell Reports Medicine, April 21, 2020

Cancer Research Institute and IQVIA Uncover the Impact of COVID-19 Pandemic on Global Oncology Clinical Trials

New study reveals impact of COVID-19 pandemic on cancer clinical trials, published in Nature Reviews Drug Discovery

– Cancer Research Institute

Nature Reviews Drug Discovery May 15, 2020.

Roswell Park Team Proposes Strategy for Making Pancreatic Tumors Respond to Checkpoint Inhibition

A possible new strategy for treating pancreatic cancer highlights the promise of collaboration between experts in both precision medicine and immunology. The findings from a team led by Agnieszka Witkiewicz, MD, and Erik Knudsen, PhD, at Roswell Park...

– Roswell Park Comprehensive Cancer Center

Gut; P30CA016056; CA211878

Genome Study Links DNA Changes to the Risks of Specific Breast Cancer Subtypes

An analysis of genetic studies covering 266,000 women has revealed 32 new sites on the human genome where variations in DNA appear to alter the risks of getting breast cancer.

– Johns Hopkins Bloomberg School of Public Health

Nature Genetics

Clinical Trial Offers Clues About Why Some Metastatic Prostate Cancers Don’t Respond to Anti-Androgen Therapy

A multi-institutional clinical trial is shedding new light on the one third of metastatic, castration-resistant prostate cancers that don't respond to enzalutamide and similar drugs.

– Michigan Medicine - University of Michigan

Proceedings of the National Academy of Sciences

Three approved drugs can curb COVID-19 virus replication

Three drugs that are already approved by the Food and Drug Administration (FDA) or other international agencies can block the production of the novel coronavirus that causes COVID-19 in human cells, according to computational and pharmaceutical studi...

– UT Southwestern Medical Center


Moffitt Cancer Center Study Suggests More Could Benefit from CAR T-Cell Therapy

Moffitt Cancer Center organized a consortium of 16 cancer treatment facilities across the U.S. that offer Yescarta as a standard-of-care therapy for patients with relapsed/refractory large B cell lymphoma. They wanted to determine if the safety and e...

– Moffitt Cancer Center

Journal of Clinical Oncology, May-2020

Moffitt Researchers Develop Model to Predict Prostate Cancer Aggressiveness

Researchers in the Center of Excellence for Evolutionary Therapy at Moffitt Cancer Center want to better understand what is happening in the tumor microenvironment to drive prostate cancer to become aggressive and grow rapidly. In a new article publi...

– Moffitt Cancer Center

Nature Ecology & Evolution, May-2020

Ticking time bomb: Malaria parasite has its own inherent clock

The activity of the parasite that causes malaria is driven by the parasite’s own inherent clock, new research led by UT Southwestern scientists suggests.

– UT Southwestern Medical Center


New CAP Guideline Improves Collection, Handling of Lung Specimens

The College of American Pathologists (CAP) released a new evidence- based guideline “Collection and Handling of Thoracic Small Biopsy and Cytology Specimens for Ancillary Studies” to clarify procedures and methods to optimize test outcomes.

– College of American Pathologists (CAP)

Archives of Pathology and Laboratory Medicine

Computer model IDs drug-resistant mutations

To counter drug resistance Penn State engineers have developed a new approach for predicting which mutation has expanded the most in a population and should be targeted to design the most effective new drug.

– National Institute of Biomedical Imaging and Bioengineering

Cell Reports, March-2020; R21EB026617

MSK Kids Study: Children with Cancer are Not at a Higher Risk for COVID-19 Infection or Morbidity

Researches from MSK Kids at Memorial Sloan Kettering Cancer Center (MSK) found that children with cancer are not at a higher risk of being affected by COVID-19.

– Memorial Sloan Kettering Cancer Center

JAMA Oncology

Survey: 60% of Americans Say They Have Gotten Sunburned So Badly Their Clothes Were Uncomfortable

Memorial Day — long considered the unofficial start of summer in the U.S. — is quickly approaching, and dermatologists from the American Academy of Dermatology are urging Americans to practice safe sun as they head outdoors, especially as shelte...

– American Academy of Dermatology

Cancer Experts and Features

New chemotherapy drug studied for malignant brain tumor in children

MTX110 is a new formulation of panobinostat, a chemotherapy drug that has shown promise in laboratory models of medulloblastoma, the most common malignant brain tumor in children. Now, MTX110 is the focus of a novel trial that places the therapy dire...

– University of Texas Health Science Center at Houston

UCLA launches clinical trial to help reduce severity of COVID-19 illness in men

UCLA researchers have launched a new clinical trial that uses a hormone suppresser commonly used to treat men with prostate cancer to help improve clinical outcomes for men infected with COVID-19.

– University of California, Los Angeles (UCLA), Health Sciences

Coping After Breast Cancer

With $3.25 million in new funding from the National Institutes of Health (NIH), a University of Delaware team will examine how the fear of cancer recurrence affects the well-being and relationships of breast cancer patients and their spouses or partn...

– University of Delaware


Creating a Vaccine against COVID-19

David Peabody, PhD, and Bryce Chackerian, PhD, are creating vaccines from particles that are the opposite of Trojan Horses: they look deadly on the outside but are harmless on the inside. Their virus-like particles may rouse the immune system into co...

– University of New Mexico Comprehensive Cancer Center


Are there any Programs for Quitting Tobacco?

For this 2020 World No Tobacco Day, experts from the Rutgers Tobacco Dependence Program discuss New Jersey quit centers and how quitting tobacco can benefit one during cancer treatment.

– Rutgers Cancer Institute of New Jersey

Cancer Announcements

National Comprehensive Cancer Network Annual Conference Sessions Now Free Online

The NCCN 2020 Annual Conference (#NCCN2020) providing the latest updates on cancer treatment recommendations was initially postponed due to COVID-19. The CE-accredited sessions are now available as online webinars.

– National Comprehensive Cancer Network® (NCCN®)

Embargo expired on 18-May-2020 at 08:30 ET

$10 million gift accelerates research to improve cancer therapies, extend benefits to more patients

The David and Etta Jonas Center for Cellular Therapy is being established at the University of Chicago Medicine to accelerate research in hard-to-treat cancers.

– University of Chicago Medical Center

Embargo expired on 18-May-2020 at 09:30 ET

MD Anderson and Innovent Biologics announce a strategic collaboration to develop anti-PD-1 therapy TYVYT® (sintilimab injection) in rare cancers

MD Anderson and Innovent Biologics have announced a strategic collaboration agreement to co-develop Innovent's anti-PD-1 monoclonal antibody for treating rare cancers in the U.S.

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 18-May-2020 at 20:00 ET





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