Acetaminophen, Supplements and Other Medications May Trigger Drug-Induced Liver Injury

AACN Advanced Critical Care journal publishes series on gastrointestinal and liver disease


  • newswise-fullscreen Acetaminophen, Supplements and Other Medications May Trigger Drug-Induced Liver Injury

    Credit: American Association of Critical-Care Nurses

    An article in AACN Advanced Critical Care discusses the clinical impact of drug-induced liver injury and reviews the medications that most frequently cause it.

Newswise — More than 1,000 medications, with acetaminophen being the most common, have been associated with drug-induced liver injury (DILI).

Diagnosis can be challenging due to the multitude of contributing factors, and timely recognition and clinical response may mean the difference between recovery and acute liver failure or even death.

DILI affects an estimated fewer than 10 people in every 10,000 exposed persons. The condition is dose-dependent or an adverse reaction to a medication, dietary supplement or other substance.

An article in the current issue of AACN Advanced Critical Care, “Drug-Induced Liver Injury,” discusses the clinical impact of DILI and reviews the medications that most frequently cause it.

The article is co-authored by Leslie Hamilton, PharmD, BCPS, BCCCP, associate professor of clinical pharmacy in the College of Pharmacy at University of Tennessee Health Science Center, Knoxville; Angela Collins-Yoder, RN, PhD, CCNS, ACNS-BC, clinical professor, University of Alabama Capstone College of Nursing, Tuscaloosa, and critical care nurse specialist, Sacred Heart Pensacola Hospital, Pensacola, Florida; and Rachel E. Collins, BA, Auburn University Harrison School of Pharmacy, Auburn, Alabama.

“The liver helps remove toxins, which makes it especially vulnerable to injury from either short-term intake above recommended levels or long-term usage that allows toxins to build up,” Collins-Yoder said. “Recognizing the clinical signs and symptoms is crucial to prompt treatment and effective patient care.”Depending on the contributing factors and the level of damage to the liver, patients with mild and moderate signs and symptoms may recover normal liver function after the triggering substance is identified and use is discontinued. Other patients may experience more severe damage, progressing to acute liver failure.

About 46 percent of persons with acute liver failure in the United States have liver damage associated with acetaminophen, making it the most common cause of DILI. Since acetaminophen is often an ingredient in over-the-counter and prescription pain medications, patients may take higher doses than needed.

A more infrequent type of DILI is triggered by an adverse reaction to prescription medications, herbal dietary supplements or other substances, including: • Nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, naproxen and others• Antibiotics and antiviral agencies, such as amoxicillin-clavulanate, sulfamethoxazole-trimethoprim and nitrofurantoin• Antileptic agents, such as volproic acid and carbamazepine• Statins• Novel anticoagulants• Proton pump inhibitors• Methotrexate• Azathioprine• Sulfasalazine• Herbal and dietary supplements

The article follows a presentation by the authors at the National Teaching Institute and Critical Care Exposition, the annual conference of the American Association of Critical-Care Nurses (AACN), which publishes the journal.

The article about DILI is part of a symposium collection of articles focusing on gastrointestinal and liver disease in the October-December 2016 issue of the peer-reviewed journal. Other articles in the series: • “Sepsis in Patients With Cirrhosis”• “Acute Liver Failure”• “Cholestatic Liver Injury: Care of Patient With Primary Biliary Cholangitis or Primary Sclerosing Cholangitis”

Symposium editor Amanda Chaney, MSN, ARNP, FNP-BC, is a liver transplant nurse practitioner at Mayo Clinic and assistant professor of medicine at Mayo Clinic College of Medicine, Jacksonville, Florida.

“Clinical management of patients with gastrointestinal and liver disease has advanced significantly in the past 10 years,” she said. “By presenting four different but related disease processes, this series aims to expand the knowledge of critical care nurses and other healthcare providers so they can continue to give excellent patient care.”

AACN Advanced Critical Care is a quarterly, peer-reviewed publication of in-depth articles intended for experienced critical care and acute care clinicians at the bedside, advanced practice nurses, and clinical and academic educators. Each issue includes a topic-based symposium, feature articles and columns of interest to critical and progressive care clinicians. Access the issue by visiting the AACN Advanced Critical Care website at www.aacnadvancedcriticalcare.com.

About AACN Advanced Critical Care: AACN Advanced Critical Care is a quarterly, peer-reviewed publication of in-depth articles intended for experienced critical care and acute care clinicians at the bedside, advanced practice nurses, and clinical and academic educators. An official publication of the American Association of Critical-Care Nurses, the journal has a circulation of 4,845 and can be accessed at http://journals.lww.com/aacnadvancedcriticalcare/pages/default.aspx.

About the American Association of Critical-Care Nurses: Founded in 1969 and based in Aliso Viejo, California, the American Association of Critical-Care Nurses (AACN) is the largest specialty nursing organization in the world. AACN represents the interests of more than half a million acute and critical care nurses and includes more than 225 chapters worldwide. The organization’s vision is to create a healthcare system driven by the needs of patients and their families in which acute and critical care nurses make their optimal contribution. www.aacn.org; facebook.com/aacnface; twitter.com/aacnme

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