Newswise — The Allen Institute has extended its contract with the Coriell Institute for Medical Research for the storage and distribution of its Allen Cell Collection, a cutting-edge collection of gene-edited human induced pluripotent stem cell lines. This collection was launched in 2016 with five cell lines, and since has grown to include more than 40 lines. The new agreement will continue this relationship for an additional three years.
Using CRISPR/Cas9, the cells in this collection have been endogenously tagged with fluorescent proteins, allowing scientists a remarkably clear view inside of a living cell. Each clonal line undergoes extensive quality control, assessing genomic, structural and pluripotency integrity of the cells. The QC data and several methods for utilizing the cells are all publicly available online.
Across the collection of 41 lines, 33 different key cellular structures have been tagged and the collection has expanded to include mono- and bi-allelic edits of the same structure, and dual and triple edited cell lines, highlighting different key structures within the same cell. This collection is ideal for live cell imaging to capture organelle dynamics and function in normal and disease models.
“The Allen Institute has created something very special with its Allen Cell Collection,” said Alissa Resch, PhD, Chief Scientific Officer at Coriell Institute. “Coriell is committed to providing scientists with the high quality cell lines they need to conduct their research and we are thrilled at the opportunity to continue our collaboration on this important collection.”
When the collection launched in 2016, these cell lines were available only to academic researchers. Since that time, availability has been opened to include commercial entities as well.
About the Coriell Institute for Medical Research
Founded in 1953, the Coriell Institute for Medical Research is a nonprofit research institute dedicated to improving human health through biomedical research. Coriell scientists lead research in personalized medicine, cancer biology, epigenetics, and the genomics of opioid use disorder. Coriell also hosts one of the world's leading biobanks—comprised of collections for the National Institutes of Health, disease foundations and private clients—and distributes biological samples and offers research and biobanking services to scientists around the globe. To facilitate drug discovery and disease study, the Institute also develops and distributes collections of induced pluripotent stem cells. For more information, visit Coriell.org.
About the Allen Institute for Cell Science
The Allen Institute for Cell Science, a division of the Allen Institute, an independent, 501(c)(3) nonprofit medical research organization, is dedicated to understanding and modeling human cell behaviors. By integrating technologies, approaches, models and data into a common standardized framework, the Allen Institute for Cell Science is creating dynamic, visual models of how genetic information is transformed into cellular behavior, and how the molecules and organelles within each cell interact and function as collective, integrated systems. These predictive models will enable the cell science community to better understand the role of cells in both health and disease. The Allen Institute for Cell Science was launched in 2014 with a contribution from founder and philanthropist, the late Paul G. Allen. The data, tools and models from the Allen Institute for Cell Science are publicly available online at allencell.org.