Article title: Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b
Authors: Ian Rochford, Jagdish Chandra Joshi, Sheikh Rayees, Mumtaz Anwar, Md Zahid Akhter, Lakshmi Yalagala, Somenath Banerjee, Dolly Mehta
From the authors: “Owing to the pivotal role of PDE4b in monocyte differentiation, we suggest that inhibition of PDE4b in [alveolar macrophages] is a potentially useful approach for the rapid generation of anti-inflammatory [alveolar macrophages] that subsequently prevent or resolve [acute lung injury].”
This study is highlighted as one of October’s “best of the best” as part of the American Physiological Society's APSselect program.
Journal Link: American Journal of Physiology-Lung Cellular and Molecular Physiology