"Body on a Chip" Project Update: Video of Mini Hearts and Livers


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    Credit: Wake Forest Baptist Medical Center

    A confocal image of a cardiac organoid with immunofluorescence showing VEGF (green). This marker indicates that the structure may be becoming vascularized, which allows for better culture health. It also shows the individual cells (blue = nucleus).

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    Credit: Wake Forest Baptist Medical Center

    A light microscopy image of a cardiac organoid shows that it is an aggregate of cells.

Newswise — WINSTON-SALEM, N.C. − April 15, 2015 − As part of a “Body on a Chip” project funded by the Defense Threat Reduction Agency, scientists at Wake Forest Institute for Regenerative Medicine, a part of Wake Forest Baptist Medical Center, in collaboration with partners from around the country, are developing miniature hearts, livers, blood vessels and lungs that will be used to predict the effects of chemical and biologic agents and used to test the effectiveness of potential treatments. The organoids will be connected to a system of micro-fluid channels and sensors to provide online monitoring of individual organoids and the overall organoid system. This approach has the potential to reduce the need for testing in animals, which is expensive, slow and provides results that aren’t always applicable to people. To learn more about the “Body on a Chip” project at Wake Forest Baptist, read the news release that announced the project in 2013: http://www.wakehealth.edu/News-Releases/2013/Wake_Forest_Baptist_Leads_$24_million_Project_to_Develop_“Body_on_a_Chip”.htm

Media contacts: Karen Richardson krchrdsn@wakehealth.edu, 336-716-4453; Mac Ingraham, mingraha@wakehealth.edu, 336-716-3487.Wake Forest Baptist Medical Center (wakehealth.edu) is a fully integrated academic medical center located in Winston-Salem, N.C. The institution comprises Wake Forest School of Medicine, a leading center for medical education and research; Wake Forest Baptist Health, the integrated clinical structure that includes nationally ranked Brenner Children’s Hospital; Wake Forest Innovations, which promotes the commercialization of research discoveries and operates Wake Forest Innovation Quarter, an urban research and technology park; plus a network of affiliated community hospitals, physician practices, outpatient services and other medical facilities. Wake Forest Baptist clinical programs and the School of Medicine are regularly ranked among the best in the country by U.S. News & World Report.

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