Newswise — August 15, 2022For many women who have undergone chemotherapy for breast cancer, cancer-related fatigue (CRF) is a persistent side effect – and one that contributes to ongoing balance problems, suggests a paper in Rehabilitation Oncology, official journal of APTA Oncology, an academy of the American Physical Therapy Association (APTA). The journal is published in the Lippincott portfolio by Wolters Kluwer.

The new research by Stephen Wechsler, PT, DPT, PhD, of MGH Institute of Health Professions, Boston, and colleagues is the first to quantify and compare the relative contribution of CRF to postural instability to that of chemotherapy-induced peripheral neuropathy (CIPN). "Our results...indicate that CRF, even several years following exposure to chemotherapy, may distinctly influence balance independent of a patient's CIPN status," the researchers write.

CRF predicts greater postural sway and changes in 'sit-to-stand' function

Following breast cancer treatment, many patients experience physical or functional limitations, including balance problems and an increased risk of falls. These balance problems are often attributed to CIPN: nerve damage that frequently occurs as an adverse effect of cancer chemotherapy. However, recent studies have suggested that CRF – another common side effect of cancer and its treatment – may also contribute to balance problems.

To examine the relationship between CRF and postural instability, Dr. Wechsler and colleagues analyzed data on 43 women who had undergone chemotherapy for breast cancer. Patients were studied an average of 3.5 years after cancer treatment. Consistent with the high reported frequency of CRF, average score for fatigue was 43 on a 0-to-100 scale, with higher scores indicating greater fatigue. More than half of the women (53.5%) had at least mild CIPN symptoms.

Participants underwent a series of standardized assessments of balance function. In a static (standing still) balance test, women with higher CRF scores had increased anteroposterior (front to back) postural sway. After adjustment for other factors, CRF score accounted for about 10% of the variation in postural sway compared to the 1% accounted for by CIPN.

Women with more severe CRF also had increased postural sway after a brief exercise task. In both tests, postural sway was not significantly related to the severity of CIPN.

Further tests evaluated the effects of CRF on dynamic balance during a standard sit-to-stand test – a key measure of physical functioning and a predictor of the risk of falling. In this test, after a fatiguing exercise targeting the muscles of the lower extremities, CRF accounted for nearly 7% of the variance in postural sway compared to the 3% accounted for by CIPN.

After exercise, participants with greater CRF showed "smaller, more conservative" forward shifts in body weight during the sit-to-stand test. That pattern is consistent with a "stabilization strategy" commonly seen in individuals with balance problems. Dr. Wechsler and colleagues note that the stabilization strategy is suggestive of impaired postural control as it relies more on lower leg strength, compared to the "momentum transfer" strategy observed in people with better balance function.

Impacts of cancer-related fatigue

The researchers discuss several clinical implications of their findings – most notably, that a lower-extremity-fatiguing task may cause or exacerbate impairments in dynamic balance among survivors with CRF. Survivors may encounter such fatiguing tasks in everyday life through performing activities of daily living, negotiating stairs or the community, or participating in a recommended exercise program.

The report adds to recent studies suggesting that CRF after chemotherapy and other treatments may contribute to balance problems and risk of falls in breast cancer survivors. "While CIPN remains a risk factor for imbalance in this population, CRF warrants consideration in clinical practice and research as a mechanism of postural instability," Dr. Wechsler and coauthors conclude.

The findings may have implications for rehabilitation professionals making exercise prescriptions for cancer survivors – particularly in terms of improving dynamic balance to reduce the risk of falls. In particular, patients with CRF after cancer treatment "may benefit from balance-related education regarding safety and coping or compensatory strategies," the researchers add.

Click here to read “Persistent Cancer-Related Fatigue After Breast Cancer Treatment Predicts Postural Sway and Postexertional Changes in Sit-to-Stand Strategy“

DOI: 10.1097/01.REO.0000000000000308


About Rehabilitation Oncology Rehabilitation Oncology is the official quarterly publication of APTA Oncology, an academy of the American Physical Therapy Association. The journal is the primary peer-reviewed, indexed resource for advancing oncologic physical therapy practice and cancer rehabilitation through the dissemination of definitive evidence, translation of clinically relevant knowledge, and integration of theory into education, practice, and research.

About APTA Oncology

APTA Oncology consists of physical therapists, physical therapist assistants, student physical therapists, and student physical therapist assistants managing the musculoskeletal, neuromuscular, integumentary and cardiopulmonary rehabilitative needs of patients living with and beyond cancer and other chronic illnesses including HIV. This encompasses acute secondary sequelae of treatments such as surgery, radiation therapy, chemotherapy, and immunotherapy as well as long-term secondary sequelae of treatments and palliative care.

About Wolters Kluwer

Wolters Kluwer (WKL) is a global leader in professional information, software solutions, and services for the clinicians, nurses, accountants, lawyers, and tax, finance, audit, risk, compliance, and regulatory sectors. We help our customers make critical decisions every day by providing expert solutions that combine deep domain knowledge with advanced technology and services.

Wolters Kluwer reported 2021 annual revenues of €4.8 billion. The group serves customers in over 180 countries, maintains operations in over 40 countries, and employs approximately 19,800 people worldwide. The company is headquartered in Alphen aan den Rijn, the Netherlands.

Wolters Kluwer provides trusted clinical technology and evidence-based solutions that engage clinicians, patients, researchers and students in effective decision-making and outcomes across healthcare. We support clinical effectiveness, learning and research, clinical surveillance and compliance, as well as data solutions. For more information about our solutions, visit and follow us on LinkedIn and Twitter @WKHealth.

For more information, visit, follow us on Twitter, Facebook, LinkedIn, and YouTube.

Journal Link: Rehabilitation Oncology