University of Michigan Sleep Expert Research Highlights at #SLEEP2023Michigan Medicine - University of Michigan
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai in May 2023.
This study provides provides the first physiological evidence from inside the human brain supporting the dominant scientific theory on how the brain consolidates memory during sleep. Further, deep-brain stimulation during a critical time in the sleep cycle appeared to improve memory consolidation.
Experts available on the correlation between binge watching television and dementia later in life
Studies have shown that sleep apnea is related to an increased risk of dementia. A new study looks at the relationship between sleep apnea and brain volume. The study is published in the May 31, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A biomarker is a characteristic that can be measured and evaluated as an indicator of normal biological processes, pathogenetic processes, or pharmacologic responses to a therapeutic intervention. In the context of Alzheimer’s disease (AD), an AD biomarker indicates the presence or progression of the disease that may be altered by drug treatment, thereby demonstrating that it is hitting its target. Today, all clinical trials for Alzheimer’s disease utilize biomarkers of some form to assess whether the drug is actually affecting the disease in the brain.
The Lewis Katz School of Medicine created the Alzheimer’s Center at Temple from funds donated by Board of Trustees member Phil Richards earlier this month. Richards’s gift created the center and established the Scott Richards North Star Charitable Foundation Chair for Alzheimer’s Research.
Did you know that music might be able to connect you with your family members affected by Alzheimer's disease (AD) in a way that words cannot? Many studies have shown that music can evoke a response or a memory in people with Alzheimer's Disease.
The risk of side effects can rise if drugs are taken for conditions other than Alzheimer's disease (AD) treatment. Some sedatives and antidepressants can deteriorate cognitive function, make people drowsy and confused, and worsen cognitive impairment, which increases the risk of falls.
Alzheimer-like changes – marked by the build-up of harmful amyloid and tau proteins – occur in the brain in Down syndrome has been unclear. But now, in new research, scientists at the Lewis Katz School of Medicine at Temple University show that reduced efficiency of a key protein transport system is partly to blame.
Diagnosing Alzheimer's disease (AD) is a complex process that doesn't rely on a single test.
Alzheimer's disease is the most common form of dementia in the elderly. Memory loss and difficulty thinking worsen progressively, with some patients eventually becoming delusional, disoriented, and vulnerable to mood swings and depression. Finding ways to slow or reverse this progression, or even prevent symptoms from developing in the first place, are major goals in Alzheimer's research.
People may endure cognitive changes as they get older, including forgetfulness and a loss of their capacity for multitasking or concentration. Although these changes are typical, they can be upsetting for elderly people.
Alzheimer's disease is a debilitating condition that affects millions of people around the world, but there is also a lot of misinformation about it. One of the most common myths is that memory loss is a natural part of aging.
According to the newly released “Alzheimer’s Disease Drug Development Pipeline: 2023,” there are currently 187 clinical trials in the Alzheimer’s drug development pipeline – the most ever on record. This momentum is driven in part by greater investment from the pharma industry and a bump in biologic therapies – particularly monoclonal antibodies – that were central to the success of both recent FDA-approved drugs. The annual report spots trends in clinical trial design and outcome measures, and also investigate the types of agents and biological targets that are being pursued.
What special considerations must physicians make when managing epilepsy in older adults? Who is considered an “older adult,” anyway? Dr. Anca Arbune interviews two authors of a recent critical review by an ILAE task force.
People with a genetic predisposition for Alzheimer’s disease may have an increased risk of epilepsy and people with a certain type of epilepsy may have an increased risk of developing Alzheimer’s disease, according to a study published in the May 24, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A University of California, Irvine-led team of researchers have discovered that the oldest-old, those who live to be 90+ and have superior cognitive skills, have similar levels of brain pathology as Alzheimer’s patients, however, they also have less brain pathology of other neurodegenerative diseases that cause memory and thinking problems.
In a noteworthy case study published in the Journal of Alzheimer’s Disease investigators report autopsy findings in a 65-year-old woman with Alzheimer’s disease (AD) who received three open label infusions of the experimental anti-amyloid beta (Aβ) antibody drug lecanemab.
Chunyu Wang, Ph.D., professor of biological sciences at Rensselaer Polytechnic Institute, has added to his body of research on Alzheimer’s disease with significant findings in Angewandte Chemie.Together with his team, which includes first author and Rensselaer doctoral student Dylan Mah, Wang performed the most comprehensive study to date of the interactions between ApoE, or Apolipoprotein E, and heparan sulfate (HS).
Scientists at Wake Forest University School of Medicine have uncovered a novel mechanism that shows increased sugar intake and elevations in blood glucose are sufficient to cause amyloid plaque buildup in the brain, which increases the risk of Alzheimer’s disease.
Blood vessel abnormalities in the eye are a major factor in the progression of Alzheimer’s disease, according to research from Cedars-Sinai investigators published in the peer-reviewed journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association.
Surviving a stroke can bring many long-term effects – including a much higher risk of dementia. But a study suggests that blood sugar may play a key role in that risk.
Impairments in the lymphatic system may contribute to brain diseases, such as neurodegenerative diseases and stroke. Researchers have found a noninvasive and nonpharmaceutical method to influence glymphatic transport using focused ultrasound, opening the opportunity to use the method to further study brain diseases and brain function.
A recent study published in Nature Neuroscience indicates that, contrary to common belief, the immune cells of the brain, known as microglia, are not all the same.
An increased risk of depression and anxiety among US older adults with dementia and poor activity participation has been demonstrated through an analysis of data from the National Health and Aging Trends Study (NHATS), a nationally representative population-based study.
UNLV study pinpoints 10 bacterial groups associated with Alzheimer’s disease, provides new insights into the relationship between gut makeup and dementia.
The anti-dementia medication lecanemab and its ancillary costs could add $2 billion to $5 billion in annual Medicare spending if the Centers for Medicare and Medicaid Services (CMS) revise their coverage decision. Currently, the medication is covered only for patients who are enrolled in clinical trials.
Researchers from the University of California, Irvine have found that exposure to traffic-related air pollution in Irvine led to memory loss and cognitive decline and triggered neurological pathways associated with the onset of Alzheimer’s disease.
Proteins tend to fold wrongly and become defective when exposed to stressors such as heat, oxidation, and pH changes. Accumulation of abnormal proteins contributes to neurodegenerative diseases like Alzheimer’s.
May is Mental Health Awareness Month. Get your mental health news here.
People who have sleep apnea and spend less time in deep sleep may be more likely to have brain biomarkers that have been linked to an increased risk of stroke, Alzheimer’s disease and cognitive decline, according to new research published in the May 10, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study does not prove that these sleep disturbances cause the changes in the brain, or vice versa. It only shows an association.
In medicine and science, the term “pathogenesis” describes the origin and development of disease. There is not, however, a broadly accepted term to describe the other half of the equation: the process of healing and recovery.
Efforts are underway to address the “epidemic of loneliness and isolation” affecting the country, as recently addressed by the U.S. Surgeon General Dr. Vivek Murthy who is laying out a “National Strategy to Advance Social Connection” initiative. Virginia Tech neuroscientist Georgia Hodes says that reports of depression and anxiety are up at least 3-fold since the start of the COVID epidemic.
During the course of Alzheimer's disease, protein fibrils appear in the spinal fluid of affected individuals. Empa researchers, together with the Department of Neurology at the Cantonal Hospital in St. Gallen, have now visualized the wide spectrum of protein aggregates from oligomers, protofibrils to fibrils in the spinal fluid.
Findings reveal a previously unknown way in which the brain and immune system talk to each other and may identify a new therapeutic target for MS and other brain disorders.
University of Minnesota Twin Cities researchers have developed a groundbreaking new diagnostic technique that will allow for faster and more accurate detection of neurodegenerative diseases that affect humans, such as Alzheimer's and Parkinson's, and similar diseases that affect animals, such as chronic wasting disease (CWD) and mad cow disease.
Football players who have had repetitive head trauma and concussion are at heightened risk for chronic traumatic encephalopathy (CTE), an irreversible condition that leads to dementia. But not every case of cognitive decline means CTE.
A team lead by Prof. Harald Steiner and Dr. Edgar Dawkins from the Biomedical Center Munich at LMU has now shown that the production of amyloid-β is influenced by the membrane thickness.
In honor of Mother’s Day, American Greetings and the Women’s Alzheimer’s Movement at Cleveland Clinic have partnered to encourage the celebration of women everywhere and raise critical research funds in the process.
A new study by NYU School of Global Health published in the Journal of the American Geriatrics Society reports that regular Internet usage was associated with approximately half the risk of dementia compared to non-regular usage.
UC San Diego researchers describe how exposure to ambient air pollution, such as car exhaust and power plant emissions — is associated with a measurably greater risk of developing dementia over time.
Stress causes the levels of Alzheimer's proteins to rise in females' brains but not males' brains, according to a new study in mice by researchers at Washington University School of Medicine in St. Louis. This difference may contribute to women's greater risk of developing Alzheimer's disease.
This agreement will enable FAU and Insightec to collaborate to advance scientific knowledge about the use of focused ultrasound to treat brain diseases, including Parkinson’s disease and Alzheimer’s disease. By harnessing acoustic energy, Insightec’s innovative technology uses focused ultrasound to treat diseases in different ways.
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai for April 2023.
Dogs with dementia suffer the same sleep disruptions that humans with dementia do.
The April 2023 issue of SLAS Technology contains four original research articles and one technical brief covering the development of robotic systems, ultrasound frequency sonification, automated algorithm development and other laboratory automation technology.
Researchers identify a protein that may allow some people to resist Alzheimer’s dementia despite amyloid beta plaque accumulation