Feature Channels: Alzheimer's and Dementia

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Released: 9-Jul-2020 11:45 AM EDT
Gene yields insights into the causes of neurodegeneration
Cornell University

Cornell researchers including Fenghua Hu, associate professor in the Department of Molecular Biology and Genetics and member of the Weill Institute for Cell and Molecular Biology, are taking a closer look at the factors that cause Alzheimer’s, FTLD and similar diseases. Hu’s latest study, “A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination,” was published June 23 in the journal Brain.

Newswise: University of Miami Miller School Plays Pivotal Role in Securing a $15 Million National Alzheimer’s Disease Research Center
Released: 7-Jul-2020 1:55 PM EDT
University of Miami Miller School Plays Pivotal Role in Securing a $15 Million National Alzheimer’s Disease Research Center
University of Miami Health System, Miller School of Medicine

University of Miami Miller School of Medicine investigators play a pivotal role in a consortium of Florida institutions just awarded a $15 million grant to collaborate on Alzheimer’s disease research. The five-year National Institutes of Health/National Institute on Aging grant brings together top Florida researchers to focus on better understanding how to diagnose, treat, prevent, and potentially cure Alzheimer’s in diverse populations.

26-Jun-2020 1:30 PM EDT
Does Deep Brain Stimulation for Parkinson’s Increase Risk of Dementia?
American Academy of Neurology (AAN)

There’s good news for people with Parkinson’s disease. A new study shows that deep brain stimulation may not increase the risk of developing dementia. The study is published in the July 1, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Released: 1-Jul-2020 3:35 PM EDT
Study shows asthma drug salbutamol's potential as Alzheimer's treatment
Lancaster University

A new study reveals that the common asthma drug salbutamol may offer potential as a treatment for Alzheimer's disease.

Newswise: Case Western Reserve University-led team develops new approach to treat certain neurological diseases
29-Jun-2020 7:20 PM EDT
Case Western Reserve University-led team develops new approach to treat certain neurological diseases
Case Western Reserve University

A team led by Case Western Reserve University medical researchers has developed a potential treatment method for Pelizaeus-Merzbacher disease (PMD), a fatal neurological disorder that produces severe movement, motor and cognitive dysfunction in children. It results from genetic mutations that prevent the body from properly making myelin, the protective insulation around nerve cells.

Released: 30-Jun-2020 10:25 AM EDT
Older adults share fewer memories as they age
University of Arizona

By the time people reach a certain age, they've accumulated enough life experience to have plenty of stories to tell about life "back in their day."

Released: 30-Jun-2020 7:55 AM EDT
Novel pathology could improve diagnosis and treatment of Huntington’s and other diseases
University of Bristol

Bristol scientists have discovered a novel pathology that occurs in several human neurodegenerative diseases, including Huntington’s disease. The article, published in Brain Pathology, describes how SAFB1 expression occurs in both spinocerebellar ataxias and Huntington's disease and may be a common marker of these conditions, which have a similar genetic background.

Released: 26-Jun-2020 10:35 AM EDT
It’s not just Alzheimer’s disease: Sanders-Brown research highlights form of severe dementia
University of Kentucky

The long-running study on aging and brain health at the University of Kentucky’s Sanders-Brown Center on Aging Alzheimer’s Disease Center has once again resulted in important new findings – highlighting a complex and under-recognized form of dementia.

19-Jun-2020 1:30 PM EDT
Why Do More Women Have Alzheimer’s than Men? It’s Not Just from Living Longer
American Academy of Neurology (AAN)

Middle-aged women are more likely than men to have changes in the brain related to Alzheimer’s disease, as detected by imaging, even when there are no differences in thinking and memory. This may be associated with hormonal changes due to menopause, specifically the loss of estrogen, according to a study published in the June 24, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Newswise: Blood Vessel Defects in Eyes May Foretell Alzheimer’s
Released: 23-Jun-2020 7:55 PM EDT
Blood Vessel Defects in Eyes May Foretell Alzheimer’s
Cedars-Sinai

Alzheimer's disease in its early stages affects the integrity of small blood vessels in the retinas of patients, according to a recent study led by Cedars-Sinai. This discovery holds promise for early diagnosis of Alzheimer's through the retina, a back-of-the-eye organ that is an extension of the brain and easily accessible for live, noninvasive imaging.

Newswise: UTEP Researchers Uncover New Brain Mechanisms in Fruit Flies That May Impact Future Learning
Released: 23-Jun-2020 7:50 PM EDT
UTEP Researchers Uncover New Brain Mechanisms in Fruit Flies That May Impact Future Learning
University of Texas at El Paso

A research team from The University of Texas at El Paso has made strides in understanding how memories are formed through the brain mechanisms of fruit flies. Their findings could enhance our understanding of brain disorders such as post-traumatic stress disorder and substance addiction.

16-Jun-2020 12:00 PM EDT
Star-Shaped Brain Cells May Play a Critical Role in Glaucoma
NYU Langone Health

After a brain injury, cells that normally nourish nerves may actually kill them instead, a new study in rodents finds. This “reactive” phenomenon may be the driving factor behind neurodegenerative diseases like glaucoma, a leading cause of blindness.

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Released: 19-Jun-2020 9:45 AM EDT
Researcher’s work a step toward “playlist” for testing neurological disorders
Missouri University of Science and Technology

Psychologists and medical researchers for years have used familiar tunes to study brain disorders such as Alzheimer’s disease and dementia, but they’ve never had a common set of songs to draw from. A new study by a neuroscientist at Missouri S&T may give those researchers a list of “greatest hits” to aid in their future studies.

Newswise: FSU researchers uncover new insights into Alzheimer’s disease
Released: 17-Jun-2020 4:55 PM EDT
FSU researchers uncover new insights into Alzheimer’s disease
Florida State University

Florida State researchers looked at memory replay in mouse models and found there was impaired functional interactions between the hippocampus and the parietal cortex.

Newswise: FAU Medicine Ushers in New Research Phase to Prevent Dementia
Released: 17-Jun-2020 8:30 AM EDT
FAU Medicine Ushers in New Research Phase to Prevent Dementia
Florida Atlantic University

FAU’s Schmidt College of Medicine and The Harry T. Mangurian, Jr. Foundation have joined forces again to usher in a new phase of research to prevent dementia. The extension of a three-year, $3 million grant from the foundation will launch the new FAU Center for Brain Health. The grant supports precision medicine approaches to prevent dementia, which will be further strengthened by leveraging multiple patient-centered platforms through state-of-the-art transdisciplinary approaches.

Released: 15-Jun-2020 2:30 PM EDT
Longitudinal Study of Brain Aging and Cognitive Change Receives $19 Million Grant
University of California San Diego Health

Researchers at UC San Diego School of Medicine, with colleagues elsewhere, will receive almost $19 million over five years for the fourth phase of the Vietnam Era Twin Study of Aging, which investigates cognition, aging and the risk for mild cognitive impairment and Alzheimer’s disease.

Newswise: New UNLV Center Advances Global Fight Against Journal of Geophysical Research: Planets
Released: 15-Jun-2020 10:55 AM EDT
New UNLV Center Advances Global Fight Against Journal of Geophysical Research: Planets
University of Nevada, Las Vegas (UNLV)

The UNLV department of brain health has formally launched the Chambers-Grundy Center for Transformative Neuroscience, offering hope through scientific discovery for patients who are suffering from Alzheimer’s, dementia and other brain and neurological diseases. The Center is the latest in a series of milestones from the department of brain health and the School of Integrated Health Sciences to better understand how a healthy brain functions, to improve care and treatment of people with brain diseases, and to identify mechanisms of brain disorders.

Newswise: UTEP Researchers Help Pave Path for Biofriendly Materials to Aid Drug Design Delivery for Neurodegenerative Disorders
Released: 5-Jun-2020 12:05 PM EDT
UTEP Researchers Help Pave Path for Biofriendly Materials to Aid Drug Design Delivery for Neurodegenerative Disorders
University of Texas at El Paso

The contributions of researchers from The University of Texas at El Paso (UTEP) have yielded the first indication that carbon quantum dots, a class of nanoparticles, can be utilized to combat neurological disorders.

Newswise: New study reveals areas of brain where recognition and identification occur
Released: 4-Jun-2020 12:05 PM EDT
New study reveals areas of brain where recognition and identification occur
University of Texas Health Science Center at Houston

Using “sub-millimeter” brain implants, researchers at The University of Texas Health Science Center at Houston (UTHealth), have been able to determine which parts of the brain are linked to facial and scene recognition.

27-May-2020 9:25 AM EDT
Nilotinib Appears Safe and Affects Biomarkers In Alzheimer’s Disease Clinical Trial
Georgetown University Medical Center

A Georgetown University Medical Center clinical trial investigating the cancer drug nilotinib in people with Alzheimer’s disease finds that it is safe and well-tolerated, and researchers say the drug should be tested in a larger study to further determine its safety and efficacy as a potential disease-modifying strategy.

Released: 26-May-2020 7:30 PM EDT
Dementia gene raises risk of severe COVID-19
University of Exeter

Having a faulty gene linked to dementia doubles the risk of developing severe COVID-19, according to a large-scale study.

19-May-2020 11:05 AM EDT
Blood Test May Help Predict Whose MS Will Get Worse
American Academy of Neurology (AAN)

A blood test may help predict which people with multiple sclerosis (MS) will get worse during the following year, according to a study published in the May 20, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Newswise: Exercise improves memory, boosts blood flow to brain
18-May-2020 10:55 AM EDT
Exercise improves memory, boosts blood flow to brain
UT Southwestern Medical Center

Scientists have collected plenty of evidence linking exercise to brain health, with some research suggesting fitness may even improve memory. But what happens during exercise to trigger these benefits?

Newswise: Protein Shapes Matter in Alzheimer's Research
Released: 19-May-2020 3:10 PM EDT
Protein Shapes Matter in Alzheimer's Research
Michigan Technological University

Even small changes may have big, long-term consequences. For amyloid beta peptides, a major hallmark of Alzheimer’s disease, a common chemical modification at a particular location on the molecule has a butterfly effect that leads to protein misfolding, aggregation and cellular toxicity.

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Released: 18-May-2020 12:45 PM EDT
Study finds that aging neurons accumulate DNA damage
Massachusetts Institute of Technology (MIT)

MIT neuroscientists have discovered that an enzyme called HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions.

Released: 13-May-2020 3:05 PM EDT
New imaging tool helps researchers see extent of Alzheimer's early damage
Yale University

New imaging technology allows scientists to see the widespread loss of brain synapses in early stages of Alzheimer's disease, a finding that one day may help aid in drug development, according to a new Yale University study.

Newswise: Interdisciplinary research team awarded $3.8M to study molecular changes in the brain caused by Alzheimer’s disease
Released: 12-May-2020 1:20 PM EDT
Interdisciplinary research team awarded $3.8M to study molecular changes in the brain caused by Alzheimer’s disease
University of California, Irvine

A team of researchers from the University of California, Irvine and San Diego have been awarded $3.8 million by the National Institute on Aging to conduct an epigenomic analysis of neural circuits in the brain. By revealing molecular changes that occur during the course of Alzheimer’s disease (AD), the team hopes to identify new therapeutic targets and molecular biomarkers for early detection and better treatment.

Newswise: 3D brain-like tissue model links Alzheimer’s disease with herpes
4-May-2020 8:30 AM EDT
3D brain-like tissue model links Alzheimer’s disease with herpes
Tufts University

Scientists used a 3D human tissue culture model mimicking the components and conditions in the brain to demonstrate a possible causal relationship between Alzheimer’s disease and herpes simplex virus I infection (HSV-1). The model will allow further studies into the causes and possible treatments of this devastating neurodegenerative condition.

Newswise: More Berries, Apples and Tea May Have Protective Benefits Against Alzheimer’s
Released: 5-May-2020 9:00 AM EDT
More Berries, Apples and Tea May Have Protective Benefits Against Alzheimer’s
Tufts University

Older adults with low intake of foods and drinks containing flavonoids, such as berries, apples, and tea, were more likely to develop Alzheimer’s disease and related dementias over 20 years, compared with people who consumed more of those items, according to a new study.

Newswise: Nanodevices for the brain could thwart formation of Alzheimer’s plaques
Released: 30-Apr-2020 9:05 AM EDT
Nanodevices for the brain could thwart formation of Alzheimer’s plaques
Argonne National Laboratory

Researchers designed a nanodevice with the potential to prevent peptides from forming dangerous plaques in the brain in order to halt development of Alzheimer’s disease.

Newswise: Research News Tip Sheet: Story Ideas From Johns Hopkins
Released: 30-Apr-2020 8:00 AM EDT
Research News Tip Sheet: Story Ideas From Johns Hopkins
Johns Hopkins Medicine

During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every Tuesday throughout the duration of the outbreak.

Released: 27-Apr-2020 9:00 AM EDT
Reducing Early Brain Inflammation Could Slow Alzheimer’s Progression
Federation of American Societies for Experimental Biology (FASEB)

In a new animal study examining Alzheimer’s disease, researchers found that disease progression could be slowed by decreasing neuroinflammation in the brain before memory problems and cognitive impairment were apparent.

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AUDIO
Released: 24-Apr-2020 3:05 PM EDT
A Silent Epidemic
Harvard Medical School

After years of progress, geriatrician Sharon Inouye worries that hard-won best practices for reducing delirium risk are getting lost in the turmoil of COVID-19 care.

20-Apr-2020 5:35 PM EDT
Which Foods Do You Eat Together? How You Combine Them May Raise Dementia Risk
American Academy of Neurology (AAN)

It’s no secret that a healthy diet may benefit the brain. However, it may not only be what foods you eat, but what foods you eat together that may be associated with your risk of dementia, according to a new study published in the April 22, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Released: 16-Apr-2020 8:35 AM EDT
أظهرت الدراسة أن المتغيرات الجينية قد تزيد من قابلية تراكم بروتين داء الزهايمر تاو
Mayo Clinic

يُعدُّ بروتين تاو السام سمة بيولوجية أساسية في أدمغة الأشخاص المصابين بداء الزهايمر. ومع ذلك، فإن العوامل التي تجعل الناس عُرضة أو مقاومة لتراكم بروتين تاو ليست مفهومة تمامًا. أظهرت دراسة أولية أجرتها مايو كلينك (Mayo Clinic) أن متغيرات الحمض النووي الوراثيقد يأتي معها نمو ترسُّبات بروتين تاو لدى البالغين الأكبر سنًّا. سيُقدم البحث في الاجتماع السنوي رقم 72 للأكاديمية الأمريكية لطب الأعصاب في تورونتو في الفترة من 25 أبريل/نيسان إلى 1 مايو/أيار

Released: 16-Apr-2020 8:35 AM EDT
Estudo mostra que as variantes genéticas podem aumentar a suscetibilidade para acumular a proteína tau do Alzheimer
Mayo Clinic

A proteína tóxica tau é uma característica essencial biológica no cérebro de pessoas com a doença de Alzheimer. No entanto, os fatores que tornam as pessoas suscetíveis ou resistentes ao acúmulo de tau não são bem compreendidos.

Released: 16-Apr-2020 8:30 AM EDT
研究显示,基因变异可能会增加阿尔茨海默病蛋白tau累积的易感性
Mayo Clinic

有毒蛋白tau是阿尔茨海默病患者大脑中的一个关键生物学特征。然而,使人对tau累积产生易感性或抵抗性的因素目前尚未明确。Mayo Clinic的一项初步研究表明,遗传的DNA变异可能与老年人出现的tau累积有关。这项研究将在4月25日至5月1日在多伦多举行的美国神经病学学会第72届年会上公开发表。

Released: 14-Apr-2020 10:00 AM EDT
Does Long-Term Exposure to Air Pollution Lead to a Steeper Rate of Cognitive Decline?
American Academy of Neurology (AAN)

People who live in urban areas with higher levels of air pollution may score lower on thinking and memory tests and may also lose cognitive skills faster over time, or it is possible they also may not, according to a study published in the April 8, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Released: 9-Apr-2020 1:35 PM EDT
University of Kentucky Researcher Leads First Human Study of Drug Targeting Brain Inflammation
University of Kentucky

A study examining MW189 in healthy adult volunteers was performed by a collaborative team from the University of Kentucky, Duke University and Northwestern University. The work by Van Eldik and the rest of the team is substantial as it is the first time MW189 had been tested in humans.

Newswise: Tips for Homebound Caregivers Coping with 
Alzheimer’s and Other Dementias during the COVID-19 Pandemic
Released: 9-Apr-2020 8:30 AM EDT
Tips for Homebound Caregivers Coping with Alzheimer’s and Other Dementias during the COVID-19 Pandemic
Florida Atlantic University

Researchers from FAU's Christine E. Lynn College of Nursing provide several coping and care strategies for caregivers to help sustain their health as well as the health of those in their care during the quarantine associated with COVID-19.

Newswise: UCI-led study finds modifiable risk factors could play a role in Alzheimer’s disease
Released: 8-Apr-2020 1:05 PM EDT
UCI-led study finds modifiable risk factors could play a role in Alzheimer’s disease
University of California, Irvine

Amyloid is a key feature of Alzheimer’s disease, but the accumulation of these sticky proteins may not be the only risk factor for developing Alzheimer’s disease, according to a new study published this week. Other, modifiable risk factors, such as the amount of fats in our blood and how efficiently our bodies generate energy could also play important roles.

Newswise: Brain discovery suggests source of lifelong behavioral issues
Released: 8-Apr-2020 12:25 PM EDT
Brain discovery suggests source of lifelong behavioral issues
University of Virginia Health System

Improper removal of faulty brain cells during neurodevelopment may cause lifelong behavioral issues, new research from the University of Virginia School of Medicine suggests. The finding also could have important implications for a wide range of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s.

Released: 7-Apr-2020 8:05 AM EDT
How to Help Loved Ones with Dementia Cope During COVID-19
Rutgers University-New Brunswick

The COVID-19 pandemic and resulting social isolation present unique challenges for more than five million Americans living with Alzheimer’s disease and their caregivers. Monica Townsend, training and consultation specialist at the Comprehensive Services on Aging at Rutgers University Behavioral Health Care, shares how caregivers can cope through the health crisis:

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Released: 1-Apr-2020 12:40 PM EDT
Caring for elderly people in the age of COVID-19
Texas State University

When Dr. Christopher Johnson, clinical professor of sociology at Texas State University, is asked about the global spread of the COVID-19 pandemic, he says: “The biggest threat to older people right now is younger people. Younger people can be carriers (of COVID-19) to older people and those with auto immune diseases.”

Released: 31-Mar-2020 8:15 AM EDT
Discovery of new biomarker in blood could lead to early test for Alzheimer’s disease
University of California San Diego

UC San Diego researchers discovered that high blood levels of RNA produced by the PHGDH gene could serve as a biomarker for early detection of Alzheimer’s disease. The work could lead to the development of a blood test to identify individuals who will develop the disease years before they show symptoms.

25-Mar-2020 9:00 AM EDT
Better controlled diabetes is associated with preserved cognitive function following stroke
Endocrine Society

Better glucose control can help people with diabetes who have a common type of stroke to preserve their cognitive function, according to a study accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting. The abstract will be published in a special supplemental issue of the Journal of the Endocrine Society.


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