Feature Channels: Alzheimer's and Dementia

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Released: 23-Jun-2021 4:35 PM EDT
Nurturing an early interest in neuroscience
University of California, Irvine

Last year’s lockdowns confined most people to their homes. For teenagers on summer break, a season usually dedicated to recreation and outdoor exploration, this meant long days of boredom. But for Nikhita Kaushik, who just finished her sophomore year at Irvine’s Arnold O. Beckman High School, the free time was a blessing. It enabled her to dive into her passion for neuroscience and establish the Southern California Youth Neuroscience Association.

Newswise: The Medical Minute: Making healthy choices may reduce Alzheimer’s risk
Released: 23-Jun-2021 4:30 PM EDT
The Medical Minute: Making healthy choices may reduce Alzheimer’s risk
Penn State Health

Research suggests that changes in lifestyle may affect the risk for dementia. Dr. Chen Zhao discusses how changes such as increased physical activity could reduce the risk for dementia.

Released: 23-Jun-2021 1:50 PM EDT
More Seniors May Have Undiagnosed Dementia Than Previously Thought
University of Michigan

Only 1 in 10 older adults in a large national survey who were found to have cognitive impairment consistent with dementia reported a formal medical diagnosis of the condition.

Released: 22-Jun-2021 10:05 AM EDT
Self-Reported Declines in Cognition May be Linked to Changes in Brain Connectivity
Wayne State University Division of Research

A team from Wayne State University recently published the results of a three-year study of cognitive changes in older adults who complained that their cognitive ability was worsening though clinical assessments showed no impairments. MRIs at 18-month intervals showed significant changes in functional connectivity in two areas of the brain.

Newswise: Protein Linked to Heart Health, Disease a Potential Therapeutic Target for Dementia
18-Jun-2021 1:25 PM EDT
Protein Linked to Heart Health, Disease a Potential Therapeutic Target for Dementia
Washington University in St. Louis

Researchers at Washington University School of Medicine in St. Louis have found that high levels of a normal protein associated with reduced heart disease also protect against Alzheimer’s-like damage in mice, opening up new approaches to slowing or stopping brain damage and cognitive decline in people with Alzheimer’s.

Newswise: Investigational Alzheimer’s Drug Improves Biomarkers of the Disease
18-Jun-2021 1:50 PM EDT
Investigational Alzheimer’s Drug Improves Biomarkers of the Disease
Washington University in St. Louis

An ongoing international Alzheimer's clinical trial has found that one drug, gantenerumab, improved biomarkers of disease despite unclear cognitive effects, prompting study leaders to offer participants the option of continuing to receive the drug and participate in follow-up examinations as part of a so-called open label extension.

Newswise: The MedWalk Diet: A Step Closer to Walking Away From Dementia
Released: 21-Jun-2021 5:30 AM EDT
The MedWalk Diet: A Step Closer to Walking Away From Dementia
University of South Australia

It’s been named the world’s best diet for weight loss, but now researchers at the University of South Australia are confident that the Mediterranean Diet – combined with a daily bout of exercise – can also stave off dementia, slowing the decline in brain function that is commonly associated with older age.

Newswise: Will Reduction in Tau Protein Protect Against Parkinson’s and Lewy Body Dementias?
Released: 18-Jun-2021 11:55 AM EDT
Will Reduction in Tau Protein Protect Against Parkinson’s and Lewy Body Dementias?
University of Alabama at Birmingham

A study suggests that reducing tau protein in brain neurons will not protect against Parkinson’s disease and Lewy body dementias. If borne out, this result differs from Alzheimer’s disease, where reducing endogenous tau levels in brain neurons is protective for multiple models of the disease.

Newswise: Unraveling the Origin of Alzheimer’s Disease
16-Jun-2021 2:55 PM EDT
Unraveling the Origin of Alzheimer’s Disease
Case Western Reserve University

Case Western Reserve University researchers studying prions—misfolded proteins that cause lethal incurable diseases—have identified for the first time surface features of human prions responsible for their replication in the brain.

Newswise: Johns Hopkins Drug Commercialization Expert Looks at Controversy over Alzheimer's Treatment
Released: 16-Jun-2021 12:35 PM EDT
Johns Hopkins Drug Commercialization Expert Looks at Controversy over Alzheimer's Treatment
Johns Hopkins University Carey Business School

Johns Hopkins Carey Business School Senior Lecturer Supriya Munshaw – an expert in the commercialization of early-stage technologies, especially in the life science and medical device industries – offers her insights into the FDA’s rationale for approving the Alzheimer's drug aducanumab, the price set by Biogen, the future of FDA leadership, and other related topics, in this Q&A.

Newswise: Neuroscience Scholarship Dedicated to Golf Journalist Tim Rosaforte ’77
Released: 15-Jun-2021 2:20 PM EDT
Neuroscience Scholarship Dedicated to Golf Journalist Tim Rosaforte ’77
University of Rhode Island

The University of Rhode Island has established an endowed scholarship for undergraduates in the field of neuroscience. The scholarship is named in honor of James Tim Rosaforte III ’77, an accomplished sports journalist and author well known in the world of professional golf. Rosaforte retired last year after being diagnosed with Alzheimer’s Disease, following a distinguished 40-year career in newspapers and television.

Newswise: Brain Cell Membranes' Lipids May Play Big Role in Alzheimer's Progression
14-Jun-2021 10:05 AM EDT
Brain Cell Membranes' Lipids May Play Big Role in Alzheimer's Progression
American Institute of Physics (AIP)

Links between lipid imbalance and disease have been established, in which lipid changes increase the formation of amyloid plaques, a hallmark of Alzheimer's disease. This imbalance inspired researchers to explore the role of lipids comprising the cellular membranes of brain cells. In Biointerphases, the researchers report on the significant role lipids may play in regulating C99, a protein within the amyloid pathway, and disease progression.

Released: 15-Jun-2021 8:05 AM EDT
Infectious Diseases Society of America Foundation Announces $1.7 Million in Grant Funding to Explore Potential Link Between Infectious Diseases and Alzheimer’s Disease
Infectious Diseases Society of America Foundation

The IDSA Foundation announces a call for applications for the 2021 Microbial Pathogenesis in Alzheimer’s Disease Grant. The $1.7 million grant, an increase from $1 million in 2020, will fund the advancement of novel research into possible links between infectious diseases and the causation of Alzheimer’s disease.

14-Jun-2021 7:00 AM EDT
New Treatment Stops Progression of Alzheimer’s Disease in Monkey Brains
NYU Langone Health

A new therapy prompts immune defense cells to swallow misshapen proteins, amyloid beta plaques and tau tangles, whose buildup is known to kill nearby brain cells as part of Alzheimer’s disease, a new study shows.

Released: 14-Jun-2021 8:05 AM EDT
Alzheimer's Association Statement: Next Steps For New Alzheimer's Treatment
Alzheimer's Association

As the global nonprofit leader in Alzheimer's research and science we have extensively reviewed the clinical trial data for Aduhelm™ (aducanumab).

Released: 10-Jun-2021 4:05 PM EDT
Study Identifies How COVID-19 Linked to Alzheimer’s Disease-like Cognitive Impairment
Cleveland Clinic

A new Cleveland Clinic-led study has identified mechanisms by which COVID-19 can lead to Alzheimer’s disease-like dementia. The findings, published in Alzheimer's Research & Therapy, indicate an overlap between COVID-19 and brain changes common in Alzheimer’s, and may help inform risk management and therapeutic strategies for COVID-19-associated cognitive impairment.

Newswise: Memory Biomarkers Confirm Aerobic Exercise Helps Cognitive Function in Older Adults
Released: 10-Jun-2021 10:25 AM EDT
Memory Biomarkers Confirm Aerobic Exercise Helps Cognitive Function in Older Adults
Florida Atlantic University

Until now, systemic biomarkers to measure exercise effects on brain function and that link to relevant metabolic responses were lacking. A study shows a memory biomarker, myokine Cathepsin B (CTSB), increased in older adults following a 26-week structured aerobic exercise training. The positive association between CTSB and cognition, and the substantial modulation of lipid metabolites implicated in dementia, support the beneficial effects of exercise training on brain function and brain health in asymptomatic individuals at risk for Alzheimer’s.

Newswise: Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
Released: 9-Jun-2021 11:00 AM EDT
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
Johns Hopkins Medicine

NEWS STORIES IN THIS ISSUE: - Study Says Failure to Rid Amyloid Beta Protein from Brain May Lead to Alzheimer’s Disease - Johns Hopkins Medicine Team Discovers Novel Mediator of Once Mysterious Chronic Itch - Study Suggests Molecular Changes in Tissue Microenvironment May Promote Colorectal Cancer - Researchers ID Anti-Inflammatory Proteins as Therapy Targets for Nasal and Sinus Problem - Johns Hopkins Children’s Center Receives NIH Award to Study Dangerous Pediatric Disease

Newswise: Personalized Soundscape Could Help People with Dementia with Time, Place Recognition
4-Jun-2021 10:00 AM EDT
Personalized Soundscape Could Help People with Dementia with Time, Place Recognition
Acoustical Society of America (ASA)

Designing a soundscape to improve quality of life for an individual is centered on putting their perception at the heart of the process. During the 180th ASA Meeting, Arezoo Talebzadeh from Ghent University will show how a personalized soundscape can help those with dementia by providing clues regarding time of day and place. The session, "Soundscape design for people with dementia; the correlation between psychoacoustic parameter and human perception," will take place Wednesday, June 9.

Released: 8-Jun-2021 4:10 PM EDT
Weak brain waves may warn of age-related neurodegenerative disease
eLife

Weakened electrical signals in the brain may be an early warning sign of age-related neurodegenerative diseases such as Alzheimer's disease, suggests a study published today in eLife.

Released: 8-Jun-2021 2:30 PM EDT
Harnessing healthy behaviors to prevent dementia
Michigan Medicine - University of Michigan

The approval of a new Alzheimer's disease drug is getting a lot of attention, but a recent scientific review of the evidence about dementia prevention shows an important role for primary care providers and patients to modify risk factors and protect brain health over the long term.

Released: 7-Jun-2021 12:20 PM EDT
FDA Approves Aducanumab for Alzheimer's Disease
Alzheimer's Association

This is the first drug that slows Alzheimer's disease. And, this is the beginning of a completely new future for Alzheimer's treatments. This is a new type of Alzheimer's treatment; it addresses the disease in a way that has never been done before, compared to currently approved drugs. Alzheimer's Association spokespeople are available.

Newswise: New drug to halt dementia after multiple head injuries
Released: 7-Jun-2021 12:05 AM EDT
New drug to halt dementia after multiple head injuries
University of South Australia

A world-first international study led by the University of South Australia has identified a new drug to stop athletes developing dementia after sustaining repeated head injuries in their career.

Newswise: New research may offer hope for Alzheimer's patients
Released: 4-Jun-2021 7:05 AM EDT
New research may offer hope for Alzheimer's patients
University of Kentucky

University of Kentucky Neuroscience Professor Greg Gerhardt's new research program will provide answers to long-standing questions about the role of neurotransmitters GABA and glutamate in the progression of Alzheimer’s disease. A culmination of his nearly 40 years of brain research, Gerhardt's study could help to develop new treatments for the disease.

Released: 3-Jun-2021 2:15 PM EDT
Secondary infections inflame the brain, worsening cognition in Alzheimer's disease
Trinity College Dublin

New research into Alzheimer's disease (AD) suggests that secondary infections and new inflammatory events amplify the brain's immune response and affect memory in mice and in humans - even when these secondary events occur outside the brain.

1-Jun-2021 8:05 PM EDT
Blood Sugar Highs and Lows Linked to Greater Dementia Risk in Type 1 Diabetes
American Academy of Neurology (AAN)

Older people with type 1 diabetes who have been to the hospital at some point for both low and high blood sugar levels may be at six times greater risk for developing dementia years later. The research is published in the June 2, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that people with type 1 diabetes who visit the hospital for just one of the blood sugar extremes may also be at greater risk for developing dementia.

28-May-2021 11:55 AM EDT
Rush Researchers Develop New Measure of Brain Health
Rush University Medical Center

A new measure of brain health developed by researchers at Rush University Medical Center may offer a novel approach to identifying individuals at risk of memory and thinking problems, according to research results published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association on June 1.

Newswise: Poor Sleep Predicts Long-term Cognitive Decline in Hispanics More So Than in Whites
Released: 26-May-2021 1:30 AM EDT
Poor Sleep Predicts Long-term Cognitive Decline in Hispanics More So Than in Whites
University of Miami Health System, Miller School of Medicine

Poor sleep impacts the risk of long-term cognitive decline in Hispanic/Latino middle aged and older adults differently than it does in non-Hispanic adults, according to research led by University of Miami Miller School of Medicine neurology faculty and the largest long-term study of U.S. Hispanic/Latinos to date.

Released: 25-May-2021 2:50 PM EDT
First Clinical Trial to Assess Alzheimer’s Gene Therapy Receives $5 Million
University of California San Diego Health

The National Institute on Aging has awarded $5 million grant to researchers at UC San Diego School of Medicine to conduct a first-in-human Phase 1 clinical trial of a gene therapy for treating Alzheimer’s disease or Mild Cognitive Impairment.

Released: 24-May-2021 8:05 AM EDT
Hackensack Meridian Health and Eisai Inc. Join Forces to Support the Expansion of Alzheimer’s Disease Detection and Services for Patients
Hackensack Meridian Health

Hackensack Meridian Health and Eisai Inc. Join Forces to Support the Expansion of Alzheimer’s Disease Detection and Services for Patients

Released: 19-May-2021 11:55 AM EDT
A complex link between body mass index and Alzheimer’s
Ohio State University

Though obesity in midlife is linked to an increased risk for Alzheimer’s disease, new research suggests that a high body mass index later in life doesn’t necessarily translate to greater chances of developing the brain disease.

Released: 17-May-2021 12:10 PM EDT
Researchers Identify Proteins That Predict Future Dementia, Alzheimer’s Risk
Johns Hopkins Bloomberg School of Public Health

The development of dementia, often from Alzheimer’s disease, late in life is associated with abnormal blood levels of dozens of proteins up to five years earlier.

Newswise: Reminiscing with confidence
Released: 12-May-2021 1:05 PM EDT
Reminiscing with confidence
West Virginia University - Eberly College of Arts and Sciences

Sounds like crickets chirping and the taste of warm buckwheat pancakes can spark the senses of people with dementia — a fact faculty and students at WVU used to develop a way for those people to experience parts of their cultural past and to relieve stress for their caregivers.

Newswise: 264717_web.jpg
Released: 12-May-2021 10:55 AM EDT
Untangling the brain: new research offers hope for Alzheimer's disease
Arizona State University (ASU)

Since the discovery of Alzheimer's disease over a century ago, two hallmarks of the devastating illness have taken center stage.

Released: 10-May-2021 9:35 AM EDT
SLU Study Finds Lower Dementia Risk in Adult Patients with Tdap Vaccinations
Saint Louis University Medical Center

Research from Saint Louis University finds that adult patients who have received a Tdap vaccination have a 42% lower risk for dementia, compared with patients who are not vaccinated.

Released: 5-May-2021 5:00 PM EDT
New Method Identifies Tau Aggregates Occurring in Healthy Body Structures
Perelman School of Medicine at the University of Pennsylvania

Researchers used microscopy and machine learning to distinguish tau protein aggregates occurring as part of healthy functions from those occurring in disease

29-Apr-2021 1:15 PM EDT
Does Eating A Mediterranean Diet Protect Against Memory Loss and Dementia?
American Academy of Neurology (AAN)

Eating a Mediterranean diet that is rich in fish, vegetables and olive oil may protect your brain from protein build up and shrinkage that can lead to Alzheimer’s disease, according to a new study. The research is published in the May 5, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology.

29-Apr-2021 1:05 PM EDT
Reduced Kidney Function Linked to Increased Risk of Dementia
American Academy of Neurology (AAN)

Chronic kidney disease is when a person’s kidneys progressively lose their ability to filter waste from the blood and eliminate fluids. Now a new study has found that people with reduced kidney function may have an increased risk of developing dementia. The study is published in the May 5, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Newswise: Pitt, WashU Awarded $10.7 Million for Alzheimer’s Disease Genetic Research
Released: 5-May-2021 9:15 AM EDT
Pitt, WashU Awarded $10.7 Million for Alzheimer’s Disease Genetic Research
Health Sciences at the University of Pittsburgh

Despite decades of research and investment, the genetic underpinnings of Alzheimer’s disease are still largely unknown, stymieing drug development and early diagnosis efforts. A new $10.7 million, five-year project aims to change that.

4-May-2021 11:00 AM EDT
New MRI Technique Can Detect Early Dysfunction of the Blood-Brain Barrier Associated With Small Vessel Disease
University of Kentucky

Collaborative research between the University of Kentucky (UK) and University of Southern California (USC) suggests that a noninvasive neuroimaging technique may index early-stage blood-brain barrier (BBB) dysfunction associated with small vessel disease (SVD).

Released: 5-May-2021 12:00 AM EDT
$3.5 Million Grant Supports Effort Led by Penn Medicine to Diversify Alzheimer’s Disease Research
Perelman School of Medicine at the University of Pennsylvania

The Pennsylvania Department of Health’s CURE program announced it will award a $3.5M grant to Penn Medicine researchers and community partners to address the underrepresentation of Black adults in Alszheimer’s Disease research. The grant supports the Aging Brain Cohort Dedicated to Diversity (ABCD2) study, a research and training initiative led by David Wolk, MD.


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