What special considerations must physicians make when managing epilepsy in older adults? Who is considered an “older adult,” anyway? Dr. Anca Arbune interviews two authors of a recent critical review by an ILAE task force.
People with a genetic predisposition for Alzheimer’s disease may have an increased risk of epilepsy and people with a certain type of epilepsy may have an increased risk of developing Alzheimer’s disease, according to a study published in the May 24, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A University of California, Irvine-led team of researchers have discovered that the oldest-old, those who live to be 90+ and have superior cognitive skills, have similar levels of brain pathology as Alzheimer’s patients, however, they also have less brain pathology of other neurodegenerative diseases that cause memory and thinking problems.
In a noteworthy case study published in the Journal of Alzheimer’s Disease investigators report autopsy findings in a 65-year-old woman with Alzheimer’s disease (AD) who received three open label infusions of the experimental anti-amyloid beta (Aβ) antibody drug lecanemab.
Chunyu Wang, Ph.D., professor of biological sciences at Rensselaer Polytechnic Institute, has added to his body of research on Alzheimer’s disease with significant findings in Angewandte Chemie.Together with his team, which includes first author and Rensselaer doctoral student Dylan Mah, Wang performed the most comprehensive study to date of the interactions between ApoE, or Apolipoprotein E, and heparan sulfate (HS).
Scientists at Wake Forest University School of Medicine have uncovered a novel mechanism that shows increased sugar intake and elevations in blood glucose are sufficient to cause amyloid plaque buildup in the brain, which increases the risk of Alzheimer’s disease.
Blood vessel abnormalities in the eye are a major factor in the progression of Alzheimer’s disease, according to research from Cedars-Sinai investigators published in the peer-reviewed journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association.
Surviving a stroke can bring many long-term effects – including a much higher risk of dementia. But a study suggests that blood sugar may play a key role in that risk.
Impairments in the lymphatic system may contribute to brain diseases, such as neurodegenerative diseases and stroke. Researchers have found a noninvasive and nonpharmaceutical method to influence glymphatic transport using focused ultrasound, opening the opportunity to use the method to further study brain diseases and brain function.
A recent study published in Nature Neuroscience indicates that, contrary to common belief, the immune cells of the brain, known as microglia, are not all the same.
An increased risk of depression and anxiety among US older adults with dementia and poor activity participation has been demonstrated through an analysis of data from the National Health and Aging Trends Study (NHATS), a nationally representative population-based study.
UNLV study pinpoints 10 bacterial groups associated with Alzheimer’s disease, provides new insights into the relationship between gut makeup and dementia.
The anti-dementia medication lecanemab and its ancillary costs could add $2 billion to $5 billion in annual Medicare spending if the Centers for Medicare and Medicaid Services (CMS) revise their coverage decision. Currently, the medication is covered only for patients who are enrolled in clinical trials.
Researchers from the University of California, Irvine have found that exposure to traffic-related air pollution in Irvine led to memory loss and cognitive decline and triggered neurological pathways associated with the onset of Alzheimer’s disease.
Proteins tend to fold wrongly and become defective when exposed to stressors such as heat, oxidation, and pH changes. Accumulation of abnormal proteins contributes to neurodegenerative diseases like Alzheimer’s.
May is Mental Health Awareness Month. Get your mental health news here.
People who have sleep apnea and spend less time in deep sleep may be more likely to have brain biomarkers that have been linked to an increased risk of stroke, Alzheimer’s disease and cognitive decline, according to new research published in the May 10, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study does not prove that these sleep disturbances cause the changes in the brain, or vice versa. It only shows an association.
In medicine and science, the term “pathogenesis” describes the origin and development of disease. There is not, however, a broadly accepted term to describe the other half of the equation: the process of healing and recovery.
Efforts are underway to address the “epidemic of loneliness and isolation” affecting the country, as recently addressed by the U.S. Surgeon General Dr. Vivek Murthy who is laying out a “National Strategy to Advance Social Connection” initiative. Virginia Tech neuroscientist Georgia Hodes says that reports of depression and anxiety are up at least 3-fold since the start of the COVID epidemic.
During the course of Alzheimer's disease, protein fibrils appear in the spinal fluid of affected individuals. Empa researchers, together with the Department of Neurology at the Cantonal Hospital in St. Gallen, have now visualized the wide spectrum of protein aggregates from oligomers, protofibrils to fibrils in the spinal fluid.
Findings reveal a previously unknown way in which the brain and immune system talk to each other and may identify a new therapeutic target for MS and other brain disorders.
University of Minnesota Twin Cities researchers have developed a groundbreaking new diagnostic technique that will allow for faster and more accurate detection of neurodegenerative diseases that affect humans, such as Alzheimer's and Parkinson's, and similar diseases that affect animals, such as chronic wasting disease (CWD) and mad cow disease.
Football players who have had repetitive head trauma and concussion are at heightened risk for chronic traumatic encephalopathy (CTE), an irreversible condition that leads to dementia. But not every case of cognitive decline means CTE.
A team lead by Prof. Harald Steiner and Dr. Edgar Dawkins from the Biomedical Center Munich at LMU has now shown that the production of amyloid-β is influenced by the membrane thickness.
In honor of Mother’s Day, American Greetings and the Women’s Alzheimer’s Movement at Cleveland Clinic have partnered to encourage the celebration of women everywhere and raise critical research funds in the process.
A new study by NYU School of Global Health published in the Journal of the American Geriatrics Society reports that regular Internet usage was associated with approximately half the risk of dementia compared to non-regular usage.
UC San Diego researchers describe how exposure to ambient air pollution, such as car exhaust and power plant emissions — is associated with a measurably greater risk of developing dementia over time.
Stress causes the levels of Alzheimer's proteins to rise in females' brains but not males' brains, according to a new study in mice by researchers at Washington University School of Medicine in St. Louis. This difference may contribute to women's greater risk of developing Alzheimer's disease.
This agreement will enable FAU and Insightec to collaborate to advance scientific knowledge about the use of focused ultrasound to treat brain diseases, including Parkinson’s disease and Alzheimer’s disease. By harnessing acoustic energy, Insightec’s innovative technology uses focused ultrasound to treat diseases in different ways.
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai for April 2023.
Dogs with dementia suffer the same sleep disruptions that humans with dementia do.
The April 2023 issue of SLAS Technology contains four original research articles and one technical brief covering the development of robotic systems, ultrasound frequency sonification, automated algorithm development and other laboratory automation technology.
Researchers identify a protein that may allow some people to resist Alzheimer’s dementia despite amyloid beta plaque accumulation
Cedars-Sinai geriatrics experts will present their latest advances in research and care at the annual scientific meeting of the American Geriatrics Society (AGS) in Long Beach, California, May 4-6.
A world-first trial at UCL and UCLH has found a new genetic therapy for Alzheimer’s disease that is able to safely and successfully lower levels of the harmful tau protein known to cause the disease.
Led by Lukas Kenner (Department of Pathology at MedUni Vienna and Department of Laboratory Animal Pathology at Vetmeduni) and Oldamur Hollóczki (Department of Physical Chemistry, University of Debrecen, Hungary) the research team was able to determine that tiny polystyrene particles could be detected in the brain just two hours after ingestion. The mechanism that enabled them to breach the blood-brain barrier was previously unknown to medical science.
Researcher will discuss the study which involved a sleeping aid known as suvorexant that is already approved by the Food and Drug Administration (FDA) for insomnia, hints at the potential of sleep medications to slow or stop the progression of Alzheimer’s disease.
People with dementia have protein build-up in astrocytes that may trigger abnormal antiviral activity and memory loss, according to a preclinical study by a team of Weill Cornell Medicine investigators.
The human brain has a sweet tooth, burning through nearly one quarter of the body’s sugar energy, or glucose, each day.
Rigshospitalet and Aarhus University have joined forces with the Danish health technology company, T&W Engineering, and they have just received DKK 15 million in funding from Innovation Fund Denmark for their potentially ground-breaking project for people with serious brain diseases.
Two doses of an FDA-approved sleeping pill reduced levels of Alzheimer’s proteins in a small study of healthy volunteers led by researchers at Washington University School of Medicine in St. Louis. The study hints at the potential of sleep medications to slow or stop the progression of Alzheimer’s disease, although much more work needs to be done to confirm the viability of such an approach.
A new study from a team led by researchers at the Johns Hopkins Bloomberg School of Public Health found that signs of common infections in a sample of middle-aged and older adults were associated with poorer performance on a test of global cognitive function.
New research suggests that having a stronger purpose in life (PiL) may promote cognitive resilience among middle-aged adults. Cognitive resilience refers to the capacity of the brain to cope with stressors, injuries and pathology, and resist the development of symptoms or disabilities.
In people with no thinking and memory problems, a simple test may predict the risk of developing cognitive impairment years later, according to a study published in the April 19, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
People who have an irregular heartbeat called atrial fibrillation that is treated with a procedure called catheter ablation may have a reduced risk of dementia compared to those who are treated with medication alone. The preliminary study released April 18, 2023, will be presented at the American Academy of Neurology’s 75th Annual Meeting being held in person in Boston and live online from April 22-27, 2023.
A UC Davis study is the first to report on a material transfer mechanism from cells, known as oligodendrocytes, to neurons in the brain of a mouse model. This discovery opens new possibilities for understanding brain maturation and finding treatments for many neurological conditions.
Bergen County Executive Jim Tedesco, the Board of County Commissioners, and the County’s Division of Senior Services under the Department of Human Services announce that the County of Bergen will launch a Dementia Friendly Initiative in partnership with the Act Now Foundation’s Dementia Resource Center.
People experiencing hearing loss who are not using a hearing aid may have a higher risk of dementia than people without hearing loss, suggests a new study published in The Lancet Public Health journal. However, using a hearing aid may reduce this risk to the same level as people without hearing loss.
Brains are like puzzles, requiring many nested and codependent pieces to function well.
Early diagnosis and treatment of Alzheimer’s disease requires reliable and cost-effective screening methods.
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