Feature Channels: Arthritis

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Released: 25-May-2022 11:45 AM EDT
ACR Urges the FTC to Examine the Impact of Pharmacy Benefit Managers on Prescription Drug Costs
American College of Rheumatology (ACR)

In comments submitted to the Federal Trade Commission (FTC), the American College of Rheumatology (ACR) urged the agency to address Pharmacy Benefit Manager (PBM) business practices that drive up costs and reduce access for the 54 million Americans living with rheumatic disease.

Released: 19-May-2022 11:05 AM EDT
Mount Sinai Microbiome Lab Joins NIH’s Accelerating Medicines Partnership
Mount Sinai Health System

The National Institutes of the Health (NIH) has awarded researchers at the Icahn School of Medicine at Mount Sinai a four-year grant to study the role of the human microbiome in rheumatoid arthritis, systemic lupus, and other autoimmune diseases. The grant is part of the NIH’s Accelerating Medicines Partnership® Autoimmune and Immune-Mediated Diseases (AMP® AIM) program, which is designed to speed the discovery of new treatments and diagnostics. It will support the Microbiome Technology and Analytic Center Hub (Micro-TEACH), a multidisciplinary team of researchers at Icahn Mount Sinai and NYU Langone Health.

Newswise: Target to make immunotherapy for cancer safer, while more effective
6-May-2022 12:40 PM EDT
Target to make immunotherapy for cancer safer, while more effective
Ochsner Health System

Researchers at MD Anderson and Ochsner Health have uncovered that in immunotherapy, a particular cytokine is expressed at higher levels in colitis tissue than in cancer tissue.

Released: 28-Apr-2022 2:45 PM EDT
Lipofilling Procedure Improves Pain and Function in Finger Osteoarthritis
Wolters Kluwer Health: Lippincott

For patients with painful finger osteoarthritis, a nonsurgical procedure called lipofilling – in which fat obtained from another part of the body is transferred into the arthritic joints – produces lasting improvements in hand function and especially pain, suggests a study in the May issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

Released: 19-Apr-2022 3:30 PM EDT
Hackensack Meridian Mountainside Medical Group Welcomes Rheumatologist Randolph Sanchez, M.D.
Hackensack Meridian Health (Mountainside Medical Center)

Mountainside Medical Group has announced that Randolph Sanchez, M.D., has joined the practice, adding rheumatology to the medical group’s specialty offerings. Dr. Sanchez treats a variety of autoimmune diseases in adult patients that can affect the bones, joints, and muscles, causing pain, swelling and deformity.

Newswise: Study: Older Adults with Rheumatoid Arthritis Still Undermedicated, Despite Aggressive Guidelines
Released: 8-Apr-2022 6:00 AM EDT
Study: Older Adults with Rheumatoid Arthritis Still Undermedicated, Despite Aggressive Guidelines
Michigan Medicine - University of Michigan

A new study shows the majority of older adults are not prescribed disease-modifying medications for rheumatoid arthritis, despite guidelines that call for early and aggressive treatment of the inflammatory autoimmune disease. Researchers say rheumatologists and primary care providers must be prepared to care for older adults with rheumatic diseases while addressing polypharmacy and multimorbidity.

Newswise: Newly Identified Neutrophil Subset Is a Promising Therapeutic Target
Released: 5-Apr-2022 3:30 PM EDT
Newly Identified Neutrophil Subset Is a Promising Therapeutic Target
University of Illinois Chicago

Using a protein nanoparticle they designed, scientists at the University of Illinois Chicago have identified two distinct subtypes of neutrophils and found that one of the subtypes can be used as a drug target for inflammatory diseases.

Released: 24-Mar-2022 4:30 PM EDT
American College of Rheumatology Honored with Sixth Consecutive Top Atlanta Workplace Designation
American College of Rheumatology (ACR)

The Atlanta Journal-Constitution (AJC) recognized the American College of Rheumatology (ACR) as one of Atlanta's top workplaces for the sixth year in a row. Only 87 small businesses and 175 organizations total received the recognition, and the ACR ranked 28th in the small business category.

Released: 22-Mar-2022 1:10 AM EDT
Medical cannabis can reduce use of opioids in patients with chronic back pain and osteoarthritis, but further study needed
American Academy of Orthopaedic Surgeons (AAOS)

Providing patients with chronic back pain and osteoarthritis (OA) access to medical cannabis can reduce or even eliminate the use of opioids for pain management, according to two studies presented at the 2022 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS).

Released: 16-Mar-2022 3:45 PM EDT
Long term exposure to air pollution linked to heightened autoimmune disease risk
BMJ

Long term exposure to air pollution is linked to a heightened risk of autoimmune disease, particularly rheumatoid arthritis, connective tissue and inflammatory bowel diseases, finds research published online in the open access journal RMD Open.

Newswise: After More than 20 Years, Scientists Have Solved the Full-Length Structure of a Janus Kinase
8-Mar-2022 2:25 PM EST
After More than 20 Years, Scientists Have Solved the Full-Length Structure of a Janus Kinase
Howard Hughes Medical Institute (HHMI)

More than two decades of effort went into a project that has now revealed the structure of a crucial signaling molecule, opening the door to new and better drugs for some cancers.

Released: 8-Mar-2022 2:15 PM EST
New Kawasaki Disease Guideline Released by American College of Rheumatology and Vasculitis Foundation
American College of Rheumatology (ACR)

The American College of Rheumatology (ACR), in partnership with the Vasculitis Foundation (VF), released a new guideline for the management of Kawasaki disease that addresses diagnostic issues relating to the disease, the treatment of high-risk patients, & the management of convalescent patients.

Released: 3-Mar-2022 9:30 AM EST
The American College of Rheumatology Releases Two Updated Guidelines for Treatment of Juvenile Idiopathic Arthritis
American College of Rheumatology (ACR)

The ACR released two updated guideline papers for the treatment and management of Juvenile Idiopathic Arthritis (JIA). These two guidelines are companions to previously updated JIA guidelines released in 2019 covering the treatment of polyarthritis, sacroiliitis, uveitis and enthesitis.

Released: 1-Mar-2022 10:35 AM EST
Younger patients seeking knee replacement have similar arthritis severity, but more risk factors for surgical complications than older patients
Wolters Kluwer Health: Lippincott

Compared to older patients being evaluated for total knee arthroplasty (TKA), younger patients – under age 60 – have similar pain, disability, and willingness to undergo surgery, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

Released: 28-Feb-2022 1:15 PM EST
Updated Guideline Introduces New Recommendations for Use of Medications Around Total Hip and Knee Replacement
American College of Rheumatology (ACR)

The ACR and the AAHKS released a summary of their updated guideline for the Perioperative Management of Antirheumatic Medication in Patients with Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty.

23-Feb-2022 3:15 PM EST
New way viruses trigger autoimmunity discovered
Washington University in St. Louis

Studying mice, researchers at Washington University School of Medicine in St. Louis have discovered that roseolovirus can trigger autoimmunity in a previously unknown way: by disrupting the process by which immune cells learn to avoid targeting their own body's cells and tissues.

Released: 17-Feb-2022 3:05 PM EST
Continuation versus discontinuation of anti-rheumatic biologics during the perioperative period: What does the evidence support?
Wolters Kluwer Health: Lippincott

For patients with rheumatic arthritis and other chronic inflammatory diseases, discontinuing biologic disease-modifying anti-rheumatic drugs (bDMARDs) prior to orthopaedic surgery does not appear to increase the risk of surgical site infections or delayed wound healing, concludes a review and meta-analysis in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

Newswise: Rogue antibodies make cells “sticky” to trigger blood clots in COVID-19 patients
Released: 17-Feb-2022 11:15 AM EST
Rogue antibodies make cells “sticky” to trigger blood clots in COVID-19 patients
Michigan Medicine - University of Michigan

Scientists have discovered that “rogue” antibodies found circulating in the blood of COVID-19 patients have the potential to cause endothelial cells to lose their resistance to clotting. These antiphospholipid autoantibodies can trigger blood clots in the arteries and veins of patients with autoimmune disorders, including lupus and antiphospholipid syndrome. The findings provide an even stronger connection between autoantibody formation and clotting in COVID-19.

Released: 9-Feb-2022 2:40 PM EST
The Osteoarthritis Action Alliance Releases OACareTools, a NEW Online Toolkit to Help Employers and their Employees Manage Osteoarthritis
Osteoarthritis Action Alliance

Osteoarthritis (OA), the most common form of arthritis, is a serious disease affecting 1 in 7 U.S. adults. Over half of adults with OA are of working age (18–64 years old).

Released: 27-Jan-2022 8:05 AM EST
Researchers Identify Osteoarthritis ‘Pain Pathway’
North Carolina State University

Researchers have discovered that a particular molecular signaling pathway plays an important role in producing osteoarthritis (OA) pain. Using a mouse model of painful osteoarthritis, they show that blocking this signaling pathway eliminates pain and results in a return to normal limb use.

Newswise: Macromolecular gel with therapeutic payload could be silver bullet for osteoarthritis
Released: 26-Jan-2022 11:15 AM EST
Macromolecular gel with therapeutic payload could be silver bullet for osteoarthritis
NYU Tandon School of Engineering

NYU researchers, including Jin Kim Montclare, professor of chemical and biomolecular engineering, along with investigators from the NYU Grossman School of Medicine have found both the molecular vehicle and therapeutic payload for delivering pharmacologic treatment to affected joints, which could halt post-traumatic osteoarthritis (PTOA) onset and progression.

Released: 24-Jan-2022 3:40 PM EST
The Latest Research News from the Health Disparities Channel
Newswise

The latest research news from the Health Disparities Channel.

Released: 11-Jan-2022 12:55 PM EST
Complimentary Press Registration Available for the 2022 Winter Rheumatology Symposium
American College of Rheumatology (ACR)

The American College of Rheumatology (ACR) welcomes members of the press to write about rheumatology research presented at the Winter Rheumatology Symposium in Snowmass Village, CO on January 22 -28, 2022.

Released: 17-Dec-2021 10:05 AM EST
Mayo Clinic researchers use AI, biomarkers to personalize rheumatoid arthritis treatment
Mayo Clinic

Treatment options for rheumatoid arthritis have often relied on trial and error. Now Mayo Clinic researchers are exploring the use of artificial intelligence (AI) and pharmacogenomics to predict how patients will respond to treatments, and to personalize care. Findings were published in Arthritis Care & Research.

Released: 14-Dec-2021 9:40 AM EST
Hyaluronic acid injections have increased for knee arthritis – despite recommendations against their use
Wolters Kluwer Health: Lippincott

For Medicare beneficiaries with knee osteoarthritis, the use of hyaluronic acid (HA) injections has increased in recent years, despite clinical guidelines recommending against the use of this treatment, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

Released: 10-Dec-2021 9:45 AM EST
New biomarkers could predict rheumatoid arthritis susceptibility
Washington State University

Cells from a cheek swab revealed biomarkers for rheumatoid arthritis that could lead to a way to diagnose and begin treatment before the disease develops, according to a study published in Scientific Reports.

Released: 9-Dec-2021 7:00 AM EST
Drug made from pig intestine helps escape the “trap” of clot-causing immune response
Michigan Medicine - University of Michigan

Two complementary studies show that defibrotide can successfully suppress the formation and progression of neutrophil extracellular traps, or NETs, which are web-like networks of toxic proteins that play a role in forming blood clots and promoting inflammation in several disease, including COVID-19. Researchers say findings may set the stage for defibrotide clinical trials in potentially several diseases.

Released: 22-Nov-2021 3:40 PM EST
Rheumatoid arthritis finding may lead to new inflammation blockers
Mayo Clinic

Mayo Clinic researchers have linked the T cell dysfunction seen in rheumatoid arthritis with a metabolic deficiency in a new Nature Immunology publication.

Released: 19-Nov-2021 12:55 PM EST
COVID-19 vaccine elicits weak antibody response in people taking immunosuppressant
Washington University in St. Louis

People taking TNF inhibitors, a kind of immunosuppressive drug used to treat rheumatoid arthritis and other autoimmune conditions, produced a weaker and shorter-lived antibody response after two doses of Pfizer's COVID-19 vaccine, according to a study from Washington University School of Medicine in St. Louis. A third vaccine dose drove antibody levels back up, indicating that this additional dose may provide protection as the virus's delta variant continues to spread.

Released: 17-Nov-2021 6:10 PM EST
Exercise increases the body’s own ‘cannabis’ which reduces chronic inflammation, says new study
University of Nottingham

Exercise increases the body’s own cannabis-like substances, which in turn helps reduce inflammation and could potentially help treat certain conditions such as arthritis, cancer and heart disease.

8-Nov-2021 9:00 AM EST
HSS Study Sheds Light on Real-World Treatment Patterns of Psoriatic Arthritis
Hospital for Special Surgery

Despite clear directives outlined in the updated guidelines published by the American College of Rheumatology/National Psoriasis Foundation (ACR/NPF) in 2018, there is limited data regarding medication use in real-world clinical practice and patient medication preferences for the treatment of psoriatic arthritis (PsA).

5-Nov-2021 5:00 PM EDT
HSS Study Identifies Risk Factors for “Long-Haul” COVID-19 in People with Rheumatic Diseases
Hospital for Special Surgery

A new study by researchers at Hospital for Special Surgery (HSS) in New York City demonstrates over half of patients with rheumatic diseases who contracted COVID-19 during the pandemic and completed a COVID-19 survey, experienced so-called “long-haul” COVID, or prolonged symptoms of the infection, including loss of taste or smell, muscle aches and difficulty concentrating, for one month or longer.

6-Nov-2021 8:30 AM EDT
Researchers Present Global Effort to Develop Machine Learning Tools for Automated Assessment of Radiographic Damage in Rheumatoid Arthritis
Hospital for Special Surgery

Crowdsourcing has become an increasingly popular way to develop machine learning algorithms to address many clinical problems in a variety of illnesses. Today at the American College of Rheumatology (ACR) annual meeting, a multicenter team led by an investigator from Hospital for Special Surgery (HSS) presented the results from the RA2-DREAM Challenge, a crowdsourced effort focused on developing better methods to quantify joint damage in people with rheumatoid arthritis (RA).

Released: 2-Nov-2021 4:30 PM EDT
Study Observes Worse COVID-19 Vaccine Response in Patients Taking Glucocorticoids or B-Cell Therapies
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that people with chronic inflammatory diseases, such as rheumatoid arthritis (RA), who take immunosuppressive therapy appear to have an impaired immunity response to SARS-CoV-2, the coronavirus that causes COVID-19, vaccines. Patients currently on glucocorticoids or B-cell depleting therapy appear to have an even more severely impeded vaccine response.

Released: 2-Nov-2021 4:20 PM EDT
Study Finds TNF Inhibitor More Effective with Regular Serum Assessment to Adjust Dose
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that proactive therapeutic drug monitoring, a newer treatment strategy where a patient’s drug serum levels are regularly assessed to adjust the dose and intervals, controlled disease more effectively than standard therapy with infliximab, a tumor necrosis factor (TNF) inhibitor.

Released: 2-Nov-2021 4:15 PM EDT
New Artificial Neural Network Detects Radiographic Sacroiliitis with Accuracy
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, found that an innovative new artificial neural network can detect radiographic sacroiliitis in patients with suspected axial spondyloarthritis, a progressive disease that is more common in young adults.

Released: 2-Nov-2021 4:05 PM EDT
Study Finds Statins Lower CVD and Mortality in People with RA, Only Modestly Increase Diabetes Risk
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that statins are associated with reduced rates of cardiovascular disease (CVD) and mortality in people with rheumatoid arthritis, but only modestly increase risk of type-2 diabetes, suggesting that statins’ benefits outweigh the risks in these patients.

Released: 2-Nov-2021 3:45 PM EDT
Study Finds Treat-to-Target ULT Strategy Manages Gout Effectively and Safely with No Cardiovascular Toxicity
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that allopurinol and febuxostat may effectively lower urate levels when used in a treat-to-target approach. Importantly, both urate-lowering therapies were very effective with 90% of patients reaching target urate levels. Additionally, both appeared safe, with no evidence of increased cardiovascular toxicity.

Released: 2-Nov-2021 2:40 PM EDT
Study Finds Disparities in RA Disease Activity and Physical Function Across Racial and Ethnic Groups
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, found that racial and ethnic disparities for disease activity persist in people with rheumatoid arthritis. Black and Hispanic patients often had higher disease activity and lower self-reported functional status when compared to white patients.

Released: 2-Nov-2021 2:35 PM EDT
Infection Rates in Psoriatic Arthritis Patients on Biologics Have Decreased, According to National Data
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows significant decreases in infections among people with psoriatic arthritis over the years 2012-2017.

Released: 2-Nov-2021 2:05 PM EDT
Early Combined Treatment with Biologic and Conventional DMARDs Could be Effective for Polyarticular Juvenile Arthritis
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, found that patients started on early, aggressive treatment with a combination of biologic and conventional disease modifying antirheumatic drugs (DMARDs) achieved clinically inactive disease in children with polyarticular juvenile idiopathic arthritis (JIA) more frequently compared to other treatment plans 24 months after starting treatment.

Released: 2-Nov-2021 1:20 PM EDT
Fear of Side Effects, Including Rheumatic Disease Flares, Driving COVID-19 Vaccine Hesitancy Among Some Patients
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that in Alabama, one in 10 racial or ethnic minority patients with a rheumatic disease in a large rheumatology clinic said they were unlikely to get vaccinated against COVID-19.

Released: 2-Nov-2021 12:40 PM EDT
Study Finds Racial Gaps in Renal Complications Persist for Children with Lupus
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, found that while hospitalized children with juvenile lupus have fewer adverse kidney outcomes overall, significant racial gaps for developing these complications persist and do not seem to be narrowing (Abstract #0956).

Released: 2-Nov-2021 11:25 AM EDT
Quadricep muscle contracts differently after ACL reconstruction; may contribute to lingering weakness
University of Michigan

After an anterior cruciate ligament reconstruction surgery, it's common to experience quadriceps weakness, which was thought to be caused primarily by muscle atrophy, or shrinkage.

Released: 2-Nov-2021 10:45 AM EDT
Race, Age, Sex and Language Affected Telemedicine Use by Rheumatology Clinic Patients During COVID-19 Pandemic
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows a significant lack of fairness among telemedicine and electronic patient portals used by rheumatology clinic patients based on their race, age, sex and English language proficiency.

Released: 1-Nov-2021 4:55 PM EDT
Patients taking Rituximab Could Benefit from Third COVID-19 Vaccine Dose
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows patients using rituximab were able to produce antibodies against COVID-19 after receiving a third vaccine dose, even if there was no development of the antibody after the first two.

Released: 1-Nov-2021 4:45 PM EDT
Study Finds Cycling JAK Inhibitors Effective Option for Patients with Difficult-to-Treat RA
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that people with difficult-to-treat rheumatoid arthritis who do not have success with JAK inhibitor can achieve success either cycling to other JAKi or switching to a biologic drug.


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