A previously unknown autoimmune muscle disease involving sudden onset of debilitating muscle pain and weakness has been identified by researchers at Washington University School of Medicine in St. Louis. The syndrome easily could be mistaken for other muscle diseases that require different treatment, so the findings are expected to help physicians treat patients appropriately, the researchers said.
Johns Hopkins Medicine researchers say mysterious, previously unseen “X cell” may be cause of type 1 diabetes
A mouse model called experimental autoimmune encephalomyelitis, or EAE, is used to discover disease mechanisms in multiple sclerosis. Researchers now report how dysregulated neutrophils cause damage in a severe, mouse model form of EAE called atypical EAE, which attacks cerebellum brain tissue.
O medicamento eculizumab, um anticorpo sintético que inibe a resposta inflamatória, reduziu significativamente o risco de recaída do doenças do espectro neuromielite óptica (NMOSD). Esse distúrbio inflamatório autoimune raro, mas grave, pode causar cegueira, paralisia e morte.
Pacientes diagnosticados com artrite reumatoide são frequentemente afetados por uma incapacidade funcional um a dois anos antes do diagnóstico da doença, de acordo com a nova pesquisa da Mayo Clinic.
يتأثر غالبًا المصابون بمرض التهاب المفاصل الروماتويدي بعجز وظيفي قبل تشخيص المرض بسنة أو اثنتين، حسب بحث جديد أجرته Mayo Clinic.
El fármaco eculizumab, un anticuerpo sintético que inhibe la respuesta inflamatoria, redujo considerablemente el riesgo de recaída en el trastorno del espectro de la neuromielitis óptica (NMOSD, por sus siglas en inglés). Este raro y grave trastorno inflamatorio autoinmunitario puede provocar ceguera, parálisis y muerte.
$3.4 million grant awarded to the University at Albany from the National Institute of Dental and Craniofacial Research will help scientists identify potential therapies for people suffering from the condition.
HSS Scientists Publish Two Studies On RA Treatment Strategies
A new grant will allow Michigan Medicine researchers to explore personalized approaches to treating autoimmune diseases such as scleroderma, lupus, rheumatoid arthritis and others.
Researchers at Joslin have found that increasing the proliferation and turnover of beta cells before signs of type 1 diabetes could halt the development of the disease.
The drug eculizumab, a synthetic antibody that inhibits the inflammatory response, significantly reduced the risk of relapse with neuromyelitis optica spectrum disorder (NMOSD). Mayo Clinic researchers and international collaborators published their findings in the New England Journal of Medicine.
Awareness campaign kicking off Myositis Awareness Month aims to ensure the over 75,000 people with the disease are diagnosed and get treated
When TET2 and TET3 proteins are genetically deleted from T-regs in mice, their suppressive function is lost over time and animals develop inflammatory disease. More importantly, because these TET2 and TET3 mutant cells had once 'experienced' being a normal T-reg, they behaved very differently.
Researchers will receive $17.8 million in federal funding to attack a key “knowledge gap” in human immunology — how B cells and antibody-secreting cells that reside in tissues and organs differ from those found in blood. It is an exploration never undertaken in a systematic way.
A research team at Massachusetts Eye and Ear has shown that microglia, the immune cells of the central nervous system—including the retina —serve as “gatekeepers” of neuroinflammation. Uveitis is one of the leading causes of blindness worldwide. In the study published in Proceedings of the National Academy of Sciences (PNAS), researchers describe for the first time a role for microglia in directing the initiation of autoimmune uveitis by orchestrating the inflammatory response within the retina.
Scientists have uncovered fresh insights into how vitamin D affects the immune system and might influence susceptibility to diseases such as multiple sclerosis.
The 2019 AARDA Champion Award will be presented to champion race car driver Kyle Marcelli at the organization's 19th annual fundraiser on May 11 at the Detroit Athletic Club.
A recent study found that nearly 18 percent of patients diagnosed with multiple sclerosis before being referred to two major Los Angeles medical centers for treatment actually had been misdiagnosed with the autoimmune disease. The investigators found that many patients who came to the medical centers with a previous diagnosis of MS did not fulfill the criteria for that diagnosis, and spent an average of four years being treated for MS before receiving a correct diagnosis.
Researchers using the world’s largest twin registry to study seven autoimmune diseases found the risk of developing the seven diseases is largely inherited, but that some diseases are more closely related than others. These results will be presented Sunday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Drug therapy may effectively treat a potentially life-threatening condition associated with cirrhosis and other chronic liver diseases, according to a new study by Mayo Clinic researchers.
UT Southwestern researchers used cryo-electron microscopy (cryo-EM) to determine the near-atomic structure of the smallest membrane protein solved to date.
Researchers at University of Utah Health have developed a new approach that targets the misfunctioning immune cells while leaving normal immune cells in place.
Autoimmune Disease Awareness Month (ADAM) takes place in March and to mark the annual event, the American Autoimmune Related Diseases Association, Inc. (AARDA) is encouraging national and local media attention through various activities.
Examining the autoimmune disease at the molecular level led researchers to a specific molecule that could be contributing to the disease progression in patients.
Legendary guitarist Peter Frampton announced Saturday that he has a rare, debilitating muscle disease called inclusion body myositis.
A new and novel outcome measure is being used to determine effectiveness of new scleroderma treatments. Learn how Michigan Medicine is leading the way.
People with two autoimmune diseases, rheumatoid arthritis (RA) and Sjögren’s syndrome, are at an increased risk for developing carpal tunnel syndrome (CTS), and should be screened for CTS and made aware of this risk.
People who have chronic inflammation in middle-age may develop problems with thinking and memory in the decades leading up to old age, according to a new study published in the February 13, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Using sophisticated gene sequencing and computing techniques, researchers at Vanderbilt University Medical Center (VUMC) and the San Diego Supercomputer Center have achieved a first-of-its-kind glimpse into how the body’s immune system gears up to fight off infection.
Together with other rare disease organizations, The Myositis Association is encouraging those who live with myositis diseases to Celebrate Your Rare by speaking out about the challenges they face and the need for more research into the causes, treatments, and possible cures for these diseases.
The conference brings together internationally recognized clinicians, scientists and educators who will share their research and clinical insights into the understanding, diagnosis and management of chronic diseases that are rising at an unprecedented rate throughout the US and internationally.
A Ludwig Cancer Research study has uncovered a cellular mechanism by which melanomas that fail to respond to checkpoint blockade may be made susceptible to such immunotherapies. Led by Ping-Chih Ho of the Lausanne Branch of the Ludwig Institute for Cancer Research and reported in the current issue of Nature Immunology, the study also identifies an existing diabetes drug that could be used to accomplish that feat.
A practical resource-based public health approach for the rapid initiation of antiretroviral therapy in HIV-infected individuals living in low- and middle-income countries could save thousands of lives, according to an Essay published January 15 in the open-access journal PLOS Medicine by Mark Tenforde of the University of Washington School of Medicine, and colleagues.
UCLA researchers led by Dr. Donald Kohn have created a method for modifying blood stem cells to reverse the genetic mutation that causes a life-threatening autoimmune syndrome called IPEX.
Scientists at Washington University School of Medicine in St. Louis have identified a previously unknown route for cellular fuel delivery, a finding that could shed light on the process of aging and the chronic diseases that often accompany it.
MSU scientists have discovered SLAMF7, an immune receptor, has the ability to tone down the body’s immune response when activated on certain white blood cells. Yet, for certain HIV patients who experience a myriad of health issues, the researchers found that these patients’ receptors don’t work properly.
When researchers unlock the mysteries of Castleman disease, they may single out 2018 as one of the years in which they laid the foundation to help them turn the key, and the University of Pennsylvania has been the epicenter.
Experts and research on important topics in the healthcare system
The American Neurological Association (ANA), the professional organization representing the nation’s top academic neurologists and neuroscientists, today released a list of the most-accessed articles of 2018 in its Annals of Neurology and Annals of Clinical & Translational Neurology (ACTN).
Of the 34 million people worldwide with HIV, and the 200 million with schistosomiasis, the majority live in Africa— where millions of people are simultaneously infected with both diseases. Now, researchers reporting in PLOS Neglected Tropical Diseases have shown that schistosomiasis infections are associated with increased HIV onward transmission, HIV acquisition in HIV negative women with urogenital schistosomiasis, and progression to death in HIV positive women.
The new Sherman Institute will advance basic research on novel therapies for a range of disorders, including autoimmune, neurodegenerative, and infectious diseases, as well as cancer.
AIDS patients suffer higher rates of cancer because they have fewer T-cells in their bodies to fight disease. But new research examines why HIV-infected patients have higher rates of cancer—among the leading causes of death among that population—than the general population.
CINCINNATI--A gene mutation that is believed to have safeguarded some people in 14th century Europe from the bubonic plague today may be protecting HIV patients co-infected with hepatitis C from potentially fatal liver scarring, says a University of Cincinnati (UC) College of Medicine physician-scientist.
Preclinical experiments by University of Alabama at Birmingham researchers suggest the cancer drugs vorinostat, belinostat and panobinostat might be repurposed to treat infections caused by human papillomaviruses, or HPVs.
Algunos virus son capaces de apoderarse de una enzima que supuestamente previene enfermedades autoinmunitarias con el fin de evitar ser detectados. Este descubrimiento de los investigadores de Mayo Clinic y de sus colaboradores se publica en PLOS Biology.
ROCHESTER, Minn. — An enzyme intended to prevent autoimmune disease can be hijacked and used by some viruses to avoid immune detection. That discovery from Mayo Clinic researchers and collaborators appears in PLOS Biology. There's also good news. The same team also defined how much viral genetic material is needed to reverse the process and instead activate the immune system against the virus.
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