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Released: 23-May-2022 12:00 PM EDT
Public Cord Blood Banks as a source of starting material for clinical grade HLA-homozygous induced pluripotent stem cells
Preprints

Belen Alvarez-Palomo, Anna Veiga, Angel Raya, Margarita Codinach, Silvia Torrents, Laura Ponce Verdugo, Clara Rodriguez-Aierbe, Leopoldo Cuellar, Raquel Alenda, Cristina Arbona, Dolores Hernández-Maraver, Cristina Fusté, Sergi Querol

Released: 23-May-2022 12:00 PM EDT
Evaluating the Safety and Efficacy of MSCs-derived Exosomes for Treatment of Resistant Perianal Fistula in IBD patients; Clinical Trial Phase I
Preprints

Hojjatollah Nazari, Asieh Heirani, Masoud Soleimani, Reza Akbari Asbagh, Behnam Behboudi, Mohammad Sadegh Fazeli, Mojgan Rahimi, Mohammad Reza Keramati, Amir Keshvari, Alireza Kazemeini, Foroogh Alborzi, Seyed Mohsen Ahmadi Tafti

Released: 23-May-2022 12:00 PM EDT
Acceptance of Murine Islet Allografts Without Immunosuppression in the Inguinal Subcutaneous White Adipose Tissue Pretreated with bFGF
Preprints

Yuki Nakafusa, Naoyoshi Nitta, Kazunari Ishii, Naoto Shirasu, Takahiro Iwamoto, Takayuki Nemoto, Masafumi Nakamura, Masafumi Goto, Hiroo Iwata, Masaru Taniguchi, Yohichi Yasunami

Released: 23-May-2022 12:00 PM EDT
Multiplexed Microfluidic Platform for Stem-Cell Derived Pancreatic Islet β Cells
Preprints

Ishan Goswami, Eleonora de Klerk, Phichitpol Carnese, Matthias Hebrok, Kevin Healy

Released: 23-May-2022 12:00 PM EDT
Characteristics of anti-CLL1 based CAR-T therapy for children with relapsed or refractory acute myeloid leukemia: the multi-center efficacy and safety interim analysis
Preprints

Min Luo, Hui Zhang, Chaoke Bu, Zhiyong Peng, Guangchao Li, Zhao Zhou, Wen Ding, Yongwei Zheng, Yingyi He, Zhengbin Hu, Kunlin Pei, Chunfu Li

Released: 20-May-2022 12:00 PM EDT
Carbonic anhydrase IX-targeted chemodynamic & photodynamic cancer stem cell therapy
Preprints

Hyo Sung Jung, Seyoung Koo, Miae Won, Seeun An, Haebeen Park, Jonathan Sessler, Jiyou Han, Jong Seung Kim

Released: 19-May-2022 12:00 PM EDT
Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model
Preprints

Sudip Paul, Masamitsu Sone, Ashwini Patil, Hisaya Kato, Yoshiro Maezawa, Motohiko Oshima, Masaki Fukuyo, Bahityar Rahmutulla, Yasuo Ouchi, Kyoko Tsujimura, Mahito Nakanishi, Atsushi Kaneda, Atsushi Iwama, Koutaro Yokote, Koji Eto, Naoya Takayama

Released: 19-May-2022 12:00 PM EDT
Mesenchymal Stromal Cells showed an alteration of differentiation potential under Environmental Micro and Nanoplastics Exposure
Preprints

Hana Najahi, Nicola Alessio, Tiziana Squillaro, Gea Oliveri Conti, Margherita Ferrante, Giovanni Di Bernardo, Umberto Galderisi, Imed Messaoudi, Sergio Minucci, Mohamed Banni

Released: 18-May-2022 12:00 PM EDT
Effects of a monoclonal antibody against (pro)renin receptor on gliomagenesis
Preprints

Takeshi Fujimori, Yuki Shibayama, Takahiro Kanda, Kenta Suzuki, Daisuke Ogawa, Ryo Ishikawa, Kyuichi Kadota, Toru Matsunaga, Keisuke Miyake, Akira Nishiyama, Takashi Tamiya

Released: 18-May-2022 12:00 PM EDT
High-throughput preclinical screening of CD123 scFv to design 3rd generation of CAR T-cell in the treatment of BPDCN patient
Preprints

Maxime Fredon, Margaux Poussard, Sabeha Biichle, Francis Bonnefoy, Evan Seffar, Elodie Bôle-Richard, Florian Renosi, Romain Boidot, François Anna, Maria Loustau, Julien Caumartin, Philippe Saas, Eric Deconinck, Etienne Daguindeau, Xavier Roussel, Olivier Adotevi, Fanny Angelot-Delettre, Jeanne Galaine, Francne Garnache-Ottou

Released: 17-May-2022 12:00 PM EDT
Downregulation of circBIRC6 and circCORO1C during differentiation of human cord blood-derived CD34 cells
Preprints

Roqaye Karimi, Amir Atashi, Mina Soufi Zomorrod, Monireh Agami, Mansoureh Ajami

Released: 17-May-2022 8:05 AM EDT
Vyriad, Inc. Raises $29.5M in Series B Funding Led by Renowned Genetics Entrepreneur
Vyriad, Inc.

Vyriad, Inc., a clinical-stage biotechnology company developing oncolytic virus therapies to treat a wide range of cancers, today announced $29.5M in new funding led by Mr. Harry Stine of Stine Seed Farms, Inc.

Released: 16-May-2022 12:00 PM EDT
A Label-Free Cell Sorting Approach to Highlight the Impact of Intratumoral Cellular Heterogeneity and Cancer Stem Cells on Response to Therapies
Preprints

Céline Hervieu, Mireille Verdier, Gaëlle Bégaud, Niki Christou, Magali Sage, Julie Pannequin, Serge Battu, Muriel Mathonnet

Released: 16-May-2022 8:35 AM EDT
Factor Bioscience to Deliver Four Presentations at the American Society of Gene & Cell Therapy (ASGCT) 25th Annual Meeting
Factor Bioscience

Factor Bioscience Inc., a Cambridge-based biotechnology company focused on developing mRNA and cell-engineering technologies, announced its participation in the American Society of Gene & Cell Therapy (ASGCT) 25th Annual Meeting to be held in Washington, D.C. from May 16-19, 2022.

Released: 16-May-2022 5:45 AM EDT
Efficacy of azacitidine in preventing relapse after hematopoietic stem cell transplantation for advanced myeloid malignancies: a systematic review and meta-analysis
Expert Review of Hematology

Background Relapse is the leading cause of death from myeloid malignancies after allogeneic hematopoietic stem cell transplantation (HSCT). Azacitidine has gained attention in recent years in the prophylaxis of relapsed refractory hematologic …

Released: 16-May-2022 5:45 AM EDT
Treosulfan plus fludarabine versus TEAM as conditioning treatment before autologous stem cell transplantation for B-cell Non-Hodgkin lymphoma
Bone Marrow Transplantation

Conditioning with treosulfan and fludarabine (Treo/Flu) has been proven to be feasible and efficient in several types of malignancies before allogeneic hematopoietic stem cell transplantation (allo-HSCT). Given its favorable reduced …

Released: 16-May-2022 5:45 AM EDT
The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
Oncogene

It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this …

Released: 16-May-2022 5:45 AM EDT
PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents
Cell Reports

… Given the important function of PTBP1 in directing lineage choice in diverse stem cell systems and the overall relevance of mRNA splicing in hematopoiesis, we hypothesized that PTBP1 might play a role as a regulator of posttranscriptional …

Released: 16-May-2022 5:45 AM EDT
T and NK Cells in IL2RG-Deficient Patient 50 Years After Hematopoietic Stem Cell Transplantation
Journal of Clinical Immunology

… To investigate the status of the T-cell compartment of UPN1 up to 51 years post-HSCT in the context of a stem cell boost at 37 years after HSCT, we aimed to combine detailed phenotyping with TCR repertoire analysis. Development of a T-cell-focused …

Released: 13-May-2022 5:45 AM EDT
Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders
Journal of Tissue Engineering

The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs development pipeline by mimicking the physiological environment and functions of human organs. The translational value of OoC is further enhanced when …

Released: 13-May-2022 5:45 AM EDT
Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival
Proceedings of the National Academy of Sciences (PNAS)

… for Atg5, the stem cell loss in vivo was more pronounced than in vitro, suggesting that additional cell populations likely depend upon Atg5 function to support ileum health. We first tested whether ATG5-dependent WNT signaling was required for …

Released: 13-May-2022 5:45 AM EDT
Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches
Nature Communications

… With Select-seq, we analyse the cancer stem cell-like microniches in relation to the tumour microenvironment of triple-negative breast cancer patients. We identify alternative splice variants, perform complementarity-determining region analysis of …

Released: 13-May-2022 5:45 AM EDT
Haematopoietic stem cell gene therapy in inborn errors of metabolism
British Journal of Haematology

Over the last 30 years, allogeneic haematopoietic stem cell transplantation (allo‐HSCT) has been adopted as a therapeutic strategy for many inborn errors of metabolism (IEM), due to the ability of donor‐derived cells to provide life‐long enzyme delivery to …

Released: 12-May-2022 12:00 PM EDT
Identification of potential crucial genes in sarcopenia: a bioinformatic analysis
Preprints

Youxiang Su, Nianhu Li, Jian Xin, Shang Gao, Yun Song, Xintian Qu, Yan Liu, Xiusen Ma

Released: 12-May-2022 5:00 AM EDT
Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia–reperfusion injure by restoring CPT1A mediated fatty acid oxidation
Stem Cell Research & Therapy

Renal fibrosis is a common pathological process of chronic kidney diseases induced by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance the efficacy of secreted extracellular vesicles (MSC-EVs) on various diseases, but it …

Released: 12-May-2022 5:00 AM EDT
Risk prediction of CMV reactivation after allogeneic stem cell transplantation using five non-HLA immunogenetic polymorphisms
Annals of Hematology

Despite advances in the understanding of the pathophysiology of cytomegalovirus (CMV) infection, it remains as one of the most common infectious complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The aim of this study …

Released: 11-May-2022 12:00 PM EDT
Short-lived booster effect and stable CD8+ T cell memory after 3rd COVID-19 vaccine dose
Preprints

Robert Thimme, Matthias Reinscheid, Hendrik Luxenburger, Vivien Karl, Anne Graeser, Sebastian Giese, Kevin Ciminski, David Reeg, Valerie Oberhardt, Natascha Röhlen, Julia Lang-Meli, Kathrin Heim, Nina Gross, Christina Baum, Siegbert Rieg, Claudius Speer, Florian Emmerich, Susanne Breisinger, Daniel Steinmann, Bertram Bengsch, Tobias Boettler, Georg Kochs, Martin Schwemmle, Christoph Neumann-Haefelin, Maike Hofmann

Released: 11-May-2022 12:00 PM EDT
ceRNA network analysis reveals the molecular mechanism by which umbilical cord mesenchymal stem cells reverse thymic epithelial cell senescence
Preprints

Zai-Ling Yang, Xiang-Qing Zhu, Tian Chuan, Zhao Jing, Guang-Ping Ruan, Pan Hang, He Jie, Wang Kai, Wang Wei, Xing-Hua Pan

Released: 11-May-2022 5:00 AM EDT
Gastruloids: Pluripotent stem cell models of mammalian gastrulation and embryo engineering
Developmental Biology

… Also, and most importantly, when comparing results across laboratories we need to bear in mind that no embryonic stem cell line is a tabula rasa. Different cell lines have been shown to exhibit biases in differentiation potential (Ortmann et al., 2020) …

Released: 11-May-2022 5:00 AM EDT
Molecular regulation of trophoblast stem cell self-renewal and giant cell differentiation by the Hippo components YAP and LATS1
Stem Cell Research & Therapy

… has led to the development of trophoblast stem cell lines which retain the capacity to … –OFF switch to regulate various hallmark processes of stem cell biology like self-renewal [15, 16… pools with temporal replenishment of the trophoblast stem cell hub …

Released: 11-May-2022 5:00 AM EDT
β-elemene suppresses tumor metabolism and stem cell-like properties of non-small cell lung cancer cells by regulating PI3K/AKT/mTOR signaling
American Journal of Cancer Research

Multi-drug resistance remains a critical issue in cancer treatment that hinders the effective use of chemotherapeutic drugs. The active components of traditional Chinese medicine have been applied as adjuvants to accentuate the anticancer …

Released: 10-May-2022 12:00 PM EDT
Nacre-mimetic cerium-doped nano-hydroxyapatite/chitosan layered composite scaffolds regulate bone regeneration via OPG/RANKL signaling pathway
Preprints

Xiao-Liang Liu, Chuan-Jian Zhang, Jing-Jing Shi, Qin-Fei Ke, Yu-Wei Ge, Zhen-An Zhu, Ya-Ping Guo

Released: 10-May-2022 8:00 AM EDT
Taking the guesswork out of journal submission with Community Review
Cell Stem Cell

This Backstory describes the development of a research article published in Cell Stem Cell that was originally submitted to Community Review, a program wherein a manuscript is simultaneously considered at multiple Cell Press journals. The article, a

Released: 10-May-2022 5:00 AM EDT
A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury
Nature Communications

… reside in the RZ, a known location for stem cells 5,11 , and that FoxA2+ cells are located in close proximity to the SOC, which is viewed as a signaling center of RZ stemness 10 , we asked whether FoxA2+ cells are different than the previously …

Released: 10-May-2022 5:00 AM EDT
p57Kip2 imposes the reserve stem cell state of gastric chief cells
Cell Stem Cell

… stem cell … stem cell state, accompanied by altered niche requirements and a mature chief cell/secretory phenotype. Following the constitutive expression of p57 in vivo, chief cells showed an impaired injury response. Thus, p57 is a gatekeeper …

Released: 10-May-2022 5:00 AM EDT
Nuclear factor programming improves stem-cell-derived hepatocyte phenotype
Cell Stem Cell

… In this issue of Cell Stem Cell, Ma et al. demonstrate that the activation of the nuclear receptor thyroid hormone receptor beta (NR1A2) improves the differentiation status of hepatocyte-like cells derived from human pluripotent stem cells. … In this …

Released: 10-May-2022 5:00 AM EDT
An instantly fixable and self-adaptive scaffold for skull regeneration by autologous stem cell recruitment and angiogenesis
Nature Communications

Limited stem cells, poor stretchability and mismatched interface fusion have plagued the reconstruction of cranial defects by cell-free scaffolds. Here, we designed an instantly fixable and self-adaptive scaffold by dopamine-modified hyaluronic acid …

Released: 9-May-2022 4:05 PM EDT
Clemson web apps calculate soil pH to help growers increase profits, reduce costs
Clemson University

Lime is a very important soil amendment used to grow crops. To help ensure the correct amount is applied where it is needed most, the Clemson University Precision Agriculture Team has developed the Reverse Lime Rate Calculator.

Newswise: Novel Course on Medical Device Innovation Adds to Skills of Future Physicians
Released: 9-May-2022 2:35 PM EDT
Novel Course on Medical Device Innovation Adds to Skills of Future Physicians
Stony Brook University

In a paper in Academic Medicine, educators at the Renaissance School of Medicine (RSOM) at Stony Brook University highlighted the success of their three-year, elective course in biodesign that has enabled students to expand their abilities as medical device innovators.

Newswise: Mobius_DanforthCenter_IN2_web.jpg
Released: 9-May-2022 9:55 AM EDT
IN2 AgTech Startups Making an Impact
Donald Danforth Plant Science Center

While our planet faces many grand challenges that are impacting global food security, the Wells Fargo Innovation Incubator (IN2) is helping to bring new AgTech innovations to the table.

Released: 9-May-2022 9:55 AM EDT
The 2022 Society for Biomaterials, Technology Innovation and Development Award goes to Dr. Guillermo Ameer and the Acuitive Technologies Team
Acuitive Technologies

The honor recognizes biomaterials research that significantly benefits patient health and outcomes.


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