Shivdasani et al. assign niche functions to specific mesenchymal cell types near stem cells at the base of intestinal crypts. They identify PDGFRAlo fibroblasts as a substantial source of requisite Wnt ligands and show that BMP signaling from crypt
Stem cell-based embryo models provide a useful system for studying early embryonic development. Li and colleagues reported the generation of cynomolgus monkey blastoids with similar characteristics to natural blastocysts. These blastoids possess the
The existence of adult beta cell neogenesis has been controversial, with numerous papers published arguing for and against over the years, and many conclusions in the field are thus based on studies that were performed years and sometimes decades ago
Marchiano and colleagues interrogate the underlying causes of ventricular arrhythmias occurring after human pluripotent stem cell-cardiomyocyte transplantation. Through stepwise analysis and gene editing of ion channel expression, they mitigate pace-
Engraftment arrhythmia (EA) compromises the safety of hPSC-CM cell therapy. We hypothesized that spontaneous graft depolarizations are the source of EAs. We used a CRISPR screen to demonstrate that targeting excitatory channels HCN4, CACNA1H, and SLC
Alzheimer’s disease (AD) is associated with reduced adult hippocampal neurogenesis and impaired hippocampal-dependent behaviors. Li et al. report that stimulating adult neurogenesis combined with new-born neuron activation ameliorates behavioral s
The process of generating adult-born neurons (ABNs) in the hippocampus is impaired in AD. Song and colleagues report a circuit-based strategy by stimulating SuM to enhance hippocampal neurogenesis in AD mice. Activation of SuM-modified ABNs restores
The paucity of hematopoietic stem cells (HSCs) presents a challenge for both transplantation and the study of HSCs.1 Sakurai et al.2 now present a cytokine-free culture system for robust ex vivo expansion of functional human HSCs that may lead to e
Magenheim et al. challenge a recent study claiming that pancreatic beta cells are generated at a physiologically important rate from progenitor cells within ducts. They show that the lineage-tracing systems used in that study do in fact pulse label
Yue and colleagues demonstrate that matrix stiffness negatively regulates the HSC niche factor expression by BMSCs. They successfully engineer a soft bone marrow niche that not only promotes HSC maintenance and lymphopoiesis but also rejuvenates midd
Small molecule-induced cell fate transitions are characterized by low efficiency and slow kinetics. An optimized chemical reprogramming approach now facilitates the robust and rapid conversion of somatic cells to pluripotent stem cells, unlocking exc
Banjac et al. review the mechanisms behind homeostasis and regeneration in the epidermis, hematopoietic system, and intestinal epithelium with an emphasis on tissue stem cells. They highlight key challenges facing the field with reference to underst
Chemical reprogramming provides a robust approach for cell fate manipulation. Here, Deng and colleagues developed a highly reproducible and efficient chemical reprogramming method for the induction of human pluripotent stem cells and revealed increas
Announcement that NeuRx ® Diaphragm Pacing System, pioneered by University Hospitals and Case Western Reserve University in Cleveland, received FDA premarket approval. The system helps spinal cord injured patients breathe without a mechanical ventilator. Co-inventor Raymond Onders, MD, has implanted the system more than anyone else, and he travels the world teaching other doctors how to do it.
A pre-market regulatory status review conducted by the United States Department of Agriculture (USDA) Animal and Plant Health Inspection Service has concluded that teff modified by genome editing to have a semi-dwarf stature is not subject to biotechnology regulation under USDA’s SECURE Rule.
As Earth’s population grows, the demands of modern lifestyles place mounting strain on the global environment. Proposed solutions to preserve and promote planetary sustainability can sometimes prove more harmful than helpful. However, technologies that harness natural processes could be more successful.
Missing crucial doses of medicines and vaccines could become a thing of the past thanks to Rice University bioengineers’ next-level technology for making time-released drugs.
The financial terms of biotechnology licenses from academic institutions are significantly less favorable than those of comparable licenses between commercial firms according to a new study from Bentley University’s Center for Integration of Science and Industry.
The kidney plays a vital role in maintaining homeostasis within the body by eliminating toxic and superfluous substances in the bloodstream, including waste generated during metabolic processes, through urine.
Researchers at the University of Washington have developed GlucoScreen, a system that could enable people to self-screen for prediabetes.
New research from Oregon Health & Science University and collaborators indicates lab-made antibodies may be able to cure people infected with yellow fever, a virus for which there is no treatment.
The Sbarro Health Research Organization (SHRO), led by Prof. Antonio Giordano, in collaboration with the Texas Scientific Italian Community (TSIC), led by Prof. Andrea Giuffrida, will present the XVII Conference of Italian Researchers in the World on Saturday April 1st from 9:30 AM to 3:00 PM at Temple University of Philadelphia.
Bioactive compounds present mostly in fruit and vegetables perform different bodily functions relating to health and well-being. Their effects are considered antioxidant, antidiabetic, antiaging and anticancer, among others.
From septic shock to sticker shock. Keep up with this ever-growing, changing sector. Below are some of the latest stories on healthcare on Newswise.
In Biophysics Reviews, researchers identify the most promising advancements and greatest challenges of artificial mitochondria and chloroplasts. The team describes the components required to construct synthetic mitochondria and chloroplasts and identifies proteins as the most important aspects for molecular rotary machinery, proton transport, and ATP production. The authors believe it is important to create artificial cells with biologically realistic energy-generation methods that mimic natural processes; replicating the entire cell could lead to future biomaterials.
Cardiomyopathy is a pathological condition characterized by cardiac pump failure due to myocardial dysfunction and the major cause of advanced heart failure requiring heart transplantation. Although optimized medical therapies have been develop
Ischemic stroke (IS) is the most prevalent form of brain disease, characterized by high morbidity, disability, and mortality. However, there is still a lack of ideal prevention and treatment measures in clinical practice. Notably, the transplan
Osteoporosis is a systemic bone disease, which leads to decreased bone mass and an increased risk of fragility fractures. Currently, there are many anti-resorption drugs and osteosynthesis drugs, which are effective in the treatment of osteopor
BACKGROUNDThe low survival rate of mesenchymal stem cells (MSCs) caused by anoikis, a form of apoptosis, limits the therapeutic efficacy of MSCs. As a proapoptotic molecule, mammalian Ste20-like kinase 1 (Mst1) can increase the production of re
For nearly 20 years, dental stem cells (DSCs) have been successfully isolated from mature/immature teeth and surrounding tissue, including dental pulp of permanent teeth and exfoliated deciduous teeth, periodontal ligaments, dental follicles, a
Most of the time, when someone gets a cut, scrape, burn, or other wound, the body takes care of itself and heals on its own. But this is not always the case. Diabetes can interfere with the healing process and create wounds that will not go away and that could become infected and fester.
An international research team has developed a meta-scale approach to quantifying the human proteome and the massive number of protein variants produced by the human body. Proteomics is a cornerstone of biology and a precursor to understanding how protein dysfunction contributes to disease.
A team of MIT researchers has come up with a kind of tiny, biodegradable tag that can be applied directly to the seeds themselves, and that provides a unique randomly created code that cannot be duplicated.
Staphylococcus aureus, Clostridioides difficile, Candida auris, Drug-resistant Shigella. These bacteria not only have difficult names to pronounce, but they are also difficult to fight off. These bacteria may infect humans and animals, and the infections they cause are harder to treat than those caused by non-resistant bacteria. Antimicrobial resistance is an urgent global public health threat.
The Center for Bioenergy Innovation has been renewed by the Department of Energy as one of four bioenergy research centers across the nation to advance robust, economical production of plant-based fuels and chemicals. CBI, led by Oak Ridge National Laboratory, is focused on the development of nonfood biomass crops and specialty processes for the production of sustainable jet fuel to help decarbonize the aviation sector.
Researchers at The Ohio State University have fabricated the first wearable sensor designed to detect and monitor muscle atrophy.
Keck Medicine of USC has launched a Phase 2 clinical trial investigating the effectiveness of a new outpatient, nonsurgical endoscopic procedure in stabilizing blood glucose levels for patients.
Scientists at University of Utah Health led research that opens up a whole new world within our cells. Their study uncovers a vast network of interactions that assist cells in adjusting in real time to withstand stresses on our health.
The paper ‘Weaponising microbes for peace’ by Anand et al, outlines the ways in which microbes and microbial technologies can be used to tackle global and local challenges that could otherwise lead to conflict, but warns that these resources have been severely underexploited to date.
Scientists previously believed that microorganisms could not use pyrite to grow in oxygen-free conditions. New research shows that certain single-celled microorganisms can dissolve pyrite in the absence of oxygen. These microorganisms mine iron and sulfur from the pyrite to build biocatalysts needed for growth. The results have potential applications in biotechnology.
Registration is now open for Lawrence Livermore National Laboratory’s (LLNL’s) summer science education programs. Summer programming includes opportunities for both teachers and students.
Cameras that can scan an entire body in a fraction of a second can give spinal surgeons an accurate assessment of how much range of motion youth with scoliosis have in their torso – a critical piece of information for guiding management of people with the condition, researchers at Hospital for Special Surgery (HSS) in New York City have found.
Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer’s disease in a mouse model, according to a new study publishing March 7th in the open access journal PLOS Biology by Rui Zhang of Air Force Medical University in Xian, Shaanxi, China. The results illuminate one pathway for entrance of peripheral immune cells into the brain, and may provide a new target for treatment of Alzheimer’s disease.
Love muffins? We’re talking about a tasty, fluffy muffin that has no artificial additives and that simultaneously contains lots of beneficial nutrients.
The Regenerative Medicine Hub continues to grow and attract top talent with the addition of Ron Hann, PhD, a former senior level official with the Department of Defense.
Dr. Sang Kyung Kim (Director) and Dr. Seungwon Jung’s research team at the Center for Augmented Safety System with Intelligence, Sensing of the Korea Institute of Science and Technology (KIST, President: Seok Jin Yoon) announced that they had developed an ultrafast PCR technology.
The Korea Institute of Machinery and Materials (President Park Sang-jin, hereinafter referred to as KIMM), an institution under the jurisdiction of the Ministry of Science and ICT, has succeeded in developing a smart, customizable prosthetic socket that automatically fills the socket with air upon detecting the empty space inside of the socket in real time based on artificial intelligence.
A research team led by Dr. Ho Sang Jung of the Surface & Nano Materials Divison of the Korea Institute of Materials Science (KIMS), a government-funded research institute under the Ministry of Science and ICT, conducted joint research with Professor Junsuk Rho of POSTECH and Professor Samjin Choi of Kyung Hee University Medical School to find metabolites in urine. They succeeded in developing a strip-type urine sensor that can amplify the light signal of metabolites in urine and in diagnosing cancer in the field.
Scientists at the University of Sussex have successfully trialed new biodegradable health sensors that could change the way we experience personal healthcare and fitness monitoring technology.
The discovery of a strain of bacteria shown to reduce inflammation in the intestine caused by irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) could bring relief to millions of sufferers after being turned into an innovative natural food supplement by University of Bristol biotech spin-out Ferryx.
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