Colorectal cancer (CRC) remains the third most prevalent cancer disease and involves a multi-step process in which intestinal cells acquire malignant characteristics. It is well established that the appearance of distal metastasis in CRC pa
Colorectal cancer (CRC) remains the third most prevalent cancer disease and involves a multi-step process in which intestinal cells acquire malignant characteristics. It is well established that the appearance of distal metastasis in CRC pa
Surgical resection, chemotherapy, and radiation are the standard therapeutic modalities for treating cancer. These approaches are intended to target the more mature and rapidly dividing cancer cells. However, they spare the relatively quies
Pathological scarring and scleroderma, which are the most common conditions of skin fibrosis, pathologically manifest as fibroblast proliferation and extracellular matrix (ECM) hyperplasia. Fibroblast proliferation and ECM hyperplasia lead
The mammalian intestinal epithelium constitutes the largest barrier against the external environment and makes flexible responses to various types of stimuli. Epithelial cells are fast-renewed to counteract constant damage and disrupted bar
Mesenchymal stem cells (MSCs), distributed in many tissues in the human body, are multipotent cells capable of differentiating in specific directions. It is usually considered that the differentiation process of MSCs depends on specialized
Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of immunoglobulin-secreting clonal plasma cells at the bone marrow (BM). The interaction between MM cells and the BM microenvironment, and specifically BM
Spinal cord injury (SCI) is a devastating condition with complex pathological mechanisms that lead to sensory, motor, and autonomic dysfunction below the site of injury. To date, no effective therapy is available for the treatment of SCI. R
BACKGROUNDMesenchymal stem cells (MSCs) have been applied to treat degenerative articular diseases, and stromal cell-derived factor-1α (SDF-1α) may enhance their therapeutic efficacy. However, the regulatory effects of SDF-1α on cartilag
Head and neck squamous cell carcinoma is the seventh most common cancer worldwide with high mortality rates. Amongst oral cavity cancers, tongue carcinoma is a very common and aggressive oral cavity carcinoma. Despite the implementation of
Extracellular vesicles (EVs) are nanometric particles that enclose cell-derived bioactive molecules in a lipid bilayer and serve as intercellular communication tools. Accordingly, in various biological contexts, EVs are reported to engage i
A team of engineers at the University of Colorado Boulder has designed a new class of tiny, self-propelled robots that can zip through liquid at incredible speeds—and may one day even deliver prescription drugs to hard-to-reach places inside the human body.
In APL Bioengineering, researchers design a novel algorithm for controlling implanted insulin pumps that accounts for the unique characteristics of individual patients. Their model, tested using an FDA-approved diabetes computer simulation, proves intraperitoneal (within the abdominal cavity) insulin delivery is fast and closely mimics natural physiological insulin delivery. They developed a model that can account for individual patient differences and validated a pump control algorithm that does not require meal announcement.
Scientists at Wake Forest University School of Medicine have uncovered a novel mechanism that shows increased sugar intake and elevations in blood glucose are sufficient to cause amyloid plaque buildup in the brain, which increases the risk of Alzheimer’s disease.
Researchers in UNC’s School of Medicine’s department of Microbiology and Immunology and the UNC-NC State Joint Department of Biomedical Engineering have developed a new strategy to improve drug-delivery into chronic wounds infections.
Arthrex, a global leader in minimally invasive orthopedic technology, launched a new patient-focused website, ACLTear.com, which illustrates the science of anterior cruciate ligament (ACL) injuries, highlights the benefits of knee preservation technology and provides tools to patients to connect with surgeons performing advanced, minimally invasive ACL procedures.
Biologists have used machine learning, a type of AI, to identify “synthetic extreme” DNA sequences with specifically designed functions in gene activation. They tested 50 million DNA sequences and found synthetic DNA sequences with activities that could be useful in biotechnology and medicine.
The American Association of Critical-Care Nurses hosts its annual National Teaching Institute & Critical Care Exposition (NTI) May 22-24 in Philadelphia. NTI -- the world’s largest conference for nurses who care for acutely and critically ill patients -- includes the Critical Care Exposition, the largest and most comprehensive trade show specifically for progressive care and critical care nurses.
CureMD Oncology, a leading provider of all-inclusive technology solutions for community oncology, is delighted to announce its partnership with Palouse Specialty Physicians, a comprehensive cancer care provider in the Pacific Northwest region.
First-generation bioresorbable vascular scaffolds (BVS) may be just as effective as drug-eluting metallic stents, which are currently the standard treatment for heart disease patients undergoing percutaneous coronary intervention (PCI).
Proteins are large, complex molecules that play many critical roles in the body and are produced following the instructions encoded in DNA. By reading their DNA letters, cells produce an intermediate RNA molecule that will give rise to the corresponding protein. Most diseases occur with altered protein levels, which are either a cause or consequence of the condition itself. RNA plays a pivotal role in diseases with altered protein levels by serving as the intermediary messenger between DNA and protein.
Skin cancer is the most prevalent form of cancer in the United States, with over 5 million cases diagnosed annually. The Centers for Disease Control and Prevention reports that melanoma alone accounts for more than 8,000 deaths each year. Thankfully, skin cancer is highly preventable, making it crucial to prioritize protection. Below are some of the latest headlines in the Dermatology channel.
Iowa State University engineers are developing advanced tools for cell manufacturing that could improve the cost and availability of therapeutic cells capable of fighting diseases such as cancers, heart disease, lupus and other autoimmune diseases.
To give the authorities a cross-sectoral view of a city’s nutrient sink status, the researchers identified and analysed a range of waste flows. Their approach distinguished four nested spatial levels: the urban area; the potential territorial recycling system; the country and the international level. Based on that analysis, the researchers focused on the origin and fate of those nutrient-containing waste flows.
A new method for analyzing protein crystals – developed by Cornell researchers and given a funky two-part name – could open up applications for new drug discovery and other areas of biotechnology and biochemistry.
UCLA researchers have developed an “all-in-one,” next-generation statistical simulator capable of assimilating a wide range of information to generate realistic synthetic data and provide a benchmarking tool for medical and biological researchers who use advanced technologies to study diseases and potential therapies.
Nonfood, plant-based biofuels have potential as a green alternative to fossil fuels, but the enzymes required for production are too inefficient and costly to produce. However, new research is shining a light on enzymes from fungi that could make biofuels economically viable.
Going beyond pregnancy and COVID-19, the world could someday soon come to rely on at-home tests for many diseases thanks in part to AI-fueled improvements.
The National Science Foundation's program to build research capacity across the country has awarded a $20 million grant to support Iowa researchers working to make the state a leader in advanced biomanufacturing. The researchers will use microbes to produce plastics for 3D printing, fibers for flexible and rigid materials and proteins for medical diagnostics and therapeutics.
Wistar Institute has formed a collaboration with the Pennsylvania Biotechnology Center and the Baruch S. Blumberg Institute to accelerate the advancement of “bench to bedside” biomedical research discoveries in the tri-state region.
Researchers from the University of California, Irvine have developed a DNA enzyme – or DNAzyme – that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact. This breakthrough “gene silencing” technology could revolutionize the development of DNAzymes for treating cancer, infectious diseases and neurological disorders.
Oak Ridge National Laboratory scientists led the development of a supply chain model revealing the optimal places to site farms, biorefineries, pipelines and other infrastructure for sustainable aviation fuel production.
University of Minnesota Twin Cities researchers have developed a groundbreaking new diagnostic technique that will allow for faster and more accurate detection of neurodegenerative diseases that affect humans, such as Alzheimer's and Parkinson's, and similar diseases that affect animals, such as chronic wasting disease (CWD) and mad cow disease.
The Association of Biomolecular Resource Facilities (ABRF) 2023 Annual Meeting will be held May 7-10 at the Sheraton Boston Hotel.
University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, announced today that Bradley A. Maron, MD, Associate Professor of Medicine at Brigham & Women’s Hospital (BWH) and Harvard Medical School (HMS), and Co-Director of the Pulmonary Vascular Disease Center at the VA Boston Healthcare System, has been appointed Co-Director of the UMB’s new Institute for Health Computing (UM-IHC), Director of Scientific Operations for the UM-IHC at UMSOM, as well as Senior Associate Dean for Precision Medicine at the UMSOM, effective May 1, 2023.
An upgraded computational tool from St. Jude Children’s Research Hospital can find potentially druggable hidden drivers of cancer and other biological processes using multi-omics data.
Using a “spooky” phenomenon of quantum physics, Caltech researchers have discovered a way to double the resolution of light microscopes.
Applying machine learning models, a type of AI, to data collected passively from wearable devices can identify a patient’s degree of resilience and well-being, according to investigators at the Icahn School of Medicine at Mount Sinai in New York. The findings, reported in the May 2nd issue of JAMIA Open, support wearable devices, such as the Apple Watch®, as a way to monitor and assess psychological states remotely without requiring the completion of mental health questionnaires.
Gene-editing therapy aimed at two targets – HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that helps the virus get into cells – can effectively eliminate HIV infection. The study is the first to combine a dual gene-editing strategy with antiretroviral drugs to cure animals of HIV-1.
What if your physician could predict if—or when—you might experience a heart attack, cardiac arrest or another heart-related problem?
Researchers, including from NTNU, are breeding bacteria-free fish fry. This pursuit is more important than you might think. The researchers have studied how bacteria affect the growth, genes and mucous membranes of the fish.
This agreement will enable FAU and Insightec to collaborate to advance scientific knowledge about the use of focused ultrasound to treat brain diseases, including Parkinson’s disease and Alzheimer’s disease. By harnessing acoustic energy, Insightec’s innovative technology uses focused ultrasound to treat diseases in different ways.
Scientists have been studying the possibility of electrical signal transfer between mushrooms and across trees via the mycelial networks. It is thought that fungi generate electrical signals in response to external stimuli and use these signals to communicate with each other, coordinating growth and other behavior.
Seven University of Utah Health projects have received seed grants that could promote the development and use of more scientifically based digital health applications in daily health care.
Multiple myeloma is a rare blood cancer caused by the uncontrolled multiplication of abnormal plasma cells. These plasma cells are a special type of white blood cells that play an important role in the immune system by producing essential antibodies in the bone marrow and lymph nodes.
Researchers have developed a biosynthetic “clock” that keeps cells from reaching normal levels of deterioration related to aging. They engineered a gene oscillator that switches between the two normal paths of aging, slowing cell degeneration and setting a record for life extension.
Developed by a research team from NYU Tandon School of Engineering and the Massachusetts Institute of Technology (MIT), a new electrical “pill”, dubbed FLASH, delivers electrical impulses to the stomach lining once it's swallowed and may be able to regulate people’s appetites without any drugs or invasive medical procedures. This targeted stimulation triggers the brain to modulate gut hormones related to hunger.
Allogeneic hematopoietic stem cell transplantation is a deterministic curative procedure for various hematologic disorders and congenital immunodeficiency. Despite its increased use, the mortality rate for patients undergoing this procedure
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