Curated News: Cell (journal)

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Newswise: Boot Camp for the Immune System
Released: 27-Jun-2022 5:45 PM EDT
Boot Camp for the Immune System
Harvard Medical School

Researchers identify new mechanism that teaches immune cells-in-training to spare the body’s own tissues while attacking pathogens.

Newswise: Knocking Out Nausea
Released: 22-Jun-2022 5:05 PM EDT
Knocking Out Nausea
Harvard Medical School

A new study in mice describes how different cell types in the brain work together to suppress nausea

Released: 17-Jun-2022 3:05 PM EDT
Tenascin Proteins Inhibit Regeneration of Cell Envelope
Ruhr-Universität Bochum

Researchers at Ruhr-Universität Bochum have been studying the role of the two proteins tenascin C and tenascin R in multiple sclerosis. In this disease, cells of the immune system destroy the myelin sheaths, i.e. the sheaths of the nerve cells.

Released: 14-Jun-2022 11:45 AM EDT
New Research Identifies More Than 1,000 Genes Linked to Severe COVID-19
University of Sheffield

University of Sheffield research collaboration with Stanford University reveals why some healthy adults with the COVID-19 infection become seriously ill, whilst others have few symptoms

Newswise: Investigators discover a ‘double life’ for a key Parkinson’s disease protein
Released: 9-Jun-2022 11:35 AM EDT
Investigators discover a ‘double life’ for a key Parkinson’s disease protein
Brigham and Women’s Hospital

Researchers have uncovered a new function for alpha-synuclein, a well-known protein marker of Parkinson’s, with relevance toward treatment for the disease

Newswise: Robot skin heals
Released: 9-Jun-2022 11:30 AM EDT
Robot skin heals
University of Tokyo

A robotic finger with living skin tissue points to future manufacturing methods.

Newswise: Rapid Ebola Diagnosis May Be Possible with New Technology
7-Jun-2022 2:05 PM EDT
Rapid Ebola Diagnosis May Be Possible with New Technology
Washington University in St. Louis

A new tool can quickly and reliably identify the presence of Ebola virus in blood samples, according to a study by researchers at Washington University School of Medicine in St. Louis and colleagues at other institutions.

Released: 8-Jun-2022 2:05 AM EDT
Double Agents: How Stomach Stem Cells Change Allegiance Upon Injury
Institute of Molecular Biotechnology

The interest of scientists in adult stem cells resides in their ability to self-renew indefinitely and differentiate into all cell types making up the organ where they reside.

Newswise: Neuroscientists Identify Role of Basolateral Amygdala Neurons
Released: 7-Jun-2022 3:05 PM EDT
Neuroscientists Identify Role of Basolateral Amygdala Neurons
Sainsbury Wellcome Centre

The basolateral amygdala (BLA) is a region of the brain that has been almost exclusively studied in the context of fear and emotion.

Newswise: Causes of Liver Cancer are Changing Around the World: Some Up, Some Down
Released: 6-Jun-2022 2:05 PM EDT
Causes of Liver Cancer are Changing Around the World: Some Up, Some Down
UC San Diego Health

UC San Diego researchers report that the causes and death rates of liver cancer are changing around the world.

Newswise: A Stem Cell Model From Mount Sinai Could Help Unravel the Complex Biology Behind Some Psychiatric Disorders
Released: 1-Jun-2022 3:30 PM EDT
A Stem Cell Model From Mount Sinai Could Help Unravel the Complex Biology Behind Some Psychiatric Disorders
Mount Sinai Health System

Researchers from the Icahn School of Medicine at Mount Sinai have applied a novel stem cell model to map disease risk variants in human neurons, which could help provide insights into the biological mechanisms that underlie neuropsychiatric disorders such as autism and schizophrenia.

Newswise: LJI scientists publish first head-to-head comparison of four COVID-19 vaccines
Released: 31-May-2022 2:05 PM EDT
LJI scientists publish first head-to-head comparison of four COVID-19 vaccines
La Jolla Institute for Immunology

"Just understanding the immune responses to these vaccines will help us integrate what is successful into vaccine designs going forward.”

Newswise: University of Kentucky Study: Asymptomatic COVID-19 Could Still Cause Pregnancy Risks
Released: 31-May-2022 12:05 PM EDT
University of Kentucky Study: Asymptomatic COVID-19 Could Still Cause Pregnancy Risks
University of Kentucky

According to a new University of Kentucky College of Medicine study, asymptomatic COVID-19 infection during pregnancy could still have potential long-term consequences for a developing baby. The study led by Ilhem Messoudi, Ph.D., chair of the Department of Microbiology, Immunology and Molecular Genetics, was published in Cell Reports May 25. The research shows that COVID-19 infection in pregnant mothers who were asymptomatic or had mild symptoms still triggered immune responses causing inflammation in the placenta.

Released: 25-May-2022 5:15 PM EDT
Double agents: How stomach stem cells change allegiance upon injury
Institute of Molecular Biotechnology

A stomach adult stem cell population can fulfill two distinct functions: either help with digestion under normal conditions or take the lead on injury response.

Released: 24-May-2022 1:20 PM EDT
Harmless cells transform into ruthless trained killers
University of Birmingham

Processes in the human body could turn groups of harmless immune cells into ruthless killers, capable of attacking other cells infected with viruses or parasites, and potentially tumour cells, a new study reveals.

Released: 24-May-2022 11:05 AM EDT
Researchers Shed Light on Genetic Mechanisms of Wilms Tumor
Ann and Robert H. Lurie Children's Hospital of Chicago

New research from Ann & Robert H. Lurie Children’s Hospital of Chicago and collaborators from other institutions provides insights into some of the genetic characteristics resulting in the development of relapse in patients with Wilms tumor (nephroblastoma), the most common type of pediatric cancer of the kidney.

Newswise: World-first discovery of cornea T cells protecting eyes from viral infections
Released: 24-May-2022 11:05 AM EDT
World-first discovery of cornea T cells protecting eyes from viral infections
The Peter Doherty Institute for Infection and Immunity

The cornea - the transparent protective outer layer of the eye critical to helping us see – produces a delicate and limited immune response to fight infections without damaging our vision, according to a ground-breaking new study from the Peter Doherty Institute for Infection and Immunity (Doherty Institute).

Newswise: Microparticles with feeling
Released: 23-May-2022 5:05 PM EDT
Microparticles with feeling
Max Planck Institute for Marine Microbiology

The surface of a coral is rugged. Its hard skeleton is populated by polyps that stretch their tentacles into the surrounding water to filter out food.

Newswise: Protein Linked to Intellectual Disability Has Complex Role
16-May-2022 3:05 PM EDT
Protein Linked to Intellectual Disability Has Complex Role
Washington University in St. Louis

Researchers at Washington University School of Medicine in St. Louis have identified a previously unknown function for the fragile X protein, the loss of which is the leading inherited cause of intellectual disability. The researchers showed that the protein modulates how neurons in the brain’s memory center process information, a central part of learning and memory.

16-May-2022 2:15 PM EDT
Scientists Nail Down 'Destination' for Protein That Delivers Zinc
Brookhaven National Laboratory

New research describes a “chaperone” protein that delivers zinc, a trace element essential for survival in all living things, to where it’s needed. The chaperone could be especially important when access to zinc is limited—for example in nutrient deficient diets and for growing crops on depleted soils.

Released: 16-May-2022 1:25 PM EDT
‘Friendly’ Gut Bacteria May Eliminate Pathogens by Competing for Energy Resources
UC Davis Health (Defunct)

New research from scientists at UC Davis Health provides clues for how friendly bacteria in the gut — probiotics — may help eradicate bacterial pathogens like Salmonella by being able to compete with them for needed resources.

Released: 16-May-2022 5:45 AM EDT
PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents
Cell Reports

… Given the important function of PTBP1 in directing lineage choice in diverse stem cell systems and the overall relevance of mRNA splicing in hematopoiesis, we hypothesized that PTBP1 might play a role as a regulator of posttranscriptional …

Newswise: Discovery of Cell Protein That Keeps Kaposi’s Sarcoma Herpesvirus Dormant
Released: 11-May-2022 12:30 PM EDT
Discovery of Cell Protein That Keeps Kaposi’s Sarcoma Herpesvirus Dormant
UC Davis Health

A study led by UC Davis Cancer Center identified a binding protein in cancer cell’s nucleus, known as CHD4, as a critical agent keeping Kaposi's sarcoma-associated herpesvirus (KSHV) dormant and undetected by the body’s immune system. CHD4 is linked to cancer cell growth in many types of cancers.

Released: 10-May-2022 3:05 PM EDT
A study confirms the relationship between an amino acid present in diet and depression
Universitat Pompeu Fabra- Barcelona

Researchers from the Girona Biomedical Research Institute (IDIBGI) and Pompeu Fabra University (UPF) in Barcelona, Spain, have identified the role of an amino acid in humans, mice and flies suffering depression.

Released: 10-May-2022 11:20 AM EDT
Moffitt Researchers Identify Pathway that Regulates Lipid Synthesis and Contributes to Tumor Survival
Moffitt Cancer Center

In a new study published in the journal Cell Reports, Moffitt Cancer Center researchers show that cancer cells in an acidic environment undergo lipid synthesis and accumulation. The team identified the key signaling molecules responsible for these changes and discovered that these alterations are associated with poor outcomes and disease progression among breast cancer patients.

Released: 10-May-2022 8:00 AM EDT
Taking the guesswork out of journal submission with Community Review
Cell Stem Cell

This Backstory describes the development of a research article published in Cell Stem Cell that was originally submitted to Community Review, a program wherein a manuscript is simultaneously considered at multiple Cell Press journals. The article, a

Released: 10-May-2022 5:00 AM EDT
p57Kip2 imposes the reserve stem cell state of gastric chief cells
Cell Stem Cell

… stem cell … stem cell state, accompanied by altered niche requirements and a mature chief cell/secretory phenotype. Following the constitutive expression of p57 in vivo, chief cells showed an impaired injury response. Thus, p57 is a gatekeeper …

Released: 10-May-2022 5:00 AM EDT
Nuclear factor programming improves stem-cell-derived hepatocyte phenotype
Cell Stem Cell

… In this issue of Cell Stem Cell, Ma et al. demonstrate that the activation of the nuclear receptor thyroid hormone receptor beta (NR1A2) improves the differentiation status of hepatocyte-like cells derived from human pluripotent stem cells. … In this …

Released: 9-May-2022 5:00 AM EDT
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool
Cell Stem Cell

… programs maintaining stem cell integrity have been identified, safety mechanisms eliminating malignant HSPCs from the stem cell pool … HSPCs and antigen-specific CD4 + T cells, causing stem cell proliferation, differentiation, and specific exhaustion …

Released: 5-May-2022 6:05 AM EDT
Disturbance of calcium homeostasis and myogenesis caused by TET2 deletion in muscle stem cells
Cell Death Discovery

… In this study, we demonstrated that TET2 deficiency impaired muscle stem cell proliferation and differentiation, leading to notable changes in mouse body weight and muscle morphology during development. We further assayed the genome-wide …

Released: 4-May-2022 12:35 PM EDT
The role of the cerebellum in absence seizures
Ruhr-Universität Bochum

Stimulation of certain cerebellar areas could help combat absence seizures.

Newswise: Researchers Manipulate Demographic of Bacterial Community with Novel Electronic Technology
28-Apr-2022 5:05 PM EDT
Researchers Manipulate Demographic of Bacterial Community with Novel Electronic Technology
University of California San Diego

Using second-long electrical shocks, UC San Diego scientists discovered they could control the types of cells in a community of bacteria. Being able to direct the ratio of cells holds implications for settings spanning agriculture to health care, where antibiotic resistance is a significant threat.

Newswise: Experiments Measure Freezing Point of Extraterrestrial Oceans to Aid Search for Life
Released: 3-May-2022 5:05 PM EDT
Experiments Measure Freezing Point of Extraterrestrial Oceans to Aid Search for Life
University of Washington

A planetary scientist worked with engineers to measure the physical limits of a liquid for salty water under high pressure. Results suggest where robotic missions should look for life on the ice-covered oceans of Jupiter’s moon Europa and Saturn’s moon Titan.

Released: 3-May-2022 12:55 PM EDT
How a bot beamed from California to Japan may prevent cancer patients from losing their breasts unnecessarily
Global Alliance for Genomics and Health

Too many women are getting unnecessary mastectomies and other invasive procedures because of a knowledge gap about differences in cancer genes. A new study offers a path to closing the gap.

   
29-Apr-2022 7:05 PM EDT
Study of Promising Alzheimer’s Marker in Blood Prompts Warning About Brain-Boosting Supplements
University of California San Diego

Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer’s disease. Research led by UC San Diego has consistently found high levels of PHGDH expression in brain tissue and blood samples of older adults with different stages of the disease.

Released: 2-May-2022 8:00 AM EDT
Biomaterials to enhance stem cell transplantation
Cell Stem Cell

… In this review, biomaterial-based advances to improve the physiological outcome of stem cell transplantation are described. The review does not aim to provide a comprehensive list of all biofunctional materials described in the literature but …

Released: 29-Apr-2022 5:00 AM EDT
Manufacturing clinical‐grade human induced pluripotent stem cell‐derived beta cells for diabetes treatment
Cell Proliferation

… This review focuses on the key processes and guidelines for clinical translation of human induced pluripotent stem cell (hiPSC)derived β cells for diabetes cell therapy. Here, we discuss the (1) key considerations of manufacturing clinical-grade hiPSCs …

Released: 27-Apr-2022 5:00 AM EDT
Tumor stem cell-derived exosomal microRNA-17-5p inhibits anti-tumor immunity in colorectal cancer via targeting SPOP and overexpressing PD-L1
Cell Death Discovery

Exosomes are known to transmit microRNAs (miRNAs) to affect human cancer progression, and miR-17-5p has been manifested to exert facilitated effects on colorectal cancer (CRC) progression, while the role of tumor stem cells-derived …

Released: 25-Apr-2022 2:10 AM EDT
Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila
Cell Reports

… a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms. … Taken together, our data describe one mechanism by which a transcription factor controls stem cell …

Released: 22-Apr-2022 4:00 AM EDT
Development and regulation of stem  cell‐based therapies in China
Cell Proliferation in Basic and Clinical Sciences

… This article briefly introduced the regulatory framework development, the progress in stem  cell clinical researches and clinical trials of commercially developed stem  cell-based products, as well as the clinical review concerns of stem  cell-based products in …

Released: 22-Apr-2022 4:00 AM EDT
Mesenchymal stem  cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia/reperfusion injury by targeting GSDMD in mice
Cell Death Discovery

… Owing to the fact that MSC-derived exosomes can further control stem  cell differentiation by carrying and transferring miRNAs, stem  cell-based exosome therapeutic regimens have been highlighted as effective means for cardiac …

Newswise: Circuit that focuses attention brings in wide array of inputs
Released: 21-Apr-2022 1:45 PM EDT
Circuit that focuses attention brings in wide array of inputs
Picower Institute for Learning and Memory at MIT

In a new brain-wide circuit tracing study, scientists at MIT’s Picower Institute for Learning and Memory focused selective attention on a circuit that governs, fittingly enough, selective attention.

Newswise: Lab Grown, Self-Sustainable Muscle Cells Repair Muscle Injury and Disease, Mouse Study Shows
Released: 20-Apr-2022 1:30 PM EDT
Lab Grown, Self-Sustainable Muscle Cells Repair Muscle Injury and Disease, Mouse Study Shows
Johns Hopkins Medicine

In proof-of-concept experiments, Johns Hopkins Medicine scientists say they have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice, potentially advancing efforts to treat muscle injuries and muscle-wasting disorders in people.

Released: 19-Apr-2022 4:45 PM EDT
Mayo researchers, collaborators affirm useful blood biomarker for group of brain disorders in new study
Mayo Clinic

A test of protein in the blood gets further support as a biomarker for patients diagnosed with frontotemporal dementia (FTD), a group of brain disorders with few treatment options. These disorders are characterized by changes in behavior, cognition, language or movement.

Released: 19-Apr-2022 10:00 AM EDT
MDS/AML with del5q: An acquired “laminopathy”?
Cell Stem Cell

In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause o

Released: 19-Apr-2022 5:00 AM EDT
Androgens increase excitement in brain organoid research
Cell Stem Cell

Despite the surrounding controversy, quantitative sex-based differences exist in the human brain. In a recent issue of Nature, Kelava et al. shed light on the mechanisms underlying increased brain volume and neuron density in males, while highlighti

Released: 19-Apr-2022 5:00 AM EDT
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes
Cell Stem Cell

Efficient maturation of in vitro-generated cells remains a challenge and the underlying mechanisms are poorly understood. Here Wickramasinghe and colleagues show that PPAR signaling acts in an isoform-specific manner to enhance metabolic and electrop

Released: 19-Apr-2022 5:00 AM EDT
Decoding the temporal and regional specification of microglia in the developing human brain
Cell Stem Cell

Our study comprehensively reveals the spatiotemporal dynamics of regional specification and state transition in the microglia of the developing human brain. By comparing microglia from mice and humans, we assess the conservation of state transitions

Released: 19-Apr-2022 5:00 AM EDT
A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration
Cell Stem Cell

Du et al. discover a chemical cocktail of five small molecules (5SM) promoting adult mammalian CM proliferation and heart regeneration after myocardial infarction. 5SM potentially targets α1 adrenergic receptor, JAK1, DYRKs, PTEN, and MCT1 and make

Released: 19-Apr-2022 5:00 AM EDT
Stem cell-derived β cells go in monkeys
Cell Stem Cell

Du et al. transplanted β cells derived from pluripotent stem cells in diabetic monkeys for the first time, as an intermediate stage toward clinical translation. They observed benefits unfolding over months but also observed immune rejection of the



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