Researchers have created a resource for analyzing how viruses infect human cells. The fruit fly-based toolkit provides a shortcut for assessing SARS-CoV-2 genes and understanding how they interact with human proteins, offering researchers a resource for new COVID-related drug therapies.
The secret to protecting your memory may be a staple of a bodybuilder’s diet. RUSH researchers recently discovered that a muscle-building supplement called beta-hydroxy beta-methylbutyrate, also called HMB, may help protect memory, reduce plaques and ultimately help prevent the progression of Alzheimer’s disease.
The human body consists of numerous trillions of cells, and 60 percent of the energy used within a cell is dedicated to a specific molecular machine. That machine is responsible for producing proteins, which are fundamental building blocks of the body.
Microbes have enormous potential to produce metabolites with potential industrial applications. To do so, microbes use groups of genes called biosynthetic gene clusters (BGCs) that code for the sets of necessary enzymes. Scientists have computationally predicted the products of hundreds of thousands of BGCs, but have experimentally confirmed fewer than 2,000 of them. Researchers have now developed a computational and experimental strategy to redesign BGCs and determine the natural chemical products they create.
UT Southwestern Medical Center biologists have developed a new stem cell-based embryo model for studying early human development, tissue formation, and differentiation, offering valuable contributions to the field of developmental biology and regenerative medicine.
More than a quarter of all stroke victims develop a bizarre disorder — they lose conscious awareness of half of all that their eyes perceive.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
As a human embryo grows, a set of molecules directs cells as they multiply and take on specific identities and spatial positions within the embryo. In one crucial step known as gastrulation, these signaling molecules guide a single layer of embryonic stem cells to form three layers of distinct cell types that will later become different parts of the body.
Researchers from SANKEN (The Institute of Scientific and Industrial Research) and the Graduate School of Frontier Biosciences at Osaka University reported the development of a sensor to look at Pcdh interactions in live neurons, which brings us closer to understanding this mystery.
Together, Notre Dame's Paul Bohn and Joshua Shrout are searching for new ways to observe microorganisms like P. aeruginosa, moving beyond the traditional process of observing cell cultures grown in a Petri dish.
What makes the vital layer of protective cells around the brain and spinal cord — the blood-brain barrier — more or less permeable has been one of the more mystifying questions in neuroscience.
Hematopoietic stem cells (HSCs) are rare cells found in the bone marrow that produce red blood cells, white blood cells, and platelets.
A Ludwig Cancer Research study has discovered that the presence of relatively high numbers of immune cells known as monocytes in tumors is linked to better outcomes in esophageal cancer patients treated with a combination of chemotherapy and immunotherapy, or immunochemotherapy.
A cochlear signal, the exact role of which has been unclear since its discovery around 70 years ago, probably gives the brain information on whether the ear is functioning normally or not.
Distinct, though neighboring, areas of the brain are activated when processing music and language, with specific sub-regions engaged for simple melodies versus complex melodies, and for simple versus complex sentences, according to research from UTHealth Houston.
Scientists have taken an important step forward in predicting who will develop Type 1 diabetes months before symptoms appear.
Using nanomagnets composites and conductive yarn, scientists have invented a smart textile that can sense and measure body movements—from muscles flexing to veins pulsing.
A study led by the University of Oxford has brought us one step closer to solving a mystery that has puzzled naturalists since Charles Darwin: when did animals first appear in the history of Earth?
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Collaborative work by teams at the Department of Medicine and Life Sciences (MELIS) at Pompeu Fabra University (UPF), University of California, Irvine (UCI), and the Institute for Research in Biomedicine (IRB Barcelona) has shown that interplay between circadian clocks in liver and skeletal muscle controls glucose metabolism.
For the first time, researchers have developed a genome-scale way to map the regulatory role of transcription factors, proteins that play a key role in gene expression and determining a plant’s physiological traits. Their work reveals unprecedented insights into gene regulatory networks and identifies a new library of DNA parts that can be used to optimize plants for bioenergy and agriculture.
An octopus devotes about 70 percent of its brain to vision. But until recently, scientists have only had a murky understanding of how these marine animals see their underwater world. A new University of Oregon study brings the octopus’s view into focus.
A new study by an international team from Africa, Asia and Europe has put forward three criteria for evaluating the success of migration as adaptation in the face of climate change: well-being, equity and sustainability.
Researchers have used heart and lung stem cells infected with the virus that causes COVID-19 to better understand how the disease impacts different organs, paving the way for more targeted treatments.
Working with live squid hatchlings at Scripps Institution of Oceanography, UC San Diego scientists find the animals can tune their proteome on the fly in response to changes in ocean temperature via the unique process of RNA recoding. The findings inspire new questions about basic protein function.
In a comprehensive metagenomic study, DZIF scientists Prof. Bärbel Stecher and Prof. Alice McHardy, together with an international research team, investigated the evolution of intestinal bacteria exposed to repeated disruptions by antibiotics.
A new study from researchers at Sanford Burnham Prebys and Eli Lilly and Company describes the science behind an autoimmune disease treatment in a Phase 2 clinical trial.
Despite getting “the munchies”, people who frequently use cannabis are leaner and less prone to diabetes than those who don’t. University of California, Irvine researchers have now uncovered a possible explanation for this paradox – and it’s not good news.
Scientists at St. Jude Children’s Research Hospital found key “on” switch, NLRP12, for innate immune cell death in diseases that cause red blood cells to rupture, which can lead to inflammation and multi-organ failure.
Scientists at La Jolla Institute for Immunology show that T cells can recognize several different viral targets, called "antigens," shared between most coronaviruses, including common cold coronaviruses and SARS-CoV-2. They also looked more in-depth at what fragments of these antigens, called “epitopes,” are recognized and how conserved they are across different coronaviruses.
The Desai Lab shows how clinical use of some monoclonal antibodies may cause life-threatening systemic fungal infections
Researchers have partnered to create a first-of-its-kind open-source, reproducible analysis platform for pediatric brain tumors. With the help of thousands of genomically sequenced samples, researchers have used this platform to identify initial findings about genetic variants associated with poorer outcomes that could help guide future diagnostic and therapeutic advances.
According to a study published in Cell Reports, the tiny implantable devices formed stable, long-lasting and seamless tissue-electrode interfaces with minimal scarring or degradation in rodents.
The discovery suggests that one possible approach to treat glioblastoma would be a therapy that targets the metabolic process in patients who have that genetic alteration.
During last year’s mpox outbreak, the virus spread for the first time outside Africa, causing over 85,000 cases of the disease to date. Men who have sex with men account for the most infections, with a marked skew towards the young.
Scientists report six structures of the Spns2 transporter, which is linked to cancer and other diseases, including while it is bound to a small molecule inhibitor, thus aiding future therapeutic design.
Cold Spring Harbor Laboratory (CSHL) researchers have flipped the script on autism spectrum disorder (ASD) genetics.
UT Southwestern Medical Center researchers have identified hundreds of genomic variants associated with autism spectrum disorder (ASD) in East African families who have a markedly higher prevalence of the neurodevelopmental condition than other populations worldwide. The study, published in Cell Genomics, is the first to investigate the genetics of ASD in an African population, an important step toward decreasing racial and ethnic health disparities for this condition, the authors said.
UC San Diego scientists develop an interactive software that enables scientists to better investigate the DNA damage response.
Researchers in UNC’s School of Medicine’s department of Microbiology and Immunology and the UNC-NC State Joint Department of Biomedical Engineering have developed a new strategy to improve drug-delivery into chronic wounds infections.
Canadian researchers have identified a new role for vitamin K and gamma-carboxylation in beta cells and their potentially protective role in diabetes, achieving a first in 15 years of basic research.
A gene regulating the F-Box and WD Repeat Domain Containing 7 (FBXW7) protein is frequently mutated or deleted in various types of human cancer, including gynecological cancers.
The MGAT5 glycosylation enzyme plays a crucial role in brain development, according to a study by University of California, Irvine researchers, a discovery that may contribute to new therapeutic purposes for neural stem cells.
A team from the University of Michigan Rogel Cancer Center and School of Dentistry, led by Yu Leo Lei, D.D.S., Ph.D., have identified a mechanism in mice for how obesity affects some oral cancers’ ability to escape from the immune system.
Investigators at Cedars-Sinai Cancer found that fatty liver, a condition closely associated with obesity, promotes the spread of colorectal cancer to the liver. Their study, published today in the peer-reviewed journal Cell Metabolism, details the process at the cellular level and could change the way doctors manage the disease in some patients.
Van Andel Institute scientists have pinpointed how a specific gene mutation triggers an inflammatory cascade that may drive development of treatment-resistant cancers.
SpaceMarkers, a new machine learning software developed by researchers at the Johns Hopkins Convergence Institute and the Johns Hopkins Kimmel Cancer Center, can identify molecular interactions among distinct types of cells in and around a tumor.
Humans smell. Each and every person has a unique body odor. People have been using commercial products to alter their scent for generations. From soaps to perfumes, people gravitate to floral and fruity smells. Whether we think these smells are good or bad is of little consequence to mosquitoes, transmitters of diseases that kill hundreds of thousands of people each year.
Going beyond pregnancy and COVID-19, the world could someday soon come to rely on at-home tests for many diseases thanks in part to AI-fueled improvements.
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