Feature Channels: Dermatology

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In a new article published today in Science Translational Medicine, a team of Moffitt Cancer Center researchers, in collaboration with NFlection Therapeutics and researchers at Stanford University, reports the identification of a new drug, NFX-179, that can be applied to the skin and was shown to prevent the development of cutaneous squamous cell carcinoma in pre-clinical models.

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For men with Peyronie's disease (PD), nonsurgical treatment including injections of collagenase clostridium histolyticum (CCH) produces high satisfaction with sexual outcomes – with fewer adverse events compared to surgery, reports a clinical trial in the October issue of The Journal of Urology®, an official journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.

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Grandmother was right: Scrubbing behind the ears and between the toes may help keep the skin in those regions healthy, or so says a new study by a team at the George Washington University.

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Below are some of the latest headlines in the Women's Health channel on Newswise.

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Eczema, which is a group of medical conditions that causes inflamed, irritated, and often itchy skin, affects millions of people worldwide. A new article published in the reveals that children diagnosed with a type of eczema called atopic dermatitis — which they usually develop by 5 years of age — may also need to be tested for a second type of eczema called allergic contact dermatitis, which has similar symptoms and can be triggered by a range of substances that cause an allergic reaction.

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Piercings can be a fun way for people to enhance their personal style. While people may get piercings on different parts of the body, some piercings, like earlobe piercings, are more common and can be less risky. However, all body piercings can cause complications if not cared for safely.

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Adults with atopic dermatitis (AD) have a 34 percent increased risk of developing new-onset inflammatory bowel disease (IBD) compared with individuals who do not have the skin condition, and children have a 44 percent increased risk, according to a new study from the Perelman School of Medicine at the University of Pennsylvania.

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For his work discovering the basis for hemoglobin gene switching and applying those insights to develop a therapy for sickle cell disease and other blood diseases, the Institute for Regenerative Medicine at the University of Pennsylvania awarded Stuart Orkin, MD the third Elaine Redding Brinster Prize in Science or Medicine.

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Acne is a skin disorder that makes life miserable for around 800 million teenagers and adults worldwide, but Australian scientists may have found an effective treatment for sufferers, delivered via tiny nanoparticles.

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University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, announced today that Shawn Kwatra, MD will become the next Chair of the UMSOM’s Department of Dermatology and Chief of Service of Dermatology at the University of Maryland Medical Center (UMMC), following an extensive national search. Dr. Kwatra, who will begin the new role in early 2024, will hold the Joseph W. Burnett Endowed Professor and Chair in Dermatology.

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Melasma is a skin condition that causes patches or freckle-like spots on the face that are darker than a person’s natural skin color. Melasma has many causes, including sun exposure, pregnancy, stress, a medical condition, or taking certain medications, such as oral contraceptive pills.

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Eczema and psoriasis are common skin conditions, and they can both appear as rashes that may itch or burn. If you get rashes often, you might wonder if you have one or the other.

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A new study led by McGill University examines why people living in Atlantic regions are more at-risk for developing melanoma than other Canadians, providing lessons on skin cancer prevention for the whole country.

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Neurons that sense different types of touch are “born” unspecialized but develop specific features based on the skin type they end up innervating.

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With triple-digit temperatures continuing across many parts of the country and the outdoor grilling season still in full swing, a UT Southwestern Medical Center physician who specializes in burn care wants to remind people to be careful around hot surfaces such as a grill or a playground slide.

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As a single organ, our skin is able to perform a broad repertoire of vital functions. Dermatology experts call for a reference guide to single-cell composition of normal human skin, which is still lacking.

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A research team co-led by UCLA investigators has shown that an immunotherapy drug combination can be an effective second-line therapy for patients with an aggressive and deadly type of melanoma that is resistant to the widely used immunotherapy drugs known as PD-1 inhibitors.

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A study published today in a supplement of the Journal of the American Academy of Dermatology titled “Alopecia: A New Frontier” reveals that a new type of medication called JAK inhibitors can effectively treat moderate to severe alopecia areata – a type of hair loss – that has historically been difficult to treat.

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The Food and Drug Administration announced yesterday the approval of HEPZATO Kit to treat ocular melanoma that has spread to the liver. HEPZATO uses a hepatic delivery system to inject the chemotherapy drug melphalan into the liver, a procedure referred to as percutaneous hepatic perfusion (PHP). Moffitt Cancer Center’s Jonathan S. Zager, M.D., was the lead international principal investigator on the multinational FOCUS phase 3 clinical trial to test the procedure, which is manufactured by Delcath Systems, Inc.

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A collaborative study undertaken by the Navarrabiomed Biomedical Research Center (Pamplona, Navarre), the Institute of Neurosciences CSIC-UMH (Sant Joan d’Alacant, Valencian Community) and IRB Barcelona (Barcelona, Catalonia) shows that the administration of ranolazine, a drug currently used to treat heart conditions, improves the efficacy of current therapies for melanoma, in mouse models of this disease.

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The first gene mapping study on human scalp hair whorls not only shows that hair whorl direction has a genetic basis, but also that it is affected by multiple genes.

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It’s a beautiful moniker, but for the world's butterfly children’ it belies a devastating reality filled with enormous pain and suffering caused by a rare skin condition – Epidermolysis Bullosa (EB).

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Dr. Andrea Maderal, a specialist in complex dermatology at the Miller School of Medicine, addresses queries about a recent spike in leprosy cases in Central Florida.

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A study of insulin pumps shows that repeated use sometimes results in pump sites becoming fibrotic, irritated and less effective at delivering insulin.

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Many need medical attention after experiencing burns from unsafe living conditions during the ongoing conflict with Russia.

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After the successful treatment, a patient shares his story to inspire others.

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Immune-checkpoint inhibitors have become the standard of care for patients with advanced melanoma to improve survival, but only some patients respond to this immunotherapy and have long-term benefits. The lack of a long-lasting response, researchers say, is related to failure of antitumor immunologic memory. Treatment options for advanced melanoma are limited for patients who do not respond to this type of therapy.

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Investigators at the Icahn School of Medicine at Mount Sinai have designed an innovative RNA-based strategy to activate dendritic cells—which play a key role in immune response—that eradicated tumors and prevented their recurrence in mouse models of melanoma.

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Hidradenitis suppurativa (HS) is a chronic inflammatory follicular disease which causes painful lumps to form under the skin. The lumps typically form in areas where skin rubs together – such as the armpits, groin, and under the breasts. HS can range in severity from occasional fluid-filled abscesses to widespread rope-like scarring, chronic pain, and increase of infection.

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Although rare, mucosal melanoma in humans has a low survival rate. It has been difficult to investigate due to a lack of similar cancers in animals for study.

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It’s easy to injure a nail by slamming a finger in a car door, wearing the wrong shoes, or getting a sports injury. While these common accidents can happen throughout our life, a board-certified dermatologist from the American Academy of Dermatology (AAD) is providing tips to help you treat an injured nail at home, so you’re prepared if it happens.

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In the largest study of its kind, researchers from Children’s Hospital of Philadelphia (CHOP) used electronic health record (EHR) data from more than 200,000 pediatric patients to describe patterns of pediatric allergies across the United States, validating a population-level pattern of allergy development known as the “allergic march,” in which allergies first present as eczema, followed by food allergies, asthma, and environmental allergies. The researchers also found that a rare food allergy called eosinophilic esophagitis (EoE), which has historically been considered a disease affecting primarily White males, is more common among non-White patients than previously reported.

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According to a new study, women who drank two glasses of dealcoholized muscadine wine daily showed significant improvements in the elasticity and water retention of their skin compared with those who consumed a placebo.

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O mito de que pessoas com pele escura são imunes ao melanoma (um tipo de câncer de pele) persiste há muitos anos.

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Hace muchos años que persiste el mito de que las personas de piel oscura son inmunes al melanoma, un tipo de cáncer de piel.