Trinity scientists, along with international colleagues, have explored the importance of sea travel in prehistory by examining the genomes of ancient Maltese humans and comparing these with the genomes of this period from across Europe.
Two recent discoveries co-led by scientists at Cedars-Sinai may help lead to new ways to treat patients with Allan-Herndon-Dudley syndrome (AHDS), a brain development disorder that causes severe intellectual disability and problems with movement.
Thanks to over a century of modern neuroscience, we have made significant strides in our understanding of the brain.
A new examination of the way different tissues read information from genes has discovered that the brain and testes appear to be extraordinarily open to the use of many different kinds of code to produce a given protein.
Genetic factors played a greater role in a person's overall wellbeing as the pandemic wore on.
The 2022 ACSM Annual Meeting will be held May 31 – June 4 at the San Diego, CA Convention Center alongside the beautiful San Diego Bay. Join us!
In a new study featured on the cover of the May 1 issue of the journal Cancer Research, Moffitt Cancer Center researchers report on their identification of biomarkers based on a type of genetic modification called methylation that predicts the type of tumor immune environment and patient outcomes.
Anonymous $11M donation will go toward research, care for Neurofibromatosis patients
Human beings, like most organisms, are constantly exposed to alternating colder or warmer temperatures.
Researchers at Washington University School of Medicine in St. Louis have identified a previously unknown function for the fragile X protein, the loss of which is the leading inherited cause of intellectual disability. The researchers showed that the protein modulates how neurons in the brain’s memory center process information, a central part of learning and memory.
Vyriad, Inc., a clinical-stage biotechnology company developing oncolytic virus therapies to treat a wide range of cancers, today announced $29.5M in new funding led by Mr. Harry Stine of Stine Seed Farms, Inc.
COVID-19, MIS-C and KD all share a similar underlying mechanism involving the over-activation of particular inflammatory pathways, UC San Diego study shows. Findings support novel drug targets for MIS-C.
A novel technique to measure the age of male sperm has the potential to predict the success and time it takes to become pregnant, according to a newly published study by researchers at the Wayne State University School of Medicine.
Scientists from the Broad Institute of MIT and Harvard have developed a first-of-its-kind cross-tissue cell atlas, and in collaboration with researchers at Mass Eye and Ear, have uncovered new clues for specific cell types and genes involved in complex diseases. In a new study published May 12 in Science, researchers described for the first time how their novel cross-tissue cell atlas derived from an analysis of nuclei from 25 frozen samples from 8 tissue types may increase understanding of the cellular and genetic underpinnings of complex diseases, including heart disease and cancers.
New research examines how cavefish developed unique metabolic adaptations to survive in nutrient-scarce environments. The study created a genome-wide map of liver tissue for two independent colonies of cavefish along with river fish to understand how cavefish metabolism evolved and how this may be applicable for humans.
For three decades, scientists have debated the underlying cause of Gulf War illness (GWI), a collection of unexplained and chronic symptoms affecting veterans of the Persian Gulf War. Now researchers led by Robert Haley, M.D., Professor of Internal Medicine and Director of the Division of Epidemiology at UT Southwestern, have solved the mystery, showing through a detailed genetic study that the nerve gas sarin was largely responsible for the syndrome.
More than half of people diagnosed with one psychiatric disorder will be diagnosed with a second or third in their lifetime. About a third have four or more.
妙佑医疗国际(Mayo Clinic) 个体化医学中心（Center for individualized Medicine ）的新研究发现，携带ASXL1突变体的慢性粒单核细胞白血病（一种罕见骨髓癌）患者中存在独特的表观遗传变化，可激活有害基因并导致癌细胞更快生长。ASXL1基因突变还能使疾病转化为更具侵袭性的急性髓细胞性白血病。
Uma nova pesquisa do Centro de Medicina Individualizada da Mayo Clinic descobre que pacientes com leucemia mielomonocítica crônica com mutação ASXL1 (um tipo incomum de câncer de medula óssea) têm alterações epigenéticas específicas que podem ativar genes nocivos e fazer com que o câncer cresça mais rapidamente.
وجد بحث جديد من مركز مايو كلينك للطب الفردي أن المرضى المصابين بابيضاض الدم المايلومونيكي المزمن بسبب طفرة ASXL1 - وهو نوع غير شائع من سرطان نخاع العظم - لديهم تغييرات لاجينية مميزة يمكنها تنشيط الجينات الضارة وتتسبب في نمو السرطان بشكل أسرع. كما يمكن لطفرة ASXL1 الجينية تحويل المرض إلى ابيضاض الدم النقوي الحاد الأكثر عدوانية.
Las nuevas investigaciones del Centro para Medicina Personalizada de Mayo Clinic descubren que los pacientes con leucemia mielomonocítica crónica con mutación en el gen ASXL1, un tipo raro de cáncer de la médula ósea, sufren cambios epigenéticos distintivos que activan genes nocivos y hacen que el cáncer se desarrolle con más rapidez.
University of North Carolina School of Medicine scientists, who report their results in the journal eLife, devised an experimental, gene-therapy-like technique to restore the normal activity of the gene deficient in people with Pitt-Hopkins syndrome.
Every species, from bacteria to humans, is capable of regeneration. Regeneration is mediated by the molecular processes that regulate gene expression to control tissue renewal, restoration and growth.
Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a new tool to help researchers interpret the clinical significance of somatic mutations in cancer. The tool, known as CancerVar, incorporates machine learning frameworks to go beyond merely identifying somatic cancer mutations and interpret the potential significance of those mutations in terms of cancer diagnosis, prognosis, and targetability. A paper describing CancerVar was published today in Science Advances.
An international team of researchers have developed advanced computer models, or “digital twins”, of diseases, with the goal of improving diagnosis and treatment.
The molecules of life, DNA, replicate with astounding precision, yet this process is not immune to mistakes and can lead to mutations.
A new software tool makes it easier to study relationships between a host, its microbiome and pathogens like HIV or SARS-CoV-2.
Rutgers scientists have developed a lab test that can quickly and easily identify which variant of the virus causing COVID-19 has infected a person, an advance expected to greatly assist health officials tracking the disease and physicians treating infected patients.
Gene editing may be a potential treatment for anxiety and alcohol use disorder in adults who were exposed to binge drinking in their adolescence, according to the results of an animal study published in the journal Science Advances. The researchers used a gene-editing tool called CRISPR-dCas9 in their experiments to manipulate the histone acetylation and methylation processes at the Arc gene in models of adult rats.
The National Academy of Sciences (NAS) today elected UT Southwestern scientist Jonathan Cohen, Ph.D., into its membership, one of the highest honors for American scientists. Dr. Cohen, Professor of Internal Medicine in the Center for Human Nutrition and the Eugene McDermott Center for Human Growth and Development at UT Southwestern, was elected by his peers in recognition of distinguished and continuing achievements in original research. His research centers on identifying genes that play major roles in the metabolism of cholesterol and triglycerides and elucidating the biological roles of their protein products.
Too many women are getting unnecessary mastectomies and other invasive procedures because of a knowledge gap about differences in cancer genes. A new study offers a path to closing the gap.
The Arizona COVID-19 Genomics Union, led by Paul Keim and others throughout the state, is positioning Arizona to play a role in the planned U.S. Pathogen Genomics Centers of Excellence, a national network funded by the U.S. Centers for Disease Control and Prevention that would expand and deepen infectious disease collaborations between U.S. public health agencies and universities.
UC San Diego scientists use lab-grown human brain tissue to identify neural abnormalities in Pitt-Hopkins Syndrome and show gene therapy tools can rescue neural structure and function.
DNA-to-protein mapping could help researchers understand some health disparities.
Two-pore channels (TPCs) are ancient ion channels present in the cells of both animals and plants.
When brain scientist Birgitte Kornum from the Department of Neuroscience recently arrived in Rome for one of the largest sleep conferences in the world, she was completely taken aback.
A Rutgers researcher will use genomics, genetics, and cell biology to identify and understand the corals’ response to heat stress conditions and to pinpoint master regulatory genes involved in coral bleaching due to global warming and climate change. The researcher and his team will use a novel gene-editing tool as a resource to knock down some gene functions with the goal of boosting the corals’ abilities to survive.
Through analyzing human DNA samples in a large biobank, Penn Medicine researchers found associations between genetic variants with severe COVID and conditions involving blood clots and respiratory issues
Researchers at UC San Diego have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen, particularly in health care settings.
UNC-Chapel Hill, Princeton, and Boston Children’s Hospital researchers show how three transcription factors inside the embryonic heart recruit the protein subunit CHD4 for their role known roles in heart health and disease.
A study published in the Journal of Youth and Adolescence shows that the connection of racial discrimination to problem drinking differs based on personality traits. People who tend to act impulsively in response to negative experiences are more likely to report problematic alcohol use that is associated with racism. But, people who enjoy seeking out new experiences are less likely to report problematic alcohol use that is associated with racism. Though this personality trait is thought to be a common risk factor for alcohol use disorder, this study suggests that people with sensation-seeking personalities can better tolerate or cope with difficult situations such as racism.
Working with tiny bacteria, Michigan State University researchers led by Lee Kroos have made a discovery that could have big implications for biology. The researchers revealed a new way that nature can inhibit or switch off important proteins known as intramembrane proteases — pronounced “pro tea aces” — which the team reported April 26th in the journal eLife.
A poor diet, irrespective of genetic risk factors, is associated with a 30% increased risk of diabetes
Inadequate genomic data on Black women with metastatic breast cancer reduces their access to targeted therapies
Hop give your beer rich flavor profiles
U of A researcher says a more holistic view portrays the disease as much more preventable, easier to understand, and potentially, far more treatable.
Alzheimer’s disease is marked by a loss of functional neurons in the brain.
Inside brain cells, errors in DNA can accumulate as we age. But in patients with Alzheimer’s disease, these errors — known as somatic mutations — may build up at a faster rate.
Scientists at UC San Diego School of Medicine and Rady Children’s Institute of Genomic Medicine describe novel methods for inferring the movement of human brain cells during fetal development by studying healthy adult individuals who have recently passed away from natural causes.
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