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NIGMS grantee and presidential award recipient Sohini Ramachandran, Ph.D., is challenging our understanding of genetic variation among human populations. She discusses her research on how the genetic composition of traits and diseases varies among populations, the value of statistical and computational work in human genetics, and what this all means for patient treatment.

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Parkinson’s disease researchers have used gene-editing tools to introduce the disorder’s most common genetic mutation into marmoset monkey stem cells and to successfully tamp down cellular chemistry that often goes awry in Parkinson’s patients.

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Combined therapy may improve clinical responses for endometrial, colorectal and gastric tumors. Enzyme inhibitor with anti-PD1 checkpoint blockade boosted efficacy over either treatment alone

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New research shows brain imaging may be able to predict when a blood test known as a liquid biopsy would or would not produce clinically actionable information

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A Team around Anthropologist Ron Pinhasi from the University of Vienna – together with researchers from the University of Florence and Harvard University – found out that prehistoric migration from Africa, Asia and Europe to the Mediterranean islands took place long before the era of the Mediterranean seafaring civilizations.

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In a special report published today in the journal Pediatrics, Roberts Individualized Medical Genetics Center researchers, physicians, and genetic and financial counselors describe the success of the model, their plans to build on that success for the future, and the important lessons learned from their first four years in operation.

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Human bodies constantly produce thousands of perfectly folded proteins, but some proteins get misfolded. An excess of these misfolded proteins can overwhelm the body's ability to remove them. When that happens, the rogue proteins bind together and form a substance called amyloid. Webs of amyloid can deposit in any tissue or organ, but some types affect the heart.

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In search of new ways to sequence human genomes and read critical alterations in DNA, researchers at Johns Hopkins Medicine say they have successfully used the gene cutting tool CRISPR to make cuts in DNA around lengthy tumor genes, which can be used to collect sequence information.