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Newswise: Look-Back Study Charts 60 Years of Treatments, Health Characteristics Among People with Dwarfism
Released: 21-Jun-2021 9:00 AM EDT
Look-Back Study Charts 60 Years of Treatments, Health Characteristics Among People with Dwarfism
Johns Hopkins Medicine

In a retrospective study believed to be one of the largest of its kind, researchers say they have successfully charted the health risks, growth patterns, and medical and surgical outcomes of 1,374 people with the most common form of dwarfism, called achondroplasia, seen over a 60-year period at four academic medical centers, including Johns Hopkins Medicine. The findings, according to the researchers, not only affirm some long-standing views and trends in the care of those with the condition, but also offer a standardized baseline, a blueprint investigators hope will serve to speed diagnosis and improve patients’ quality of life and health.

Newswise: Genetic Cause of Neurodevelopmental Disorder Discovered
Released: 21-Jun-2021 7:05 AM EDT
Genetic Cause of Neurodevelopmental Disorder Discovered
University of Maryland School of Medicine

University of Maryland School of Medicine (UMSOM) researchers identified a new gene that may be linked to certain neurodevelopmental disorders and intellectual disabilities.

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Embargo will expire: 24-Jun-2021 2:00 PM EDT Released to reporters: 17-Jun-2021 2:00 PM EDT

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Newswise: Study Adds to Evidence that Most Cancer Cells Grown in a Dish have Little in Common Genetically with Cancer Cells in People
Released: 17-Jun-2021 2:00 PM EDT
Study Adds to Evidence that Most Cancer Cells Grown in a Dish have Little in Common Genetically with Cancer Cells in People
Johns Hopkins Medicine

In a bid to find or refine laboratory research models for cancer that better compare with what happens in living people, Johns Hopkins Medicine scientists report they have developed a new computer-based technique showing that human cancer cells grown in culture dishes are the least genetically similar to their human sources.

Released: 17-Jun-2021 1:50 PM EDT
How Cells “Read” Artificial Ingredients Tossed into Genetic Recipe
University of California San Diego Health

UC San Diego School of Medicine researchers discovered that the enzyme RNA polymerase II recognizes and transcribes artificially added base pairs in genetic code, a new insight that could help advance the development of new vaccines and medicines.

Released: 17-Jun-2021 1:50 PM EDT
Red meat consumption may promote DNA damage-assoc. mutation in colorectal cancer patients
American Association for Cancer Research (AACR)

Genetic mutations indicative of DNA damage were associated with high red meat consumption and increased cancer-related mortality in patients with colorectal cancer.

15-Jun-2021 11:40 AM EDT
Antibiotic Novobiocin Found to Kill Tumor Cells with DNA-Repair Glitch
Dana-Farber Cancer Institute

An antibiotic developed in the 1950s and largely supplanted by newer drugs, effectively targets and kills cancer cells with a common genetic defect, laboratory research by Dana-Farber Cancer Institute scientists shows. The findings have spurred investigators to open a clinical trial of the drug, novobiocin, for patients whose tumors carry the abnormality.

Released: 17-Jun-2021 9:35 AM EDT
Hackensack Meridian CDI Scientists Develop ‘CATCHER’ for Crucial Biomarkers
Hackensack Meridian Health

The EV-CATCHER methodology identifies and captures tiny pieces of genetic material – and shows value in COVID-19 plasma

Released: 16-Jun-2021 4:35 PM EDT
UCLA Health receives $4.8M NIH grant to improve genetic estimates of disease risk in diverse populations
University of California, Los Angeles (UCLA), Health Sciences

UCLA Health will receive a $4.8 million grant from The National Institutes of Health to develop methods that will improve genetic risk estimates – polygenic risk scores – for specific diseases in people from diverse populations and mixed ancestries.

11-Jun-2021 12:50 PM EDT
Researchers Identify New Gene that May Increase Risk of ALS
American Academy of Neurology (AAN)

Researchers have identified a new gene that may increase a person’s risk of developing ALS, according to a new study published in the June 16, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The gene, called TP73, produces a protein to help regulate the life cycle of a cell. Researchers found that some people with ALS have mutations in this gene and that the mutations may interfere with nerve cell health.

Released: 16-Jun-2021 1:55 PM EDT
UM School of Medicine Researchers Awarded $5 Million NIH Grant to Improve Use of Genetic Risk Scores in Diverse Populations
University of Maryland Medical Center

Researchers at the University of Maryland School of Medicine (UMSOM) have received a $5 million federal grant to pool genomic information from existing and new datasets – predominantly in African and African American populations -- in order to calculate the risk of developing specific diseases. They will use sophisticated modeling and genetic datasets to calculate the risk, known as a polygenic risk score, with an emphasis on studying people from different ancestries.

Released: 16-Jun-2021 12:05 PM EDT
A Distinctive Inflammatory Signature Found in a Genetic Form of ALS
Thomas Jefferson University

Researchers find an increase in inflammatory molecules in serum and cerebrospinal fluid of C90RF72 patients, informing future anti-inflammatory therapies.

Released: 16-Jun-2021 11:40 AM EDT
MD Anderson Research Highlights for June 16, 2021
University of Texas M. D. Anderson Cancer Center

The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts. Current advances include a new combination therapy for acute myeloid leukemia (AML), a greater understanding of persistent conditions after AML remission, the discovery of a universal biomarker for exosomes, the identification of a tumor suppressor gene in hepatocellular carcinoma (HCC) and characterization of a new target to treat Clostridioides difficile (C. difficile) infections.

Newswise: Scientists Demonstrate Promising New Approach for Treating Cystic Fibrosis
Released: 16-Jun-2021 8:05 AM EDT
Scientists Demonstrate Promising New Approach for Treating Cystic Fibrosis
University of North Carolina School of Medicine

Scientists created a potentially powerful new strategy for treating cystic fibrosis and potentially other diseases; it involves small, nucleic acid molecules called oligonucleotides that can correct some of the gene defects that underlie CF but are not addressed by existing modulator therapies.

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Released: 15-Jun-2021 12:30 PM EDT
From symmetry to asymmetry: The two sides of life
Osaka University

On the outside, animals often appear bilaterally symmetrical with mirror-image left and right features.

Released: 15-Jun-2021 12:10 PM EDT
Cancer cells fight for their footing by using an ageing gene
University of Helsinki

Researchers at the University of Helsinki and the Beatson Institute for Cancer Research in Glasgow have discovered how mutated cells promote their chances to form cancer.

Released: 15-Jun-2021 11:55 AM EDT
Researchers Develop More Reliable Rapid Tests for COVID-19
University of Maryland Medical Center

Researchers Develop More Reliable Rapid Tests for COVID-19 Public Release Date: 15-Jun-2021 00:00:00 US Eastern Time (24hr) Research News Release Contact Person: Deborah Kotz Contact Phone: 410-706-4255 Contact E-mail: Journal: Nature Protocols DOI: 10.1038/s41596-021-00546-w Funder: Grant Number(s): Meeting: Primary Keyword: Medicine/Health Keywords: Medicine/Health -> Diagnostics Medicine/Health -> Infectious/Emerging Diseases Subtitle: Tests Use Innovative Techniques That Improve Accuracy Rivaling Gold Standard PCR Test Summary: Researchers at the University of Maryland School of Medicine (UMSOM) have developed two rapid diagnostic tests for COVID-19 that are nearly as accurate as the gold-standard test currently used in laboratories. Unlike the gold standard test, which extracts RNA and uses it to amplify the DNA of the virus, these new tests can detect the presence of the virus in as little as five minutes using different methods.

Released: 15-Jun-2021 10:40 AM EDT
Pew Supports 22 Scientists Exploring Innovative Solutions to Biomedical Challenges
PEW Charitable Trusts

The Pew Charitable Trusts today announced that 22 early-career researchers have been selected to join the Pew Scholars Program in the Biomedical Sciences.

Released: 15-Jun-2021 10:35 AM EDT
5 Pew-Stewart Scholars Chosen to Advance Cutting-Edge Cancer Research
PEW Charitable Trusts

The Pew Charitable Trusts and the Alexander and Margaret Stewart Trust announced today the 2021 class of the Pew-Stewart Scholars Program for Cancer Research.

Released: 14-Jun-2021 11:30 AM EDT
Leading Scientist Working to Complete the Human Genome to Join UCSC Faculty
University of California, Santa Cruz

Leading scientist known for working to complete the human genome will join UCSC faculty; Karen Miga is a longtime Genomics Institute researcher, recently named “one to watch” by the journal Nature.

14-Jun-2021 10:05 AM EDT
Making a Meal of DNA in the Seafloor
University of Vienna

While best known as the code for genetic information, DNA is also a nutrient for specialised microbes. An international team of researchers led by Kenneth Wasmund and Alexander Loy from the University of Vienna has discovered several bacteria in sediment samples from the Atlantic Ocean that use DNA as a food source.

7-Jun-2021 9:05 PM EDT
Discovery Identifies a Highly Efficient Human Reverse Transcriptase that can Write RNA Sequences into DNA
Thomas Jefferson University

Researchers show that polymerase theta can efficiently convert RNA sequences back into DNA, a feat more common in viruses than eukaryotic cells.

Released: 11-Jun-2021 2:05 AM EDT
Black and White Women Have Same Mutations Linked to Breast Cancer Risk
Perelman School of Medicine at the University of Pennsylvania

The prevalence of genetic mutations associated with breast cancer in Black and white women is the same.

Released: 10-Jun-2021 11:40 AM EDT
Researchers' algorithm to make CRISPR gene editing more precise
University of Copenhagen, Faculty of Health and Medical Sciences

It eventually became a Nobel prize-winning revolution when researchers first engineered CRISPR as a gene editing technology for bacterial, plant, animal and human cells.

Released: 9-Jun-2021 4:15 PM EDT
Nearly 1 in 5 Patients Who Die from Unexplained Sudden Cardiac Death Have Suspicious Gene
University of Maryland Medical Center

.Researchers from the University of Maryland School of Medicine (UMSOM) and their colleagues found that nearly 20 percent of patients with unexplained sudden cardiac death – most of whom were under age 50 – carried rare genetic variants. These variants likely raised their risk of sudden cardiac death.

Newswise: Not Just A Phase For RNAS
Released: 9-Jun-2021 11:05 AM EDT
Not Just A Phase For RNAS
UT Southwestern Medical Center

DALLAS – June 9, 2021 – A phenomenon in which an RNA named NORAD drives a protein named Pumilio to form liquid droplets in cells, much like oil in water, appears to tightly regulate the activity of Pumilio. A new study led by UT Southwestern scientists suggests that such RNA-driven “phase separation,” in turn, protects against genome instability, premature aging, and neurodegenerative diseases, and may represent a previously unrecognized way for RNAs to regulate cellular processes.

Newswise: Meiosis: Mind the gap
Released: 9-Jun-2021 9:00 AM EDT
Meiosis: Mind the gap
University of Vienna

Meiosis is a specialized cell division process required to generate gametes, the reproductive cells of an organism. During meiosis, paternal and maternal chromosomes duplicate, pair, and exchange parts of their DNA in a process called meiotic recombination. In order to mediate this exchange of genetic material, cells introduce double strand breaks (DSBs) into their chromosomal DNA. Scientists from the lab of Franz Klein from the Department of Chromosome Biology at the Max Perutz Labs, a joint venture of the University of Vienna and the Medical University of Vienna, have now discovered that cells sometimes liberate DNA fragments at sites of paired, or double, DSBs. Whilst this presents an obvious risk of germline mutations as a consequence of erroneous repair or of integration of fragments from elsewhere at break sites, it may also be a source of evolutionary diversity. The study is published as a research article in Nature.

Released: 7-Jun-2021 2:50 PM EDT
Popularity runs in families
Rice University

If identical versions of 20 people lived out their lives in dozens of different worlds, would the same people be popular in each world?

Released: 7-Jun-2021 7:00 AM EDT
High Caffeine Consumption may be Associated with Increased Risk of Blinding Eye Disease
Mount Sinai Health System

Frequent caffeine intake could more than triple risk of glaucoma for those genetically predisposed to higher eye pressure

Released: 4-Jun-2021 2:55 PM EDT
Gene protection for COVID-19 identified
Newcastle University

The first evidence of a genetic link explaining why some people who catch Covid-19 don't become sick has been discovered.

Newswise:Video Embedded newly-approved-drug-effective-against-lung-cancer-caused-by-genetic-mutation
1-Jun-2021 3:35 PM EDT
Newly approved drug effective against lung cancer caused by genetic mutation
Washington University in St. Louis

The new drug sotorasib reduces tumor size and shows promise in improving survival among patients with lung tumors caused by a specific DNA mutation, according to results of a global phase 2 clinical trial led by Washington University School of Medicine in St. Louis. The drug is designed to shut down the effects of the mutation, which is found in about 13% of patients with lung adenocarcinoma, a common type of non-small-cell lung cancer.

Newswise: UTHealth professor awarded CPRIT grant for research training program
Released: 4-Jun-2021 9:30 AM EDT
UTHealth professor awarded CPRIT grant for research training program
University of Texas Health Science Center at Houston

Zhongming Zhao, PhD, MS, with The University of Texas Health Science Center at Houston (UTHealth), has been awarded nearly $4 million from the Cancer Prevention and Research Institute of Texas (CPRIT) to provide research training to help with cancer prevention.

Newswise: Patient of Monroe Carell Jr. Children’s Hospital at Vanderbilt First in World to Receive New Investigational Gene Editing Therapy
Released: 3-Jun-2021 4:20 PM EDT
Patient of Monroe Carell Jr. Children’s Hospital at Vanderbilt First in World to Receive New Investigational Gene Editing Therapy
Vanderbilt University Medical Center

A 9-year-old patient of Monroe Carell Jr. Children’s Hospital at Vanderbilt is the first in the world to receive an investigational gene editing therapy for Methylmalonic Acidemia (MMA), a rare genetic disorder diagnosed at birth.

2-Jun-2021 2:05 PM EDT
Expression of “fat” genes correlate with metabolic and behavioral changes linked to obesity
University of Chicago Medical Center

A collection of genetic variants influences the expression of obesity-associated genes in both the brain and fat tissue, according to a new study from researchers at the University of Chicago.

1-Jun-2021 11:00 AM EDT
Predictive Model Identifies Patients for Genetic Testing
Vanderbilt University Medical Center

Patients who, perhaps unbeknownst to their health care providers, are in need of genetic testing for rare undiagnosed diseases can be identified en masse based on routine information in electronic health records (EHRs), a research team reported today in the journal Nature Medicine.

Newswise: Milk makeover: a great start for a healthy heart
Released: 3-Jun-2021 5:30 AM EDT
Milk makeover: a great start for a healthy heart
University of South Australia

A dash of milk could make all the difference to a healthy heart as new research from the University of South Australia finds that people who regularly consume milk have a lower risk of heart disease.

Released: 2-Jun-2021 3:45 PM EDT
Metal Contamination, Gene Signatures, Bisphenol F, and More Featured in June 2021 Toxicological Sciences
Society of Toxicology

Toxicological Sciences delivers the latest research in toxicology, in areas such as clinical and translational toxicology; emerging technologies, methods, and models; and environmental toxicology.

Newswise: Atlantic Medical Group doses first patient in U.S. for new gene therapy for phenylketonuria
Released: 2-Jun-2021 8:05 AM EDT
Atlantic Medical Group doses first patient in U.S. for new gene therapy for phenylketonuria
Atlantic Health System

New treatment could help people with phenylketonuria (PKU), a genetic disorder that prevents people from metabolizing phenylalanine. Newborns are tested for PKU, which, if not diagnosed early, can have devastating effects. Patients with PKU follow a specific diet for most of their lives.

Newswise:Video Embedded synthetic-species-developed-for-use-as-a-confinable-gene-drive
1-Jun-2021 2:55 PM EDT
Synthetic SPECIES Developed for Use as a Confinable Gene Drive
University of California San Diego

Scientists have developed a gene drive with a built-in genetic barrier that is designed to keep the drive under control. The researchers engineered synthetic fly species that, upon release in sufficient numbers, act as gene drives that can spread locally and be reversed if desired.

Newswise: UCI-led study sheds light on mysterious genotype-phenotype associations
Released: 1-Jun-2021 1:45 PM EDT
UCI-led study sheds light on mysterious genotype-phenotype associations
University of California, Irvine

A new study analyzing the association between an individual’s genetics (genotype) and their observable characteristics resulting from the interaction of genetics and the environment (phenotype), contributes new knowledge to the understanding of human complex traits and diseases.

27-May-2021 11:15 AM EDT
Genetic mutation linked to childhood ALS
Uniformed Services University of the Health Sciences (USU)

Scientists have identified a novel form of Amyotrophic Lateral Sclerosis (ALS), or Lou Gehrig’s Disease, that affects children, according to an international collaborative study, “Childhood Amyotrophic Lateral Sclerosis Caused by Excess Sphingolipid Synthesis,” published May 30, 2021, in Nature Medicine. This is the first example of a mutation that perturbs a specific metabolic pathway as causative for ALS.

Newswise:Video Embedded researchers-create-new-crispr-tools-to-help-contain-mosquito-disease-transmission
Released: 28-May-2021 2:00 PM EDT
Researchers Create New CRISPR Tools to Help Contain Mosquito Disease Transmission
University of California San Diego

Scientists have developed a toolkit that helps pave the way to a gene drive designed to stop Culex mosquitoes from spreading disease. Culex mosquitoes spread devastating afflictions stemming from West Nile virus, Japanese encephalitis virus and the pathogen causing avian malaria.

Newswise:Video Embedded new-tool-activates-deep-brain-neurons-by-combining-ultrasound-genetics
Released: 28-May-2021 1:50 PM EDT
New tool activates deep brain neurons by combining ultrasound, genetics
Washington University in St. Louis

A team at Washington University in St. Louis has developed a new brain stimulation technique using focused ultrasound that is able to turn specific types of neurons in the brain on and off and precisely control motor activity without surgical device implantation.

Newswise: Same Difference: Two Halves of The Hippocampus Have Different Gene Activity
Released: 28-May-2021 1:45 PM EDT
Same Difference: Two Halves of The Hippocampus Have Different Gene Activity
UT Southwestern Medical Center

DALLAS – May 28, 2021 – A study of gene activity in the brain’s hippocampus, led by UT Southwestern researchers, has identified marked differences between the region’s anterior and posterior portions. The findings, published today in Neuron, could shed light on a variety of brain disorders that involve the hippocampus and may eventually help lead to new, targeted treatments.

Released: 28-May-2021 1:15 PM EDT
Solving a double murder arouses international interest
Linkoping University

The technology using DNA-based genealogy that solved a double murder in Linköping opens completely new possibilities in investigating serious crime.

Released: 27-May-2021 4:25 PM EDT
Roots of major depression revealed in all its genetic complexity
Yale University

A massive genome-wide association study (GWAS) of genetic and health records of 1.2 million people from four separate data banks has identified 178 gene variants linked to major depression, a disorder that will affect one of every five people during their lifetimes.

Released: 27-May-2021 3:10 PM EDT
Levels of Certain Blood Proteins May Explain Why Some People Derive More Benefits from Exercise than Others
Beth Israel Lahey Health

A new study led by investigators at Beth Israel Deaconess Medical Center (BIDMC) provides insights into the mechanistic links between physical fitness and overall health, as well as the reasons why the same exercise can have different effects in different people.

25-May-2021 2:50 PM EDT
Global Study Finds Each City Has Unique Microbiome Fingerprint of Bacteria and Viruses
University of Maryland Medical Center

Each city has its own unique microbiome, a "fingerprint" of viruses and bacteria that uniquely identify it, according to a new study from an international consortium of researchers that included a team from the University of Maryland School of Medicine (UMSOM). The international project, which sequenced and analyzed samples collected from public transit systems and hospitals in 60 cities around the world, was published today in the journal Cell.

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