Feature Channels: Genetics

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Released: 6-May-2024 12:05 PM EDT
Using Advanced Genetic Techniques, Scientists Create Mice With Traits of Tourette Disorder
Rutgers University-New Brunswick

In research that may be a step forward toward finding personalized treatments for Tourette disorder, scientists at Rutgers University–New Brunswick have bred mice that exhibit some of the same behaviors and brain abnormalities seen in humans with the disorder. As reported in the Proceedings of the National Academy of Sciences, the researchers, using a technique known as CRISPR/Cas9 DNA editing, inserted the same genetic mutations found in humans with Tourette disorder into the corresponding genes in mouse embryos.

Released: 6-May-2024 9:00 AM EDT
Penn Medicine at the American Society of Gene and Cell Therapy 27th Annual Meeting
Perelman School of Medicine at the University of Pennsylvania

Researchers from the Gene Therapy Program (GTP) at the Perelman School of Medicine at the University of Pennsylvania will present ten research abstracts, two invited talks, and a workshop presentation highlighting their translational science and discovery research on gene therapy, gene editing, and adeno-associated virus (AAV) vector technology at the American Society of Cell and Gene Therapy (ASGCT) 27th Annual Meeting on May 7 - 11, 2024 in Baltimore, Maryland.

30-Apr-2024 10:05 AM EDT
Survey of U.S. Parents Highlights Need for More Awareness About Newborn Screening, Cystic Fibrosis and What to Do if Results are Abnormal
Ann and Robert H. Lurie Children's Hospital of Chicago

A national survey led by Ann & Robert H. Lurie Children’s Hospital of Chicago found that parents have insufficient knowledge of newborn screening in general and of cystic fibrosis (CF) in particular.

Released: 3-May-2024 6:05 AM EDT
A Revolution In Gene Therapy Is Unfolding, Bringing Hope for Vision Loss
American Macular Degeneration Foundation (AMDF)

A new approach to gene therapy resets cell homeostasis. Clinical trials to treat the retinal disorders Retinitis Pigmentosa, Stargardt's, and Geographic Atrophy (late dry macular degeneration) are underway and showing promise.

Released: 3-May-2024 2:05 AM EDT
Genetics, not lack of oxygen, causes cerebral palsy in quarter of cases
University of Adelaide

The world’s largest study of cerebral palsy (CP) genetics has discovered genetic defects are most likely responsible for more than a quarter of cases in Chinese children, rather than a lack of oxygen at birth as previously thought.

     
Newswise: Revealed: how cancer cells harness energy to drive disease progression
Released: 2-May-2024 7:05 AM EDT
Revealed: how cancer cells harness energy to drive disease progression
Chinese Academy of Sciences

Researchers have revealed crucial insights into how the Warburg effect causes the dedifferentiation of cancer cells through epigenetic reprogramming. This discovery potentially opens up new avenues for cancer treatments that target cellular metabolism.

Newswise: Researchers Discover Key Functions of Therapeutically Promising Jumbo Viruses
Released: 2-May-2024 12:05 AM EDT
Researchers Discover Key Functions of Therapeutically Promising Jumbo Viruses
University of California San Diego

Viruses known as “jumbo” phages are seen as a potential tool against deadly bacterial infections. But scientists must first decipher the extraordinary makeup of these mysterious viruses. Researchers have now uncovered a key piece of jumbo phage development that helps them counter bacteria.

29-Apr-2024 1:05 PM EDT
CHOP Researchers Identify Causal Genetic Variant Linked to Common Childhood Obesity
Children's Hospital of Philadelphia

Researchers have identified a causal genetic variant strongly associated with childhood obesity. The study provides new insight into the importance of the hypothalamus of the brain and its role in common childhood obesity and the target gene may serve as a druggable target for future therapeutic interventions.

Newswise: An electrifying discovery may help doctors deliver more effective gene therapies
Released: 30-Apr-2024 2:30 PM EDT
An electrifying discovery may help doctors deliver more effective gene therapies
University of Wisconsin–Madison

In an effort to improve delivery of costly medical treatments, a team of researchers in electrical engineering at the University of Wisconsin–Madison has developed a stimulating method that could make the human body more receptive to certain gene therapies.

Newswise: New gene signature could transform immunotherapy for gastrointestinal cancers
Released: 30-Apr-2024 11:05 AM EDT
New gene signature could transform immunotherapy for gastrointestinal cancers
Chinese Academy of Sciences

A recent study in gastrointestinal (GI) cancer research reveals a promising advancement in predicting patient responses to immune checkpoint inhibitor (ICI) therapy. The newly developed DNA damage response-related immune activation (DRIA) signature could serve as a groundbreaking biomarker, providing valuable guidance for ICI therapy decisions.

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This news release is embargoed until 30-Apr-2024 7:00 AM EDT Released to reporters: 26-Apr-2024 3:15 PM EDT

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Newswise: Unlocking the Genetic Mysteries Behind Plant Adaptation: New Insights into the Evolution of a Water-Saving Trait in the Pineapple Family (Bromeliaceae)
29-Apr-2024 7:00 AM EDT
Unlocking the Genetic Mysteries Behind Plant Adaptation: New Insights into the Evolution of a Water-Saving Trait in the Pineapple Family (Bromeliaceae)
University of Vienna

Researchers at the University of Vienna, along with collaborators from France, Germany, Switzerland and the USA, have achieved a major breakthrough in understanding how genetic drivers influence the evolution of a specific photosynthesis mechanism in Tillandsia (air plants). This sheds light on the complex actions that cause plant adaptation and ecological diversity. The results of their study are now published in Plant Cell.

Newswise: Iowa State researchers identify genes linked to rice resiliency
Released: 29-Apr-2024 11:05 AM EDT
Iowa State researchers identify genes linked to rice resiliency
Iowa State University

Researchers at Iowa State University have identified two genes that can help rice defend itself against diseases, including the devastating fungal blast pathogen that regularly causes significant losses of rice production worldwide.

Newswise: After 25 Years, Researchers Uncover Genetic Cause of Rare Neurological Disease
25-Apr-2024 5:00 AM EDT
After 25 Years, Researchers Uncover Genetic Cause of Rare Neurological Disease
University of Utah Health

Spinocerebellar ataxia 4 is a devastating progressive movement disorder. A multinational study has now conclusively identified the genetic difference that causes the disease, bringing answers to families and opening the door to future treatments.

Newswise: Automated machine learning robot unlocks new potential for genetics research
Released: 26-Apr-2024 7:00 AM EDT
Automated machine learning robot unlocks new potential for genetics research
University of Minnesota College of Science and Engineering

University of Minnesota Twin Cities researchers have constructed a robot that uses machine learning to fully automate a complicated microinjection process used in genetic research.

Newswise: Genetic variations may predispose people to Parkinson’s disease following long-term pesticide exposure, study finds
22-Apr-2024 3:05 PM EDT
Genetic variations may predispose people to Parkinson’s disease following long-term pesticide exposure, study finds
University of California, Los Angeles (UCLA), Health Sciences

A new UCLA Health study found certain genetic variants could help explain how long-term pesticide exposure could increase the risk of Parkinson’s disease.

Newswise: Revolutionizing Sweetpotato Genetics: A Comprehensive Update to the 'Taizhong 6' Genome Annotation
Released: 25-Apr-2024 12:05 AM EDT
Revolutionizing Sweetpotato Genetics: A Comprehensive Update to the 'Taizhong 6' Genome Annotation
Chinese Academy of Sciences

A research team has substantially enhanced the annotation of the sweetpotato genome 'Taizhong 6', introducing a more comprehensive and detailed version, v1.0.a2.

24-Apr-2024 2:05 PM EDT
Researchers Publish Final Results of Key Clinical Trial for Gene Therapy for Sickle Cell Disease
Children's Hospital of Philadelphia

An international consortium published the final results of a key clinical trial of the gene therapy CASGEVY (exagamglogene autotemcel) for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs).

Newswise: Newly discovered alteration of brain network condition could possibly predict extremely painful vaso-occlusive crisis in patients with sickle cell disease
Released: 24-Apr-2024 1:05 PM EDT
Newly discovered alteration of brain network condition could possibly predict extremely painful vaso-occlusive crisis in patients with sickle cell disease
Indiana University

A new study led by Indiana University School of Medicine researchers found a brain network condition called “explosive synchronization” could be the cause of extreme pain crises in people with sickle cell disease.

Released: 24-Apr-2024 12:00 PM EDT
MD Anderson Research Highlights for April 24, 2024
University of Texas MD Anderson Cancer Center

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

   
Newswise: The first chromosome-level reference genomes of the ornamental banana and pink banana
Released: 24-Apr-2024 11:05 AM EDT
The first chromosome-level reference genomes of the ornamental banana and pink banana
Chinese Academy of Sciences

The genus Musa, encompassing approximately 70 herbaceous species, is predominantly found in the tropical and subtropical regions of Asia and Oceania.

Newswise: Unveiling the Genetic Blueprint of Safflower: A Leap Forward in Crop Breeding and Biomedical Research
Released: 24-Apr-2024 11:05 AM EDT
Unveiling the Genetic Blueprint of Safflower: A Leap Forward in Crop Breeding and Biomedical Research
Chinese Academy of Sciences

A research team completes a high-quality chromosome-scale assembly of the 'Chuanhonghua 1' safflower genome.

Released: 24-Apr-2024 11:05 AM EDT
UC Irvine to lead study of how DNA genetic variations might influence nicotine addiction
University of California, Irvine

A three-year, $1.19 million grant from the Tobacco-Related Disease Research Program will allow University of California, Irvine researchers to explore how specific sections of DNA might influence nicotine addiction. Deeper insights into these neurological processes may lead to more effective prevention and treatment strategies for cigarette smoking and vaping habits.

Released: 24-Apr-2024 10:05 AM EDT
Global consortium to study Pick's disease, rare form of early-onset dementia
Mayo Clinic

Pick's disease, a neurodegenerative disease of unknown genetic origin, is a rare type of frontotemporal dementia that affects people under the age of 65.

Newswise: Electronic Health Records Unlock Genetics of Tobacco Use Disorder
Released: 17-Apr-2024 9:00 AM EDT
Electronic Health Records Unlock Genetics of Tobacco Use Disorder
University of California San Diego

By utilizing the power of electronic medical records, researchers from UC San Diego are uncovering the genetics of tobacco use, which would help scientists discover new ways to stop occasional tobacco use from evolving into tobacco use disorder.

Newswise: Polyploidy in vegetables: Unveiling genetic secrets for crop evolution and breeding success
Released: 16-Apr-2024 6:05 AM EDT
Polyploidy in vegetables: Unveiling genetic secrets for crop evolution and breeding success
Chinese Academy of Sciences

A research team has elucidated the role of polyploidy in the evolution and breeding of vegetable crops, leveraging advanced sequencing technologies to dissect the genetic and epigenetic nuances of polyploids.

Newswise: Deciphering the palette: Unveiling the genetic secrets of Rhododendron flower color diversity
Released: 16-Apr-2024 4:05 AM EDT
Deciphering the palette: Unveiling the genetic secrets of Rhododendron flower color diversity
Chinese Academy of Sciences

A research team has made strides in uncovering the genetic foundations of flower color variation within the Rhododendron genus.

Newswise: Unraveling the role of DlBGAL9 and AGL61/80 in Longan somatic embryogenesis and heat stress tolerance: A multi-omics approach
Released: 15-Apr-2024 9:05 PM EDT
Unraveling the role of DlBGAL9 and AGL61/80 in Longan somatic embryogenesis and heat stress tolerance: A multi-omics approach
Chinese Academy of Sciences

A research team has unveiled 20 β-galactosidase (BGAL) genes within the longan genome, highlighting their crucial roles in embryogenic development and heat stress adaptation.

Newswise: Researchers Identify New Genetic Risk Factors for Persistent HPV Infections
Released: 11-Apr-2024 9:05 AM EDT
Researchers Identify New Genetic Risk Factors for Persistent HPV Infections
University of Maryland School of Medicine

Human papillomavirus (HPV) is the second most common cancer-causing virus, accounting for 690,000 cervical and other cancers each year worldwide.

Newswise: Study sheds light on how genes work together to influence smoking habits
Released: 10-Apr-2024 5:05 PM EDT
Study sheds light on how genes work together to influence smoking habits
University of Colorado Boulder

A new CU Boulder study sheds light on how genes associated with smoking work in conjunction with the rest of the genome, paving the way for more personalized approaches to help people kick the habit.

Newswise: The Surprising Connection Between Male Infertility and Family Cancer Risk
Released: 10-Apr-2024 11:05 AM EDT
The Surprising Connection Between Male Infertility and Family Cancer Risk
Huntsman Cancer Institute at the University of Utah

A study by Joemy Ramsay, PhD, suggests families with infertile male relatives may face elevated cancer risks. Tapping into genetic data, families could help personalize cancer risk assessments.

Newswise: Characterization of mutational “coldspots” in the cancer genome
Released: 10-Apr-2024 9:05 AM EDT
Characterization of mutational “coldspots” in the cancer genome
Fundació Institut de Recerca Biomèdica (IRB BARCELONA)

Researchers at IRB Barcelona report mutation rate variation across the human genome. Regions with low mutation rates correlate with hypomethylation (low methylation levels), a way cells control which genes are turned on or off.

Newswise: Unlocking the body's hidden weapon against cancer: the role of broken chromosomes
Released: 9-Apr-2024 11:05 AM EDT
Unlocking the body's hidden weapon against cancer: the role of broken chromosomes
Chinese Academy of Sciences

Scientists have unraveled the mechanisms of the Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling pathway activated by micronuclei, as well as its significant effects on tumor immunity.

Released: 8-Apr-2024 8:05 PM EDT
A gene mutation associated with a rare neurological disorder and increased susceptibility to viral infections may be treatable with oleic acid
University of California, Los Angeles (UCLA), Health Sciences

A mutation in a protein regulating natural killer (NK) cells’ function is at the root of immune deficiency in some people with a rare genetic condition characterized by cognitive and developmental delay, seizures, and other manifestations. The findings also have broader implications for immunity and cell therapies.

Newswise: Native UM Student Works to Create Missing Persons Database
Released: 8-Apr-2024 6:05 AM EDT
Native UM Student Works to Create Missing Persons Database
University of Montana

Haley Omeasoo was already studying forensic science at the University of Montana when she saw the poster that redefined her life.

Newswise: UC Irvine-led research team builds first tandem repeat expansions genetic reference maps
Released: 8-Apr-2024 6:05 AM EDT
UC Irvine-led research team builds first tandem repeat expansions genetic reference maps
University of California, Irvine

A research team led by the University of California, Irvine has built the first genetic reference maps for short lengths of DNA repeated multiple times which are known to cause more than 50 lethal human diseases, including amyotrophic lateral sclerosis, Huntington’s disease and multiple cancers.

Newswise: Toothed whale echolocation organs evolved from jaw muscles
Released: 8-Apr-2024 3:00 AM EDT
Toothed whale echolocation organs evolved from jaw muscles
Hokkaido University

Genetic analysis finds evidence suggesting that acoustic fat bodies in the heads of toothed whales were once the muscles and bone marrow of the jaw.

Newswise: A Deep Dive Into the Genetics of Alcohol Consumption
4-Apr-2024 1:30 PM EDT
A Deep Dive Into the Genetics of Alcohol Consumption
University of California San Diego

Some people have genes that protect them from alcohol abuse. An examination of databases at 23andMe reveal that those same alcohol-protective variants have associations with conditions and behaviors that may have nothing to do with alcohol.

Released: 3-Apr-2024 12:05 PM EDT
Lurie Children’s Hospital First in Illinois to Treat Duchenne Muscular Dystrophy with FDA-Approved Gene Therapy
Ann and Robert H. Lurie Children's Hospital of Chicago

On March 27, 2024, Ann & Robert H. Lurie Children’s Hospital of Chicago treated its first patient with ELEVIDYS (delandistrogene moxeparvovec-rokl), the first gene therapy for Duchenne muscular dystrophy – a rare, genetic disease characterized by progressive muscle damage and weakness.

Newswise: Study of MADS-box Genes in Passion Fruit (Passiflora edulis) Illuminates Plant Organ Development and Stress Responses
Released: 3-Apr-2024 10:05 AM EDT
Study of MADS-box Genes in Passion Fruit (Passiflora edulis) Illuminates Plant Organ Development and Stress Responses
Chinese Academy of Sciences

Passion fruit (Passiflora edulis), renowned for its nutritional richness and aromatic fruits, is widely cultivated in tropical and subtropical regions.

Newswise: Unraveling Ethylene's Role in Carnation Postharvest Life: Insights into Varietal Sensitivity and Genetic Regulation
Released: 3-Apr-2024 10:05 AM EDT
Unraveling Ethylene's Role in Carnation Postharvest Life: Insights into Varietal Sensitivity and Genetic Regulation
Chinese Academy of Sciences

Carnation (Dianthus caryophyllus L.) is a flower widely cultivated for its appealing apperance and frangance.

Newswise: DNA Reveals What 6th Century Emperor Wu Looked Like
Released: 1-Apr-2024 7:05 PM EDT
DNA Reveals What 6th Century Emperor Wu Looked Like
Newswise Review

A team of researchers used DNA to reconstruct the appearance of Chinese Emperor Wu of Northern Zhou, who lived 1,500 years ago.

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Released: 1-Apr-2024 6:05 PM EDT
A Clinic for Ovarian Cancer ‘Previvors’
Cedars-Sinai

When Elisa Schoenfeld, a child development specialist, learned she had tested positive for a BRCA gene mutation, she knew it raised her risk for breast and ovarian cancer. She and her daughter, Amira, who received similar genetic test results, visited the BRCA Ovarian Previvor Clinic at Cedars-Sinai.

Released: 1-Apr-2024 4:05 PM EDT
From Economics to Electrocardiograms, Data Science Projects Get a Boost From New Seed Grants
University of Utah Health

The seven funded projects range from an investigation of the potential benefits of virtual reality-based “nature” experiences for hospital patients, to tools that allow scientists to make full use of huge databases of biomedical information.

   
Newswise: 1920_cedars-sinai-cancer-research.jpg?10000
Released: 29-Mar-2024 5:05 PM EDT
March Monthly Research Highlights Newsletter
Cedars-Sinai

A roundup of the latest medical discoveries and faculty news at Cedars-Sinai for March 2024.



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