Feature Channels: Immunology

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As one of the most insidious diseases in the world, cancer has few treatments that work to eradicate it completely. Now, a new ground-breaking approach pioneered by two researchers working at the University of Missouri’s Roy Blunt NextGen Precision Health building shows promising results in preventing lung cancer caused by a carcinogen in cigarettes — a discovery that immunologists Haval Shirwan and Esma Yolcu rank among the most significant of their careers.

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A study that assesses the effects of hypochlorous acid (HOCI), commonly known as bleach, as it is generated during the immune response of a cell (phagocytosis) when fighting a common fungal pathogen, Candida albicans, reveals that HOCI is a potent killing agent. The laboratory finding is highlighted in the journal mBio.

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La inmunoterapia aprovecha el sistema inmunitario del organismo para combatir el cáncer. El tratamiento con linfocitos T con receptor quimérico para el antígeno (tratamiento con linfocitos T-CAR) es una forma de inmunoterapia en la que los profesionales de atención médica extraen las células T de una persona (conocidas como linfocitos que participan en la respuesta del sistema inmunitario) y las modifican genéticamente para que produzcan receptores quiméricos para el antígeno. A continuación, estos linfocitos T-CARse reintroducen en el torrente sanguíneo del paciente, donde se dirigen a las células cancerosas y las destruyen.

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A new study from researchers at Wake Forest University School of Medicine shows that dopamine release in the human brain plays a crucial role in encoding both reward and punishment prediction errors.

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Incorporating navy beans into the diet of colorectal cancer survivors has the potential to positively impact both gut and host health by modulating markers linked to obesity and disease, according to new research from The University of Texas MD Anderson Cancer Center.

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SEATTLE — Nov. 30, 2023 — The 65th Annual Meeting & Exposition of the American Society of Hematology (ASH) will take place in San Diego, Calif. and online Dec. 9-13.Below are highlights of Fred Hutchinson Cancer Center research to be presented and experts available to comment on news.

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For the first time, scientists have begun to figure out why the disfiguring skin lesions caused by cutaneous leishmaniasis don’t hurt.

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A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.

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Adding a modular chimeric cytokine receptor to CAR T cells increased their efficacy. Learn how this modular system could improve brain and solid tumor therapy.

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Researchers at the UCLA Jonsson Comprehensive Cancer Center have found certain immune cells can still fight cancer even when the cancer cells lack an important protein that the immune system relies on to help track down cancer cells.

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Hospital germs and pathogens are not always transmitted directly from person to person. They can also spread via germ-contaminated surfaces and objects.

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Traditional cancer treatments such as chemotherapy and radiation can come with collateral damage. In the process of killing cancer, the treatments harm normal cells, too, leading to both short- and long-term side effects. Even today’s targeted drugs and immunotherapy can have effects on normal tissues.

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In a new Cell study, scientists at La Jolla Institute for Immunology (LJI) and Massachusetts General Hospital, Harvard Medical School, show how a protein called IKAROS helps "weave" the genome.

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AAI announces it has been awarded the IUIS 2023 Day of Immunology Award for Best Theme

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Scientists at UChicago discover that trans-vaccenic acid (TVA), a fatty acid found in beef, lamb, and dairy products, improves the ability of immune cells to fight tumors.

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HIV (human immunodeficiency virus), the virus that causes AIDS (acquired immunodeficiency syndrome), can hide in the body for many years before symptoms appear.

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O HIV (vírus da imunodeficiência humana) que causa a AIDS (síndrome de imunodeficiência adquirida) pode ficar oculto no corpo por muitos anos antes da manifestação dos sintomas.

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El VIH (virus de la inmunodeficiencia humana), el virus que causa el SIDA (síndrome de inmunodeficiencia adquirida), se puede esconder en el organismo durante muchos años antes de que aparezcan los síntomas.

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Stay informed! Keep up with the latest research on the COVID-19 virus in the Coronavirus channel on Newswise.

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Cleveland Clinic researchers analyzed genes and brain tissue of patients with Alzheimer’s and found that differences in brain immunometabolism – the interactions between the immune system and the ways cells create energy – may contribute to women’s increased risk for the disease and its severity.

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Immunotherapy using modified chimeric antigen receptor (CAR) T cells has greatly improved survival rates for relapsed and recurrent pediatric leukemia and lymphomas, but not brain and solid tumors.

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Immunologists found the difference between antibodies that react to birch pollen allergens in healthy people and patients with allergies. The authors also found out why not all classes of antibodies can protect against allergies. The results were published in Allergy.

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Clarivate calls these scientists "pioneers," noting that ranking on the Highly Cited Researchers list is a sign that a scientist has published significant findings and influenced their field of study.

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St. Jude scientists mapped the gene regulatory networks responsible for progressive differentiation states of tumor-infiltrating T cells, using a technology known as single-cell CRISPR screening to knock out or genetically perturb multiple genes potentially involved.

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The Department of Immunology and Immunotherapy and the Icahn Genomics Institute (IGI) at the Icahn School of Medicine at Mount Sinai have been awarded a $5 million grant from the National Cancer Institute (NCI) of the National Institutes of Health to establish a state-of-the-art center dedicated to the discovery and development of cutting-edge targets for cancer therapy.

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A phase 1 clinical trial conducted exclusively at Roswell Park Comprehensive Cancer Center shows that a novel treatment regimen can make immunotherapy more effective in patients with metastatic triple-negative breast cancer (mTNBC).

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The James P. Allison Institute at MD Anderson hosted its inaugural scientific symposium on Nov. 10, bringing together more than 400 leading scientists in immunotherapy and immunobiology.

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For years, researchers and clinicians have known that lupus, an autoimmune condition, occurs in women at a rate nine times higher than in men.

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Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.

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Investigators from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) presented new research findings in antiphospholipid syndrome (APS) at the American College of Rheumatology (ACR) Convergence 2023, the ACR’s annual meeting.

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The American Association of Immunologists (AAI) is pleased to announce the appointment of Gwen Fortune-Blakely, M.B.A, CAE, as its new chief membership and engagement officer.

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UT Southwestern Medical Center will lead a multi-institution effort to gather and assimilate information on the billions of sequences employed by immune receptors of the adaptive immune system. The project, funded by the National Institutes of Health, aims to improve the understanding of immunity and help facilitate the development of improved vaccines and treatments for many diseases.

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Jennifer Oyler-Yaniv is studying human diseases to learn about the immune system. She hopes that diseases such as cancer will reveal fundamental principles of how immune cells communicate

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Un nuevo estudio que se presentará en la Reunión Científica Anual del ACAAI de este año en Anaheim (California) determinó que tanto un régimen de solución salina de dosis baja como de dosis alta parecían estar asociadas a menores tasas de hospitalización en comparación con los controles en las infecciones por SARS-CoV-2.

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Un nuevo estudio que se presentará en la Reunión Científica Anual del ACAAI de este año en Anaheim (California) muestra que el 42% de los médicos de atención primaria (PCP) encuestados no estaban familiarizados con los productos biológicos para tratar el asma.

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A new study being presented at this year’s ACAAI Annual Scientific Meeting in Anaheim, Calif. shows that 42% of the primary care physicians (PCPs) surveyed were unfamiliar with asthma biologics.

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A new late breaking abstract being presented at this year’s ACAAI Annual Scientific Meeting in Anaheim, Calif. demonstrates that a specially formulated toothpaste can be successfully used for Oral Mucosal Immunotherapy (OMIT).

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PNNL scientists took thousands of measurements of firefighters in training to learn more about how the body responds to vigorous exercise.