Curated News: JAMA

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Released: 21-Dec-2015 11:05 AM EST
Low Blood Flow in Back of Brain Increases Risk of Recurrent Stroke
University of Illinois Chicago

Patients who have had a stroke in the back of the brain are at greater risk of having another within two years if blood flow to the region is diminished, according to results of a multicenter study led by researchers at the University of Illinois at Chicago.

15-Dec-2015 11:00 AM EST
Family Members at Higher Risk When Cancers of Unknown Origin Strike Relatives
University of Utah Health

When a cancer of unknown origin strikes, patients' family members are at a higher risk for those and other types of cancer.

15-Dec-2015 3:45 PM EST
Early Childhood Depression Alters Brain Development​
Washington University in St. Louis

The brains of children who suffer clinical depression as preschoolers develop abnormally, compared with the brains of preschoolers unaffected by the disorder, according to new research at Washington University School of Medicine in St. Louis. Their gray matter is lower in volume and thinner in the cortex, a part of the brain important in the processing of emotions.

Released: 15-Dec-2015 3:05 PM EST
Study Finds that Eliminating Cost for Colorectal Cancer Screening Doesn’t Improve Screening Rates
University Hospitals Cleveland Medical Center

Making colonoscopy available at no cost to eligible Medicare beneficiaries under the Affordable Care Act (ACA) did not increase the number of people in this target population who regularly undergo the procedure, says a new large scale national study from University Hospitals Case Medical Center Seidman Cancer Center. Interestingly, the same analysis found that rates of routine mammography significantly increased following the ACA’s mandate for low or no cost screenings for Medicare recipients.

10-Dec-2015 7:05 AM EST
Taking Antidepressants During Pregnancy Increases Risk of Autism by 87%
Universite de Montreal

Using antidepressants during pregnancy greatly increases the risk of autism, Professor Anick Bérard of the University of Montreal and its affiliated CHU Sainte-Justine children’s hospital revealed today

10-Dec-2015 11:00 AM EST
Delaying Chemotherapy in Breast Cancer Patients Reduces Overall Survival, Especially for Those with Triple-Negative Breast Cancer
University of Texas MD Anderson Cancer Center

Postponing the start of adjuvant chemotherapy for more than 90 days following surgery may significantly increase risk of death for breast cancer patients, particularly those with triple-negative breast cancer (TNBC), according to a new study from The University of Texas MD Anderson Cancer Center.

Released: 9-Dec-2015 4:05 PM EST
Is Stroke Prevention Taking a Back Seat to Stroke Treatment?
University of California, Irvine

Many strokes that required immediate treatment in emergency rooms may have been preventable, according to a University of California, Irvine study. While therapy for acute stroke continues to advance and improve patient outcomes, the findings stress that stroke prevention – including the close monitoring of blood pressure, cholesterol levels and cardiac conditions – needs to keep pace.

Released: 9-Dec-2015 3:05 PM EST
Recently Approved Heart Drug Poses Potential Risk to Brain & Eye, Temple Researcher Warns
Temple University Health System

Patients with mild heart failure stand to benefit from a new drug that can halt the progression of their disease and reduce their risk of cardiovascular-related death. But the drug -- a tablet that combines the agents valsartan and sacubitril, sold under the trade name Entresto by drugmaker Novartis -- may be too good to be true, according to Arthur M. Feldman, MD, PhD, Executive Dean of the Lewis Katz School of Medicine at Temple University (LKSOM), Chief Academic Officer of the Temple University Health System, and Laura H. Carnell Professor of Medicine at LKSOM.

Released: 9-Dec-2015 3:05 PM EST
Recently Approved Heart Drug Poses Potential Risk to Brain & Eye, Temple Researcher Warns
Temple University Health System

Patients with mild heart failure stand to benefit from a new drug that can halt the progression of their disease and reduce their risk of cardiovascular-related death. But the drug -- a tablet that combines the agents valsartan and sacubitril, sold under the trade name Entresto by drugmaker Novartis -- may be too good to be true, according to Arthur M. Feldman, MD, PhD, Executive Dean of the Lewis Katz School of Medicine at Temple University (LKSOM), Chief Academic Officer of the Temple University Health System, and Laura H. Carnell Professor of Medicine at LKSOM.

3-Dec-2015 4:05 PM EST
One in Four New Doctors May Be Depressed – and Their Patients May Suffer Because of It
Michigan Medicine - University of Michigan

More than one in four doctors in the early stages of their careers has signs of depression, a comprehensive new study finds. And the grueling years of training for a medical career may deserve some of the blame.

8-Dec-2015 9:05 AM EST
Medical Student Presence Does Not Slow Care in Emergency Departments, Penn Medicine Study Finds
Perelman School of Medicine at the University of Pennsylvania

Medical students in Emergency Departments often perform an initial evaluation of stable patients prior to supervising residents or attending physicians, who meanwhile provide care to other patients. Despite some concern over the possible effect to patients, new research shows the presence of medical students in the Emergency Department adds less than five minutes to the average length of a patient’s stay. The findings, from a team of researchers at the Perelman School of Medicine at the University of Pennsylvania, are published in the December 8 Medical Education issue of JAMA.

30-Nov-2015 4:00 PM EST
U-M Researchers Find Adults with Cerebral Palsy More Likely to Have Chronic Health Conditions
Michigan Medicine - University of Michigan

A new study from the University of Michigan finds adults with cerebral palsy are more likely to have secondary chronic health conditions, such as diabetes and high blood pressure, than adults without cerebral palsy.

23-Nov-2015 9:10 AM EST
NYU Langone Enhances Patient Experience by Reducing Referrals to Rehab Facilities after Major Surgery
NYU Langone Health

NYU Langone study finds referring a patient to an acute care facility after major surgery, rather than the patient’s own home, may not always be necessary.

Released: 19-Nov-2015 11:05 AM EST
Can a Website Keep Suicidal Thoughts Away? Study in Stressed Young Doctors Suggests So
Michigan Medicine - University of Michigan

If you think your life is stressful, try being a new doctor. Their first year especially is a time of stress, sleeplessness and self-doubt – and four times the usual rate of suicidal thoughts. But a new study shows that a free web-based tool to support their mental health may cut that rate in half.

12-Nov-2015 4:05 PM EST
Studies Find Decline in Rates of PSA Screening, Early-Stage Prostate Cancer
JAMA - Journal of the American Medical Association

Two studies in the November 17 issue of JAMA examine the change in prostate-specific antigen (PSA) screening and prostate cancer incidence before and after the 2012 U.S. Preventive Services Task Force (USPSTF) screening recommendations.

12-Nov-2015 4:05 PM EST
Early Use of Antibiotic for Recurrent, Severe Lower Respiratory Illness in Children
JAMA - Journal of the American Medical Association

Among young children with histories of recurrent severe lower respiratory tract illness (LRTI), the use of azithromycin early during an apparent RTI compared with placebo significantly reduced the risk of experiencing progression to severe LRTI, according to a study in the November 17 issue of JAMA.

12-Nov-2015 4:05 PM EST
Study Compares Risk of Anaphylaxis Among Marketed IV Iron Products
JAMA - Journal of the American Medical Association

Cunlin Wang, M.D., Ph.D., of the U.S. Food and Drug Administration, Silver Spring, Md., and colleagues studied recipients of intravenous (IV) iron (n = 688,183) enrolled in the fee-for-service Medicare program from January 2003 to December 2013. The study appears in the November 17 issue of JAMA.

16-Nov-2015 4:05 PM EST
For Kids Prone to Wheezing with Respiratory Infections, Early Antibiotics Help​
Washington University in St. Louis

In children whose colds tend to progress and lead to severe wheezing and difficulty breathing — such that they are given oral corticosteroids as rescue therapy — researchers have shown that giving a common antibiotic at the first sign of cold symptoms can reduce the risk of the episode developing into a severe lower respiratory tract illness. The new study, led by researchers at Washington University School of Medicine in St. Louis, appears online Nov. 17 in JAMA.

16-Nov-2015 10:00 AM EST
National Study: For Low-Income Children, Preventive Care Is More Likely in Medicaid and CHIP Than Under Private Insurance
Children's Hospital of Philadelphia

Researchers say that children in low-income families experience greater access to preventive medical and dental care under Medicaid or the Children’s Health Insurance Program than children covered by private insurance. However, for all types of insurance, access to pediatric specialty care is a challenge.

Released: 9-Nov-2015 3:05 PM EST
Mayo Clinic Study: One Energy Drink May Increase Heart Disease Risk in Young Adults
Mayo Clinic

New research shows that drinking one 16-ounce energy drink can increase blood pressure and stress hormone responses significantly. This raises the concern that these response changes could increase the risk of cardiovascular events.

Released: 9-Nov-2015 2:05 PM EST
Use of Rarely Appropriate Angioplasty Procedures Declined Sharply
American College of Cardiology (ACC)

The number of angioplasty procedures classified as rarely appropriate declined sharply between 2010 and 2014, as did the number of those performed on patients with non-acute conditions, according to a study published today in the Journal of the American Medical Association and simultaneously presented at a meeting of the American Heart Association in Orlando.

Released: 9-Nov-2015 2:05 PM EST
Use of Rarely Appropriate Angioplasty Procedures Declined Sharply
American College of Cardiology (ACC)

The number of angioplasty procedures classified as rarely appropriate declined sharply between 2010 and 2014, as did the number of those performed on patients with non-acute conditions, according to a study published today in the Journal of the American Medical Association and simultaneously presented at a meeting of the American Heart Association in Orlando.

6-Nov-2015 3:05 PM EST
Penn Study Asks: To Improve Patients’ Health, Should you Pay Physicians, Patients, or Both?
Perelman School of Medicine at the University of Pennsylvania

Providing financial incentives to both primary care physicians and patients leads to a greater reduction in low-density lipoprotein (LDL) cholesterol in patients than paying only the physician or only the patient, according to a new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania. The study, which is the first to test physician-only and patient-only incentives compared to incentives shared by patients and physicians, is published in the November 10 issue of JAMA.

3-Nov-2015 4:30 PM EST
First Precision Medicine Trial in Cancer Prevention Identifies Molecular-based Chemoprevention Strategy
UC San Diego Health

A team of scientists, led by researchers at University of California, San Diego Moores Cancer Center and The University of Texas MD Anderson Cancer Center, report that a genetic biomarker called loss of heterozygosity or LOH is able to predict which patients with premalignant mouth lesions are at highest risk of developing oral cancer. The findings, published in the November 5, 2015 online issue of Journal of the American Medical Association Oncology, present a new tool that could be used to identify patients most likely to benefit from chemoprevention — and may be applicable to preventing other types of cancer.

Released: 2-Nov-2015 11:45 AM EST
Conventional Heart Drug Stops the Progression of Cancer
Texas Tech University Health Sciences Center El Paso

A common heart drug may stop the progression of angiosarcoma, a cancer of the inner lining of blood vessels, according to a study by researchers at Texas Tech University Health Sciences Center (TTUHSC) El Paso.

Released: 28-Oct-2015 1:05 PM EDT
Marital Status Linked to Better Functional Outcomes Following Cardiac Surgery, Penn Medicine Study Finds
Perelman School of Medicine at the University of Pennsylvania

Patients who are divorced, separated or widowed had an approximately 40 percent greater chance of dying or developing a new functional disability in the first two years following cardiac surgery than their married peers, according to a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania published in this week’s JAMA Surgery.

22-Oct-2015 4:05 PM EDT
Decreases Seen in Leading Causes of Death
JAMA - Journal of the American Medical Association

An analysis of deaths in the United States between 1969 and 2013 finds an overall decreasing trend in the age-standardized death rate for all causes combined and for heart disease, cancer, stroke, unintentional injuries, and diabetes, although the rate of decrease appears to have slowed for heart disease, stroke, and diabetes, according to a study in the October 27 issue of JAMA.

22-Oct-2015 4:05 PM EDT
Study Compares Combination Treatments for Black Adults with Asthma
JAMA - Journal of the American Medical Association

Among black adults with asthma treated with an inhaled corticosteroid, adding a long-acting beta-agonist did not improve the time to an asthma exacerbation compared with adding the anticholinergic tiotropium, according to a study in the October 27 issue of JAMA.

22-Oct-2015 4:05 PM EDT
Study Examines Lack of Specialists in Insurance Plans of Affordable Care Act
JAMA - Journal of the American Medical Association

In a study of federal marketplace insurance plans, nearly 15 percent completely lacked in-network physicians for at least 1 specialty, a practice found among multiple states and issuers, raising concerns regarding patient access to specialty care, according to a study in the October 27 issue of JAMA.

22-Oct-2015 1:00 PM EDT
Too Much, Too Late: Doctors Should Cut Back on Some Medications in Seniors, Two Studies Suggest
Michigan Medicine - University of Michigan

Anyone who takes medicine to get their blood sugar or blood pressure down – or both – knows their doctor prescribed it to help them. But what if stopping, or at least cutting back on, such drugs could help even more? Two new studies suggest doctors should be doing that more.

Released: 22-Oct-2015 9:05 AM EDT
Preeclampsia Increases Risk of Heart Defects in Infants
Universite de Montreal

Pregnant women with preeclampsia have a higher risk of delivering an infant with a congenital heart defect.

Released: 21-Oct-2015 2:45 PM EDT
American Cancer Society Revises Mammogram Guidelines, Causing Some Confusion
Newswise Trends

The American Cancer Society has issued new recommendations on when women should get mammograms and how frequently they should get them. This is in contrast to the previous guidelines which stated that women should get them at age 40.

14-Oct-2015 5:45 PM EDT
Memo to Docs: Mind the Nonresistant Bugs Too
Johns Hopkins Medicine

Drug-resistant bacteria have dominated news headlines and the attention of public health experts, but a study by experts at the Johns Hopkins Children’s Center and the Duke Clinical Research Institute shows that nonresistant bacterial infections occur far more often and can take just as great a toll on newborns as their drug-resistant cousins.

16-Oct-2015 3:05 PM EDT
Determining Accurate Life Expectancy of Older Adults Requires Provider, Patient Discussion
University of California, San Francisco (UCSF)

Health care providers must have detailed discussions with their older adult patients to better determine their true life expectancy, as older adults do not accurately predict their own prognosis, a key factor in making decisions about future health interventions, according to researchers at UC San Francisco and San Francisco Veterans Affairs Medical Center.

8-Oct-2015 3:05 PM EDT
Number of Addicted Rises, but Percentage in Drug Treatment Remains Stagnant
Johns Hopkins Bloomberg School of Public Health

Despite the quadrupling of heroin overdose deaths over the past decade and a dramatic rise in deaths from prescription painkillers, the percentage of people getting treatment for their opioid abuse and dependence has remained the same, new Johns Hopkins Bloomberg School of Public Health research suggests.

7-Oct-2015 4:00 PM EDT
Study Examines Cancer-Care Outcomes Among US Hospitals
Memorial Sloan Kettering Cancer Center

A new JAMA Oncology study from Memorial Sloan Kettering Cancer Center finds that risk-adjusted Medicare claims data — without information about the cancer stage of individual patients — may be sufficient to calculate the long-term survival rates at hospitals providing cancer care in the United States.

5-Oct-2015 7:05 PM EDT
Gay and Bisexual Men Report Higher Rates of Both Indoor Tanning and Skin Cancer than Heterosexual Men
University of California, San Francisco (UCSF)

Gay and bisexual men were up to six times more likely than heterosexual men to take part in indoor tanning, and twice as likely to report a history of skin cancer, including nonmelanoma and melanoma, according to a study led by UC San Francisco researchers.

5-Oct-2015 7:05 PM EDT
Online Advertising Can Deliver Targeted Cancer Prevention Messages, UCSF Study Finds
University of California, San Francisco (UCSF)

Online advertising based on Google search terms is a potentially effective way to deliver targeted cancer prevention education, according to a study led by Eleni Linos, MD, DrPH, an assistant professor of dermatology at UC San Francisco.

28-Sep-2015 3:05 PM EDT
Placebo Power: Depressed People Who Respond to Fake Drugs Get the Most Help From Real Ones
Michigan Medicine - University of Michigan

When it comes to treating depression, how well a person responds to a fake medicine may determine how well they’ll respond to a real one, a new study shows. Those who can muster their brain’s own chemical forces against depression have a head start in overcoming symptoms with help from medication.

Released: 22-Sep-2015 11:05 AM EDT
Death & Money in the ICU: Pneumonia Findings Surprise Researchers
Michigan Medicine - University of Michigan

When an older person gets hospitalized for pneumonia, where’s the best place to care for them? New research findings about deaths and health care costs in such patients fly in the face of conventional wisdom – and could change where doctors decide to treat them.

Released: 15-Sep-2015 12:05 PM EDT
Study Identifies Why More People Die After Hip Fracture Surgery Than Hip Replacement Surgery
McMaster University

The researchers studied almost 700,000 hip surgery patients more than 45 years old in France between 2010 and 2013, and found that the total hip replacement patients were younger, more commonly men and had less other medical problems than hip fracture patients.

11-Sep-2015 11:05 AM EDT
Additional Time Spent Outdoors by Children Results in Decreased Rate of Nearsightedness
JAMA - Journal of the American Medical Association

The addition of a daily outdoor activity class at school for three years for children in Guangzhou, China, resulted in a reduction in the rate of myopia (nearsightedness, the ability to see close objects more clearly than distant objects), according to a study in the September 15 issue of JAMA.

11-Sep-2015 11:05 AM EDT
Sex Differences in Academic Faculty Rank, Institutional Support for Biomedical Research
JAMA - Journal of the American Medical Association

Women are less likely than men to be full professors at U.S. medical schools, and receive less start-up support from their institutions for biomedical research, according to two studies in the September 15 issue of JAMA.

11-Sep-2015 11:05 AM EDT
Factors for Higher Risk of Death Following Hip Fracture Surgery Compared to Hip Replacement
JAMA - Journal of the American Medical Association

Patients undergoing surgery for a hip fracture were older and had more medical conditions than patients who underwent an elective total hip replacement, factors that may contribute to the higher risk of in-hospital death and major postoperative complications experienced by hip fracture surgery patients, according to a study in the September 15 issue of JAMA.

Released: 10-Sep-2015 2:05 PM EDT
Reduced Heart Rate Variability May Indicate Greater Vulnerability to PTSD
UC San Diego Health

A prospective longitudinal study of U.S. Marines suggests that reduced heart rate variability – the changing time interval between heartbeats – may be a contributing risk factor for post-traumatic stress disorder (PTSD). The findings are reported in the September 9 online issue of JAMA Psychiatry by researchers at the University of California, San Diego School of Medicine and Veterans Affairs San Diego Healthcare System.

Released: 9-Sep-2015 3:05 PM EDT
Paying Women to Have Mammograms Is Unethical, Penn Medicine Ethicist Says
Perelman School of Medicine at the University of Pennsylvania

The widespread practice of incentivizing mammogram completion via cash payments, typically by insurance companies and ranging from $10 to $250, is unethical according to a Viewpoint article published this week in JAMA by an expert from the Perelman School of Medicine at the University of Pennsylvania. Instead, incentives should be offered to women to use evidence-based decision aids to decide if they want a mammogram, even if this policy likely averts fewer breast cancer deaths overall.

Released: 8-Sep-2015 2:15 PM EDT
NEI Team in Liberia Investigates Ocular Effects Among Ebola Survivors
NIH, National Eye Institute (NEI)

Following the 2014 Ebola outbreak in West Africa that took the lives of more than 11,200 people in the region, the National Eye Institute, part of the National Institutes of Health, has deployed a team of clinicians and technical experts to Monrovia, Liberia to investigate the long-term effects of Ebola on the eye.

3-Sep-2015 4:05 PM EDT
Outcomes Improve for Extremely Preterm Infants
JAMA - Journal of the American Medical Association

Over the last 20 years, complications have decreased and survival has improved for extremely preterm infants, according to a study in the September 8 issue of JAMA.

3-Sep-2015 4:05 PM EDT
Iron Supplementation During Pregnancy and Risk of Malaria in Malaria-Endemic Region
JAMA - Journal of the American Medical Association

Among women in a malaria-endemic region in Kenya, daily iron supplementation during pregnancy did not result in an increased risk of malaria, according to a study in the September 8 issue of JAMA. Iron supplementation did result in increased birth weight, gestational duration, neonatal length, and a decreased risk of low birth weight and prematurity.

3-Sep-2015 4:05 PM EDT
Lack of Adherence to Usability Testing Standards for Electronic Health Record Products
JAMA - Journal of the American Medical Association

The lack of adherence to usability testing standards among several widely used electronic health record (EHR) products that were certified as having met these requirements may be a major factor contributing to the poor usability of EHRs, according to a study in the September 8 issue of JAMA.



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