A longitudinal cohort study of persons with a history of injection drug use has found that more people who inject drugs (PWID) are receiving Hepatitis C virus (HCV) treatment, which is associated with significant reductions in liver disease and mortality.
Researchers at Saint Louis University's School of Medicine, in collaboration with Arrowhead Pharmaceuticals and Takeda Pharmaceuticals, report the first effective drug to treat a rare, genetic liver disease that formerly could only be treated with a liver transplant.
The growing incidence of a potentially cancer-causing liver disease in children is associated with prenatal exposure to several endocrine-disrupting chemicals, Mount Sinai researchers report.
The July issue of The American Journal of Gastroenterology highlights new clinical science including using a smartphone app to assess stool form, rural-urban disparities in cirrhosis mortality, and lung infection risk in severe alcohol-related hepatitis. This issue also includes articles on pediatric IBD, therapy options for Crohn’s disease, a novel endoscopic suturing device, proton pump inhibitors, and more.
UNC School of Medicine scientists discovered that hepatitis A viral replication requires specific interactions between a human protein and a group of enzymes, and they used a molecule to stop replication at this key interactive step, making it impossible for the virus to infect liver cells.
New Mayo Clinic research finds that machine-learning algorithms can help health care staff distinguish the two conditions. In an article published in Mayo Clinic Proceedings, researchers show how algorithms may be effective predictive tools using a few simple variables and routinely available structured clinical information.
Carbon monoxide is best known as a potentially deadly gas. However, in small doses it also has beneficial qualities: It has been shown to reduce inflammation and can help stimulate tissue regeneration.
The human liver has amazing regeneration capabilities: Even if up to 70 percent of it is removed, the remaining tissue can regrow a full-sized liver within months.
In a pair of studies, UC San Diego School scientists have deepened investigations into the genetic origins of nonalcoholic fatty liver disease in children, describing multiple gene variants that contribute to disease risk.
For the first time, a team led by UAH, a part of the University of Alabama System, has characterized the metabolic function of a phosphatase enzyme called mitogen-activated protein kinase phosphatase-2 (MKP-2), as well as the enzyme’s pathophysiology in obesity, Type 2 diabetes and nonalcoholic fatty liver disease.
Afzal A. Siddiqui, Ph.D., director of the Center for Tropical Medicine and Infectious Disease and chair of the Department of Immunology and Molecular Microbiology at the Texas Tech University Health Sciences Center School of Medicine, began his quest to develop a schistosomiasis vaccine in 1991. With funding from the National Institutes of Allergies and Infectious Diseases (NIAID) at the National Institutes of Health (NIH) and the Thrasher Foundation, he began conducting bench studies and pre-clinical development of what was known as the Sm-p80/GLA-SE schistosomiasis vaccine, which would eventually be branded SchistoShield®.
Researchers conducted an original research study utilizing the U.S. Centers for Disease Control and Prevention’s Wide-ranging Online Data for Epidemiologic Research (WONDER) to compare trends in mortality from alcoholic cirrhosis in the U.S. in 1999 with those 20 years later in 2019.
Here are some of the latest articles that have been added to the Aging channel on Newswise, a free source for journalists.
A study of more than 90,000 postmenopausal women found that those who consumed at least one sugar-sweetened beverage daily faced a 78% higher risk of developing liver cancer compared with people who consumed less than three servings per month of such beverages.
Growth hormone improves liver health in patients with nonalcoholic fatty liver disease (NAFLD) by reducing liver fat and inflammation, according to a new study presented Tuesday, June 14 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.
UC San Diego researchers describe connection between pediatric liver disease and increased risk of developing type 2 diabetes. Both rates are rising in children.
While many 21-year-olds celebrate their coming of age in bars and nightclubs, Andrew Solis is celebrating freedom by finally going home—equipped with a new heart and liver—after nearly eight months at Cedars-Sinai.
High fructose consumption should be avoided to prevent the development of non-alcoholic fatty liver disease (NAFLD), according to research being presented Sunday, June 12 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.
Racial and ethnic minorities diagnosed with advanced liver cancer have a lower chance of receiving immunotherapy, the most effective treatment for patients with the disease, according to a new study led by Cedars-Sinai Cancer investigators.
According to ARRS’ American Journal of Roentgenology (AJR), ultrasound-derived fat fraction (UDFF) is strongly associated with MRI proton-density fat fraction (PDFF) and provides high sensitivity for detecting hepatic steatosis.
UC San Diego researchers report that the causes and death rates of liver cancer are changing around the world.
The Liver4Life research team owes its perfusion machine, which was developed in house, to the fact that it became possible to implant a human organ into a patient after a storage period of three days outside a body.
Cells produce proteins like little factories. But if they make too much at the wrong times it can lead to diseases like cancer, so they control production with a process called RNA interference (RNAi).
Scientists have identified a new disease in a ground-breaking discovery that could help patients with unexplained liver and kidney problems.
Nowadays doctors define and diagnose most diseases on the basis of symptoms.
An advanced radiotherapy technique called radiation segmentectomy may be effective against very early to early-stage hepatocellular carcinoma (HCC), a type of liver cancer that cannot be treated surgically or thermally.
A multicenter study performed by a large international consortium that includes UT Southwestern has outlined a set of risk factors and outcomes for patients with autoimmune hepatitis (AIH) that recurs after liver transplantation. The findings, published in the Journal of Hepatology, represent a first step toward better managing and potentially preventing this uncommon condition.
A national policy change to facilitate the broader sharing of donor livers through “acuity circles” has resulted in procurement delays, according to a researcher at the University of Miami Miller School of Medicine.
Scientists make inroads in understanding the relationship between certain enzymes that are normally produced in the body and their role in regulating obesity and controlling liver diseases.
The National Academy of Sciences (NAS) today elected UT Southwestern scientist Jonathan Cohen, Ph.D., into its membership, one of the highest honors for American scientists. Dr. Cohen, Professor of Internal Medicine in the Center for Human Nutrition and the Eugene McDermott Center for Human Growth and Development at UT Southwestern, was elected by his peers in recognition of distinguished and continuing achievements in original research. His research centers on identifying genes that play major roles in the metabolism of cholesterol and triglycerides and elucidating the biological roles of their protein products.
Exercise supports the treatment of non-alcoholic fatty liver disease by impacting on several metabolic pathways in the body, a new study from the University of Eastern Finland shows.
Nanotherapeutics have shed new light onto HCC treatment by enabling site-specific in vivo delivery of chemotherapeutics specifically to neoplastic hepatocytes without affecting normal hepatocytes.
A hormone that triggers puberty and controls fertility in humans might be developed as a treatment for non-alcoholic fatty liver disease, according to new Rutgers research.
Since the start of the COVID-19 pandemic, alcohol use has been on the rise ― and so is alcohol-associated liver disease. Two Penn State Health doctors discuss what alcohol does to the liver and when it’s time for a transplant in this week’s Medical Minute.
A vaccine for hepatitis C has eluded scientists for more than 30 years, for several reasons.
Throughout the month of April—Donate Life Month—experts from Cedars-Sinai Comprehensive Transplant Center and the Smidt Heart Institute are available for interviews on issues related to transplantation, immunology and organ donation.
Here are some of the latest articles that have been added to the Clinical Trials channel on Newswise.
Results from a new study suggest that two sugar substitutes disrupt the function of a protein that plays a vital role in liver detoxification and the metabolism of certain drugs. These sugar substitutes, also known as non-nutritive sweeteners, provide a sweet taste with few or no calories.
While 2021 proved to be a record-breaking year for organ donation in the U.S., many people are still hesitant to register to become a donor. Nationwide, only about 48% of people are registered to be organ donors, according to LifeSource. That's despite surveys showing that 95% of people in the U.S. support organ donation.
The April issue of The American Journal of Gastroenterology includes two new guidelines—an update to the 2016 guidelines on Barrett’s Esophagus and a joint society guideline on the management of antithrombotics during GI bleeding and the periendoscopic period.
Results from a preclinical study add new evidence that a multi-mineral dietary supplement known as Aquamin could be a simple and effective way to reduce the long-term health consequences of non-alcoholic fatty liver disease. Aquamin, which is derived from calcified red marine algae, is rich in calcium, magnesium and 72 other minerals and trace elements.
Embargoed press materials are now available for the Experimental Biology (EB) 2022 meeting, featuring cutting-edge research from across the life sciences. EB 2022, to be held April 2–5 in Philadelphia, is the annual meeting of five scientific societies bringing together thousands of scientists and 25 guest societies in one interdisciplinary community.
Hepatitis screening rates climbed to 80 percent for patients whose doctors didn’t need to opt in to order a screening
Mayo Clinic experts will discuss recent advances in gastroenterology and hepatology at the first Mayo Clinic International-Sheikh Shakhbout Medical City Congress in Gastroenterology and Hepatology in Abu Dhabi, United Arab Emirates.
سيناقش خبراء مايو كلينك التطورات الحديثة في طب الجهاز الهضمي والكبد في مؤتمر مايو كلينك الدولي الأول في مدينة الشيخ شخبوط الطبية لطب الجهاز الهضمي والكبد في أبوظبي، الإمارات العربية المتحدة. وقد دخلت مايو كلينك وشركة أبوظبي للخدمات الصحية "صحة" في مشروع مشترك عام 2019 لتشغيل مدينة الشيخ شخبوط الطبية.
Don't miss these articles in our Staff Picks channel
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts. Current findings include immunotherapy advances for AML, liver cancer, HPV-related cancers and other solid tumors, biomarkers of response to TIL therapy in melanoma, a greater understanding of the cells regulating skin wound repair, and data confirming the safety of proton therapy for pediatric brain cancer.
A high-fat diet is not enough to cause short-term fatty liver disease. However, if this diet is combined with the intake of beverages sweetened with liquid fructose, the accumulation of fats in the liver accelerates and hypertriglyceridemia —a cardiovascular risk factor— can appear.
Women with long or irregular periods are known to have a higher risk of type 2 diabetes and heart disease, but researchers found these women may also be at risk for nonalcoholic fatty liver disease (NAFLD), according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology and Metabolism.
Exercise may help certain patients with nonalcoholic fatty liver disease reduce their risk of developing blood clots, according to a new study by Penn State College of Medicine researchers.
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