Curated News: National Institute of Dental and Craniofacial Research (NIDCR)

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Newswise: You’ve got some nerve
Released: 16-May-2023 12:45 PM EDT
You’ve got some nerve
Michigan Medicine - University of Michigan

Researchers at the University of Michigan Rogel Cancer Center and the School of Dentistry identified a new metric to articulate the relationship between nerve density and oral cancer.

Newswise: Healing the unhealable: New approach helps bones mend themselves
Released: 19-Apr-2023 4:30 PM EDT
Healing the unhealable: New approach helps bones mend themselves
University of Pittsburgh

University of Pittsburgh researchers developed a novel approach that promoted bone regeneration in mice without implantation of bone tissue or biomaterials.

Newswise: Regenerative drug restores bone in Lankenau research study
Released: 19-Jan-2023 12:30 PM EST
Regenerative drug restores bone in Lankenau research study
Main Line Health

A study led by pioneering Lankenau Institute for Medical Research scientist Ellen Heber-Katz, PhD, has demonstrated the ability of an experimental regenerative medicine developed in her lab to restore bone in an animal.

Newswise: P53 could be key to therapies for salivary gland cancer
Released: 8-Dec-2022 11:05 AM EST
P53 could be key to therapies for salivary gland cancer
Michigan Medicine - University of Michigan

Researchers at the University of Michigan Rogel Cancer Center and School of Dentistry found that certain drugs can change the fundamental makeup of cancer stem cells in mouse models of mucoepidermoid carcinoma – a lethal form of salivary gland cancer that currently has no treatment options. These results appeared in Clinical Cancer Research.

11-Nov-2022 6:25 PM EST
Two new studies from Fred Hutchinson Cancer Center show how bacteria could help tumors progress and resist treatment
Fred Hutchinson Cancer Center

Two new studies from researchers at Fred Hutchinson Cancer Center in Seattle reveal how bacteria infiltrate tumors and could be helping tumors progress and spread and suggest a link between oral health and cancer, as microbes in the mouth are associated with cancers elsewhere in the body. The two papers – one published Nov. 15 in Cell Reports and the other published Nov. 16 in Nature – focus on an oral bacterium called Fusobacterium nucleatum, which has been linked to colorectal cancer.

3-Mar-2022 2:05 PM EST
New research underscores South Carolina’s growing strength as a biomedical research hub
Clemson University

South Carolina is strengthening its position as a hub for high-impact biomedical research with a new multi-million-dollar project that undergirds the long-standing partnership between Clemson University and the Medical University of South Carolina (MUSC) and loops in crucial support from the National Institute of Dental and Craniofacial Research (NIDCR) at the National Institutes of Health (NIH).

Newswise: Making the Invisible Visible: A Clearer ‘Picture’ of Blood Vessels in Health and Disease Thanks to New Imaging Approach
Released: 28-Feb-2022 9:00 AM EST
Making the Invisible Visible: A Clearer ‘Picture’ of Blood Vessels in Health and Disease Thanks to New Imaging Approach
Johns Hopkins Medicine

Johns Hopkins Medicine researchers have developed and tested a new imaging approach they say will accelerate imaging-based research in the lab by allowing investigators to capture images of blood vessels at different spatial scales.

Newswise: A Stunning 3d Map of Blood Vessels and Cells in a Mouse Skull Could Help Scientists Make New Bones
Released: 18-Nov-2021 11:00 AM EST
A Stunning 3d Map of Blood Vessels and Cells in a Mouse Skull Could Help Scientists Make New Bones
Johns Hopkins Medicine

Johns Hopkins Medicine scientists have used glowing chemicals and other techniques to create a 3D map of the blood vessels and self-renewing “stem” cells that line and penetrate a mouse skull. The map provides precise locations of blood vessels and stem cells that scientists could eventually use to repair wounds and generate new bone and tissue in the skull.

Released: 18-Aug-2021 1:30 PM EDT
New Study Planned to Help Understand Oral Health Outcomes for Children in Low-Income Areas
University of Illinois Chicago

University of Illinois Chicago researchers have received funding from the National Institute of Dental and Craniofacial Research, a branch of the U.S. National Institutes of Health, for a five-year study to understand the oral health of children in low-income communities. Caries — or cavities — is the most common disease of childhood and can result in serious health issues including pain, difficulty eating, speech problems, and infections which can lead to hospitalization and surgeries for tooth extractions.

Released: 25-May-2021 9:55 AM EDT
New wiki on salivary proteins may transform diagnostic testing and personalized medicine
University at Buffalo

To improve the development of new saliva-based diagnostic tests and personalized medicine, the National Institute of Dental and Craniofacial Research (NIDCR) has supported the development of the Human Salivary Proteome Wiki, the first public platform that catalogs and curates data on each of the thousands of proteins within our saliva.

Released: 12-Feb-2021 9:00 AM EST
The Scarred Villain: Study Explores Neurocognitive Basis of Bias Against People Who Look Different
Perelman School of Medicine at the University of Pennsylvania

A new brain-and-behavior study from researchers in the Perelman School of Medicine at the University of Pennsylvania clarifies how the “anomalous-is-bad” stereotype manifests, and implicates a brain region called the amygdala as one of the likely mediators of this stereotype.

Released: 14-Jan-2021 10:10 AM EST
Behaviors Surrounding Oral Sex May Increase HPV-Related Cancer Risk
Johns Hopkins Medicine

A wide breadth of behaviors surrounding oral sex may affect the risk of oral HPV infection and of a virus-associated head and neck cancer that can be spread through this route, a new study led by researchers at the Johns Hopkins Kimmel Cancer Center suggests. These findings add nuance to the connection between oral sex and oropharyngeal cancer — tumors that occur in the mouth and throat — and could help inform research and public health efforts aimed at preventing this disease.

Released: 25-Sep-2020 12:05 PM EDT
NYU College of Dentistry Awarded NIH Grant to Investigate Endosomal Receptors as Targets for Chronic Pain Treatment
New York University

The NIH has awarded NYU College of Dentistry researchers Nigel Bunnett, PhD, and Brian Schmidt, DDS, MD, PhD, a $3.9 million grant to study targeting endosomal receptors for the treatment of chronic pain. The five-year grant will support Bunnett and Schmidt’s collaborative research, which aims to ultimately yield improved pain management without the need for opioids.

Released: 14-Sep-2020 1:10 PM EDT
Botox for TMJ Disorders May Not Lead to Bone Loss in the Short Term, But More Research is Needed on Higher Dose, Long-Term Use
New York University

Botox injections to manage jaw and facial pain do not result in clinically significant changes in jaw bone when used short term and in low doses, according to researchers at NYU College of Dentistry. However, they found evidence of bone loss when higher doses were used.

Released: 30-Jul-2020 4:55 PM EDT
Precision Medicine Identifies Key Recurring Mutation in Head and Neck Cancers
UC San Diego Health

Researchers at UC San Diego School of Medicine and Moores Cancer Center report that an investigational drug candidate called tipifarnib showed promise in treating key recurring mutation in head and neck cancers.

Released: 21-Jul-2020 11:35 AM EDT
Smile: Atomic imaging finds root of tooth decay
Cornell University

A collaboration between researchers from Cornell University, Northwestern University and University of Virgina combined complementary imaging techniques to explore the atomic structure of human enamel, exposing tiny chemical flaws in the fundamental building blocks of our teeth. The findings could help scientists prevent or possibly reverse tooth decay.

17-Jul-2020 6:10 PM EDT
Researchers ID new target in drive to improve immunotherapy for cancer
University of California, Los Angeles (UCLA), Health Sciences

Researchers at the UCLA Jonsson Comprehensive Cancer Center and UCLA School of Dentistry have identified a potential new combination therapy to treat advanced head and neck squamous cell carcinoma, the most common type of head and neck cancer.

Released: 4-Jun-2020 8:30 AM EDT
Immune from Chronic Stress? Limit Inflammatory Signaling to Specific Brain Circuits
Florida Atlantic University

Chronic stress is associated with the pathogenesis of psychological disorders such as depression. A study is the first to identify the role of a neuronal receptor that straddles the intersection between social stress, inflammation, and anxiety in rodent models of stress. Findings suggest the possibility of developing better medications to treat the consequences of chronic stress by limiting inflammatory signaling not just generally, which may not be beneficial in the long run, but to specific brain circuits.

Released: 16-Apr-2020 9:30 AM EDT
NYU Dentistry Awarded $2.2 Million NIH Grant to Investigate How Oral Cancer Causes Pain
New York University

The National Institute of Dental and Craniofacial Research has awarded NYU College of Dentistry’s Yi Ye, PhD, a $2.2 million, five-year grant to study the role of Schwann cells, the most prevalent type of cell supporting neurons in the peripheral nervous system, in oral cancer progression and pain.

8-Mar-2020 9:00 PM EDT
Mimicking Cancer’s Evasive Tactics, Microparticles Show Promise Against Transplant Rejection
Health Sciences at the University of Pittsburgh

Inspired by a tactic cancer cells use to evade the immune system, University of Pittsburgh researchers have engineered tiny particles that can trick the body into accepting transplanted tissue as its own, while leaving the immune system intact.

19-Feb-2020 1:10 PM EST
Vaping Changes Oral Microbiome, Increasing Risk for Infection
New York University

Using e-cigarettes alters the mouth’s microbiome—the community of bacteria and other microorganisms—and makes users more prone to inflammation and infection, finds a new study led by researchers at NYU College of Dentistry.

18-Feb-2020 8:00 AM EST
Study Reveals How Too Much Fluoride Causes Defects in Tooth Enamel
New York University

Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel—a novel explanation for how dental fluorosis, a condition caused by overexposure to fluoride during childhood, arises. The study, led by researchers at NYU College of Dentistry, is published in Science Signaling.

11-Feb-2020 2:15 PM EST
Absent p53, oral cancers recruit and reprogram nerves to fuel tumor growth
University of Texas MD Anderson Cancer Center

Loss of an important tumor-suppressing gene allows head and neck cancer to spin off signals to nearby nerves, changing their function and recruiting them to the tumor, where they fuel growth and cancer progress.

Released: 5-Dec-2019 11:00 AM EST
Mouse Study Shows Nerve Signaling Pathway Critical to Healing Fractures
Johns Hopkins Medicine

Sticks and stones may break one’s bones, but healing them requires the production of a protein signal that stimulates the generation, growth and spread of vital nerve cells, or neurons, throughout the injured area. That’s the finding of a recent Johns Hopkins Medicine study that used mice to demonstrate what likely takes place during human fracture repair as well.

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