Curated News: National Institute of Dental and Craniofacial Research (NIDCR)

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Newswise: New wiki on salivary proteins may transform diagnostic testing and personalized medicine
Released: 25-May-2021 9:55 AM EDT
New wiki on salivary proteins may transform diagnostic testing and personalized medicine
University at Buffalo

To improve the development of new saliva-based diagnostic tests and personalized medicine, the National Institute of Dental and Craniofacial Research (NIDCR) has supported the development of the Human Salivary Proteome Wiki, the first public platform that catalogs and curates data on each of the thousands of proteins within our saliva.

Released: 12-Feb-2021 9:00 AM EST
The Scarred Villain: Study Explores Neurocognitive Basis of Bias Against People Who Look Different
Perelman School of Medicine at the University of Pennsylvania

A new brain-and-behavior study from researchers in the Perelman School of Medicine at the University of Pennsylvania clarifies how the “anomalous-is-bad” stereotype manifests, and implicates a brain region called the amygdala as one of the likely mediators of this stereotype.

Newswise: Behaviors Surrounding Oral Sex May Increase HPV-Related Cancer Risk
Released: 14-Jan-2021 10:10 AM EST
Behaviors Surrounding Oral Sex May Increase HPV-Related Cancer Risk
Johns Hopkins Medicine

A wide breadth of behaviors surrounding oral sex may affect the risk of oral HPV infection and of a virus-associated head and neck cancer that can be spread through this route, a new study led by researchers at the Johns Hopkins Kimmel Cancer Center suggests. These findings add nuance to the connection between oral sex and oropharyngeal cancer — tumors that occur in the mouth and throat — and could help inform research and public health efforts aimed at preventing this disease.

Newswise: NYU College of Dentistry Awarded NIH Grant to Investigate Endosomal Receptors as Targets for Chronic Pain Treatment
Released: 25-Sep-2020 12:05 PM EDT
NYU College of Dentistry Awarded NIH Grant to Investigate Endosomal Receptors as Targets for Chronic Pain Treatment
New York University

The NIH has awarded NYU College of Dentistry researchers Nigel Bunnett, PhD, and Brian Schmidt, DDS, MD, PhD, a $3.9 million grant to study targeting endosomal receptors for the treatment of chronic pain. The five-year grant will support Bunnett and Schmidt’s collaborative research, which aims to ultimately yield improved pain management without the need for opioids.

Released: 14-Sep-2020 1:10 PM EDT
Botox for TMJ Disorders May Not Lead to Bone Loss in the Short Term, But More Research is Needed on Higher Dose, Long-Term Use
New York University

Botox injections to manage jaw and facial pain do not result in clinically significant changes in jaw bone when used short term and in low doses, according to researchers at NYU College of Dentistry. However, they found evidence of bone loss when higher doses were used.

Newswise: Precision Medicine Identifies Key Recurring Mutation in Head and Neck Cancers
Released: 30-Jul-2020 4:55 PM EDT
Precision Medicine Identifies Key Recurring Mutation in Head and Neck Cancers
University of California San Diego Health

Researchers at UC San Diego School of Medicine and Moores Cancer Center report that an investigational drug candidate called tipifarnib showed promise in treating key recurring mutation in head and neck cancers.

Released: 21-Jul-2020 11:35 AM EDT
Smile: Atomic imaging finds root of tooth decay
Cornell University

A collaboration between researchers from Cornell University, Northwestern University and University of Virgina combined complementary imaging techniques to explore the atomic structure of human enamel, exposing tiny chemical flaws in the fundamental building blocks of our teeth. The findings could help scientists prevent or possibly reverse tooth decay.

Newswise: Researchers ID new target in drive to improve immunotherapy for cancer
17-Jul-2020 6:10 PM EDT
Researchers ID new target in drive to improve immunotherapy for cancer
University of California, Los Angeles (UCLA), Health Sciences

Researchers at the UCLA Jonsson Comprehensive Cancer Center and UCLA School of Dentistry have identified a potential new combination therapy to treat advanced head and neck squamous cell carcinoma, the most common type of head and neck cancer.

Newswise: Immune from Chronic Stress? Limit Inflammatory Signaling to Specific Brain Circuits
Released: 4-Jun-2020 8:30 AM EDT
Immune from Chronic Stress? Limit Inflammatory Signaling to Specific Brain Circuits
Florida Atlantic University

Chronic stress is associated with the pathogenesis of psychological disorders such as depression. A study is the first to identify the role of a neuronal receptor that straddles the intersection between social stress, inflammation, and anxiety in rodent models of stress. Findings suggest the possibility of developing better medications to treat the consequences of chronic stress by limiting inflammatory signaling not just generally, which may not be beneficial in the long run, but to specific brain circuits.

Released: 16-Apr-2020 9:30 AM EDT
NYU Dentistry Awarded $2.2 Million NIH Grant to Investigate How Oral Cancer Causes Pain
New York University

The National Institute of Dental and Craniofacial Research has awarded NYU College of Dentistry’s Yi Ye, PhD, a $2.2 million, five-year grant to study the role of Schwann cells, the most prevalent type of cell supporting neurons in the peripheral nervous system, in oral cancer progression and pain.

Newswise: Mimicking Cancer’s Evasive Tactics, Microparticles Show Promise Against Transplant Rejection
8-Mar-2020 9:00 PM EDT
Mimicking Cancer’s Evasive Tactics, Microparticles Show Promise Against Transplant Rejection
Health Sciences at the University of Pittsburgh

Inspired by a tactic cancer cells use to evade the immune system, University of Pittsburgh researchers have engineered tiny particles that can trick the body into accepting transplanted tissue as its own, while leaving the immune system intact.

19-Feb-2020 1:10 PM EST
Vaping Changes Oral Microbiome, Increasing Risk for Infection
New York University

Using e-cigarettes alters the mouth’s microbiome—the community of bacteria and other microorganisms—and makes users more prone to inflammation and infection, finds a new study led by researchers at NYU College of Dentistry.

Newswise:Video Embedded study-reveals-how-too-much-fluoride-causes-defects-in-tooth-enamel
VIDEO
18-Feb-2020 8:00 AM EST
Study Reveals How Too Much Fluoride Causes Defects in Tooth Enamel
New York University

Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel—a novel explanation for how dental fluorosis, a condition caused by overexposure to fluoride during childhood, arises. The study, led by researchers at NYU College of Dentistry, is published in Science Signaling.

11-Feb-2020 2:15 PM EST
Absent p53, oral cancers recruit and reprogram nerves to fuel tumor growth
University of Texas M. D. Anderson Cancer Center

Loss of an important tumor-suppressing gene allows head and neck cancer to spin off signals to nearby nerves, changing their function and recruiting them to the tumor, where they fuel growth and cancer progress.

Newswise: Mouse Study Shows Nerve Signaling Pathway Critical to Healing Fractures
Released: 5-Dec-2019 11:00 AM EST
Mouse Study Shows Nerve Signaling Pathway Critical to Healing Fractures
Johns Hopkins Medicine

Sticks and stones may break one’s bones, but healing them requires the production of a protein signal that stimulates the generation, growth and spread of vital nerve cells, or neurons, throughout the injured area. That’s the finding of a recent Johns Hopkins Medicine study that used mice to demonstrate what likely takes place during human fracture repair as well.


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