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Newswise: Jianhua Zhao awarded $2.4M to reveal cancer targets through atomic-resolution imaging
Released: 2-Aug-2022 6:05 PM EDT
Jianhua Zhao awarded $2.4M to reveal cancer targets through atomic-resolution imaging
Sanford Burnham Prebys

Assistant Professor Jianhua Zhao, Ph.D., has been awarded a unique and competitive grant from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health (NIH). The five-year, $2.4 million grant aims to give researchers greater research flexibility to work on fundamental questions in biology.

Newswise: Protein Parts Must Indeed Wiggle and Jiggle to Work Right, New Research Suggests
14-Jul-2022 11:00 AM EDT
Protein Parts Must Indeed Wiggle and Jiggle to Work Right, New Research Suggests
Johns Hopkins Medicine

Johns Hopkins Medicine scientists report they have probed the atomic structure of proteins to add to evidence that the wobbles, shakes and quivers of proteins play a critical role in their ability to function. The findings of the research may help scientists design new drugs that can modify or disrupt the intricate “dances” of proteins to alter their functions.

Newswise: Research Centered on Single Cells May Open Doors to New Discoveries on Disease Processes
Released: 22-Jun-2022 2:15 PM EDT
Research Centered on Single Cells May Open Doors to New Discoveries on Disease Processes
Stony Brook University

Gábor Balázsi, PhD, and his research team in the Laufer Center and the Department of Biomedical Engineering at Stony Brook University are embarking upon a new way to research cells, the building blocks of life and often triggers to disease when their behavior changes.

   
Newswise: Johns Hopkins Medicine Researchers Link Sugar-Studded Protein to Alzheimer’s Disease
Released: 25-May-2022 12:40 PM EDT
Johns Hopkins Medicine Researchers Link Sugar-Studded Protein to Alzheimer’s Disease
Johns Hopkins Medicine

Johns Hopkins Medicine researchers say they discovered that a special sugar molecule could play a key role in the development of Alzheimer’s disease. If further research confirms the finding, the molecule, known as a glycan, could serve as a new target for early diagnostic tests, treatments and perhaps prevention of Alzheimer’s disease, say the researchers.

Newswise:Video Embedded university-of-kentucky-receives-renewed-11-4-million-grant-to-further-cancer-research
VIDEO
Released: 25-May-2022 9:55 AM EDT
University of Kentucky Receives Renewed $11.4 Million Grant to Further Cancer Research
University of Kentucky

The University of Kentucky’s Center for Cancer and Metabolism (CCM) will continue its critical mission to research the metabolism of cancer with a renewed Centers of Biomedical Research Excellence (COBRE) grant award from the National Institutes of General Medical Sciences, part of the National Institutes of Health. The prestigious grant — totaling $11.4 million — will continue to fund UK’s CCM over the next five years.

Released: 19-May-2022 2:45 PM EDT
Without ‘work-life balance,’ this protein may promote disease
Ohio State University

A family of proteins that have a role in ensuring many types of cells move and maintain their shape may promote disease when they act like workaholics and disrupt the cellular environment, new research suggests.

Newswise: Biologists Pinpoint Key Factor in Immune System Response to Viral Infection
Released: 13-Jan-2022 8:05 PM EST
Biologists Pinpoint Key Factor in Immune System Response to Viral Infection
University of California San Diego

Researchers studying how small worms defend themselves against pathogens have discovered a gene that acts as a first-line response against infection. They identified “ZIP-1” as a centralized hub for immune response, a finding could have implications for understanding human immunity against viruses.

Newswise: Newsroom%20Michael%20s%20Nov%2030%20release%20barcoded%20cells_4_pyramid.jpg
Released: 30-Nov-2021 12:10 PM EST
Johns Hopkins Study: Biosensor Barcodes Identify, Detail ‘Chatting’ Among Cancer Cells
Johns Hopkins Medicine

Ever since the first barcode appeared on a pack of chewing gum in 1974, the now-ubiquitous system has enabled manufacturers, retailers and consumers to quickly and effectively identify, characterize, locate and track products and materials. In a paper first posted online Nov. 26, 2021, in the journal Cell, researchers at Johns Hopkins Medicine and The Johns Hopkins University demonstrate how they can do the same thing at the molecular level, studying the ways cancer cells “talk” with one another.

Newswise:Video Embedded master-developmental-genes-play-role-in-adulthood-according-to-new-study
VIDEO
Released: 18-Nov-2021 10:45 AM EST
Master developmental genes play role in adulthood, according to new study
Stowers Institute for Medical Research

Among their many extraordinary feats, some planarian flatworms reproduce by tearing off pieces of themselves to regenerate new worms. Now, researchers at the Stowers Institute for Medical Research have discovered that this process is controlled by Hox genes, a family of genes known to orchestrate important aspects of early development.

Newswise: Newsroom%20Nov%2015%20Rachel%20sub%20image%20GettyImages-1266337672-1.jpg
11-Nov-2021 8:20 AM EST
Mouse Cell Studies Show That Correcting DNA Disorganization Could Aid Diagnosis and Treatment of Rare Inherited Diseases
Johns Hopkins Medicine

Hopkins Medicine researchers say they have found that a protein that helps form a structural network under the surface of the cell’s “command center” — its nucleus — is key to ensuring that DNA inside it remains orderly.

Newswise: 1636473244371.jpg
9-Nov-2021 8:00 AM EST
Safety concerns raised for neuroblastoma candidate drug
St. Jude Children's Research Hospital

St. Jude Children’s Research Hospital scientists have identified the primary target of the experimental cancer drug CX-5164, revealing a possible risk for late effects of treatment.

Released: 13-Oct-2021 9:00 AM EDT
High Molecular Weight DNA Now Available from NIGMS and NHGRI Collections
Coriell Institute for Medical Research

The NIGMS Human Genetic Cell Repository (HGCR) and NHGRI Sample Repository for Human Genetic Research (SRHGR) now offer high molecular weight (HMW) DNA samples isolated from cell lines in the collections. HMW DNA is useful for long-read next-generation sequencing and studies that investigate large-scale genomic variation such as structural variation.

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Released: 23-Jul-2021 11:50 AM EDT
Research Identifies Potential Role of 'Junk DNA' Sequence in Aging, Cancer
Washington State University

The human body is essentially made up of trillions of living cells.

Newswise: Wayne State Receives $1.97 Million NIH Grant to Provide Research Training to Undergraduates
Released: 21-Jun-2021 10:05 AM EDT
Wayne State Receives $1.97 Million NIH Grant to Provide Research Training to Undergraduates
Wayne State University Division of Research

Researchers at Wayne State University recently received a nearly $1.97 million grant from the National Institute of General Medical Sciences of the National Institutes of Health for the T34 program, Maximizing Access to Research Careers (MARC).

Newswise: New grant-funded research could help improve therapies for sepsis
Released: 6-May-2021 1:05 PM EDT
New grant-funded research could help improve therapies for sepsis
University of Kentucky

A University of Kentucky College of Medicine professor has been awarded a $1.9 million NIH grant for his research on the body’s immune response to sepsis, which could potentially help to improve therapies for the common disease.

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Released: 14-Apr-2021 11:10 AM EDT
Shape-shifting Ebola virus protein exploits human RNA to change shape
La Jolla Institute for Immunology

In a new Cell Reports study, researchers at La Jolla Institute for Immunology demonstrate how Ebola virus has found a different way to get things done. The virus encodes only eight proteins but requires dozens of functions in its lifecycle. The new study shows how one of Ebola virus’s key proteins, VP40, uses molecular triggers in the human cell to transform itself into different tools for different jobs.

Newswise: Newsroom%20Wasta%20April%2013%20release%20Fig%208A.jpg
Released: 13-Apr-2021 11:00 AM EDT
Amoeba Biology Reveals Potential Treatment Target for Lung Disease
Johns Hopkins Medicine

In a series of experiments that began with amoebas — single-celled organisms that extend podlike appendages to move around — Johns Hopkins Medicine scientists say they have identified a genetic pathway that could be activated to help sweep out mucus from the lungs of people with chronic obstructive pulmonary disease a widespread lung ailment.

Newswise: A clue to how some fast-growing tumors hide in plain sight
22-Mar-2021 8:20 AM EDT
A clue to how some fast-growing tumors hide in plain sight
La Jolla Institute for Immunology

Viruses churn out genetic material in parts of the cell where it's not supposed to be. Cancer cells do too. A new study shows that a tumor-suppressor enzyme called DAPK3 is an essential component of a multi-protein system that senses misplaced genetic material in tumor cells, and slows tumor growth by activating the fierce-sounding STING pathway.

Released: 8-Mar-2021 1:20 PM EST
New discovery explains antihypertensive properties of green and black tea
University of California, Irvine

A new study from the University of California, Irvine shows that compounds in both green and black tea relax blood vessels by activating ion channel proteins in the blood vessel wall. The discovery helps explain the antihypertensive properties of tea and could lead to the design of new blood pressure-lowering medications.

Released: 2-Mar-2021 5:15 PM EST
Supercomputers Illustrate the Mechanical Process of Cancer Growth
University of California San Diego

According to the World Health Organization, one in six worldwide deaths are attributed to cancer, but not due to initial malignant tumors. They were caused by the spread of cancer cells to surrounding tissues, which consist largely of collagen. That was the focus of a recent study by Stanford University and Purdue University researchers.

   
31-Jan-2021 7:00 PM EST
Study May Help Pregnant Women and Others ‘Scratch’ Spinal Morphine-Induced Itch
Health Sciences at the University of Pittsburgh

Researchers identified spinal cord neurons responsible for an itchy sensation after an epidural morphine injection and found a drug that may fix the problem without reducing morphine’s pain-killing effects.

Newswise: BCI_e.coli_diagram_inset2_.png
Released: 9-Dec-2020 11:05 AM EST
When Strains of E.coli Play Rock-Paper-Scissors, It’s Not the Strongest That Survives
University of California San Diego

What happens when different strains of bacteria are present in the same system? Do they co-exist? Do the strongest survive? In a microbial game of rock-paper-scissors, researchers at the University of California San Diego’s BioCircuits Institute uncovered a surprising answer.

   
Newswise: jesus_structure_cover_copy%20rotate%201600%20crop_0.png
Released: 4-Nov-2020 4:50 PM EST
SLAC, Stanford to host national service center for cryo-ET sample preparation
SLAC National Accelerator Laboratory

The NIH is establishing a national service center at the SLAC and Stanford where biomedical researchers can learn how to prepare extremely thin specimens that are frozen into a glassy state for cryogenic electron tomography (cryo-ET), a powerful tool for directly visualizing cellular components in 3D.

Newswise: 1600451877141.jpg
Released: 22-Sep-2020 1:20 PM EDT
UB biophysicist to explore molecular mysteries of protein-RNA droplets
University at Buffalo

Inside human cells, proteins and RNA can cluster together to form spherical droplets that play vital roles in cellular processes as well as in certain human diseases. A $2 million grant will allow biophysicist Priya Banerjee's team at UB to explore the molecular details of protein-RNA condensates.

Released: 31-Aug-2020 8:15 AM EDT
Microgel Immuno-acceptance Method Could Improve Pancreatic Islet Transplant Success
Georgia Institute of Technology

Researchers at the Georgia Institute of Technology and University of Missouri developed a new microgel drug delivery method that could extend the effectiveness of pancreatic islet transplantations — from several years to possibly the entire lifespan of a recipient.

Newswise: LRRK2_graphical_abstract.jpg
Released: 19-Aug-2020 4:55 PM EDT
Leading-edge Technology Unmasks Protein Linked to Parkinson’s Disease
UC San Diego Health

Parkinson’s is a neurological disorder that progressively attacks motor functions, leading to lasting damage in movement and coordination. Researchers studying the primary causes of the disease have focused on mutations of the protein known as leucine-rich repeat kinase 2, or LRRK2.

Released: 19-Aug-2020 10:50 AM EDT
COVID-19 patients who experience cytokine storms may make few memory B cells
Cell Press

The release of massive amounts of proteins called cytokines can lead to some of the most severe symptoms of COVID-19.

Newswise: zanders-elife.jpg
Released: 17-Aug-2020 12:05 PM EDT
Survival of the fit-ish
Stowers Institute for Medical Research

It can be hard to dispute the common adage ‘survival of the fittest’. After all, “most of the genes in the genome are there because they’re doing something good,” says Sarah Zanders, PhD, assistant investigator at the Stowers Institute for Medical Research. But, she says, “others are just there because they’ve figured out a way to be there.”

Released: 3-Aug-2020 12:00 PM EDT
ASBMB receives grant to promote faculty diversity
American Society for Biochemistry and Molecular Biology (ASBMB)

The American Society for Biochemistry and Molecular Biology has won an almost $1.27 million five-year grant from the National Institute of General Medical Sciences (NIGMS) to develop and execute a program that will support scientists from diverse backgrounds as they prepare for and launch their careers as independent faculty members.

Released: 29-Jul-2020 8:05 AM EDT
Study Provides New Insight on Colorectal Cancer Growth
University of Kentucky

A new study by researchers at the University of Kentucky identifies a novel function of the enzyme spermine synthase to facilitate colorectal cancer growth.

21-Jul-2020 10:55 AM EDT
New Computational Model by CHOP Researchers Identifies Noncoding Mutations Across Five Pediatric Cancers
Children's Hospital of Philadelphia

Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a new computational algorithm that has, for the first time, identified a spectrum of mutations in the noncoding portion of the human genome across five major pediatric cancers. The study, which was published today in Science Advances, used the algorithm to analyze more than 500 pediatric cancer patients’ mutations and gene expression profiles to develop a comprehensive list of potentially cancer-causing mutations.

Newswise:Video Embedded researchers-3d-print-a-working-heart-pump-with-real-human-cells2
VIDEO
Released: 15-Jul-2020 12:35 PM EDT
Researchers 3D print a working heart pump with real human cells
University of Minnesota College of Science and Engineering

In a groundbreaking new study, researchers at the University of Minnesota have 3D printed a functioning centimeter-scale human heart pump in the lab. The discovery could have major implications for studying heart disease, the leading cause of death in the United States killing more than 600,000 people a year.

Newswise: Pickled%20capers%20web.jpg
Released: 13-Jul-2020 12:05 PM EDT
Pickled capers activate proteins important for human brain and heart health
University of California, Irvine

A compound commonly found in pickled capers has been shown to activate proteins required for normal human brain and heart activity, and may even lead to future therapies for the treatment of epilepsy and abnormal heart rhythms.

Released: 8-Jul-2020 11:05 PM EDT
New Clues from Fruit Flies about the Critical Role of Sex Hormones in Stem Cell Control
Huntsman Cancer Institute at the University of Utah

In one of the first studies addressing the role of sex hormones’ impact on stem cells in the gut, scientists outline new insights showing how a steroidal sex hormone that is structurally and functionally similar to human steroid hormones drastically alters the way intestinal stem cells behave, ultimately affecting the overarching structure and function of this critical organ. The authors found that ecdysone, a steroid hormone produced by fruit flies, stimulates intestinal stem cell growth and causes the gut of the female fruit fly to grow in size, as well as other critical changes.

Newswise: UTEP Research Reveals More About Path Bacterial Pathogen Travels to Cause Tuberculosis
Released: 30-Jun-2020 4:55 PM EDT
UTEP Research Reveals More About Path Bacterial Pathogen Travels to Cause Tuberculosis
University of Texas at El Paso

Jianjun Sun, Ph.D., associate professor in UTEP’s Department of Biological Sciences, led the research on Mycobacterium tuberculosis (Mtb). Sun’s lab has been investigating the mechanisms of Mtb pathogenesis for more than 10 years at UTEP with a specific focus on EsxA, which is a virulence factor essential for Mtb virulence and a preferred target for developing novel anti-TB drugs and vaccines.

Released: 30-Jun-2020 9:50 AM EDT
Electrochemical reaction powers new drug discoveries
Cornell University

A Cornell-led collaboration is flipping the switch on traditional synthetic chemistry by using electricity to drive a new chemical reaction that previously stumped chemists who rely on conventional methods.

Released: 24-Jun-2020 11:30 AM EDT
Exploring Nature’s Treasure Trove of Helpful Compounds
NIH, National Institute of General Medical Sciences (NIGMS)

Compounds that plants, fungi, bacteria, and animals produce can sometimes help people as well. In fact, many medicines, molecules used in research, and other useful compounds originated in nature. Learn more about recent discoveries in the fascinating field of natural products research.

   
Released: 27-May-2020 1:10 PM EDT
Helium: An Abundant History and a Shortage Threatening Scientific Tools
NIH, National Institute of General Medical Sciences (NIGMS)

Scientists first discovered helium burning on the surface of the sun, but today liquid helium plays an essential role in supercooling scientific equipment. Unfortunately, our complex history with the element has led to a recent shortage that threatens some types of scientific research.

Newswise:Video Embedded they-remember-communities-of-microbes-found-to-have-working-memory
VIDEO
24-Apr-2020 3:35 PM EDT
They Remember: Communities of Microbes Found to Have Working Memory
University of California San Diego

Biologists studying bacterial communities have discovered that these simple organisms feature a robust memory capacity. Using light, they were able to encode memory patterns and visualize cells with memory. The discovery reveals parallels between low-level organisms and sophisticated neurons.

Newswise: 800%20Amoeba%20Capture.jpg
Released: 12-Mar-2020 8:00 AM EDT
Statins Starve Cancer Cells to Death
Johns Hopkins Medicine

More than 35 million Americans take statin drugs daily to lower their blood cholesterol levels. Now, in experiments with human cells in the laboratory, researchers at Johns Hopkins Medicine have added to growing evidence that the ubiquitous drug may kill cancer cells and have uncovered clues to how they do it.

6-Mar-2020 8:30 AM EST
New Study on Covid-19 Estimates 5.1 Days for Incubation Period
Johns Hopkins Bloomberg School of Public Health

An analysis of publicly available data on infections from the new coronavirus, SARS-CoV-2, that causes the respiratory illness COVID-19 yielded an estimate of 5.1 days for the median disease incubation period, according to a new study led by researchers at Johns Hopkins Bloomberg School of Public Health.

Newswise: Version_1%20sm.jpg
Released: 27-Feb-2020 8:35 AM EST
Bifunctional nanobodies proven effective at protecting against botulinum neurotoxins including Botox
University of California, Irvine

New study reveals potential for developing novel antibody-based antitoxins against botulinum neurotoxins (BoNTs), including the most commonly used, yet most toxic one, Botox.

Newswise: Computer model mines medicines
Released: 3-Feb-2020 9:35 AM EST
Computer model mines medicines
National Institute of Biomedical Imaging and Bioengineering

Most medicines work by binding to and blocking the effect of disease-causing molecules. Now to accelerate the identification of potential new medicines, bioengineers have created a computer model that mimics the way molecules bind.


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