UCLA researchers and colleagues at Emory University and other research centers have combined data simulation and experimental observation to bridge a gap between two major properties of large-scale organization of the human brain – stationary and traveling waves of activity.
Researchers at UC San Diego School of Medicine provide some of the first empirical evidence that brain ripples exist. These electrical waves have long been hypothesized as a way for the brain to integrate and encode memories.
A global study published in BMC Psychiatry reports that 34% of people with premenstrual dysphoric disorder have attempted suicide. The findings offer the strongest scientific evidence to date that the disorder is likely an independent contributor to suicidal thoughts and actions.
A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies. The research is published in the May 11, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A University of California, Irvine-led team of researchers, along with members of the Pritzker Research Consortium, have developed an approach to identify blood biomarkers that could predict the suicide risk of major depressive disorder (MDD) patients.
It has long been understood that environmental and socio-economic factors – including income disparity, family poverty, and air pollution – increase a person’s risk of developing psychotic-like experiences, such as subtle hallucinations and delusions that can become precursors to a schizophrenia diagnosis later in life.
Scientists at UC San Diego School of Medicine and Rady Children’s Institute of Genomic Medicine describe novel methods for inferring the movement of human brain cells during fetal development by studying healthy adult individuals who have recently passed away from natural causes.
Researchers from the University of California, Irvine, participated with the international SCHEMA (SCHizophrenia Exome Meta-Analysis) Consortium in a landmark genetic study of more than 121,000 people which has identified extremely rare protein-disrupting mutations in 10 genes that strongly increase an individual's risk of developing schizophrenia — in one instance, by more than 20-fold.
An international team including researchers from the Lifespan Brain Institute (LiBI) of Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania have created a new tool that benchmarks brain development over the human lifespan, based on magnetic resonance imaging (MRI) data from more than 100,000 individuals. The work was jointly led by LiBI researchers and colleagues at the University of Cambridge. Described today in Nature, the interactive open resource, known as BrainChart, harmonizes brain images in a way that will allow researchers to measure brain development against reference charts like those used for evaluating children’s height and weight.
Irvine, Calif., Feb. 9, 2022 — New research from the University of California, Irvine reveals that sex differences in learning and memory mechanisms are triggered by biological events occurring during puberty. Findings show prepubescent female rodents have much better hippocampal long-term potentiation (LTP) and spatial learning than same-age males, but puberty has opposite consequences for synaptic plasticity in the two sexes.
Researchers have developed a new method of measuring motor imitation, adding to a growing set of computational behavior analysis tools that can detect and characterize motor differences in children with autism.
A 13-year effort to track the mental health of new doctors in their most stressful time of training shows signs that things have gotten better. But those first-year residents, also called interns, still have a sizable risk of developing depression. And many who do still don’t seek help.
Women who use cannabis during pregnancy, potentially to relieve stress and anxiety, may inadvertently predispose their children to stress susceptibility and anxiety, according to a study conducted by researchers from the Icahn School of Medicine at Mount Sinai and the City University of New York published Monday, November 15, in the Proceedings of the National Academy of Science (PNAS).
The University of California, Irvine Center for Neural Circuit Mapping (CNCM) has been awarded three new grants: a four year, $4.8M grant from the National Institute on Aging; a three year, $1.8M grant from the Food and Drug Administration (FDA); and, a one year, $.5M grant from the National Institute of Mental Health. The grants will support the efforts of CNCM Investigators to develop powerful new molecular tools and will enhance resources offered by the Center to neurosciences researchers worldwide.
New research by the University of Washington and New York University explored gender, racial and ethnic differences among teens who think about and/or attempt suicide, as well as associated behavioral and environmental factors.
Have you ever met someone you instantly liked, or at other times, someone who you knew immediately that you did not want to be friends with, although you did not know why? Now, a new study from the University of Maryland School of Medicine (UMSOM) suggests that there may be a biological basis behind this instantaneous compatibility reaction.
NIH-funded researchers at Carnegie Mellon University have demonstrated the potential of a neuromodulation approach that uses low-intensity ultrasound energy, called transcranial focused ultrasound—or tFUS.
In a Journal of the American Medical Association Psychiatry study led by Pearl Chiu and Brooks King-Casas of the Fralin Biomedical Research Institute at VTC, brain imaging and mathematical modeling reveal previously unreported mechanistic features of symptoms associated with major depressive disorder.
Researchers at the University of Maryland School of Medicine (UMSOM) launched a new online tool that could more quickly advance medical discoveries to reverse progressive hearing loss. The tool enables easy access to genetic and other molecular data from hundreds of technical research studies involving hearing function and the ear.
Researchers successfully used a protein called parapinopsin to turn off brain circuits. This protein is found in lamprey – an ancient lineage of jawless fish similar to eel. Researchers said the ability to inhibit neurons could eventually lead to turning off mood disorders and unwanted behaviors like depression and addiction.
Chemotherapy can induce a painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment. Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used a mouse model to demonstrate the pivotal role of cholesterol in CIPN, and proposed a novel therapeutic approach to reverse it.
University of Maryland School of Medicine (UMSOM) researchers have shown that psilocybin—the active chemical in “magic mushrooms”— still works its antidepressant-like actions, at least in mice, even when the psychedelic experience is blocked.
Researchers from the University of Minnesota Twin Cities College of Science and Engineering and Medical School have developed a unique head-mounted mini-microscope device that allows them to image complex brain functions of freely moving mice in real time over a period of more than 300 days. The groundbreaking study provides new insight into fundamental research that could improve human brain conditions such as concussions, autism, Alzheimer’s, and Parkinson’s disease, as well as better understanding the brain’s role in addiction.
UC San Diego scientists have taken the connection between wisdom, loneliness and biology one step further, reporting that wisdom and loneliness appear to influence — and/or be influenced by — microbial diversity of the gut.
A new UCLA-led study analyzed a national sample of the views of Black men and white men found that Black men of all income levels reported experiencing higher levels of discrimination than their white counterparts.
In a study published in the March 5, 2021 online edition of Cerebral Cortex, researchers at University of California San Diego School of Medicine found that specific regions of the brain respond to emotional stimuli related to loneliness and wisdom in opposing ways.
The drug buprenorphine is an effective treatment for opioid use disorder, but many who misuse opioids also take benzodiazepines — drugs that treat anxiety and similar conditions. Many treatment centers hesitate to treat patients addicted to opioids who also take benzodiazepines. Researchers at Washington University School of Medicine in St. Louis studied overdose risk in people taking buprenorphine and found that the drug lowered risk, even in people taking benzodiazepines.
In a study at Penn researchers found that Pennsylvania’s financial incentive policy encouraged hospitals to enact rapid changes to support treatment for opioid use disorder for patients visiting the ED, and evaluates the efficacy of the Opioid Hospital Quality Improvement Program.
Feeding method and affectionate touch patterns in depressed and non-depressed mothers and babies as well as infant’s EEG activity showed that mother-infant affectionate touch differed as a function of mood and feeding method (breastfeeding and bottle-feeding). Infants in the depressed and bottle-fed group reduced touch toward their mothers while breastfeeding had a positive effect on both mother and baby. Infants of depressed and breastfeeding mothers showed neither behavioral nor brain development dysregulation previously found in infants of depressed mothers.
More than a dozen drugs are known to treat symptoms such as hallucinations, erratic behaviors, disordered thinking and emotional extremes associated with schizophrenia, bipolar disorder and other severe mental illnesses. But, drug treatments specifically able to target the learning, memory and concentration problems that may accompany such disorders remain elusive.
This research helps illuminate the neural roots of emotions, and points to the possibility that a population of arousal-related neurons might be a target of future treatments for anxiety disorders and other illnesses involving abnormal arousal responses.
A team of researchers from Michigan State University, University of Michigan and tech-training company SIMmersion received a $3 million grant from the National Institute of Mental Health to develop a virtual reality training tool for youth with autism spectrum disorder, or ASD, to improve their social skills as they transition from high school to the workforce.
Research shows that collaborative care programs in which primary-care providers work with a depression care manager and a designated psychiatric consultant can more than double the likelihood of improving depression outcomes. But a new study published in Health Affairs shows that not all care is equal.
New findings from scientists at Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago have revealed previously unknown information about the genetic basis for Armfield XLID syndrome, a rare intellectual disability linked to genetic defects in the X chromosome.
Scientists at Wake Forest School of Medicine have recorded real time changes in dopamine and serotonin levels in the human brain that are involved with perception and decision-making. These same neurochemicals also are critical to movement disorders and psychiatric conditions, including substance abuse and depression.
Researchers at University of Illinois Chicago are studying a novel approach to delivering care to those with moderate depression and anxiety: through artificial intelligence, or AI. The first part of the two-phase, five-year project will develop and test a voice-enabled, AI virtual agent named Lumen, trained to deliver Problem Solving Therapy (PST), for patients with moderate, untreated depressive and/or anxiety symptoms. This first phase is awarded for two years.
A $3.6 million NIMH grant awarded to the Perelman School of Medicine at the University of Pennsylvania will help improve the implementation of an evidence-based firearm safety program and identify the best approach for deploying this program as a suicide prevention strategy.
New research could improve the odds that people with obsessive-compulsive disorder will receive a therapy that really works for them – something that eludes more than a third of those who currently get OCD treatment. The study suggests the possibility of predicting which of two types of therapy will help people with OCD: One that exposes them to the subject of their obsessive thoughts and behaviors, or one that focuses on stress reduction and problem-solving.
A team led by UT Southwestern researchers has identified brain circuitry that plays a key role in the dysfunctional social, repetitive, and inflexible behavioral differences that characterize autism spectrum disorders (ASD). The findings, published online this week in Nature Neuroscience, could lead to new therapies for these relatively prevalent disorders.