In the 25 years since the Nobel Prize was awarded for discovering the role that nitric oxide (NO) plays in the cardiovascular system, researchers have been racing to learn more about how this mysterious signaling molecule works to repair blood vessels damaged by a heart attack, stroke or other cardiovascular event.
Joel M. Smith, an assistant professor of Chemistry and Biochemistry, received the Maximizing Investigators’ Research Award, or MIRA, from the National Institute of General Medical Sciences to study the potential that synthesizing small, complex molecules could have on the biomedical and pharmaceutical industries.
SMU biology professor Zhihao Wu has received a $1.8 million, 5-year Maximizing Investigators' Research Award (MIRA) from the National Institutes of Health to determine if different quality control pathways in our bodies might be working together to repair damaged components in cells.
Dr. Weiping Zhang, professor in the Department of Pathobiology, was recently awarded a five-year, $5.6 million R01 grant from the National Institutes of Health (NIH) to optimize a promising vaccine against enterotoxigenic Escherichia coli (ETEC).
A Florida State University researcher has received a five-year, $1.86 million grant from the National Institutes of Health to study how a little-understood part of the brain affects our sense of smell.
The University of Miami School of Nursing and Health Studies (SONHS) has been awarded an unprecedented $23.57 million grant from the National Institutes of Health (NIH) to join the Environmental influences on Child Health Outcomes (ECHO) Program.
Disrupted connections between memory and appetite regulating brain circuits are directly proportional to BMI, notably in patients who suffer from disordered or overeating that can lead to obesity, such as binge eating disorder, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
The National Institutes of Health and the higher education non-profit VentureWell have selected 10 winners and five honorable mentions of the Design by Biomedical Undergraduate Teams (DEBUT) Challenge, who are set to receive prizes totaling $145,000.
Short-lived proteins control gene expression in cells to carry out a number of vital tasks, from helping the brain form connections to helping the body mount an immune defense. These proteins are made in the nucleus and are quickly destroyed once they’ve done their job.
A two-year study found that spikes of post-vaccination SARS-CoV-2 viral infections (commonly known as COVID-19 breakthrough cases) remain common, yet hospitalization rates have dramatically dropped following the first wave of the virus’ omicron subvariant.
A research team co-led by UCLA investigators has shown that an immunotherapy drug combination can be an effective second-line therapy for patients with an aggressive and deadly type of melanoma that is resistant to the widely used immunotherapy drugs known as PD-1 inhibitors.
New research shows blood cancers are often misdiagnosed, an NCI grant to develop a urine test for prostate cancer, a surgeon-scientist receives Sylvester’s first DoD grant to study pancreatic cancer, bolstering emergency preparedness for climate-driven disasters, and more are included in this month’s tip sheet .
The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of full-strength signals between neurons, according to a study in mice from the National Eye Institute (NEI) and the University of Freiberg, Germany.
For the first time, researchers have found a potential drug candidate that improved outcomes for patients with a type of childhood brain tumor for which there are no effective treatments. The compound, called ONC201, nearly doubled survival for patients with diffuse midline glioma (DMG) or diffuse intrinsic pontine glioma (DIPG), compared to previous patients.
Our brains constantly make memories and learn new skills. Understanding the role of the complex sugar molecules responsible for this “plasticity” could also make it possible to repair neural circuits after injury. The researchers will present their results today at ACS Fall 2023.
Bacteria draw from an arsenal of weapons to combat the drugs intended to kill them. Among the most prevalent of these weapons are ribosome-modifying enzymes. These enzymes are growing increasingly common, appearing worldwide in clinical samples in a range of drug-resistant bacteria.
Bioengineers can tailor the genomes of cells to create “cellular therapies” that fight disease, but they have found it difficult to design specialized activating proteins called transcription factors that can throw the switch on bioengineered genes without occasionally turning on some of the cell’s naturally occurring genes.
Led by Washington University School of Medicine in St. Louis and other institutions around the world, the Clinical Proteomic Tumor Analysis Consortium has completed a deep analysis of the proteins driving cancer across multiple tumor types, information that can’t be assessed by genome sequencing alone. Understanding how proteins operate in cancer cells raises the prospect of new therapies.
The National Institutes of Health has awarded $2.6 million to a Virginia Tech team over five years for a study of high frequency irreversible electroporation (H-FIRE) for tumor ablation and immune system activation in cases of pancreatic cancer.
Chronic pain can be debilitating and can limit the quality of life for the millions who suffer from it. Unfortunately, treatments to manage chronic pain are often ineffective because the functional changes that accompany a disease are not fully understood. Many patients develop chronic pain after surgery, but unfortunately, it is not yet possible to predict which patients are at risk.
Gene therapy might offer a one-time, sustained treatment for patients with serious alcohol addiction, also called alcohol use disorder, according to a new study led by a researcher at The Ohio State University Wexner Medical Center and College of Medicine.
While engaging in cell division research, Silke Hauf and members of her lab made a surprisingly quiet discovery. When cells express RNA, there are always some fluctuations, or noise, in how much RNA is produced. Hauf’s group found several genes whose noise dips below a previously established minimum threshold, known as the noise floor, during expression “We have solid data for this phenomenon,” said Hauf, associate professor in the Department of Biological Sciences at Virginia Tech.
A new study of mice and lab-grown human colon “organoids” indicates that an experimental drug developed by Johns Hopkins Medicine researchers can substantially reduce symptoms of inflammatory bowel disease (IBD) in pre-clinical models.
Deep-learning technology developed by a team of Johns Hopkins engineers and cancer researchers can accurately predict cancer-related protein fragments that may trigger an immune system response. If validated in clinical trials, the technology could help scientists overcome a major hurdle to developing personalized immunotherapies and vaccines.
Nanozymes—artificial enzymes that can carry out pre-determined chemical reactions—could selectively activate a cancer drug within a tumor while minimizing damage to healthy tissue in a mouse model of triple negative breast cancer.
A five-year, $3.1 million grant to study preventive strategies for sudden unexpected death in epilepsy (SUDEP) has been awarded to UTHealth Houston by the National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke.
In their continuing work to limit the impact of COVID-19, Emory University researchers have, for the first time in nonhuman primates, studied how modulating the signaling of type 1 Interferon (IFN-I), one of the body’s initial defenses against infection, impacts SARS-CoV-2 viral replication and disease progression.
A new study analyzing toxins produced by Microcystis, the main type of cyanobacteria that compose the annual harmful algal bloom (HAB) in Lake Erie, suggests that the toxicity of the bloom may be overestimated in earlier warm months and underestimated later in the summer.
Loss of a gene known as SYNCRIP in prostate cancer tumors unleashes cellular machinery that creates random mutations throughout the genome that drive resistance to targeted treatments, a team led by UT Southwestern Medical Center researchers discovered. The findings, published in Cancer Cell, could lead to new interventions that thwart this process in prostate and other cancer types, making them far easier to treat.
The University of Miami Miller School of Medicine Department of Otolaryngology has received a new $3.2 million, five-year grant from the National Institutes of Health (NIH) to support their multidisciplinary translational research program on human genetic hearing loss (HL), a common sensory disorder affecting more than 28 million Americans.
Researchers at Dana-Farber Cancer Institute have created an AI-based tool that uses tumor gene sequencing data to predict the primary source of a patient’s cancer. The study, published in in Nature Medicine, suggests that this predictive tool, called OncoNPC, could help guide treatment of cancer and improve outcomes in difficult to diagnose cases.
Researchers with Sylvester Comprehensive Cancer Center and collaborating organizations will study how new technology can help cancer patients manage symptoms and related stress from cancer treatment while at home.
In a new preclinical study from Wake Forest University School of Medicine, scientists provide the first evidence that changes in the gut microbiome have significant effects on cocaine use and cravings after withdrawal.
New research shows how using molecular tools and alternative gene splicing can make a protein called CEACAM1 more protective against liver injury during transplantation, thus reducing organ injury and ultimately improving post-transplant outcomes.
Suvranu De, dean of the FAMU-FSU College of Engineering, is building a better simulator — one that uses brain stimulation to improve learning for physicians undergoing training for robotic surgeries for oral cancers.
With a $16 million grant from the National Institute on Aging, the University of California, San Francisco and the University of California, Irvine will work with community partners to improve the representation of Asian American, Native Hawaiian and Pacific Islander adults in research on aging, caregiving, and Alzheimer’s disease and related dementias.
Cedars-Sinai Cancer investigators are spearheading a project, funded by a five-year, $11.2 million grant from the National Cancer Institute, part of the National Institutes of Health, to advance scientific knowledge of how biological differences between men and women affect bladder cancer.
Viruses often mutate or hide themselves within cells. But by mimicking the way the immune system naturally deals with invaders, researchers reporting in ACS Infectious Diseases have developed a “peptoid” antiviral therapy that effectively inactivates three viruses in lab tests.
Cholesterol plays many critical roles in biology and medicine. Researchers have revealed for the first time how cholesterol behaves in cells at the atomistic level, information that could have broad implications for future studies of health and disease.