Curated News: National Institutes of Health (NIH)

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Newswise: New Study Finds Abnormal Response to Cellular Stress is Associated with Huntington’s Disease
Released: 23-Jun-2021 3:05 PM EDT
New Study Finds Abnormal Response to Cellular Stress is Associated with Huntington’s Disease
University of California, Irvine

A new University of California, Irvine-led study finds that the persistence of a marker of chronic cellular stress, previously associated with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), also takes place in the brains of Huntington’s disease (HD) patients.

Newswise: New NIH Grant Supports Ongoing UTSW Investigation of Debilitating Complications of Blood Clots in Teens
Released: 23-Jun-2021 11:15 AM EDT
New NIH Grant Supports Ongoing UTSW Investigation of Debilitating Complications of Blood Clots in Teens
UT Southwestern Medical Center

DALLAS – June 23, 2021 – UT Southwestern will lead a multicenter investigation into why children and young adults experience decreased physical activity and shortness of breath after experiencing blood clots, thanks to a four-year $2.97 million grant from the National Institutes of Health (NIH).

Newswise: Language Trade-off? No, Bilingual Children Reliably Acquire English by Age 5
Released: 23-Jun-2021 8:30 AM EDT
Language Trade-off? No, Bilingual Children Reliably Acquire English by Age 5
Florida Atlantic University

A first-of-its kind study in U.S.-born children from Spanish-speaking families finds that minority language exposure does not threaten the acquisition of English by children in the U.S. and that there is no trade-off between English and Spanish. Rather, children reliably acquire English by age 5, and their total language knowledge is greater to the degree that they also acquire Spanish. Children’s level of English knowledge was independent of their level of Spanish knowledge.

16-Jun-2021 7:00 AM EDT
Implantable Brain Device Relieves Pain in Early Study
NYU Langone Health

A computerized brain implant effectively relieves short-term and chronic pain in rodents, a new study finds.

Newswise: NIH-Funded Study Shows Children Recycle Brain Regions When Acquiring New Skills
Released: 21-Jun-2021 9:45 AM EDT
NIH-Funded Study Shows Children Recycle Brain Regions When Acquiring New Skills
NIH, National Eye Institute (NEI)

Scientists studied the brain activity of school-aged children during development and found that regions that activated upon seeing limbs (hands, legs, etc.) subsequently activated upon seeing faces or words when the children grew older. The research, by scientists at Stanford University, Palo Alto, California, reveals new insights about vision development in the brain and could help inform prevention and treatment strategies for learning disorders. The study was funded by the National Eye Institute and is published in Nature Human Behaviour.

Newswise: NIH-Funded Study Shows Children Recycle Brain Regions When Acquiring New Skills
Released: 21-Jun-2021 9:45 AM EDT
NIH-Funded Study Shows Children Recycle Brain Regions When Acquiring New Skills
NIH, National Eye Institute (NEI)

Scientists studied the brain activity of school-aged children during development and found that regions that activated upon seeing limbs (hands, legs, etc.) subsequently activated upon seeing faces or words when the children grew older. The research, by scientists at Stanford University, Palo Alto, California, reveals new insights about vision development in the brain and could help inform prevention and treatment strategies for learning disorders. The study was funded by the National Eye Institute and is published in Nature Human Behaviour.

Newswise: Study Reveals New Therapeutic Target for C. Difficile Infection
Released: 18-Jun-2021 12:05 PM EDT
Study Reveals New Therapeutic Target for C. Difficile Infection
University of California, Irvine

A new study paves the way for the development of next generation therapeutics for the prevention and treatment of Clostridioides difficile infection (CDI), the most frequent cause of healthcare-acquired gastrointestinal infections and death in developed countries.

Newswise: Trojan horses and tunneling nanotubes: Ebola virus research at Texas Biomed gets NIH funding boost
Released: 17-Jun-2021 2:05 PM EDT
Trojan horses and tunneling nanotubes: Ebola virus research at Texas Biomed gets NIH funding boost
Texas Biomedical Research Institute

Scientists have a general idea of how viruses invade and spread in the body, but the precise mechanisms are actually not well understood, especially when it comes to Ebola virus. Olena Shtanko, Ph.D., a Staff Scientist at the Texas Biomedical Research Institute (Texas Biomed), has received more than $1 million from the National Institutes of Health (NIH) to explore different aspects of Ebola virus infection.

Newswise: Study Adds to Evidence that Most Cancer Cells Grown in a Dish have Little in Common Genetically with Cancer Cells in People
Released: 17-Jun-2021 2:00 PM EDT
Study Adds to Evidence that Most Cancer Cells Grown in a Dish have Little in Common Genetically with Cancer Cells in People
Johns Hopkins Medicine

In a bid to find or refine laboratory research models for cancer that better compare with what happens in living people, Johns Hopkins Medicine scientists report they have developed a new computer-based technique showing that human cancer cells grown in culture dishes are the least genetically similar to their human sources.

Released: 17-Jun-2021 1:50 PM EDT
How Cells “Read” Artificial Ingredients Tossed into Genetic Recipe
University of California San Diego Health

UC San Diego School of Medicine researchers discovered that the enzyme RNA polymerase II recognizes and transcribes artificially added base pairs in genetic code, a new insight that could help advance the development of new vaccines and medicines.

Newswise: UC Davis Clinical Translational Science Center Awarded 5-year Grant Renewal From NIH
Released: 17-Jun-2021 8:00 AM EDT
UC Davis Clinical Translational Science Center Awarded 5-year Grant Renewal From NIH
UC Davis Health

The UC Davis Clinical Translational Science Center (CTSC) received notice of its third National Institutes of Health (NIH) award renewal. The 5-year award, almost $33 million, provides critical funding to continue CTSC’s essential services for the UC Davis research community.

Released: 16-Jun-2021 4:35 PM EDT
UCLA Health receives $4.8M NIH grant to improve genetic estimates of disease risk in diverse populations
University of California, Los Angeles (UCLA), Health Sciences

UCLA Health will receive a $4.8 million grant from The National Institutes of Health to develop methods that will improve genetic risk estimates – polygenic risk scores – for specific diseases in people from diverse populations and mixed ancestries.

Newswise: Scientists unravel the function of a sight-saving growth factor
Released: 16-Jun-2021 4:05 PM EDT
Scientists unravel the function of a sight-saving growth factor
NIH, National Eye Institute (NEI)

Researchers at the National Eye Institute (NEI) have determined how certain short protein fragments, called peptides, can protect neuronal cells found in the light-sensing retina layer at the back of the eye. The peptides might someday be used to treat degenerative retinal diseases, such as age-related macular degeneration (AMD).

Newswise: Scientists unravel the function of a sight-saving growth factor
Released: 16-Jun-2021 4:05 PM EDT
Scientists unravel the function of a sight-saving growth factor
NIH, National Eye Institute (NEI)

Researchers at the National Eye Institute (NEI) have determined how certain short protein fragments, called peptides, can protect neuronal cells found in the light-sensing retina layer at the back of the eye. The peptides might someday be used to treat degenerative retinal diseases, such as age-related macular degeneration (AMD).

11-Jun-2021 12:50 PM EDT
Researchers Identify New Gene that May Increase Risk of ALS
American Academy of Neurology (AAN)

Researchers have identified a new gene that may increase a person’s risk of developing ALS, according to a new study published in the June 16, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The gene, called TP73, produces a protein to help regulate the life cycle of a cell. Researchers found that some people with ALS have mutations in this gene and that the mutations may interfere with nerve cell health.

Newswise: Genetically Engineered Nanoparticle Delivers Dexamethasone Directly to Inflamed Lungs
15-Jun-2021 2:25 PM EDT
Genetically Engineered Nanoparticle Delivers Dexamethasone Directly to Inflamed Lungs
University of California San Diego

Nanoengineers at the University of California San Diego have developed immune cell-mimicking nanoparticles that target inflammation in the lungs and deliver drugs directly where they’re needed. As a proof of concept, the researchers filled the nanoparticles with the drug dexamethasone and administered them to mice with inflamed lung tissue. Inflammation was completely treated in mice given the nanoparticles, at a drug concentration where standard delivery methods did not have any efficacy.

Released: 16-Jun-2021 1:55 PM EDT
UM School of Medicine Researchers Awarded $5 Million NIH Grant to Improve Use of Genetic Risk Scores in Diverse Populations
University of Maryland Medical Center

Researchers at the University of Maryland School of Medicine (UMSOM) have received a $5 million federal grant to pool genomic information from existing and new datasets – predominantly in African and African American populations -- in order to calculate the risk of developing specific diseases. They will use sophisticated modeling and genetic datasets to calculate the risk, known as a polygenic risk score, with an emphasis on studying people from different ancestries.

Released: 16-Jun-2021 8:05 AM EDT
Wayne State awarded $2.5 million NIH grant to grow graduate training programs
Wayne State University Division of Research

Wayne State University recently received an Initiative for Maximizing Student Development (IMSD) T32 training program grant from the National Institute of General Medical Sciences of the National Institutes of Health. This $2.5 million grant will aid in growing Wayne State’s successful IMSD R25 graduate training program in biomedical sciences and behavioral research.

Newswise: Scientists Demonstrate Promising New Approach for Treating Cystic Fibrosis
Released: 16-Jun-2021 8:05 AM EDT
Scientists Demonstrate Promising New Approach for Treating Cystic Fibrosis
University of North Carolina School of Medicine

Scientists created a potentially powerful new strategy for treating cystic fibrosis and potentially other diseases; it involves small, nucleic acid molecules called oligonucleotides that can correct some of the gene defects that underlie CF but are not addressed by existing modulator therapies.

Newswise: Yale Cancer Center Study Reveals New Pathway for Brain Tumor Therapy
Released: 15-Jun-2021 12:05 PM EDT
Yale Cancer Center Study Reveals New Pathway for Brain Tumor Therapy
Yale Cancer Center

In a new study led by Yale Cancer Center, researchers show the nucleoside transporter ENT2 may offer an unexpected path to circumventing the blood-brain barrier (BBB) and enabling targeted treatment of brain tumors with a cell-penetrating anti-DNA autoantibody.

Released: 15-Jun-2021 9:35 AM EDT
Southwest National Primate Research Center at Texas Biomed receives $37 million NIH grant
Texas Biomedical Research Institute

The Southwest National Primate Research Center (SNPRC) at Texas Biomed has been awarded more than $37 million from the National Institutes of Health to continue operations into 2026. The P51 grant, given by the NIH Office of Research Infrastructure Programs, provides essential funding to house and care for nearly 2,500 non-human primates that are part of life-science research programs at Texas Biomed and partners around the globe.

14-Jun-2021 7:00 AM EDT
New Treatment Stops Progression of Alzheimer’s Disease in Monkey Brains
NYU Langone Health

A new therapy prompts immune defense cells to swallow misshapen proteins, amyloid beta plaques and tau tangles, whose buildup is known to kill nearby brain cells as part of Alzheimer’s disease, a new study shows.

14-Jun-2021 11:40 AM EDT
Study Finds Association Between Head Impacts and Imaging Changes in Youth Football Players Over Consecutive Seasons
Wake Forest Baptist Health

With preseason football training on the horizon, a new study shows that head impacts experienced during practice are associated with changes in brain imaging of young players over multiple seasons.

Newswise: New Tissue-Closure Model May Aid in Promotion of Faster Wound Healing
Released: 14-Jun-2021 11:35 AM EDT
New Tissue-Closure Model May Aid in Promotion of Faster Wound Healing
Penn State Materials Research Institute

The observation of a previously undetected biological mechanism for closing gaps in living tissue improves basic understanding of the wound-healing process and may one day inform strategies to speed healing after surgery and could hold other medical benefits, according to a team of Penn State and Singapore researchers.

Released: 11-Jun-2021 11:15 AM EDT
Financial toxicity associated with cancer care impacts nearly 50% of women with gynecologic cancer
Beth Israel Deaconess Medical Center

Researchers report on how a diverse cohort of gynecologic cancer patients are affected by financial distress, also called “financial toxicity” in acknowledgment of the health hazards it can pose, in the International Journal of Gynecological Cancer.

Released: 10-Jun-2021 5:35 PM EDT
Senolíticos reducen síntomas de COVID-19 en estudios preclínicos
Mayo Clinic

Los investigadores de Mayo Clinic y sus colegas de la Universidad de Minnesota demostraron que la COVID-19 exacerba las consecuencias nocivas de las células senescentes en el cuerpo. En estudios preclínicos, los fármacos senolíticos descubiertos en Mayo redujeron considerablemente la inflamación, la enfermedad y la mortalidad debida a la infección por covid en ratones ancianos. Los resultados se publican en la revista Science.

Released: 10-Jun-2021 5:30 PM EDT
Senolíticos reduzem os sintomas de COVID-19 em estudos pré-clínicos
Mayo Clinic

Os pesquisadores da Mayo Clinic e colegas da Universidade de Minnesota mostraram que o COVID-19 intensifica o impacto prejudicial das células senescentes no corpo. Em estudos pré-clínicos, os medicamentos senolíticos descobertos na Mayo reduziram significativamente a inflamação, a gravidade da doença e a mortalidade da infecção por COVID em camundongos mais velhos. Essas conclusões foram publicadas na revista Science.

Released: 10-Jun-2021 5:05 PM EDT
الأدوية المحللة للشيخوخة تقلل من أعراض فيروس كورونا المستجد (كوفيد-19) في الدراسات ما قبل السريرية
Mayo Clinic

أظهر باحثو مايو كلينك وزملاؤهم في جامعة مينيسوتا أن فيروس كورونا المستجد (كوفيد-19) يفاقم التأثير الضار للخلايا الشائخة في الجسم. ففي الدراسات ما قبل السريرية، قللت الأدوية المحللة لالشيخوخة التي تم اكتشافها في مايو بشكل كبير من الالتهاب والمرض والوفيات الناجمة عن عَدوى فيروس كورونا المستجد في الفئران الأكبر سنًا. النتائج منشورة في مجلة ساينس.

Released: 10-Jun-2021 4:55 PM EDT
抗衰老药物在临床前研究中减少COVID-19症状。
Mayo Clinic

妙佑医疗国际(Mayo Clinic)的研究人员和明尼苏达大学的同事表明,COVID-19(2019冠状病毒病)加剧了体内衰老细胞的破坏性影响。在临床前研究中,妙佑医疗国际研发的抗衰老药物显著降低了老年实验鼠因COVID(冠状病毒病)感染引起的炎症、疾病和死亡率。该研究结果已发表在《科学》期刊中。

Newswise:Video Embedded astronomy-meets-pathology-to-identify-predictive-biomarkers-for-cancer-immunotherapy
VIDEO
9-Jun-2021 2:00 PM EDT
Astronomy Meets Pathology to Identify Predictive Biomarkers for Cancer Immunotherapy
Johns Hopkins Medicine

Pairing sky-mapping algorithms with advanced immunofluorescence imaging of cancer biopsies, researchers at The Mark Foundation Center for Advanced Genomics and Imaging at Johns Hopkins University and the Bloomberg~Kimmel Institute for Cancer Immunotherapy developed a robust platform to guide immunotherapy by predicting which cancers will respond to specific therapies targeting the immune system.

7-Jun-2021 9:45 AM EDT
Major Study of Diabetes Trends Shows Americans’ Blood Sugar Control is Getting Worse
Johns Hopkins Bloomberg School of Public Health

Blood sugar control among adults with diabetes in the United States declined significantly in the past decade, according to a nationwide study from researchers at the Johns Hopkins Bloomberg School of Public Health.

Released: 9-Jun-2021 2:45 PM EDT
New research indicates maternal adult characteristics do not predict stillbirth, early neonatal death 
University of Illinois at Chicago

University of Illinois Chicago researchers studying birth outcomes in marmoset monkeys found there were no adult maternal characteristics like age or weight gain during pregnancy to predict stillbirth or early neonatal death, but that a mother’s birth weight or litter size were associated with early neonatal death. “Our findings of early life contributions to adult pregnancy outcomes in the common marmoset disrupt mother-blaming narratives of pregnancy outcomes in humans,” the paper states.

Released: 8-Jun-2021 12:10 PM EDT
Senolytics reduce COVID-19 symptoms in preclinical studies
Mayo Clinic

Mayo Clinic researchers and colleagues at the University of Minnesota showed that COVID-19 exacerbates the damaging impact of senescent cells in the body. In preclinical studies, the senolytic drugs discovered at Mayo significantly reduced inflammation, illness, and mortality from COVID infection in older mice. The findings appear in the journal Science.

Newswise: Microgel coating gives donor cells a boost in reversing pulmonary fibrosis
Released: 8-Jun-2021 11:45 AM EDT
Microgel coating gives donor cells a boost in reversing pulmonary fibrosis
University of Illinois at Chicago

Researchers have shown that even after lung tissue has been damaged, it may be possible to reverse fibrosis and promote tissue repair through treatment with microgel-coated mesenchymal stromal cells.

Released: 7-Jun-2021 1:35 PM EDT
Drop in Convalescent Plasma Use at U.S. Hospitals Linked to Higher COVID-19 Mortality Rate
Johns Hopkins Bloomberg School of Public Health

A new study from researchers at Johns Hopkins Bloomberg School of Public Health and colleagues suggests a slowdown in the use of convalescent plasma to treat hospitalized COVID-19 patients led to a higher COVID-19 mortality during a critical period during this past winter’s surge.

Newswise: Trained Viruses Prove More Effective at Fighting Antibiotic Resistance
Released: 7-Jun-2021 1:20 PM EDT
Trained Viruses Prove More Effective at Fighting Antibiotic Resistance
University of California San Diego

Research reveals that phage viruses that undergo special evolutionary training increase their capacity to subdue bacteria. The results provide hope for the antibiotic resistance crisis, a rising threat as deadly bacteria continue to evolve to render many modern drugs ineffective.

Released: 7-Jun-2021 11:55 AM EDT
New Potential Therapy for Fatty Liver Disease
Michigan Medicine - University of Michigan

In a subset of patients with partial lipodystrophy and/or NASH, the hormone leptin can be leveraged as a therapeutic agent to move fat out of the liver.

Newswise: Giving Brown Fat A Boost to Fight Type 2 Diabetes
Released: 4-Jun-2021 10:00 AM EDT
Giving Brown Fat A Boost to Fight Type 2 Diabetes
UT Southwestern Medical Center

DALLAS – June 4, 2021 – Increasing a protein concentrated in brown fat appears to lower blood sugar, promote insulin sensitivity, and protect against fatty liver disease by remodeling white fat to a healthier state, a new study led by UT Southwestern scientists suggests. The finding, published online in Nature Communications, could eventually lead to new solutions for patients with diabetes and related conditions.

Newswise: New research may offer hope for Alzheimer's patients
Released: 4-Jun-2021 7:05 AM EDT
New research may offer hope for Alzheimer's patients
University of Kentucky

University of Kentucky Neuroscience Professor Greg Gerhardt's new research program will provide answers to long-standing questions about the role of neurotransmitters GABA and glutamate in the progression of Alzheimer’s disease. A culmination of his nearly 40 years of brain research, Gerhardt's study could help to develop new treatments for the disease.

Released: 3-Jun-2021 2:10 PM EDT
Analyzing the Tumor Microenvironment at the Single Cell Level Sheds Light on Metastatic Melanoma Outcomes, Moffitt Study Shows
Moffitt Cancer Center

In a new article published in Clinical Cancer Research, Moffitt Cancer Center researchers reveal how different therapies impact the surrounding immune environment of metastatic melanoma tumors according to location and identify a rare population of immune cells that is associated with improved overall survival.

2-Jun-2021 7:05 PM EDT
The NIH Common Fund Data Ecosystem Portal is Live
Globus

The Common Fund Data Ecosystem (CFDE) was established to provide the infrastructure needed to help solve key challenges facing DCCs. The CFDE portal, which is now live and open for data submissions, links multiple data platforms that have been established through Common Fund programs.

Newswise: Huntsman Cancer Institute Researchers Yield New Insights into the Origins of Synovial Sarcoma
Released: 2-Jun-2021 5:40 PM EDT
Huntsman Cancer Institute Researchers Yield New Insights into the Origins of Synovial Sarcoma
Huntsman Cancer Institute at the University of Utah

A new study published today in Cancer Discovery, a journal of the American Association for Cancer Research, reports findings that may change the understanding of how synovial sarcoma develops and spreads. The study was led by Kevin B. Jones, MD and Bradley R. Cairns, PhD from Huntsman Cancer Institute.

Newswise: UM Avenir Award Recipient to Leverage Telehealth to Reach Injection Drug Users
Released: 2-Jun-2021 12:10 PM EDT
UM Avenir Award Recipient to Leverage Telehealth to Reach Injection Drug Users
University of Miami Health System, Miller School of Medicine

The $2.3 million, four-year Avenir Award will support his innovative research project, “Tele-Harm Reduction for Rapid Initiation of Antiretrovirals in People Who Inject Drugs: A Randomized Controlled Trial.”

Newswise: UCI-led study sheds light on mysterious genotype-phenotype associations
Released: 1-Jun-2021 1:45 PM EDT
UCI-led study sheds light on mysterious genotype-phenotype associations
University of California, Irvine

A new study analyzing the association between an individual’s genetics (genotype) and their observable characteristics resulting from the interaction of genetics and the environment (phenotype), contributes new knowledge to the understanding of human complex traits and diseases.

Newswise: Diet Plays Critical Role in NASH Progressing to Liver Cancer in Mouse Model
Released: 1-Jun-2021 1:20 PM EDT
Diet Plays Critical Role in NASH Progressing to Liver Cancer in Mouse Model
University of California San Diego Health

Researchers at University of California San Diego School of Medicine found in a mouse model that when fed a Western diet rich in calories, fat and cholesterol, the mice progressively became obese, diabetic and developed NASH, which progressed to HCC, chronic kidney and cardiovascular disease.

Newswise:Video Embedded new-research-could-lead-to-treatment-for-aortic-aneurysms
VIDEO
Released: 1-Jun-2021 10:10 AM EDT
New research could lead to treatment for aortic aneurysms
University of Kentucky

Thanks to a $5.6 million grant from the NIH, a University of Kentucky College of Medicine team will study the culprit behind thoracic aortic aneurysms, which could lead to a treatment for the potentially deadly disease.

Newswise: Same Difference: Two Halves of The Hippocampus Have Different Gene Activity
Released: 28-May-2021 1:45 PM EDT
Same Difference: Two Halves of The Hippocampus Have Different Gene Activity
UT Southwestern Medical Center

DALLAS – May 28, 2021 – A study of gene activity in the brain’s hippocampus, led by UT Southwestern researchers, has identified marked differences between the region’s anterior and posterior portions. The findings, published today in Neuron, could shed light on a variety of brain disorders that involve the hippocampus and may eventually help lead to new, targeted treatments.

Newswise: Research Uncovers How ‘Non-professional’ Cells Can Trigger Immune Response
Released: 26-May-2021 1:30 PM EDT
Research Uncovers How ‘Non-professional’ Cells Can Trigger Immune Response
University of California San Diego

Researchers are finding new details on the complex dynamics involved in how organisms sense an infection from pathogens. The researchers found that worms can sense changes in their metabolism in order to unleash protective defenses, even if they don’t directly sense an incursion from pathogens.

Newswise: Maximizing cancer survival, minimizing treatment side effects with AI
Released: 25-May-2021 10:30 AM EDT
Maximizing cancer survival, minimizing treatment side effects with AI
University of Illinois at Chicago

Computer scientists at the University of Illinois Chicago are developing a computational artificial intelligence system they hope will serve as a decision support tool for doctors prescribing treatment for head and neck cancer. The work is supported by a $2.8 million grant from the National Institutes of Health.

Newswise: Case Western Reserve-led research team aims to determine which diabetic individuals can successfully donate corneas for transplant (and which should not)
Released: 25-May-2021 9:20 AM EDT
Case Western Reserve-led research team aims to determine which diabetic individuals can successfully donate corneas for transplant (and which should not)
Case Western Reserve University

In a new study, supported by a five-year, $6.4 million grant from the National Eye Institute of the National Institutes of Health, researchers from Case Western Reserve University, University Hospitals and the Jaeb Center for Health Research, aim to finally determine which diabetic individuals can successfully donate their corneas for keratoplasty (and which should not).


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