A new tool can quickly and reliably identify the presence of Ebola virus in blood samples, according to a study by researchers at Washington University School of Medicine in St. Louis and colleagues at other institutions.
Byron Lam and collaborators at the University of Miami reported results from an 8-patient phase 1 gene therapy clinical trial for the degenerative retinal disease Leber hereditary optic neuropathy. They found no significant safety concerns; however, treatment failed to improve or slow vision loss, with even the highest dose.
Irvine, Calif., June 7, 2022 — The University of California, Irvine has been awarded a five-year, $14 million grant from the National Institutes of Health to study brain circuits that are susceptible to aging and Alzheimer’s disease. The research findings will advance the development of early diagnostic tools and the discovery of new treatment strategies.
Rampant inflammation has long been linked to cancer but exactly how it pushes healthy cells to transform into malignant ones has remained a mystery. Now, scientists at Van Andel Institute have found one culprit behind this connection.
A new study, led by researchers from the University of California, Irvine, reveals the unique cell-to-cell communication networks that can perpetuate inflammation and prevent repigmentation in patients with vitiligo disease.
UC San Diego researchers report that the causes and death rates of liver cancer are changing around the world.
A compound synthesized by a team led by UT Southwestern scientists kills a range of hard-to-treat cancer types by targeting a previously unexploited vulnerability, a new study reports. The findings, published in Nature Cancer, could eventually lead to new drugs to fight these cancers, which currently have few effective treatments.
A breakdown in how brain cells rid themselves of waste precedes the buildup of debris-filled plaques known to occur in Alzheimer’s disease, a new study in mice shows.
Investigators at Cedars-Sinai have comprehensively mapped molecular activity in the brain and spinal cord that is responsible for regulating the body's response to central nervous system (CNS) disorders such as Alzheimer’s, Huntington's disease and spinal cord injuries.
Researchers at UC San Diego have received a $25.6 million grant from the National Institutes of Health and National Institute on Aging to continue the Study of Latinos-Investigation of Neurocognitive Aging, a 12-year assessment of cognitive and brain aging and impairment among aging Latinos.
New laboratory research directed by investigators at the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins Bloomberg School of Public Health finds that secreted age-induced changes in distant sites such as the lung can effectively reactivate dormant cells and cause them to grow.
A review of studies about the effect of food insecurity on digestive diseases found a dearth of information, even as diet can often be both a direct cause of and a solution for many gastrointestinal conditions.
A new University of California, Irvine-led study identifies sex-specific circuits of muscle signaling to other tissues and that the organs and processes muscle impacts are markedly different between males and females. This new discovery provides insight into how muscle functions, such as exercise, promote healthy longevity, metabolism and improve cognition.
Consortium of Hackensack Meridian CDI, Rockefeller University, Columbia University, Memorial Sloan Kettering Cancer Center, Rutgers University, Merck, Tri-Institutional Therapeutics Discovery Institute, Inc., and Aligos Therapeutics to combine expertise to ‘accelerate’ new breakthroughs
UC San Diego researchers describe biological mechanism that allows sleep to build relational memories — associations between unrelated items.
With a $2.5 million National Institutes of Health grant, researchers at the University of Washington will explore one of the most important questions related to a federal emergency policy change: whether those changes helped with another opioid-related crisis — the unequal access experienced by Black and Latinx patients to buprenorphine.
Cedars-Sinai investigators have identified a gene that plays an essential role in the innate human immune system. The gene, NLRP11, helps activate the inflammatory response that tells the body’s white blood cells to go on the attack against a foreign presence.
New research from Cornell University has big implications for genomic medicine. Scientists have defined with atomic precision a new genome editing tool that is less than half the size of CRISPR-Cas9 – currently the most reliable genome editing system. This new tool would allow scientists to fit genetic editors into smaller viral delivery systems to fix a variety of diseases.
New research shows that comorbidities such as chronic kidney disease are associated with higher plasma p-tau levels.
A $2.3 million National Institutes of Health (NIH) grant will fund Jianjun Guan and Fuzhong Zhang’s effort to develop and deliver therapeutic proteins to help treat injured limbs.
For the first time, scientists have found that brain differences in the visual brain systems of infants who later are diagnosed with autism are associated with inherited genetic factors.
UCLA researchers have taken the initial step in identifying what may be an effective way to detect gestational diabetes mellitus (GDM) earlier in pregnancy, potentially improving diagnosis and treatment for what is the most common disorder of pregnancy.
In a new study, researchers at the University of Chicago Medicine Comprehensive Cancer Center and the University of Amsterdam have brought insight into one crucial step in the anti-cancer immune response process: T cell priming.
The University of Kentucky’s Center for Cancer and Metabolism (CCM) will continue its critical mission to research the metabolism of cancer with a renewed Centers of Biomedical Research Excellence (COBRE) grant award from the National Institutes of General Medical Sciences, part of the National Institutes of Health. The prestigious grant — totaling $11.4 million — will continue to fund UK’s CCM over the next five years.
Keck Medicine of USC study demonstrates the need for early cochlear implant use for deaf children, regardless of developmental impairments
Rutgers will provide antibody testing to help determine the incidence and long-term effects of COVID-19 in children as part of an initiative by the National Institutes of Health.
The National Institutes of the Health (NIH) has awarded researchers at the Icahn School of Medicine at Mount Sinai a four-year grant to study the role of the human microbiome in rheumatoid arthritis, systemic lupus, and other autoimmune diseases. The grant is part of the NIH’s Accelerating Medicines Partnership® Autoimmune and Immune-Mediated Diseases (AMP® AIM) program, which is designed to speed the discovery of new treatments and diagnostics. It will support the Microbiome Technology and Analytic Center Hub (Micro-TEACH), a multidisciplinary team of researchers at Icahn Mount Sinai and NYU Langone Health.
UT Southwestern researchers have discovered a molecular pathway that allows cells to sense when their lipid supplies become depleted, prompting a flurry of activity that prevents starvation. The findings, reported in Nature, might someday lead to new ways to combat metabolic disorders and a variety of other health conditions.
People who are highly responsive to food lost more weight and kept it off using a new weight loss program that targets internal hunger cues and the ability to resist food, reports University of California San Diego Herbert Wertheim School of Public Health and Human Longevity Science.
COVID-19, MIS-C and KD all share a similar underlying mechanism involving the over-activation of particular inflammatory pathways, UC San Diego study shows. Findings support novel drug targets for MIS-C.
Researchers at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis have found a way to help more patients who want to stop smoking. The successful strategy involves using electronic medical records to help identify smokers when they visit their oncologists and offering help with quitting during such visits.
In a new study published in the journal Cell Reports, Moffitt Cancer Center researchers show that cancer cells in an acidic environment undergo lipid synthesis and accumulation. The team identified the key signaling molecules responsible for these changes and discovered that these alterations are associated with poor outcomes and disease progression among breast cancer patients.
Researchers at The University of Texas MD Anderson Cancer Center have identified a novel strategy to reduce immune-related adverse events from immunotherapy treatment by targeting the cytokine interleukin-6 (IL-6).
Access to newer supermarkets that offer fresh foods in some of New York City’s poorest neighborhoods was linked to a 1% decline in obesity rates among public school students living nearby, a new study shows. The modernized markets were also tied to reductions of between 4% and 10% in the average student BMI-z score, a measure of body weight based on height for each age group by gender.
Imagine being able to measure your blood sugar levels, know if you’ve had too much to drink, and track your fatigue during a workout, all in one small device worn on your skin. UC San Diego engineers developed a prototype of such a wearable that continuously monitors several health stats at once.
Scientists make inroads in understanding the relationship between certain enzymes that are normally produced in the body and their role in regulating obesity and controlling liver diseases.
Researchers have identified distinct differences among the cells comprising a tissue in the retina that is vital to human visual perception. The scientists from the National Eye Institute (NEI) discovered five subpopulations of retinal pigment epithelium (RPE)—a layer of tissue that nourishes and supports the retina’s light-sensing photoreceptors. Using artificial intelligence, the researchers analyzed images of RPE at single-cell resolution to create a reference map that locates each subpopulation within the eye.
Researchers have identified distinct differences among the cells comprising a tissue in the retina that is vital to human visual perception. The scientists from the National Eye Institute (NEI) discovered five subpopulations of retinal pigment epithelium (RPE)—a layer of tissue that nourishes and supports the retina’s light-sensing photoreceptors. Using artificial intelligence, the researchers analyzed images of RPE at single-cell resolution to create a reference map that locates each subpopulation within the eye.
UC San Diego researchers describe the underlying signaling pathway that results in pulmonary arterial hypertension and a novel monoclonal antibody therapy that blocks the abnormal blood vessel formation characterizing the disease.
Scar-like cells that make up a sizable portion of malignant pancreatic tumors and shield these cancers from immune attack are derived from mesothelial cells that line tissues and organs, a new study led by UT Southwestern researchers suggests. The findings, published in Cancer Cell, could offer a new strategy to fight pancreatic cancer, a deadly disease for which no truly effective treatments exist.
A new software tool makes it easier to study relationships between a host, its microbiome and pathogens like HIV or SARS-CoV-2.
The National Institutes of Health (NIH) has awarded Albert Einstein College of Medicine a five-year, $11.3 million grant to renew the Einstein-Rockefeller-CUNY Center for AIDS Research (ERC-CFAR) and expand its efforts to prevent, treat and cure HIV infection, and thereby reduce the burden of HIV, locally, nationally, and internationally.
What do gunpowder, penicillin and Teflon all have in common? They were inventions that took the world by storm, but they were all created by complete accident.
UC San Diego scientists use lab-grown human brain tissue to identify neural abnormalities in Pitt-Hopkins Syndrome and show gene therapy tools can rescue neural structure and function.
DNA-to-protein mapping could help researchers understand some health disparities.
The Imaging and Behavioral Neuroscience facility will be built on the first floor of the Interdisciplinary Research Building as part of a $5 million grant from the National Institutes of Health.
Scientists pinpoint the molecular epicenter of deep-sleep regulation. The findings, based on research in mice, identify a gene that makes a protein that regulates delta waves—electrical signals between neurons that occur during the deepest phases of relaxation and are a hallmark of restorative sleep.
Researchers from the Washington University Center for the Study of Itch and Sensory Disorders have identified a specific neuropeptide and a neural circuit that transmit pleasant touch from the skin to the brain. The findings eventually may help scientists better understand and treat disorders characterized by touch avoidance and impaired social development.
Through analyzing human DNA samples in a large biobank, Penn Medicine researchers found associations between genetic variants with severe COVID and conditions involving blood clots and respiratory issues
Scientists have demonstrated in mice that the benefits of exercise may also span generations.
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