Curated News: NEJM

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7-Jun-2021 9:45 AM EDT
Major Study of Diabetes Trends Shows Americans’ Blood Sugar Control is Getting Worse
Johns Hopkins Bloomberg School of Public Health

Blood sugar control among adults with diabetes in the United States declined significantly in the past decade, according to a nationwide study from researchers at the Johns Hopkins Bloomberg School of Public Health.

Newswise: New treatment demonstrated for people with vaccine clots
8-Jun-2021 10:50 AM EDT
New treatment demonstrated for people with vaccine clots
McMaster University

The treatment’s effectiveness was described in a report describing three Canadian patients who received the AstraZeneca vaccine, and who subsequently developed VITT. Two suffered clotting in their legs and the third had clots blocking arteries and veins inside their brain.

Newswise:Video Embedded newly-approved-drug-effective-against-lung-cancer-caused-by-genetic-mutation
VIDEO
1-Jun-2021 3:35 PM EDT
Newly approved drug effective against lung cancer caused by genetic mutation
Washington University in St. Louis

The new drug sotorasib reduces tumor size and shows promise in improving survival among patients with lung tumors caused by a specific DNA mutation, according to results of a global phase 2 clinical trial led by Washington University School of Medicine in St. Louis. The drug is designed to shut down the effects of the mutation, which is found in about 13% of patients with lung adenocarcinoma, a common type of non-small-cell lung cancer.

Newswise: Newly approved targeted therapy sotorasib prolongs survival in KRAS G12C-mutated lung cancer
4-Jun-2021 10:10 AM EDT
Newly approved targeted therapy sotorasib prolongs survival in KRAS G12C-mutated lung cancer
University of Texas M. D. Anderson Cancer Center

Results from the Phase II cohort of the CodeBreaK 100 study showed that treatment with the KRAS G12C inhibitor sotorasib achieved 12.5 months median overall survival in previously treated patients with KRAS G12C-mutated non-small cell lung cancer, according to researchers from The University of Texas MD Anderson Cancer Center.

Newswise: New findings offer improved therapy of early-stage, BRCA mutation-associated breast cancer
Released: 4-Jun-2021 10:35 AM EDT
New findings offer improved therapy of early-stage, BRCA mutation-associated breast cancer
Houston Methodist

Results were released this week on a new treatment with the potential to improve the outcomes for patients with hereditary BRCA mutations and high-risk, early-stage breast cancer. These results represent the first time a drug that blocks cancer cells from repairing their DNA (called a PARP inhibitor) has been shown to significantly reduce the risk of breast cancer returning in high-risk patients following completion of standard chemotherapy, surgery and radiation therapy.

Newswise: Immunotherapy after Bladder Cancer Surgery May Reduce Recurrence, Study Shows
Released: 3-Jun-2021 4:30 PM EDT
Immunotherapy after Bladder Cancer Surgery May Reduce Recurrence, Study Shows
Memorial Sloan Kettering Cancer Center

New research from Memorial Sloan Kettering Cancer Center (MSK) medical oncologist Dean Bajorin, MD, and colleagues found that patients who received nivolumab (Opdivo®) after bladder cancer surgery reduced their overall risk for high-grade bladder cancer recurrence. This research was published today in the New England Journal of Medicine.

1-Jun-2021 11:15 AM EDT
Immunotherapy After Surgery Is Shown to Reduce Deadly Relapse Risk in Advanced Bladder Cancer
Mount Sinai Health System

A phase 3 clinical trial co-led by Mount Sinai researchers is the first to show that immunotherapy after surgery to remove bladder cancer can reduce the risk of relapse for patients who are at high risk of their cancer returning in a deadly metastatic form, according to results published in The New England Journal of Medicine. The immunotherapy nivolumab was used as an adjuvant therapy, which is given after surgery in the hopes of maximizing its effectiveness.

Released: 24-May-2021 10:45 AM EDT
UH authors ‘design for value’ to improve patient and physician experience for referrals
University Hospitals Cleveland Medical Center

A new paper describes how a framework called "designing for value" was used to re-imagine the referral system of patients from primary care doctors to psychiatrists. The results seems to be an improved experience for patients, primary care doctors, and psychiatrists who participated in the model.

Released: 19-May-2021 6:05 PM EDT
Final results of SPRINT study confirm controlling blood pressure critically important in preventing heart disease and stroke
University Hospitals Cleveland Medical Center

News release about the follow-up data from the landmark SPRINT study of the effect of high blood pressure on cardiovascular disease have confirmed that aggressive blood pressure management — lowering systolic blood pressure to less than 120 mm Hg -- dramatically reduces the risk of heart disease, stroke, and death from these diseases, as well as death from all causes, compared to lowering systolic blood pressure to less than 140 mm Hg.

Released: 17-May-2021 2:55 PM EDT
Novel Rehab Program Improves Outcome for Older Heart-failure Patients, Study Finds
Wake Forest Baptist Health

Heart failure (HF) – when the heart can’t pump enough blood and oxygen through the body – affects approximately 6.2 million adults in the United States and is the primary cause of hospitalization in the elderly. Unfortunately, older adults with heart failure often have poor outcomes resulting in reduced quality of life, high mortality and frequent rehospitalizations.

Released: 15-May-2021 9:05 AM EDT
Lower- and higher-dose aspirin achieve similar protection and safety for people with cardiovascular disease
Duke Clinical Research Institute

People with cardiovascular disease (CVD) taking aspirin to lower their chances of suffering a heart attack or stroke experienced similar health benefits, including reduced death and hospitalization for heart attack and stroke, whether they took a high or low dose of aspirin, according to a study presented today at ACC.21, the American College of Cardiology’s 70th Annual Scientific Session and published in the New England Journal of Medicine.

Newswise: Simple surgery prevents strokes in heart patients
11-May-2021 1:40 PM EDT
Simple surgery prevents strokes in heart patients
McMaster University

The study tracked 4,811 people in 27 countries who are living with atrial fibrillation and taking blood thinners. Consenting patients undertaking cardiopulmonary bypass surgery were randomly selected for the additional left atrial appendage occlusion surgery; their outcomes compared with those who only took medicine. They were all followed for a median of four years.

Newswise: No Lasting Benefit to Tubes Over Antibiotics for Childhood Ear Infections, Trial Shows
10-May-2021 3:20 PM EDT
No Lasting Benefit to Tubes Over Antibiotics for Childhood Ear Infections, Trial Shows
Health Sciences at the University of Pittsburgh

There is no long-term benefit to surgically placing tubes in a young child’s ears to reduce recurrent ear infections, compared with giving oral antibiotics, a randomized trial determined.

Released: 29-Apr-2021 2:50 PM EDT
New article examines impact of a randomized trial on the use of minimally invasive surgery for cervical cancer
University Hospitals Cleveland Medical Center

In a Correspondence to the New England Journal of Medicine, researchers found that many medical centers changed surgical practices for early cervical cancer based on findings from the LACC study in 2018, but non-academic medical centers could improve in making the change compared with academic centers.

Newswise: Huntsman Cancer Institute Research Shows Melanoma Incidence and Mortality Higher in Utah Compared to Rest of U.S.
Released: 12-Apr-2021 9:00 AM EDT
Huntsman Cancer Institute Research Shows Melanoma Incidence and Mortality Higher in Utah Compared to Rest of U.S.
Huntsman Cancer Institute at the University of Utah

A letter published today by Huntsman Cancer Institute (HCI) at the University of Utah (U of U) in the New England Journal of Medicine reports that melanoma mortality among Utahns outpaced that of the rest of the United States during the period from 1975 to 2013. Melanoma death rates have been decreasing in recent years both in Utah and the United States, a trend likely attributable to new, more effective treatments, like immunotherapy. However, melanoma remains the deadliest type of skin cancer, and the incidence of melanoma diagnoses in Utahns is higher than in any other state.

Released: 12-Apr-2021 3:05 AM EDT
Vaccinating 3,000 People in 3 Saturdays: An Approach to Covid-19 Vaccination Equity for Black Neighborhoods
Perelman School of Medicine at the University of Pennsylvania

Nationwide, the rollout for the COVID-19 vaccine has been inequitable, with white individuals being vaccinated at higher rates compared to Black individuals.

Newswise: Johns Hopkins Medicine Expert Creates Comprehensive Guide to New Diabetes Drugs
Released: 7-Apr-2021 2:00 PM EDT
Johns Hopkins Medicine Expert Creates Comprehensive Guide to New Diabetes Drugs
Johns Hopkins Medicine

New medicines for people who have diabetes seem to pop up all the time. Drugs that help the body break down carbohydrates, drugs that increase excretion of glucose in the urine, drugs that help muscles respond to insulin and drugs that stimulate the pancreas to produce it — the list of pharmaceutical options to treat diabetes gets longer and longer.

Released: 1-Apr-2021 2:45 PM EDT
Houston Methodist among largest providers of monoclonal antibody treatment for Covid-19
Houston Methodist

Among the nation’s largest providers of monoclonal antibodies for Covid-19, Houston Methodist has infused nearly 4,000 patients. The hospital system was able to quickly ramp up its program by leveraging numerous resources through interdisciplinary collaboration. A commentary outlining challenges, resources and benchmarks published online March 29 in the New England Journal of Medicine and serves as a valuable model as more hospitals begin to treat Covid-19 with mAB therapy.

Newswise: Resident’s NEJM essay discusses combating anti-Asian hate
Released: 24-Mar-2021 5:15 PM EDT
Resident’s NEJM essay discusses combating anti-Asian hate
University of Washington School of Medicine

Dr. James Lee is a Korean-American resident in psychiatry at the University of Washington School of Medicine. His perspective, “Combating anti-Asian sentiment — a practical guide for clinicians,” was published March 24 in The New England Journal of Medicine.

Newswise: Real-World Data At UT Southwestern Shows Benefit of Early Vaccination on Health Care Workforce
Released: 23-Mar-2021 12:50 PM EDT
Real-World Data At UT Southwestern Shows Benefit of Early Vaccination on Health Care Workforce
UT Southwestern Medical Center

DALLAS – March 23, 2021 – Vaccinating health care workers resulted in an immediate and notable reduction of positive COVID-19 cases among employees, reducing the number of required isolations and quarantines by more than 90 percent, according to data at UT Southwestern Medical Center published in the New England Journal of Medicine.

Released: 23-Mar-2021 12:35 PM EDT
Though Risk is Minuscule, Infection after COVID-19 Vaccination is Possible
University of California San Diego Health

Investigators from UC San Diego and UCLA report COVID-19 infection rates for a cohort of health care workers previously vaccinated for the novel coronavirus. Risk of infection is minuscule, but exists.

Released: 18-Mar-2021 9:00 AM EDT
Antibody Mediated Prevention (AMP) trials data published by the New England Journal of Medicine
HIV Vaccine Trials Network

The proof-of-concept AMP studies demonstrated that a broadly neutralizing antibody (bnAb) called VRC01 was effective at preventing the acquisition of HIV strains to the 30% of strains that were sensitive to the bnAb. This finding was seen both in Sub-Saharan Africa and the U.S. and South America. VRCO1 did not prevent the acquisition of HIV to strains that were resistant to the bNAb.

Released: 17-Mar-2021 11:40 AM EDT
South African Oxford AstraZeneca Covid-19 vaccine study a global game-changer
University of the Witwatersrand

This is a landmark study in so far as being the first to raise the alarm that, despite early successes with Covid-19 vaccines, further research is warranted on a next generation of Covid-19 vaccines.

Released: 10-Mar-2021 5:00 PM EST
Mount Sinai Researchers Find that a Second Shot of COVID-19 Vaccine May Not be Necessary in Previously Infected Individuals
Mount Sinai Health System

A single shot of one of the currently authorized COVID-19 vaccines may be sufficient to provide immunity to individuals who have previously been infected by the virus, thus eliminating the need for a second dose and helping to stretch severely limited vaccine supplies, a study from Mount Sinai has found

Newswise: Promising role for whole genome sequencing in guiding blood cancer treatment
8-Mar-2021 11:25 AM EST
Promising role for whole genome sequencing in guiding blood cancer treatment
Washington University in St. Louis

A new study from Washington University School of Medicine in St. Louis shows that whole genome sequencing is at least as accurate and often better than conventional genetic tests that help determine the treatment for a patient’s blood cancer. Genome sequencing technology continuously is decreasing in cost and recently reached a level similar to that of conventional testing.

Newswise: New CAR T-Cell Therapy Extends Remission In Heavily Relapsed Multiple Myeloma Patients
Released: 8-Mar-2021 11:20 AM EST
New CAR T-Cell Therapy Extends Remission In Heavily Relapsed Multiple Myeloma Patients
UT Southwestern Medical Center

DALLAS – March 8, 2021 – A new type of CAR T-cell therapy more than triples the expected length of remission for multiple myeloma patients who have relapsed several times, according to an international clinical trial with UT Southwestern as the lead enrolling site.

Released: 5-Mar-2021 10:20 AM EST
After the Elderly, Those with Intellectual Disabilities are at Greatest Risk of Death from COVID-19
Thomas Jefferson University

A study of national data shows the devastating impact the pandemic has had on those with intellectual disabilities and their caregivers.

Newswise:Video Embedded yearofcovid-the-evolution-of-care
VIDEO
Released: 1-Mar-2021 5:05 PM EST
#YearofCOVID: The Evolution of Care
Cedars-Sinai

Peter Chen, MD, remembers those early days of March 2020 as one of swirling hyperactivity in the intensive care unit he leads at Cedars-Sinai. Chen and his team were struggling to respond to an emerging health crisis that was quickly growing into a global pandemic.

Newswise: Repurposed Arthritis Drug Did Not Significantly Improve Severe COVID-19 Pneumonia
Released: 1-Mar-2021 4:10 PM EST
Repurposed Arthritis Drug Did Not Significantly Improve Severe COVID-19 Pneumonia
University of California San Diego Health

A repurposed drug used to treat arthritis did not significantly improve the outcomes of patients with severe COVID-19 pneumonia. Tocilizumab did not significantly improve clinical status or mortality rate at 28 days for participants who received it compared to a placebo.

Newswise: Global study finds diet high in poor quality carbohydrates increases heart disease and death
22-Feb-2021 1:55 PM EST
Global study finds diet high in poor quality carbohydrates increases heart disease and death
McMaster University

A total of 137,851 people aged 35 to 70 years old were followed for a median of 9.5 years through the Population Urban and Rural Epidemiology (PURE) study run by the Population Health Research Institute (PHRI) of McMaster University and Hamilton Health Sciences.

Newswise: CAR T-cell therapy generates lasting remissions in patients with multiple myeloma
24-Feb-2021 2:30 PM EST
CAR T-cell therapy generates lasting remissions in patients with multiple myeloma
Dana-Farber Cancer Institute

In a major advance in the treatment of multiple myeloma, a CAR T-cell therapy has generated deep, sustained remissions in patients who had relapsed from several previous therapies, an international clinical trial has found.

Released: 17-Feb-2021 7:05 PM EST
Five Years Later: Penn-developed CAR T Therapy Shows Long-lasting Remissions in Non-Hodgkin Lymphomas
Perelman School of Medicine at the University of Pennsylvania

A significant number of non-Hodgkin lymphoma (NHL) patients in a Penn Medicine-initiated clinical trial continue to be in remission five years after receiving the chimeric antigen receptor (CAR) T cell therapy Kymriah™, researchers in Penn’s Abramson Cancer Center reported today in the New England Journal of Medicine.

15-Feb-2021 4:30 PM EST
Study Discovers Safe, Effective Oral Treatment for Uterine Fibroids
University of Chicago Medical Center

A University of Chicago Medicine researcher working with an international team of scientists has developed a daily oral combination therapy that is reliable, safe and effective for long-term treatment of uterine fibroids.

15-Feb-2021 9:50 AM EST
Medication Keeps More Patients with ANCA-Associated Vasculitis in Remission Than Steroids
Perelman School of Medicine at the University of Pennsylvania

Avacopan, which targets a receptor that attracts the cells that cause inflammation, was shown to be more effective at keeping patients in remission for a year than prednisone

15-Feb-2021 11:55 AM EST
High Patient Uptake for Text Message System Monitoring Opioid Use in Real-Time
Perelman School of Medicine at the University of Pennsylvania

Among the orthopaedic surgery patients in a study using text messaging to monitor opioid use, 61 percent of their tablets were found to be left over

Released: 16-Feb-2021 10:05 PM EST
Os achados do estudo melhoram a precisão das estimativas de risco de câncer de mama para mulheres sem histórico familiar
Mayo Clinic

Um novo estudo multi-institucional liderado pelo Fergus Couch, Ph.D, um patologista da Mayo Clinic, fornece estimativas mais precisas do risco de câncer de mama para mulheres dos EUA que têm mutações herdadas nos genes de predisposição do câncer de mama.

13-Feb-2021 12:05 PM EST
Immunotherapy – targeted drug combination improves survival in advanced kidney cancer
Dana-Farber Cancer Institute

Patients with advanced kidney cancer, who received a targeted drug combined with a checkpoint-blocker immunotherapy agent had longer survival than patients treated with the standard targeted drug, said an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial.

Newswise: Yale Cancer Center Study Shows Targeted Therapy Improves Survival for Advanced Bladder Cancer
12-Feb-2021 10:45 AM EST
Yale Cancer Center Study Shows Targeted Therapy Improves Survival for Advanced Bladder Cancer
Yale Cancer Center

In a new study led by researchers at Yale Cancer Center, the drug enfortumab vedotin significantly prolonged survival as compared with standard chemotherapy in patients with locally advanced or metastatic urothelial carcinoma or bladder cancer, who had previously received platinum-based treatment and a PD-1–PD-L1 inhibitor.

Newswise:Video Embedded implant-improves-balance-movement-and-quality-of-life-for-people-with-inner-ear-disorder
VIDEO
Released: 11-Feb-2021 9:30 AM EST
Implant Improves Balance, Movement and Quality of Life for People with Inner Ear Disorder
Johns Hopkins Medicine

Getting around without the need to concentrate on every step is something most of us can take for granted because our inner ears drive reflexes that make maintaining balance automatic. However, for about 1.8 million adults worldwide with bilateral vestibular hypofunction (BVH) — loss of the inner ears’ sense of balance — walking requires constant attention to avoid a fall. Now, Johns Hopkins Medicine researchers have shown that they can facilitate walking, relieve dizziness and improve quality of life in patients with BVH by surgically implanting a stimulator that electrically bypasses malfunctioning areas of the inner ear and partially restores the sensation of balance.

Released: 3-Feb-2021 8:15 AM EST
研究结果提高了无家族史女性乳腺癌风险评估的准确性
Mayo Clinic

妙佑医疗国际(Mayo Clinic) 病理学家Fergus Couch博士主持的一项新的多机构研究为携带乳腺癌易感基因遗传突变的美国女性提供了更准确的乳腺癌风险评估。于1月20日星期三发表在《New England Journal of Medicine》(新英格兰医学杂志)上的CARRIERS Consortium研究结果让医疗服务提供者能够更好地评估女性患乳腺癌的风险(其中许多女性都没有乳腺癌家族史),并提供更合适的风险管理策略。

Released: 3-Feb-2021 8:05 AM EST
نتائج دراسة تحسّن دقة تقديرات مخاطر الإصابة بسرطان الثدي للنساء بلا تاريخ عائلي للإصابة بالمرض
Mayo Clinic

تقدم دراسة جديدة شاركت فيها مؤسسات متعددة بقيادة فيرجوس كوتش، الحاصل على درجة الدكتوراه، أخصائي علم الأمراض في مايو كلينك، تقديرات أكثر دقة لخطر الإصابة بسرطان الثدي بالنسبة للنساء الأمريكيات اللاتي يحملن طفرات وراثية في جينات الأُهبة لسرطان الثدي. قد تتيح نتائج دراسة كاريرز كونسورتيوم، التي نُشرت يوم الأربعاء، 20 كانون الثاني/يناير في مجلة نيو إنجلاند الطبية، لمزودي الرعاية الصحية إجراء تقييم أفضل لخطر الإصابة بسرطان الثدي بالنسبة للنساء - وكثير منهن بلا تاريخ عائلي لسرطان الثدي- وتقدِّم استراتيجيات أنسب لإدارة المخاطر

1-Feb-2021 12:40 PM EST
Study finds recommended ICU sedatives equally safe, effective
Vanderbilt University Medical Center

A study published today in the New England Journal of Medicine provides the most definitive evidence to date that, of the two drugs recommended for light sedation of patients receiving mechanical ventilation in the ICU, one is as effective and safe as the other.

Released: 28-Jan-2021 1:05 PM EST
Resultados de estudio ofrecen más exactitud para calcular el riesgo de cáncer de mama en mujeres sin antecedentes familiares
Mayo Clinic

Un nuevo estudio llevado a cabo en varias instituciones y dirigido por el Dr. Fergus Couch, patólogo en Mayo Clinic, aporta un cálculo más exacto sobre el riesgo de cáncer de mama en las mujeres estadounidenses con mutaciones heredadas en los genes de predisposición a ese tipo de cáncer.

25-Jan-2021 1:05 PM EST
Hormonal IUDs Are a Viable and Underutilized Method for Emergency Contraception
University of Utah Health

in a first-of-its-kind study, University of Utah Health scientists found that hormonal IUDs were comparable to copper IUDs for use as emergency contraceptives. The researchers say the finding supports adding hormonal IUDs to current emergency contraception options.

Released: 26-Jan-2021 7:40 AM EST
恢复期血浆抗体水平与COVID-19致死风险
Mayo Clinic

妙佑医疗国际(Mayo Clinic) 的研究人员和合作者发现,在未使用呼吸机的COVID-19住院患者中,输注含高水平抗体的恢复期血浆与COVID-19死亡率下降有关。研究结果“恢复期血浆抗体水平与COVID-19致死风险”于2021年1月13日发表在《New England Journal of Medicine》(新英格兰医学杂志)上。

Released: 25-Jan-2021 5:50 PM EST
Los niveles de anticuerpos en plasma convaleciente y el riesgo de muerte por COVID-19
Mayo Clinic

Investigadores y colaboradores de Mayo Clinic descubrieron una asociación entre la administración de plasma convaleciente con alta carga de anticuerpos y menores tasas de mortalidad en pacientes internados con COVID-19 sin respirador.

Released: 22-Jan-2021 8:25 AM EST
Mutations Commonly Linked to Breast Cancer Found to Pose No Increased Risk, Population Study Reveals
Perelman School of Medicine at the University of Pennsylvania

Several genetic mutations previously linked to breast cancer and included on commercial genetic tests, including direct-to-consumer tests, were found not to increase a woman’s risk of disease, according to a population study of more than 64,000 women published online today in the New England Journal of Medicine from several institutions, including Penn Medicine.

Released: 21-Jan-2021 8:10 AM EST
Study findings improve accuracy of breast cancer risk estimates for women with no family history
Mayo Clinic

A new multi-institution study led by Fergus Couch, Ph.D., a Mayo Clinic pathologist, provides more accurate estimates of breast cancer risk for U.S. women who harbor inherited mutations in breast cancer predisposition genes.

Released: 20-Jan-2021 4:55 PM EST
CRISPR technology to cure sickle cell disease at UIC
University of Illinois at Chicago

University of Illinois Chicago is one of the U.S. sites participating in clinical trials to cure severe red blood congenital diseases such as sickle cell anemia or Thalassemia by safely modifying the DNA of patients’ blood cells.

Released: 15-Jan-2021 1:30 PM EST
New England Journal of Medicine publishes COVID-19 treatment trial results
University of Texas at San Antonio

A clinical trial involving COVID-19 patients hospitalized at UT Health San Antonio and University Health, among roughly 100 sites globally, found that a combination of the drugs baricitinib and remdesivir reduced time to recovery, according to results published Dec. 11 in the New England Journal of Medicine.


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