University of South Australia researchers are pioneering a new method to more accurately diagnose Parkinson’s disease, a neurodegenerative brain disorder which affects around 10 million people worldwide, resulting in a loss of control of body movements.
There’s good news for people with Parkinson’s disease. A new study shows that deep brain stimulation may not increase the risk of developing dementia. The study is published in the July 1, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Bristol scientists have discovered a novel pathology that occurs in several human neurodegenerative diseases, including Huntington’s disease.
The article, published in Brain Pathology, describes how SAFB1 expression occurs in both spinocerebellar ataxias and Huntington's disease and may be a common marker of these conditions, which have a similar genetic background.
UC San Diego and Deerfield Management created Poseidon Innovation to support researchers working to advance disease-curing therapeutics by funding early stage projects and expediting the drug-development cycle. Poseidon announces it is funding three researchers.
UC San Diego researchers have discovered that a single treatment to inhibit a gene called PTB in mice converts native astrocytes, brain support cells, into neurons that produce the neurotransmitter dopamine. As a result, the mice’s Parkinson’s disease symptoms disappear.
After a brain injury, cells that normally nourish nerves may actually kill them instead, a new study in rodents finds. This “reactive” phenomenon may be the driving factor behind neurodegenerative diseases like glaucoma, a leading cause of blindness.
UCLA scientists have developed a method for restoring oxygen-consumption activity to previously frozen mitochondria samples. By speeding up research, investigators hope to accelerate the diagnosis of people living with mitochondrial diseases and secondary disorders in which mitochondria play a key role, including diseases related to aging, metabolism and the heart.
A 2003 hypothesis says Parkinson’s disease is caused by a gut pathogen that could spread to the brain through the nervous system. No evidence was found until now; researchers report for the first time a significant overabundance of a cluster of opportunistic pathogens in the PD gut.
DALLAS – June 14, 2020 – Recently developed MRI techniques used to more precisely target a small area in the brain linked to Parkinson’s disease and essential tremor may lead to better outcomes without surgery and with less risk of negative effects, a new study led by UT Southwestern researchers suggests.
DALLAS – June 11, 2020 – Dopamine, a chemical that sends messages between different parts of the brain and body, plays a key role in a variety of diseases and behaviors by interacting with receptors on cells. But despite their importance in physiology and pathology, the structure of these receptors embedded in a phospholipid membrane – their natural environment on the cell surface – was unknown. A new study led by UT Southwestern researchers reveals the structure of the active form of one type of dopamine receptor, known as D2, embedded in a phospholipid membrane.
A blood test may help predict which people with multiple sclerosis (MS) will get worse during the following year, according to a study published in the May 20, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Even small changes may have big, long-term consequences. For amyloid beta peptides, a major hallmark of Alzheimer’s disease, a common chemical modification at a particular location on the molecule has a butterfly effect that leads to protein misfolding, aggregation and cellular toxicity.
Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve efficacy. The study was published in Cell Reports.
The Association of Rehabilitation Nurses is proud to announce that ARN Board Member Maureen Musto, MS RN APRN-CNS ACNS-BC CRRN, has been selected to serve on the Development Group for Traumatic Brain Injury and Parkinson’s Disease working on development of the World Health Organization (WHO) Rehabilitation Programme’s Package of Interventions for Rehabilitation (PRI).
A new study co-led by scientists at the La Jolla Institute for Immunology (LJI) adds increasing evidence that Parkinson’s disease is partly an autoimmune disease. In fact, the researchers report that signs of autoimmunity can appear in Parkinson’s disease patients years before their official diagnosis.
Improper removal of faulty brain cells during neurodevelopment may cause lifelong behavioral issues, new research from the University of Virginia School of Medicine suggests. The finding also could have important implications for a wide range of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s.
Experts writing in the Journal of Parkinson's Disease discuss potentially grave consequences for Parkinson's disease patients related to social distancing, but also opportunities like new avenues for research and initiatives that may offer positive help and support
Depression is common in people with Parkinson’s disease and contributes to faster physical and mental decline, but it is often overlooked and undertreated.
The good news is that participating in cognitive-behavioral therapy by telephone may be effective in reducing depression symptoms for people with Parkinson’s, according to a study published in the April 1, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
People with Parkinson’s disease who engage in cognitive behavioral therapy — a form of psychotherapy that increases awareness of negative thinking and teaches coping skills — are more likely to overcome depression and anxiety, according to a Rutgers study.
Researchers at the University of Georgia’s Regenerative Bioscience Center and their colleagues have found that “natural killer” white blood cells could guard against the cascade of cellular changes that lead to Parkinson’s disease and help stop its progression.
Parkinson’s disease takes a lot from its victims.Patients often notice its onset as a tremor in one of their hands. As it progresses, it can impair balance, change speech patterns, alter thinking and dramatically affect movement.There is no cure, but there are ways to improve symptoms.
Vision and eye problems like blurry vision, dry eyes, trouble with depth perception, and problems adjusting to rapid changes in light are much more common in people with Parkinson’s disease than in people without the disorder, according to a study published in the March 11, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found such problems can influence a person’s daily activities.
Sandia National Laboratories has received a $6 million grant from the the National Institutes of Health to build a prototype medical device that would make magnetoencephalography (MEG) — a type of noninvasive brain scan — more comfortable, more accessible and potentially more accurate.
People with Parkinson’s disease who participate in a special, non-contact boxing program may have better quality of life and be more likely to exercise than those who do not participate, according to a preliminary study released today that will be presented at the American Academy of Neurology’s 72nd Annual Meeting in Toronto, Canada, April 25 to May 1, 2020.
A team of researchers at the University of Arizona has found that low-intensity ultrasound waves directed at a particular region of the brain’s prefrontal cortex in healthy subjects can elevate mood, and decrease connectivity in a brain network that has been shown to be hyperactive in psychiatric disorders. The method uses transcranial focused ultrasound (‘tFUS’), a painless, non-invasive technique to modulate brain function comparable to transcranial magnetic stimulation (‘TMS’), and transcranial direct current stimulation (‘tDCS’). This study shows, for the first time, a correlation between tFUS-induced mood enhancement, and reorganization of brain circuits.
Parkinson’s disease researchers have used gene-editing tools to introduce the disorder’s most common genetic mutation into marmoset monkey stem cells and to successfully tamp down cellular chemistry that often goes awry in Parkinson’s patients.
Pingpong may hold promise as a possible form of physical therapy for Parkinson’s disease. People with Parkinson’s who participated in a pingpong exercise program once a week for six months showed improvement in their Parkinson’s symptoms, according to a preliminary study released today that will be presented at the American Academy of Neurology’s 72nd Annual Meeting in Toronto, Canada, April 25 to May 1, 2020.
As out-of-pocket costs go up for drugs for the neurologic disorders Alzheimer’s disease, peripheral neuropathy and Parkinson’s disease, people are less likely to take the drugs as often as their doctors prescribed, according to a study funded by the American Academy of Neurology and published in the February 19, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The top contributor to familial Parkinson’s disease is mutations in leucine-rich repeat kinase 2 (LRRK2), whose large and difficult structure has finally been solved, paving the way for targeted therapies.
Researchers at Washington University School of Medicine in St. Louis have discovered that the genetic variant APOE4 – long linked to dementia – spurs the spread of harmful clumps of Parkinson’s proteins through the brain. The findings suggest that therapies that target APOE might reduce the risk of dementia for people with Parkinson’s disease.
Scientists have found a way to distinguish between two progressive neurodegenerative diseases, Parkinson’s disease (PD) and multiple system atrophy (MSA), using a technology developed by a researcher at UTHealth. The discovery was published today in Nature.
People who develop Parkinson's disease before age 50 may have been born with disordered brain cells that went undetected for decades, according to EMBARGOED Cedars-Sinai research that will publish Jan. 27 in the journal Nature Medicine. The research points to a drug that potentially might help correct these disease processes.
In an article published recently in Microgravity, a Nature Journal, researchers at Rensselaer Polytechnic Institute demonstrate a unique method for studying the mechanisms behind the formation of amyloid fibrils associated with diseases like Alzheimer’s and Parkinson’s.
GB Sciences, Inc. (OTCQB: GBLX) announced significant preclinical results for their Parkinson's disease ("PD") formulations from the midterm report for their preclinical study being performed by Dr. Lee Ellis of the National Research Council (NRC) in Halifax, Nova Scotia, CANADA.
A clinical trial investigating the repurposed cancer drug nilotinib in people with Parkinson’s disease finds that it is reasonably safe and well tolerated. Researchers also report finding an increase in dopamine, the chemical lost as a result of neuronal destruction, and a decrease in neurotoxic proteins in the brain among study participants. Finally, they say nilotinib, a tyrosine kinase inhibitor, potentially halts motor and non-motor decline.
Researchers at Washington University School of Medicine in St. Louis have mapped nine functional networks in the deep-brain structures of 10 healthy people, an accomplishment that could lead to improvements in deep-brain stimulation therapy for severe cases of Parkinson’s disease and other neurological conditions.
An article published in Proceedings of the National Academy of Sciences (PNAS) describes a new pathway in the central nervous system to expel waste substances from the brain through the creation of corpora amylacea (CA), aggregates formed by glucose polymers amassing waste products.
Researchers have identified nine cases of people who lost their ability to swim after having a deep brain stimulation device implanted to control symptoms of Parkinson’s disease. The new research is published in the November 27, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology. All nine people had been good swimmers even after their Parkinson’s disease diagnosis. But once they had deep brain stimulation surgery, researchers found while other movement symptoms improved, their swimming skills deteriorated.
While most of us are enjoying the traditional turkey and pumpkin pie on Thanksgiving Day, employees at Cedars-Sinai will be hand-feeding stem cells their special daily formula, carefully monitoring the incubator temperatures and caring for the cells that may become part of important research that could one day lead to treatments for diseases that have plagued humans for years.
The five-year award will support the NINDS Human Genetics Resource Center, a collection of biological samples and corresponding demographic, clinical, and genetic data made available to qualified researchers around the world. This repository includes samples from subjects with various diseases – such as cerebrovascular disease, dystonia, epilepsy, motor neuron disease, parkinsonism, and Tourette Syndrome.