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Embargo will expire: 26-May-2022 11:00 AM EDT Released to reporters: 24-May-2022 5:05 PM EDT

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Released: 24-May-2022 1:05 PM EDT
Common diabetes drug not effective against early-stage breast cancer, landmark trial reveals
Lunenfeld-Tanenbaum Research Institute

A widely used and inexpensive Type 2 diabetes drug, once hoped to hold enormous promise in treating breast cancer, does not prevent or stop the spread of the most common forms of the disease, according to new findings.

Newswise: Sidekick Microbubbles Carry Anti-Cancer Drugs, Damage Tumor Vessels #ASA182
17-May-2022 8:50 AM EDT
Sidekick Microbubbles Carry Anti-Cancer Drugs, Damage Tumor Vessels #ASA182
Acoustical Society of America (ASA)

Naomi Matsuura, of the University of Toronto, and her team are adapting microbubbles to become more potent tools for cancer therapy. By shrinking the bubbles and directly loading them with anti-cancer drugs, the bubbles can lower the dose of free drug that is injected and diffuses into nontumor tissue in the body. This results in more targeted treatment and fewer side effects for the patient. Matsuura will discuss her team's results in her presentation, "Ultrasound-stimulated, drug-loaded bubbles for cancer therapy," as part of the 182nd Meeting of the Acoustical Society of America at the Sheraton Denver Downtown Hotel. The session will take place May 24 at 11:30 a.m. Eastern U.S.

Newswise: Recommendations for Interventional Pain Procedures During Contrast Shortage
Released: 24-May-2022 10:05 AM EDT
Recommendations for Interventional Pain Procedures During Contrast Shortage
American Society of Regional Anesthesia and Pain Medicine (ASRA)

Pain medicine practitioners should take measures to reduce the use of iodinated contrast medium in interventional pain procedures due to the current shortage of iohexol. Clinicians are advised to consider using alternate image guidance, such as ultrasound, delaying non-urgent procedures, and using alternative contrast agents, according to guidance just released by ASRA Pain Medicine.

Released: 23-May-2022 5:05 PM EDT
New research may explain unexpected effects of common painkillers
Yale University

Now, a new Yale-led study has uncovered a previously unknown process by which some NSAIDs affect the body.

Released: 23-May-2022 11:05 AM EDT
The Drug Gabapentin May Boost Functional Recovery After a Stroke
Ohio State University

The drug gabapentin, currently prescribed to control seizures and reduce nerve pain, may enhance recovery of movement after a stroke by helping neurons on the undamaged side of the brain take up the signaling work of lost cells, new research in mice suggests.

Newswise: Scientists Find Sea Corals are Source of Sought After
18-May-2022 4:05 PM EDT
Scientists Find Sea Corals are Source of Sought After "Anti-Cancer" Compound
University of Utah Health

The bottom of the ocean is full of mysteries but scientists have recently uncovered one of its best-kept secrets. For 25 years, drug hunters have been searching for the source of a natural chemical that had shown promise in initial studies for treating cancer. Now, researchers at University of Utah Health report that easy-to-find soft corals make the elusive compound.

Released: 23-May-2022 10:05 AM EDT
Experts stress importance of monitoring for post-treatment opioid use in young sarcoma patients
Wiley

New analysis finds more than half of U.S. adolescents and young adults with sarcoma—a type of cancer in the bones or soft tissues—are often prescribed opioids to treat their pain.

Released: 19-May-2022 1:55 PM EDT
Epilepsy Drug Stops Nervous System Tumor Growth in Mice
Washington University in St. Louis

People with neurofibromatosis type 1 (NF1) develop tumors on nerves throughout their bodies. Researchers at Washington University School of Medicine in St. Louis have discovered that nerve cells with the mutation that causes NF1 are hyperexcitable and that suppressing this hyperactivity with the epilepsy drug lamotrigine stops tumor growth in mice.

Released: 19-May-2022 10:05 AM EDT
New Report Provides Strategies for Managing Contrast Shortage
Radiological Society of North America (RSNA)

Recent disruptions in a pharmaceutical supply chain have impacted the global availability of GE Healthcare Omnipaque™ iohexol iodinated contrast media (ICM) for radiologic examinations. A new Special Report published in the journal Radiology provides consensus recommendations for dealing with the shortage of ICM in the near term and discusses long-term issues and potential solutions to supply chain problems.

Released: 18-May-2022 5:05 PM EDT
Blood Pressure Medicine May Lower Frailty for Older Adults
University of Texas Health Science Center at Houston

A commonly used blood pressure medication may help improve measures of frailty in prefrail older adults, according to a new study by researchers with UTHealth Houston. The study was published in The Journals of Gerontology.

Released: 18-May-2022 1:05 PM EDT
Rutgers Pair Creates Monitoring Toolkit to Speed Production of Biologic Drugs
Rutgers University-New Brunswick

Two Rutgers engineers specializing in the process of making drugs derived from living organisms have created an analytical tool they expect will accelerate the discovery and production of biologic drugs that are often at the cutting edge of biomedical research.

Newswise: In STOP-COVID19 Trial, Brensocatib Did Not Improve Condition of Patients with Severe COVID-19
9-May-2022 4:00 PM EDT
In STOP-COVID19 Trial, Brensocatib Did Not Improve Condition of Patients with Severe COVID-19
American Thoracic Society (ATS)

Brensocatib did not improve the clinical status of patients hospitalized with severe SARS-CoV-2 infection in the double-blind randomized, placebo-controlled STOP-COVID19 multicenter clinical trial, according to research published at the ATS 2022 international conference.

Released: 18-May-2022 12:05 PM EDT
Study Shows Family Medicine Physicians Face Many Barriers to Providing Medical Abortions
UC Davis Health

A study by UC Davis and UC San Francisco identified multiple barriers that family physicians navigate to provide abortion services to their patients. The barriers include lack of physician training and federal, state and institutional restrictions on providing medication abortion.

Newswise: Imatinib Shows Improved Outcomes for Patients with Severe COVID-19 in the CounterCOVID Clinical Trial
9-May-2022 4:00 PM EDT
Imatinib Shows Improved Outcomes for Patients with Severe COVID-19 in the CounterCOVID Clinical Trial
American Thoracic Society (ATS)

Patients with severe COVID-19 who were given imatinib had lower mortality rates at 90-day follow-up, according to research published at the ATS 2022 international conference.

9-May-2022 4:00 PM EDT
Substudy of ADVOCATE Trial for ANCA-Associated Vasculitis Finds Avacopan Reduces Need for Glucocorticoids, Respiratory and ENT Involvement
American Thoracic Society (ATS)

Avacopan was better than prednisone in reducing respiratory as well as ear, nose and throat (ENT) involvement and enabled reduced glucocorticoid use in ANCA-associated vasculitis patients participating in the phase 3 ADVOCATE trial. Study results were published at the ATS 2022 international conference. The study was a subgroup analysis of results from the larger trial, which led to FDA approval of avacopan.

Released: 17-May-2022 8:05 AM EDT
Vyriad, Inc. Raises $29.5M in Series B Funding Led by Renowned Genetics Entrepreneur
Vyriad, Inc.

Vyriad, Inc., a clinical-stage biotechnology company developing oncolytic virus therapies to treat a wide range of cancers, today announced $29.5M in new funding led by Mr. Harry Stine of Stine Seed Farms, Inc.

Newswise: NAVIGATOR Data Show Half of Patients with Severe, Uncontrolled Asthma Improved with Tezepelumab Therapy
9-May-2022 4:00 PM EDT
NAVIGATOR Data Show Half of Patients with Severe, Uncontrolled Asthma Improved with Tezepelumab Therapy
American Thoracic Society (ATS)

A greater proportion of patients with severe, uncontrolled asthma had more significant clinical responses to tezepelumab than placebo, according to research published at the ATS 2022 international conference. The study showed that nearly half of those enrolled achieved complete response to treatment across measures of exacerbation reduction, asthma control, lung function, and clinician assessment.

Released: 16-May-2022 3:30 PM EDT
IU Study Explored How People's Beliefs Impact Overdose Education and Naloxone Distribution Programs
Indiana University

A new study by Indiana University researchers explored people’s beliefs about overdose and naloxone as a step to understanding why some communities are not using the reversal medication.

Released: 16-May-2022 11:05 AM EDT
Drug Combination Reduces the Risk of Asthma Attacks
Rutgers University-New Brunswick

A global study of asthma patients by Rutgers and an international team of researchers found a combination of two drugs dramatically reduces the chances of suffering an asthma attack.

Released: 16-May-2022 10:05 AM EDT
Diverted Buprenorphine May Help Prepare People With Opioid-Use Disorder for Treatment
Rutgers University-New Brunswick

People addicted and dependent on opioids who used buprenorphine not prescribed by a physician at the time they enter a treatment center are more likely to remain in treatment for opioid use disorder, according to a Rutgers study.

Released: 16-May-2022 8:00 AM EDT
Mount Sinai Receives Landmark Gift from Royalty Pharma to Advance Health Equity
Mount Sinai Health System

Marking a major advance in its efforts to achieve equity in the delivery of health care, the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) announced today that its Institute for Health Equity Research (IHER) has received a landmark $20 million gift over five years from Royalty Pharma plc (Nasdaq: RPRX) and certain members of its management team.

Newswise: Potentially Dangerous Synthetic Cooling Agents Are Used at High Levels in E-Cigarettes and Refillable Vaping Liquids
9-May-2022 4:00 PM EDT
Potentially Dangerous Synthetic Cooling Agents Are Used at High Levels in E-Cigarettes and Refillable Vaping Liquids
American Thoracic Society (ATS)

E-cigarette makers are adding potentially dangerous levels of the synthetic cooling agents WS-3 and WS-23 to disposable e-cigarettes and e-cigarette refills sold in the U.S., according to research published at the ATS 2022 international conference.

Newswise: Pharmacists at Higher Risk of Suicide than General Population, Study Finds
Released: 13-May-2022 5:05 PM EDT
Pharmacists at Higher Risk of Suicide than General Population, Study Finds
University of California San Diego Health

UC San Diego study shows suicide rates were higher in pharmacists than in the general population between 2003 and 2018, with job problems being the most significant feature associated with the suicides.

Released: 13-May-2022 3:55 PM EDT
Antibiotic use associated with inflammatory bowel disease in older adults
American Gastroenterological Association (AGA)

The more antibiotics prescribed to patients 60 and older, the more likely they were to develop inflammatory bowel disease, suggesting antibiotic use could explain some of the growth in Crohn’s disease and ulcerative colitis in older people, according to a review of 2.3 million patient records in a study selected for presentation at Digestive Disease Week® (DDW) 2022.

Released: 13-May-2022 12:25 PM EDT
Hospices vary widely in prescribing of “comfort kit” medications
Michigan Medicine - University of Michigan

Hospices often prescribe medicines like Xanax, Haldol and Seroquel to patients to ease end-of-life symptoms, but a new study shows very wide variation in the chances patients will get these drugs.

Newswise: Early Study Finds New Lymphoma Drug Effective
Released: 13-May-2022 10:50 AM EDT
Early Study Finds New Lymphoma Drug Effective
Michigan Medicine - University of Michigan

In early research led by the University of Michigan Health Rogel Cancer Center, the oral medication zanubrutinib was found to help most patients with a slow-growing type of cancer known as marginal zone lymphoma.

Released: 12-May-2022 3:30 PM EDT
Common steroids after ‘long Covid’ recovery may cut risk of death by up to 51%
Frontiers

Evidence continues to gather that ‘long Covid’, that is, continued negative health impacts months after apparent recovery from severe Covid-19, is an important risk for some patients.

Released: 12-May-2022 3:05 PM EDT
When unconscious, the brain is anything but "silent"
University of Basel

The cerebral cortex is thought to be the seat of conscious processing in the brain.

Newswise: Study Finds Nanomedicine Targeting Lymph Nodes Key to Triple Negative Breast Cancer Treatment
Released: 12-May-2022 1:05 PM EDT
Study Finds Nanomedicine Targeting Lymph Nodes Key to Triple Negative Breast Cancer Treatment
Michigan Medicine - University of Michigan

Research from the University of Michigan Rogel Cancer Center could provide a new approach to treating an aggressive form of breast cancer. A study led by Duxin Sun, Ph.D., found that targeting the immune microenvironment in lymph nodes and tumors simultaneously led to long-term tumor remission in mice models of metastatic triple negative breast cancer.

Newswise: First Mutation-Targeted Bladder Cancer Drug May Be Under-Used
Released: 12-May-2022 11:05 AM EDT
First Mutation-Targeted Bladder Cancer Drug May Be Under-Used
Perelman School of Medicine at the University of Pennsylvania

The first bladder cancer drug targeting a cancer-driving gene mutation has been used relatively little despite its clear efficacy in a clinical trial, suggests a JAMA Oncology study led by the University of Pennsylvania. Researchers analyzed a large, nationwide database of cancer cases and found that bladder cancer patients potentially eligible for erdafitinib (Balversa) treatment, fewer than half had a record of being tested for the relevant gene mutation. Of those who were tested and found to have the mutation, fewer than half received the treatment.

9-May-2022 10:25 AM EDT
Common steroids after ‘long Covid’ recovery may cut risk of death by up to 51%
Frontiers

Researchers show that severe inflammation during hospitalization for Covid-19 increases risk of death within one year from seeming recovery by 61%. This risk is mitigated if anti-inflammatory steroids are prescribed upon discharge. We need to think of Covid-19 as a potentially chronic disease that requires long-term management, argue the authors.

9-May-2022 12:45 PM EDT
Antidepressant Use During Pregnancy Not Linked to Epilepsy in Children
American Academy of Neurology (AAN)

A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies. The research is published in the May 11, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Newswise: New Oral Antiviral Drug Reduces Death in Early COVID-19
Released: 11-May-2022 8:30 AM EDT
New Oral Antiviral Drug Reduces Death in Early COVID-19
Florida Atlantic University

Researchers note that health care providers are now able to add to their armamentarium against COVID-19 their prescription of this new antiviral drug for high-risk, newly-infected patients as soon as possible following diagnosis or within five days of the onset of symptoms.

Newswise: Moffitt Researchers Identify Key Factors Impacting Adaptive Therapy
Released: 9-May-2022 11:25 AM EDT
Moffitt Researchers Identify Key Factors Impacting Adaptive Therapy
Moffitt Cancer Center

Researchers in the Center of Excellence for Evolutionary Therapy at Moffitt Cancer Center have been investigating an alternative treatment approach called adaptive therapy that focuses on maintaining disease control instead of complete tumor cell elimination. In a new study published in Communications Medicine, the researchers used mathematical modeling to reveal that the spatial organization of a tumor is an important factor that governs how cells compete with one another and the effectiveness of adaptive therapy.

Released: 6-May-2022 2:05 PM EDT
The newly released Pfizer documents do not show that their COVID-19 vaccine is unsafe
Newswise

Pfizer has NOT declared their COVID vaccines unsafe for pregnancy and breastfeeding women, despite misleading claims on social media, nor have they said that the real efficacy rate for their vaccine (COMIRNATY) is 12 percent.

Newswise: TTUHSC Names New Dean for the Jerry H. Hodge School of Pharmacy
Released: 6-May-2022 12:05 PM EDT
TTUHSC Names New Dean for the Jerry H. Hodge School of Pharmacy
Texas Tech University Health Sciences Center

Texas Tech University Health Sciences Center (TTUHSC) announced Grace Kuo, Ph.D., Pharm.D., has been named dean of the Jerry H. Hodge School of Pharmacy.

5-May-2022 7:00 AM EDT
Prescription Drug Spending per Covered Member Grew Much Faster in Individual Health Plans than Large Group Plans
Johns Hopkins University Carey Business School

Prescription drug spending per member covered—both before and after manufacturer rebates—grew much faster for those enrolled in individual health insurance plans compared to those enrolled in large group plans, according to new research.

Released: 6-May-2022 10:35 AM EDT
“Digital twins” – an aid to give individual patients the right treatment at the right time
Linkoping University

An international team of researchers have developed advanced computer models, or “digital twins”, of diseases, with the goal of improving diagnosis and treatment.

Released: 6-May-2022 9:55 AM EDT
May 2022 Toxicological Sciences Features Leading Research in Respiratory Hazards, Proteomics, and More
Society of Toxicology

The May 2022 issue of Toxicological Sciences, the Society of Toxicology’s official journal, is now available and features leading research in carcinogenesis, computational toxicology and databases, and more.

Released: 5-May-2022 2:45 PM EDT
Combining certain meds with ibuprofen can permanently injure kidneys
University of Waterloo

Anyone who is taking a diuretic and a renin-angiotensin system (RSA) inhibitor for high blood pressure should be cautious about also taking ibuprofen, according to new research.

Newswise: UCSF Names Kathy Giacomini Dean of Pharmacy School
Released: 5-May-2022 8:00 AM EDT
UCSF Names Kathy Giacomini Dean of Pharmacy School
University of California, San Francisco (UCSF)

Kathy Giacomini, PhD, a world-renowned scientist and leading expert on pharmacogenomics, has been appointed dean of the UCSF School of Pharmacy.

Newswise: The Medical Minute: A checklist for staying healthy overseas
Released: 4-May-2022 9:05 PM EDT
The Medical Minute: A checklist for staying healthy overseas
Penn State Health

While planning for an overseas adventure, it’s important to include a few key preventative measures to help keep you healthy during your travels, like getting the appropriate shots and packing the right medications.

Newswise: In-House Pharmacists Essential for Aged Care
Released: 4-May-2022 8:05 PM EDT
In-House Pharmacists Essential for Aged Care
University of South Australia

New research from the University of South Australia shows that regular visits from pharmacists to aged-care residents can reduce problems due to medicines and improve health outcomes.

Newswise: UAH collaboration creates self-learning AI platform to discover new drugs
Released: 4-May-2022 9:35 AM EDT
UAH collaboration creates self-learning AI platform to discover new drugs
University of Alabama Huntsville

A cross-college collaboration at The University of Alabama in Huntsville (UAH) has developed a self-learning artificial intelligence (AI) platform that uses big data analytics to discover how new pharmaceutical drugs and various molecules work inside living cells.

Released: 3-May-2022 8:05 AM EDT
Anti-bleeding drug is safe for 'high-risk' patients undergoing hip fracture surgery
Wolters Kluwer Health: Lippincott

Tranexamic acid (TXA) – a medication given to reduce the risk of bleeding during some orthopaedic surgical procedures – can be safely used in patients with intertrochanteric (IT) hip fractures who are at high risk of blood clot-related complications, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

Newswise: UTSW Study Finds New Pain Management Approach Reduced Opioid Use After C-Sections
Released: 2-May-2022 6:05 PM EDT
UTSW Study Finds New Pain Management Approach Reduced Opioid Use After C-Sections
UT Southwestern Medical Center

For years, women recovering from cesarean section (C-section) deliveries have been given devices that let them, with a button, control the flow of opioid painkillers into their IV line. But as researchers and policymakers push to curb the use of opioids, clinicians are developing new strategies for treating pain after C-sections.


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