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A widely used and inexpensive Type 2 diabetes drug, once hoped to hold enormous promise in treating breast cancer, does not prevent or stop the spread of the most common forms of the disease, according to new findings.
Naomi Matsuura, of the University of Toronto, and her team are adapting microbubbles to become more potent tools for cancer therapy. By shrinking the bubbles and directly loading them with anti-cancer drugs, the bubbles can lower the dose of free drug that is injected and diffuses into nontumor tissue in the body. This results in more targeted treatment and fewer side effects for the patient. Matsuura will discuss her team's results in her presentation, "Ultrasound-stimulated, drug-loaded bubbles for cancer therapy," as part of the 182nd Meeting of the Acoustical Society of America at the Sheraton Denver Downtown Hotel. The session will take place May 24 at 11:30 a.m. Eastern U.S.
Pain medicine practitioners should take measures to reduce the use of iodinated contrast medium in interventional pain procedures due to the current shortage of iohexol. Clinicians are advised to consider using alternate image guidance, such as ultrasound, delaying non-urgent procedures, and using alternative contrast agents, according to guidance just released by ASRA Pain Medicine.
The drug gabapentin, currently prescribed to control seizures and reduce nerve pain, may enhance recovery of movement after a stroke by helping neurons on the undamaged side of the brain take up the signaling work of lost cells, new research in mice suggests.
The bottom of the ocean is full of mysteries but scientists have recently uncovered one of its best-kept secrets. For 25 years, drug hunters have been searching for the source of a natural chemical that had shown promise in initial studies for treating cancer. Now, researchers at University of Utah Health report that easy-to-find soft corals make the elusive compound.
People with neurofibromatosis type 1 (NF1) develop tumors on nerves throughout their bodies. Researchers at Washington University School of Medicine in St. Louis have discovered that nerve cells with the mutation that causes NF1 are hyperexcitable and that suppressing this hyperactivity with the epilepsy drug lamotrigine stops tumor growth in mice.
Recent disruptions in a pharmaceutical supply chain have impacted the global availability of GE Healthcare Omnipaque™ iohexol iodinated contrast media (ICM) for radiologic examinations. A new Special Report published in the journal Radiology provides consensus recommendations for dealing with the shortage of ICM in the near term and discusses long-term issues and potential solutions to supply chain problems.
A commonly used blood pressure medication may help improve measures of frailty in prefrail older adults, according to a new study by researchers with UTHealth Houston.
The study was published in The Journals of Gerontology.
Two Rutgers engineers specializing in the process of making drugs derived from living organisms have created an analytical tool they expect will accelerate the discovery and production of biologic drugs that are often at the cutting edge of biomedical research.
Brensocatib did not improve the clinical status of patients hospitalized with severe SARS-CoV-2 infection in the double-blind randomized, placebo-controlled STOP-COVID19 multicenter clinical trial, according to research published at the ATS 2022 international conference.
A study by UC Davis and UC San Francisco identified multiple barriers that family physicians navigate to provide abortion services to their patients. The barriers include lack of physician training and federal, state and institutional restrictions on providing medication abortion.
Avacopan was better than prednisone in reducing respiratory as well as ear, nose and throat (ENT) involvement and enabled reduced glucocorticoid use in ANCA-associated vasculitis patients participating in the phase 3 ADVOCATE trial. Study results were published at the ATS 2022 international conference. The study was a subgroup analysis of results from the larger trial, which led to FDA approval of avacopan.
Vyriad, Inc., a clinical-stage biotechnology company developing oncolytic virus therapies to treat a wide range of cancers, today announced $29.5M in new funding led by Mr. Harry Stine of Stine Seed Farms, Inc.
A greater proportion of patients with severe, uncontrolled asthma had more significant clinical responses to tezepelumab than placebo, according to research published at the ATS 2022 international conference. The study showed that nearly half of those enrolled achieved complete response to treatment across measures of exacerbation reduction, asthma control, lung function, and clinician assessment.
People addicted and dependent on opioids who used buprenorphine not prescribed by a physician at the time they enter a treatment center are more likely to remain in treatment for opioid use disorder, according to a Rutgers study.
Marking a major advance in its efforts to achieve equity in the delivery of health care, the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) announced today that its Institute for Health Equity Research (IHER) has received a landmark $20 million gift over five years from Royalty Pharma plc (Nasdaq: RPRX) and certain members of its management team.
E-cigarette makers are adding potentially dangerous levels of the synthetic cooling agents WS-3 and WS-23 to disposable e-cigarettes and e-cigarette refills sold in the U.S., according to research published at the ATS 2022 international conference.
UC San Diego study shows suicide rates were higher in pharmacists than in the general population between 2003 and 2018, with job problems being the most significant feature associated with the suicides.
The more antibiotics prescribed to patients 60 and older, the more likely they were to develop inflammatory bowel disease, suggesting antibiotic use could explain some of the growth in Crohn’s disease and ulcerative colitis in older people, according to a review of 2.3 million patient records in a study selected for presentation at Digestive Disease Week® (DDW) 2022.
In early research led by the University of Michigan Health Rogel Cancer Center, the oral medication zanubrutinib was found to help most patients with a slow-growing type of cancer known as marginal zone lymphoma.
Research from the University of Michigan Rogel Cancer Center could provide a new approach to treating an aggressive form of breast cancer. A study led by Duxin Sun, Ph.D., found that targeting the immune microenvironment in lymph nodes and tumors simultaneously led to long-term tumor remission in mice models of metastatic triple negative breast cancer.
The first bladder cancer drug targeting a cancer-driving gene mutation has been used relatively little despite its clear efficacy in a clinical trial, suggests a JAMA Oncology study led by the University of Pennsylvania. Researchers analyzed a large, nationwide database of cancer cases and found that bladder cancer patients potentially eligible for erdafitinib (Balversa) treatment, fewer than half had a record of being tested for the relevant gene mutation. Of those who were tested and found to have the mutation, fewer than half received the treatment.
Researchers show that severe inflammation during hospitalization for Covid-19 increases risk of death within one year from seeming recovery by 61%. This risk is mitigated if anti-inflammatory steroids are prescribed upon discharge. We need to think of Covid-19 as a potentially chronic disease that requires long-term management, argue the authors.
A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies. The research is published in the May 11, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Researchers note that health care providers are now able to add to their armamentarium against COVID-19 their prescription of this new antiviral drug for high-risk, newly-infected patients as soon as possible following diagnosis or within five days of the onset of symptoms.
Researchers in the Center of Excellence for Evolutionary Therapy at Moffitt Cancer Center have been investigating an alternative treatment approach called adaptive therapy that focuses on maintaining disease control instead of complete tumor cell elimination. In a new study published in Communications Medicine, the researchers used mathematical modeling to reveal that the spatial organization of a tumor is an important factor that governs how cells compete with one another and the effectiveness of adaptive therapy.
Pfizer has NOT declared their COVID vaccines unsafe for pregnancy and breastfeeding women, despite misleading claims on social media, nor have they said that the real efficacy rate for their vaccine (COMIRNATY) is 12 percent.
Prescription drug spending per member covered—both before and after manufacturer rebates—grew much faster for those enrolled in individual health insurance plans compared to those enrolled in large group plans, according to new research.
The May 2022 issue of Toxicological Sciences, the Society of Toxicology’s official journal, is now available and features leading research in carcinogenesis, computational toxicology and databases, and more.
While planning for an overseas adventure, it’s important to include a few key preventative measures to help keep you healthy during your travels, like getting the appropriate shots and packing the right medications.
A cross-college collaboration at The University of Alabama in Huntsville (UAH) has developed a self-learning artificial intelligence (AI) platform that uses big data analytics to discover how new pharmaceutical drugs and various molecules work inside living cells.
Tranexamic acid (TXA) – a medication given to reduce the risk of bleeding during some orthopaedic surgical procedures – can be safely used in patients with intertrochanteric (IT) hip fractures who are at high risk of blood clot-related complications, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
For years, women recovering from cesarean section (C-section) deliveries have been given devices that let them, with a button, control the flow of opioid painkillers into their IV line. But as researchers and policymakers push to curb the use of opioids, clinicians are developing new strategies for treating pain after C-sections.