Heavy alcohol use creates a vicious cycle: It changes signaling pathways in the brain, which in turn affects cognitive functions like decision-making and impulse control — and makes the individual more likely to drink. The mechanism behind this may involve the brain’s immune system, according to new research from Binghamton University, State University of New York.
Overdose mortality among people age 65 and older quadrupled over 20 years, suggesting the need for greater mental health and substance use disorder policies addressed at curbing the trend.
The American Society of Anesthesiologists (ASA) urges the public to help fight the opioid epidemic by learning to recognize and respond to an overdose. This includes understanding how to use naloxone, a life-saving medication approved today for sale over the counter by the U.S. Food and Drug Administration.
Recordings of media briefings will be posted by 10 a.m. Eastern Time on each day. Watch recorded media briefings at: www.acs.org/ACSSpring2023briefings.
Rates of prescriptions for naloxone to people at high risk for opioid overdose, as well as co-prescribing with opioids, has increased in emergency departments throughout the United States over the past decade, providing insight on the positive impact of federal policies and regulations, according to a Rutgers study.
There is new evidence that fibromyalgia, and the chronic pain associated with it, could worsen opioid use disorder. Researchers at The Ohio State University Wexner Medical Center, College of Medicine and University of Michigan report their findings in the journal PAIN.
Tammy Chung, director of the Center for Population Behavioral Health at Rutgers Institute for Health, explains cannabis use disorder and the challenges of diagnosing the disorder in the context of cannabis used for therapeutic purposes.
Countries must intensify efforts to track HIV and hepatitis C virus (HCV) incidence among people who inject drugs, and to prioritise this group in prevention and elimination work, according to new University of Bristol-led research, published online in The Lancet Gastroenterology & Hepatology.
Naloxone can reverse potentially fatal overdoses, but it’s less effective against powerful fentanyl. To develop alternatives, researchers are looking to a component of marijuana, CBD. They will present their results at ACS Spring 2023.
New research from Boston Medical Center found that substance use disorders do not increase the likelihood of dying from COVID-19. Published in Substance Abuse: Research and Treatment, the study showed that the increased risk for severe COVID-19 in people with SUD that has been seen may be the result of co-occurring medical conditions.
A statewide effort to treat the pain of surgery patients without increasing their risk of long-term dependence on opioids has paid off in Michigan, a study shows.
A study led by a team of computer scientists at Stony Brook University and published in Nature Digital Medicine presents a unique approach using artificial intelligence (AI) and social media posts to predict opioid mortality rates. The findings revealed that an AI algorithm that was able to surprisingly predict opioid death rates going back to previous years and actual rates.
New research led by Washington University School of Medicine in St. Louis identifies a common genetic signature that may increase a person's risk of developing substance use disorders. The work eventually could lead to universal therapies to treat multiple substance use disorders and potentially help people diagnosed with more than one.
A new study from Boston University Chobanian & Avedisian School of Medicine has found that a brief stigma intervention that specifically targets people with HIV who inject drugs was effective in increasing engagement in substance use care as well as improving their ART adherence.
Recently incarcerated people with opioid use disorder have trust in working with peer support specialists who recovered from addiction and faced similar life experiences, according to a Rutgers study.
Anthony DiStefano, professor of public health at Cal State Fullerton, believes that the sudden social isolation that occurred during the COVID-19 pandemic had an influence on mental health and drug overdose deaths.
It's sleep awareness week, according to the National Sleep Foundation. It’s important to understand how sleep deprivation can impact your health. Most people recognize that if they don’t get enough sleep, their mood and memory will suffer the next day.
People living in the United States must travel significantly farther to access methadone treatment for opioid addiction than Canadians, suggests a new study led by Washington State University researchers.
For some people receiving methadone for treatment of opioid use disorder (OUD), the co-use of opioids and stimulants such as cocaine is an issue. Now, a new study led by Johns Hopkins Medicine researchers found that bupropion, an antidepressant medication also used for smoking cessation, may help people stop using cocaine while in treatment for OUD.
Investigators have developed a fast, point-of-care molecular diagnostic test that identifies a subset of individuals who are most likely to benefit from hypnosis interventions for pain treatment.
The COVID-19 pandemic has had a long-lasting impact on adolescent mental health and substance use according to a new population-based study are based on survey responses from a nationwide sample of over 64,000 13–18-year-old North American and Icelandic adolescents assessed prior to and up to two years into the pandemic.
Opioids are commonly prescribed to patients that are discharged after a total knee and hip arthroplasty. Patients are typically given larger prescriptions of opioids that can result in an excess of the medication in their home after recovery is over.
New findings expand on previous research suggesting that Black newborns are more likely to be screened for prenatal drug exposure compared to other racial and ethnic groups, even in the absence of risk factors for substance use disorders.
A United States Food and Drug Administration mandate to limit the dosage of acetaminophen in pills that combine acetaminophen and opioid medications is significantly associated with subsequent reductions in serious liver injury.
Over the past 20 years, the death rate from drug poisonings in the U.S. has tripled and suicide and alcoholic liver disease death rates have increased by 30 percent — particularly among middle-aged white Americans. Daniel Hungerman, professor of economics at the University of Notre Dame, and his co-authors studied the connection between a sharp downturn of religious participation in the late 1980s and the swift rise in these "deaths of despair" among white Americans ages 45 to 54 in the early 1990s.
Adults with Alcohol Use Disorder (AUD) seeking to moderate their drinking respond differently to interventions depending on their age, a new study suggests.
Recommendations from research published today on the diagnosis and treatment of spinal cord damage caused by nitrous oxide abuse have been simultaneously adopted as official clinical practice guidelines by the Association of British Neurologists.
For men undergoing surgery to repair scarring in the urethra (urethroplasty), a new approach to pain management can reduce the need for strong opioid drugs without compromising pain control, reports a study in Urology Practice®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Prazosin, a medication FDA-approved for hypertension and used off-label for alcohol use disorder, may help prevent drinking relapse in people with cardiovascular or behavioral symptoms of alcohol withdrawal, according to a new study involving active-duty soldiers.
As cocaine use continues to climb across the United States, scientists have struggled to develop an effective pharmacological approach to treat the devastating disorder. But by seamlessly combining artificial intelligence (AI), human intelligence, clinical testing and computer analysis, researchers at Case Western Reserve University have unearthed an existing option that appears to hold promise.
The U.S. methamphetamine mortality rate increased fiftyfold between 1999 and 2021, with most of the added deaths also involving heroin or fentanyl, researchers report in the American Journal of Public Health.
ROCKVILLE, MD – Approximately three million Americans suffer from opioid use disorder, and every year more than 80,000 Americans die from overdoses. Opioid drugs, such as heroin, fentanyl, oxycodone and morphine, activate opioid receptors. Activating mu-opioid receptors leads to pain relief and euphoria, but also physical dependence and decreased breathing, the latter leading to death in the case of drug overdose.
In a letter to the U.S. Food and Drug Administration (FDA), the American Society of Anesthesiologists (ASA) expressed its strong support of naloxone nasal spray products for non-prescription use. Naloxone, a safe life-saving medication that rapidly reverses an opioid overdose and significantly reduces the incidence of opioid overdose deaths, should be available to all patients across the United States as a nonprescription treatment, according to the ASA.
Naloxone is an opioid receptor antagonist that rapidly reverses or blocks the effects of opioids, restores normal respiration and heart rhythm, and reverses the potentially fatal effects of an overdose. Although naloxone is included in U.S. CDC recommendations, the drug is currently prescribed to less than 1 in 70 patients prescribed high-dose opioid prescriptions. Researchers propose a call to action for all health providers and state medical societies to ensure the widest distribution and easy availability of naloxone, including over the counter, which is likely to be FDA-approved very soon.
A new study finds evidence from the DNA methylome that the biological age – different from the chronological age – of cells in Brodmann Area 9 of the prefrontal cortex might be greater in people with cocaine use disorder. This suggests that cocaine abuse makes these cells age faster according to the ‘epigenetic clock’. The authors also find differences in methylation in 20 genes, mainly involved in regulation of the activity of neurons and their connectivity. This post-mortem study is one of the first to directly look at the methylome of brain cells in human donors with cocaine use disorder, rather than in rodents.