Feature Channels: Transplantation

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Here are some of the latest articles that have been added to the Drugs and drug abuse channel.

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UC San Diego Health is now offering a new treatment for patients with low-grade upper tract urothelial cancer that could safely avoid removal of the entire kidney, which may prevent the need for dialysis or kidney transplant in the future.

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There is a small, but growing, subset of livers that have been transplanted and have a cumulative age of more than 100 years.

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Antonia “Toni” Perez is one in a million. She’s one of 1 million patients in the U.S. who have received an organ transplant, a milestone the nation celebrated last month.

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Keki R. Balsara, MD, MBA, has been appointed surgical director of Heart Failure and Transplantation at MedStar Heart & Vascular Institute. Dr. Balsara, a renowned cardiothoracic surgeon, will lead the heart transplantation and mechanical circulatory support programs based at MedStar Washington Hospital Center in Washington, D.C.

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In the six decades since blood and marrow transplantation was used to treat patients with blood cancers, this once experimental treatment has become a vital cancer-fighting tool. Mayo Clinic in Rochester, Minnesota, is celebrating the 10,000th blood and marrow transplant used in the treatment of blood cancers and related disorders.

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The University of Chicago Medicine's heart transplant program is making history once again. The program's transplant survival rates and transplant wait times are not only the best in the country, but they're the best in the history of heart transplantation, according to an analysis of Scientific Registry of Transplant Recipients (SRTR) data.

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Researchers at The University of Texas MD Anderson Cancer Center have identified a specific gut bacterium involved in the progression of graft-versus-host disease (GVHD) after antibiotic treatment of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and discovered that nutritional supplementation can prevent antibiotic-induced GVHD in preclinical models, according to a study published today in Cell.

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Today, advocates of the American Society of Nephrology (ASN) and 21 other kidney health professional and patient organizations are meeting with their congressional delegations, calling on them to protect living donors and improve access to transplantation

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In an analysis from The Netherlands, the proportion of employed stable kidney transplant recipients was 56%.

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New advances around perfusion devices are changing the game by keeping transplant livers alive longer, allowing for transportation of longer distances. New technology also enhances marginal donor livers, keeping them stimulated and alive longer, and therefore making many more livers available for transplantation. This in-person conference will provide groundbreaking insights on the technology and techniques around the use of preservation devices and examine the different strategies for successful perfusion/preservation of donor livers.

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New clinical equations that estimate individuals’ kidney function have eliminated an adjustment for Black race. This study examined the impact of using these new race-free equations on the accumulation of waiting time for kidney transplantation before a patient needs dialysis.

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After a rare disease caused organ failure, UC San Diego Heath transplant teams performed a heart, liver and kidney transplant on a patient. The surgery is a first for UC San Diego Health and a first in the nation to use three organs from a donor after circulatory death.

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The latest research and expert commentary on pain management.

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UHN’s Ajmera Transplant Centre and The Centre for Living Organ Donation announce today the launch of a new campaign, Great Actions Leave a Mark, www.greatactions.ca. The campaign showcases through artistic photos and video, the stories and scars (the mark) from 39 living organ donors and transplant recipients across Canada.

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Children's Hospital Los Angeles is hosting the 26th annual meeting of the Society of Pediatric Liver Transplantation, a multidisciplinary, multicenter consortium focused on optimizing outcomes in pediatric liver transplantation through research, advocacy and dissemination of best practices in the field.

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A Roundup of the Latest Medical Discoveries and Faculty News at Cedars-Sinai

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Kidney transplant recipients experience immune-insufficiency during acute COVID-19.

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The latest research and expert commentary on the monkeypox outbreak.

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In a choice-based study of patients who were waiting for or had received a kidney transplant, the average respondent would accept a kidney today with 6.5 years of expected survival of the transplanted organ to avoid waiting 2 additional years for a kidney with 11 years of expected survival.

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New medication now available at UC San Diego Health allows for less frequent visits for patients, helping improve quality of life.

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Hospital is one of only five in the U.S. selected to participate in early clinical trial for the minimally invasive Impella BTR technology

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Do pediatric kidney transplant patients have better long-term outcomes when their kidney comes from living, biologically unrelated donors compared to deceased donors? A new UC Davis Health study published in the journal Pediatric Transplantation finds that they do.

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Solid organ transplants — heart, lung, liver, and kidney — are resource-intensive operations that require patients to take immunosuppressive drugs after the procedure to keep the body from rejecting the new organ.

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A new report on lung transplantation success rates confirms that Cedars-Sinai patients experienced one-year survival outcomes of 91.49%, an achievement above the national average of 89.46%.

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Researchers and entrepreneurs have developed an implant made of collagen protein from pig’s skin, which resembles the human cornea.

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The August issue of The American Journal of Gastroenterology highlights new clinical science, including a brand new ACG clinical guideline for the diagnosis and treatment of patients with gastroparesis.

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Experts are hoping a new requirement that all U.S. transplant centers use a race-neutral formula to determine eligibility for a kidney transplant will improve African American access to lifesaving transplants.

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The American Society of Nephrology (ASN) supports efforts by Congress to improve the US transplant system. Today, the Senate Finance Committee will conduct an oversight hearing, A System in Need of Repair: Addressing Organizational Failures of the U.S.’s Organ Procurement and Transplantation Network (OPTN).

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Black people and women with severe heart failure who might be good candidates for surgery to implant a heart-assisting device have a lower chance of actually getting that operation than white patients, or male patients, a new study finds.

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Here are some of the latest articles that have been added to the Drug Resistance channel on Newswise, a free source for journalists.

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A Roundup of the Latest Medical Discoveries and Faculty News at Cedars-Sinai

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Physicians and researchers from UK HealthCare's Transplant Center and the University of Kentucky Markey Cancer Center conducted a study of patients over the age of 70 with a type of liver cancer called hepatocellular carcinoma (HCC) and how the outcomes of ablative treatments compare to liver transplants. The findings were published in the May 2022 issue of the Journal of the American College of Surgeons.

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• Kidney transplant recipients typically take the immunosuppressant drug tacrolimus to prevent rejection, and some patients experience large fluctuations in blood levels of tacrolimus even when the dose is unchanged. • In a recent study, pediatric kidney transplant recipients with such variability had higher risks of developing antibodies against the transplanted kidney, putting them at risk of rejection.

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The Organ Transplantation Division at Hackensack Meridian Hackensack University Medical Center, one of only a few certified transplant centers in New Jersey, is bringing its world-class services to satellite locations in the central and southern regions of New Jersey. Consultations, testing and follow up care of transplants are now available at Jersey Shore University Medical Center in Neptune and JFK University Medical Center in Edison.

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Adding immunotherapy to standard anti-rejection medication could change the lives of thousands of kidney transplant patients with incurable cancer, as new research shows it can reduce this risk of organ rejection and eliminate cancer in a quarter of patients.

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No more packing donor lungs on ice. UChicago Medicine is deploying a new ice-free, temperature-controlled cold storage cooler to transport donor lungs.

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Cleveland Clinic has successfully performed a first-in-the-world full multi-organ transplant to treat a patient with a rare form of appendix cancer called pseudomyxoma peritonei (PMP). Upon completion of the lifesaving transplant surgery, the patient received five digestive organs.

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Six months ago, University of Maryland School of Medicine surgeon-scientists successfully implanted a genetically modified pig heart into a 57 year-old patient with terminal heart disease in a first-of-its-kind surgery.

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“The potential for xenotransplantation to allow for an unlimited donor supply and resolve the organ shortage is now closer than ever,” according to a new paper published today in JACC: Basic to Translational Science.

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Two physician leaders from the Cedars-Sinai Comprehensive Transplant Center have been honored by two prestigious national groups.

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While many 21-year-olds celebrate their coming of age in bars and nightclubs, Andrew Solis is celebrating freedom by finally going home—equipped with a new heart and liver—after nearly eight months at Cedars-Sinai.

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UC San Francisco’s Cardiovascular team is welcoming two highly regarded cardiac surgeons to its renowned program. The specialists will join the newly formed Advanced Heart Failure Comprehensive Care Center (AHF CCC).