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Cystic Fibrosis, Precision Medicine

New Simple Test Could Help Cystic Fibrosis Patients Find Best Treatment


While new CF drugs are life-changing for some patients, they don’t work for everyone. Now, UNC and UAB researchers present a simple test that aims to predict which treatment is most likely to work for each patient, an approach known as personalized or precision medicine.



Cancer, Head And Neck Cancer, Metastasis, Breast Cancer, Prostate Cancer, Lung Cancer


A reporter's PressPass is required to access this story until the embargo expires on 30-Nov-2017 12:00 PM EST



Cystic Fibrosis, Microbiome, Bacteria

Study Describes the Good and Bad Lung Bacteria in Cystic Fibrosis Patients


A large multicenter study found that patients with cystic fibrosis (CF) – who tend to develop chronic lung infections – had more good and bad bacteria in their lungs compared to controls. The study used bronchoalveolar lavage, in which a bronchoscope is directed into the lung to directly collect lung secretions, and also found less diversity of bacteria in the lungs of CF patients who were older and had more lung disease or inflammation. Results, published in the European Respiratory Journal, provide a basis for future treatment studies.



Nasal Spray, Sinus, Drug Delivery, fluid pathways, sinus paths, nasal cavities, Fluid Dynamics, Saikat Basu, Zainab Farzal, Julia S. Kimbell, University Of North Carolina, Division of Fluid Dynamics, DFD, American Physical Society, APS

'Magic' Sinus Paths Could Mean New Instructions for Nasal Sprays


Sinus infections, inflammation and nasal congestion constantly plague Americans, often leading to unpleasant symptoms and even missed days of work. Traditional nasal spray anti-inflammatory medications attempt to treat the symptoms noninvasively, but are not very efficient in transmitting the active drug ingredients directly into the sinus cavities. Researchers from the University of North Carolina will present their research on the anatomy-based flow physics in nasal cavities which generate “magical” streamlines for sinus drug delivery at the 70th meeting of the Division of Fluid Dynamics, Nov. 19-21, 2017.



Cystic Fibrosis

A New Test to Measure the Effectiveness of CF Drugs

UNC School of Medicine researchers have developed a new laboratory model to measure and compare the responses of CF and normal airway cells to CF-related infectious/inflammatory factors.



Clinical Guidelines, Lung Disease, rare lung diseases, lymphangioleiomyomatosis , Pulmonary

New Guidelines Issued for Diagnosis and Care of LAM, a Rare Lung Disease


The American Thoracic Society (ATS) and the Japanese Respiratory Society (JRS) have published additional clinical practice guidelines regarding four specific questions related to the diagnosis of lymphangioleiomyomatosis (LAM) and management of pneumothoraces in patients with LAM.



Law and Public Policy


Tobacco, Cigarettes, Big Tobbaco, tobacco addiction, tobacco advertising, Smoking and children, smoking and health, Lung Cancer, Tobacco and youth, Flavored, Smoking and cancer, Smoking Cessation

Editorial: Use Big Tobacco’s Nov 26 Corrective Statements to Reduce Smoking


The court-ordered publication of “corrective statements” by major U.S. tobacco companies later this month should serve as a reminder that tobacco addiction remains a major health problem in the country and that Big Tobacco has a long history of marketing practices aimed at hooking a new generation on a lethal product, according to an editorial published online in the Annals of the American Thoracic Society.



COPD, Lung Transplant, BODE

Study: Process Used to Select Lung Transplant Patients May Need to Be Changed


New research from the University of Maryland School of Medicine suggests that the system for choosing transplant recipients in chronic obstructive pulmonary disease (COPD) may underestimate how long a person might survive without a lung transplant and therefore, may mislead clinicians.



Deadly Lung Cancers Are Driven by Multiple Genetic Changes


A new UC San Francisco–led study challenges the dogma in oncology that most cancers are caused by one dominant “driver” mutation that can be treated in isolation with a single targeted drug.



Cancer, Cornell University, Testicular Cancer, Chemotherapy, Medicine, Embryos

This Is Why Testicular Cancer Is So Responsive to Chemo


Cornell researchers have taken a major step toward answering a key question in cancer research: Why is testicular cancer so responsive to chemotherapy, even after it metastasizes?

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