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Journal of Experimental Medicine

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  • Embargo expired:
    16-May-2019 9:00 AM EDT

Article ID: 712629

Antibiotic treatment alleviates Alzheimer’s disease symptoms in male mice, study reveals

The Rockefeller University Press

Researchers at The University of Chicago have demonstrated that the type of bacteria living in the gut can influence the development of Alzheimer’s disease symptoms in mice. The study, which will be published May 16 in the Journal of Experimental Medicine, shows that, by altering the gut microbiome, long-term antibiotic treatment reduces inflammation and slows the growth of amyloid plaques in the brains of male mice, though the same treatment has no effect on female animals.

Released:
13-May-2019 9:00 AM EDT
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Article ID: 712434

Obesity reprograms immune cells in breasts to promote tumor formation

University of Chicago Medical Center

Macrophages in adipose tissue (fat) link obesity to triple-negative breast cancer. Instead of fighting breast cancer, these immune cells actually promote it.

Released:
6-May-2019 1:05 PM EDT
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  • Embargo expired:
    8-Apr-2019 9:00 AM EDT

Article ID: 710761

Researchers identify early indicators of pregnancy complications in lupus patients

The Rockefeller University Press

A study of pregnant women with systemic lupus erythematosus has identified early changes in the RNA molecules present in the blood that could be used to determine the likelihood of them developing preeclampsia. The study, which will be published April 8 in the Journal of Experimental Medicine, may also help researchers develop treatments to prevent other pregnancy complications associated with lupus, including miscarriage and premature birth.

Released:
4-Apr-2019 10:05 AM EDT
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  • Embargo expired:
    3-Apr-2019 9:00 AM EDT

Article ID: 710311

Researchers discover why men are more likely to develop liver cancer

The Rockefeller University Press

Researchers in Spain have discovered that a hormone secreted by fat cells that is present at higher levels in women can stop liver cells from becoming cancerous. The study, which will be published April 3 in the ournal of Experimental Medicine, helps explain why hepatocellular carcinoma (HCC) is more common in men, and could lead to new treatments for the disease, which is the fourth leading cause of cancer-related death worldwide.

Released:
27-Mar-2019 11:05 AM EDT
  • Embargo expired:
    1-Apr-2019 9:00 AM EDT

Article ID: 710110

Researchers Discover How Tumor-Killing Immune Cells Attack Lymphomas in Living Mice

The Rockefeller University Press

In a study that will be published April 1 in the Journal of Experimental Medicine, researchers from the Institut Pasteur and INSERM reveal that chimeric antigen receptor (CAR) T cells can induce tumor regression by directly targeting and killing cancer cells, uncovering new details of how these immune cells work and how their effectiveness could be improved in the treatment of non-Hodgkin’s lymphoma and other B cell cancers.

Released:
25-Mar-2019 9:00 AM EDT
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  • Embargo expired:
    19-Mar-2019 9:00 AM EDT

Article ID: 709614

Epigenetic protein could be new therapeutic target in acute myeloid leukemia, study suggests

The Rockefeller University Press

British researchers have discovered that an epigenetic protein called EZH2 delays the development of acute myeloid leukemia (AML) but then switches sides once the disease is established to help maintain tumor growth. The study, which will be published March 19 in the Journal of Experimental Medicine, suggests that targeting EZH2 could therefore be an effective treatment for AML, an aggressive blood cancer expected to kill over 10,000 people in the US alone this year.

Released:
14-Mar-2019 8:05 AM EDT
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  • Embargo expired:
    12-Feb-2019 9:00 AM EST

Article ID: 707611

German Researchers Discover How Sleep Can Fight an Infection

The Rockefeller University Press

Researchers in Germany have discovered why sleep can sometimes be the best medicine. Sleep improves the potential ability of some of the body’s immune cells to attach to their targets, according to a new study that will be published February 12 in the Journal of Experimental Medicine. The study, led by Stoyan Dimitrov and Luciana Besedovsky at the University of Tübingen, helps explain how sleep can fight off an infection, whereas other conditions, such as chronic stress, can make the body more susceptible to illness.

Released:
6-Feb-2019 9:00 AM EST
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  • Embargo expired:
    8-Feb-2019 9:00 AM EST

Article ID: 707450

Researchers develop human cell-based model to study small cell lung cancer

The Rockefeller University Press

Researchers from Weill Cornell Medicine have used human embryonic stem cells to create a new model system that allows them to study the initiation and progression of small cell lung cancer (SCLC). The study, which will be published February 8 in the Journal of Experimental Medicine, reveals the distinct roles played by two critical tumor suppressor genes that are commonly mutated in these highly lethal cancers.

Released:
4-Feb-2019 9:35 AM EST
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  • Embargo expired:
    25-Jan-2019 9:00 AM EST

Article ID: 706830

Study Suggests Aspirin May Help Some Patients Survive Head and Neck Cancer

The Rockefeller University Press

Regular use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) may help some patients with head and neck cancer survive the disease, according to a study led by Professor Jennifer Grandis at the University of California, San Francisco. The study, which will be published January 25 in the Journal of Experimental Medicine, indicates that NSAIDs are effective in patients with mutations in a gene called PIK3CA, likely by lowering the levels of an inflammatory molecule called prostaglandin E2.

Released:
22-Jan-2019 9:50 AM EST
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  • Embargo expired:
    25-Jan-2019 9:00 AM EST

Article ID: 706876

Anti-flu antibodies can inhibit two different viral proteins, NIH study reveals

The Rockefeller University Press

Researchers from the National Institutes of Health have discovered that antibodies that may form the basis of a universal flu vaccine inhibit a second viral protein in addition to the one that they bind. The study, to be published January 25 in the Journal of Experimental Medicine, reveals that antibodies that recognize the viral surface protein hemagglutinin can also inhibit the viral neuraminidase, and that this enhances antibody neutralization of the virus and the activation of innate immune cells with anti-viral activity.

Released:
22-Jan-2019 2:05 PM EST

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