Press "esc" to clear
Go to Advanced Search

Showing results

110 of 73
Cardinezetal.jpg
  • Embargo expired:
    18-Oct-2018 9:00 AM EDT

Article ID: 702172

Researchers Describe Novel Immune Syndrome

The Rockefeller University Press

Researchers from Australia and Japan have discovered a new human immunodeficiency syndrome in two patients on separate continents. The study, which will be published October 18 in the Journal of Experimental Medicine, reveals that a mutation in a gene called IKBKB disrupts the immune system, leading to excessive inflammation and the loss of both T and B white blood cells.

Released:
15-Oct-2018 9:45 AM EDT
Wongetal2018.large.jpg

Article ID: 701162

T Cells in the Urine of Bladder Cancer Patients Reflect Tumor Environment

The Rockefeller University Press

Scientists in the UK have shown for the first time that immune cells in the urine of bladder cancer patients accurately reflect those in the tumor environment, according to the study “Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment,” by Wong et al., published today in the Journal of Experimental Medicine.

Released:
26-Sep-2018 12:05 PM EDT
Nestoretal.jpg
  • Embargo expired:
    5-Sep-2018 9:00 AM EDT

Article ID: 699905

Hypertension Drugs Could Prevent Memory Loss in Lupus Patients, Study Suggests

The Rockefeller University Press

Researchers from The Feinstein Institute for Medical Research have discovered that the activation of brain cells called microglia likely contributes to the memory loss and other cognitive impairments suffered by many patients with systemic lupus erythematosus (SLE). The study, which will be published September 5 in the Journal of Experimental Medicine, shows that ACE inhibitors—a class of drugs commonly used to treat hypertension—can block this process in mice and might therefore be used to preserve the memory of lupus patients.

Released:
4-Sep-2018 8:05 AM EDT
Chakrabartyetal.jpg
  • Embargo expired:
    29-Aug-2018 9:00 AM EDT

Article ID: 699337

Researchers Identify New Potential Biotherapy for Alzheimer’s Disease

The Rockefeller University Press

Researchers at the University of Florida have discovered that a modified version of an important immune cell protein could be used to treat Alzheimer’s disease. The study, which will be published August 29 in the Journal of Experimental Medicine, reveals that soluble versions of a protein called TLR5 can reduce the buildup of amyloid plaques in the brains of Alzheimer’s disease model mice and prevent the toxic peptide that forms these plaques from killing neurons.

Released:
22-Aug-2018 9:50 AM EDT
caron_cell_2018.jpg
  • Embargo expired:
    16-Aug-2018 9:00 AM EDT

Article ID: 699041

Researchers Reveal Miscarriage Cause, Key Cellular Targets of Potential Drugs

University of North Carolina Health Care System

Researchers discovered a gene mutation underlying hydrops fetalis – a fatal condition to fetuses. The proteins at the center of this finding are implicated in a number of diseases, opening avenues of potential drug discovery related to migraines, diabetes, osteoporosis, and other conditions.

Released:
15-Aug-2018 1:05 PM EDT
Nakajimaetal_Colitis.jpg
  • Embargo expired:
    24-Jul-2018 9:00 AM EDT

Article ID: 697514

Host Antibodies Shape Gut Microbiome by Changing Bacteria Gene Expression

The Rockefeller University Press

Researchers at the RIKEN Center for Integrative Medical Science in Japan have discovered how antibodies secreted in the gut promote the growth of beneficial bacteria. Their study, which will be published July 24 in the Journal of Experimental Medicine, shows that immunoglobulin A (IgA) antibodies can alter the expression of bacterial genes, allowing different bacterial species to cooperate with each other and form a community that can protect the body from disease.

Released:
17-Jul-2018 10:50 AM EDT
RS20254_Laurie_Harrington_Horiz-scr_edited.jpg

Article ID: 696660

Immune Cells That Create and Sustain Chronic Inflammatory Bowel Disease Identified

University of Alabama at Birmingham

In preclinical experiments, Laurie Harrington and colleagues have discovered a subset of immune cells that create and sustain chronic inflammatory bowel disease. These cells could become potential therapeutic targets to ameliorate or cure Crohn’s disease and ulcerative colitis.

Released:
26-Jun-2018 2:05 PM EDT
Norrisetal.jpg
  • Embargo expired:
    25-Jun-2018 9:00 AM EDT

Article ID: 696245

Researchers Identify Brain Cells Responsible for Removing Damaged Neurons After Injury

The Rockefeller University Press

Researchers at the University of Virginia School of Medicine have discovered that microglia, specialized immune cells in the brain, play a key role in clearing dead material after brain injury. The study, which will be published June 25 in the Journal of Experimental Medicine, reveals that microglia gobble up the remnants of injured neurons, which could prevent the damage from spreading to neighboring neurons and causing more extensive neurodegeneration.

Released:
19-Jun-2018 9:00 AM EDT
Mitchelletal_horizontal.jpg
  • Embargo expired:
    17-May-2018 9:00 AM EDT

Article ID: 694507

Single Surface Protein Boosts Multiple Oncogenic Pathways in Acute Myeloid Leukemia, Study Reveals

The Rockefeller University Press

Researchers from the Albert Einstein College of Medicine in New York have discovered that a signaling protein elevated in patients with acute myeloid leukemia (AML) plays a much wider role in the disease than previously thought. The study, which will be published May 17 in the Journal of Experimental Medicine, raises hopes that current efforts to target this signaling protein could be a successful strategy to treat AML and other blood cancers.

Released:
14-May-2018 10:05 AM EDT
Schmidt1.jpg
  • Embargo expired:
    16-May-2018 9:00 AM EDT

Article ID: 694259

Cell Type Switch Helps Colon Cancer Evade Treatment, Study Suggests

The Rockefeller University Press

Researchers in Germany have discovered that colon cancers are often resistant to existing drug treatments because they are composed of two different cell types that can replace each other when one cell type is killed. The study, which will be published May 16 in the Journal of Experimental Medicine, suggests that combination therapies targeting both cell types at once may be more effective at treating colorectal cancer, the third highest cause of cancer-related death in the United States.

Released:
9-May-2018 9:05 AM EDT

Showing results

110 of 73

Chat now!