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Embargo will expire:
19-Dec-2018 9:00 AM EST
Released to reporters:
12-Dec-2018 10:05 AM EST

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Article ID: 704971

Tuberculosis survives by using host system against itself

University of Notre Dame

In a new study published in the Journal of Experimental Medicine, scientists at the University of Notre Dame have discovered that the pathogen Mycobacterium tuberculosis (MTB) releases RNA into infected cells.

Released:
5-Dec-2018 12:05 PM EST
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  • Embargo expired:
    23-Nov-2018 9:00 AM EST

Article ID: 704067

Breast Cancers Enhance Their Growth by Recruiting Cells From Bone Marrow

The Rockefeller University Press

Researchers in Israel have discovered that breast tumors can boost their growth by recruiting stromal cells originally formed in the bone marrow. The study, which will be published November 23 in the Journal of Experimental Medicine, reveals that the recruitment of bone marrow–derived fibroblasts lowers the odds of surviving breast cancer, but suggests that targeting these cells could be an effective way of treating the disease.

Released:
15-Nov-2018 10:05 AM EST
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  • Embargo expired:
    18-Oct-2018 9:00 AM EDT

Article ID: 702172

Researchers Describe Novel Immune Syndrome

The Rockefeller University Press

Researchers from Australia and Japan have discovered a new human immunodeficiency syndrome in two patients on separate continents. The study, which will be published October 18 in the Journal of Experimental Medicine, reveals that a mutation in a gene called IKBKB disrupts the immune system, leading to excessive inflammation and the loss of both T and B white blood cells.

Released:
15-Oct-2018 9:45 AM EDT
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Article ID: 701162

T Cells in the Urine of Bladder Cancer Patients Reflect Tumor Environment

The Rockefeller University Press

Scientists in the UK have shown for the first time that immune cells in the urine of bladder cancer patients accurately reflect those in the tumor environment, according to the study “Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment,” by Wong et al., published today in the Journal of Experimental Medicine.

Released:
26-Sep-2018 12:05 PM EDT
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  • Embargo expired:
    5-Sep-2018 9:00 AM EDT

Article ID: 699905

Hypertension Drugs Could Prevent Memory Loss in Lupus Patients, Study Suggests

The Rockefeller University Press

Researchers from The Feinstein Institute for Medical Research have discovered that the activation of brain cells called microglia likely contributes to the memory loss and other cognitive impairments suffered by many patients with systemic lupus erythematosus (SLE). The study, which will be published September 5 in the Journal of Experimental Medicine, shows that ACE inhibitors—a class of drugs commonly used to treat hypertension—can block this process in mice and might therefore be used to preserve the memory of lupus patients.

Released:
4-Sep-2018 8:05 AM EDT
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  • Embargo expired:
    29-Aug-2018 9:00 AM EDT

Article ID: 699337

Researchers Identify New Potential Biotherapy for Alzheimer’s Disease

The Rockefeller University Press

Researchers at the University of Florida have discovered that a modified version of an important immune cell protein could be used to treat Alzheimer’s disease. The study, which will be published August 29 in the Journal of Experimental Medicine, reveals that soluble versions of a protein called TLR5 can reduce the buildup of amyloid plaques in the brains of Alzheimer’s disease model mice and prevent the toxic peptide that forms these plaques from killing neurons.

Released:
22-Aug-2018 9:50 AM EDT
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  • Embargo expired:
    16-Aug-2018 9:00 AM EDT

Article ID: 699041

Researchers Reveal Miscarriage Cause, Key Cellular Targets of Potential Drugs

University of North Carolina Health Care System

Researchers discovered a gene mutation underlying hydrops fetalis – a fatal condition to fetuses. The proteins at the center of this finding are implicated in a number of diseases, opening avenues of potential drug discovery related to migraines, diabetes, osteoporosis, and other conditions.

Released:
15-Aug-2018 1:05 PM EDT
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  • Embargo expired:
    24-Jul-2018 9:00 AM EDT

Article ID: 697514

Host Antibodies Shape Gut Microbiome by Changing Bacteria Gene Expression

The Rockefeller University Press

Researchers at the RIKEN Center for Integrative Medical Science in Japan have discovered how antibodies secreted in the gut promote the growth of beneficial bacteria. Their study, which will be published July 24 in the Journal of Experimental Medicine, shows that immunoglobulin A (IgA) antibodies can alter the expression of bacterial genes, allowing different bacterial species to cooperate with each other and form a community that can protect the body from disease.

Released:
17-Jul-2018 10:50 AM EDT
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Article ID: 696660

Immune Cells That Create and Sustain Chronic Inflammatory Bowel Disease Identified

University of Alabama at Birmingham

In preclinical experiments, Laurie Harrington and colleagues have discovered a subset of immune cells that create and sustain chronic inflammatory bowel disease. These cells could become potential therapeutic targets to ameliorate or cure Crohn’s disease and ulcerative colitis.

Released:
26-Jun-2018 2:05 PM EDT

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