A team led by scientists at the Case Western Reserve University School of Medicine has identified a new therapeutic approach for combating neurodegenerative diseases.
Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson's disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and resulted in functional improvements.
For 21 years, nurses have consistently been the most trusted profession, according to the yearly Gallup poll. (The new poll will be issued by the end of January). Dr Rushton, who specializes in burnout, will speak on trust, moral injury, and how nurses cope in this day and age.
A team of University of Wisconsin–Madison scientists has developed the first 3D-printed brain tissue that can grow and function like typical brain tissue.
Hydrogen peroxide is crucial in cell metabolism, playing key roles in cell proliferation, differentiation, and migration. However, elevated levels of hydrogen peroxide (H2O2) are linked to several diseases, including cancer and neurodegenerative disorders like Alzheimer's and Parkinson's disease.
University Hospitals has been selected by the Global Parkinson’s Genetics Program as one of four new study sites for the Black and African American Connections to Parkinson’s Disease (BLAAC PD) study.
New findings published in the journal Nature Neuroscience have shed light on a mysterious pathway between the reward center of the brain that is key to how we form habits, known as the basal ganglia, and another anatomically distinct region where nearly three-quarters of the brain’s neurons reside and assist in motor learning, known as the cerebellum.
Is it possible to amp up the energy production of mitochondria, the “power centers” of cells, without also boosting potentially harmful byproducts? If so, such a method could be used to treat a host of neurodegenerative diseases in which impaired mitochondria are believed to play a central role.
Certa manhã, bem cedo, enquanto examinava uma paciente adormecida no Centro de Medicina do Sono, o Dr. Erik St. Louis percebeu algo peculiar. A paciente, uma mulher na faixa dos 60 anos, começou a correr debaixo dos lençóis.
Una mañana temprano, mientras revisaba a una paciente dormida en el Centro de Medicina del Sueño, el Dr. Erik St. Louis observó algo particular. La paciente, una mujer de unos 60 años, había empezado a correr debajo de las sábanas. A media que sus párpados se agitaban, las piernas se pusieron en marcha, lentamente al principio, pero luego aceleraron rápidamente el paso, lo que la impulsó a lo largo de un camino que solo ella podía ver. Después de correr durante aproximadamente 30 segundos, se detuvo bruscamente y abrió los ojos. No era el comportamiento que el Dr. St. Louis esperaba de una persona con apnea del sueño.
مدينة روتشستر، ولاية مينيسوتا— يومًا ما في الصباح الباكر، أثناء فحص حالة نائمة في مركز طب النوم، لاحظ الدكتور إريك سانت لويس أمرًا غريبًا. حيث بدأت الحالة، وهي مريضة في أوائل الستينات من عمرها، تركض تحت غطاء سريرها. حيث بدأت ساقاها تنطلقان ببطء في البداية ثم أخذت تزيد سرعتها لتندفع في طريق لا يراه أحد غيرها، وكان جفناها يرتعشان في نفس الوقت. وبعد الركض لمدة حوالي 30 ثانية، توقفت فجأة وفتحت عينيها. ولم يتوقع الدكتور سانت لويس أن يصدر مثل هذا التصرف من مريض انقطاع النفس النومي.
Among the accomplishments of this year’s awardees are discoveries related to the role of altered pharmacokinetics in non-alcoholic fatty liver disease, the mechanisms of Parkinson’s disease neurodegeneration, the risk of COVID-19 to smokers and vapers, and the role of the microbiome in pregnancy and early developmental programming.
Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and the Boston University Sargent College of Health & Rehabilitation Sciences have used a soft, wearable robot to help a person living with Parkinson’s walk without freezing.
The Speech Accessibility Project has expanded its recruitment and is inviting U.S. and Puerto Rican adults living with amyotrophic lateral sclerosis to participate.
Scientists at St. Jude Children’s Research Hospital used cryo-electron microscopy to characterize the interaction of two proteins implicated in Parkinson’s disease.
A new report by a UCLA neurologist and collaborators draws upon patient voices and lived experiences to identify the common pitfalls of Parkinson’s diagnoses and create a guidebook for how medical providers – from seasoned specialists to rural community physicians – can avoid them.
With the rise in machine learning applications and artificial intelligence, it's no wonder that more and more scientists and researchers are turning to supercomputers. Supercomputers are commonly used for making predictions with advanced modeling and simulations. This can be applied to climate research, weather forecasting, genomic sequencing, space exploration, aviation engineering and more.
NEMO, a protein that is primarily associated with signaling processes in the immune system, prevents the deposition of protein aggregates that occur in Parkinson’s disease. For this purpose, it binds to certain protein chains that serve as markers for cellular waste removal, thus promoting the degradation of the harmful aggregates.
A so-called pathological protein long associated with Parkinson’s disease has been found in a new study to trigger cells to increase protein synthesis, an event that eventually kills the subset of brain cells that die off in this neurodegenerative condition.
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Researchers at the University of Central Florida College of Medicine (UCF COM) in Orlando, Florida completed research that is very promising in the treatment of Parkinson's disease
A team of researchers from The University of Texas at El Paso found that caffeic-acid based Carbon Quantum Dots (CACQDs), which can be derived from spent coffee grounds, have the potential to protect brain cells from the damage caused by several neurodegenerative diseases.
As part of a five-year, $3.9 million grant from the National Institutes of Health, Adriana Pérez, PhD, professor in the Department of Biostatistics and Data Science with UTHealth Houston School of Public Health in Austin, received a $1.9 million subcontract to determine the scope and drivers of low-value and unequal care for patients with Parkinson’s disease and Parkinson’s disease dementia.
Researchers performed complementary experiments showing that inhibiting a specific enzyme in a mouse model protects the dopamine-producing neurons that are normally lost as Parkinson's disease progresses, effectively halting the progression of the disease. The findings open the door to the development of novel therapeutics targeting the enzyme that may slow or prevent the progression of Parkinson's disease in people—a major unmet need.
Published in Environment International, a groundbreaking study from the Institute of Biological Chemistry and Centre for Microbiology and Environmental Systems Science (CeMESS) at the University of Vienna, in collaboration with the University of Konstanz and the Albert Einstein College of Medicine, reveals a microbial metabolite's role in inducing Parkinson's-like symptoms.
Until recently, our understanding of Parkinson's disease has been quite limited, which has been apparent in the limited treatment options and management of this debilitating condition.
The cyanobacterial origin of β-N-methylamino-L-alanine (BMAA), an environmental neurotoxin, remains controversial. With a carefully designed genetic system as a control, we found no evidence for the production of BMAA by cyanobacteria from lab cultures or bloom samples.
A new Northwestern Medicine study challenges a common belief in what triggers Parkinson’s disease. Degeneration of dopaminergic neurons is widely accepted as the first event that leads to Parkinson’s.
Even the best treatment approaches for Parkinson’s disease are inadequate if they do not address patients’ feelings of social rejection, isolation, loneliness and other psychosocial effects of stigma, according to a report from experts specializing in Parkinson’s and other movement disorders.
SMU biology professor Zhihao Wu has received a $1.8 million, 5-year Maximizing Investigators' Research Award (MIRA) from the National Institutes of Health to determine if different quality control pathways in our bodies might be working together to repair damaged components in cells.
A recent study by the University of Eastern Finland and Balettakademien Stockholm found that performing in a dance company and being involved in its activities play a significant role in the identity and disease-related identity negotiation in people with Parkinson’s disease.