For the first time in Thailand, lecturers at Chulalongkorn University’s Faculty of Pharmaceutical Sciences have successfully developed antibody from tobacco plants with inhibitory effects on the growth of cancer cells in laboratory animals. This signals hope for access to effective cancer medication and treatment at a lower cost.
Loss of a gene known as SYNCRIP in prostate cancer tumors unleashes cellular machinery that creates random mutations throughout the genome that drive resistance to targeted treatments, a team led by UT Southwestern Medical Center researchers discovered. The findings, published in Cancer Cell, could lead to new interventions that thwart this process in prostate and other cancer types, making them far easier to treat.
A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.
In a breakthrough study, researchers have revealed a new understanding of the role played by RNA modification in the progression of pancreatic ductal adenocarcinoma (PDAC), a leading cause of cancer-related deaths. The research pinpoints how the long non-coding RNA (lncRNA), LINC00901, and its N6-methyladenosine (m6A) modification, contribute to the disease, offering a potential new avenue for therapeutic interventions.
Some of the open research questions revolving Wnt signalling revolve around the extraordinary complexity in the number of Wnt pathway members, functioning both inside, outside, and at the surface of cells, and how different outputs of the pathway are achieved via the use of specific members. A team of scientists, led by Professor Antónia Monteiro from the Department of Biological Sciences at the National University of Singapore’s Faculty of Science, has uncovered some of this complexity by using butterfly wings as a model system. Butterfly wings function as a large two-dimensional canvas of cells that talk to each other during development to pattern exquisite and detailed colour patterns.
University of Melbourne researchers have developed a fast, inexpensive and scalable method for engineering blood vessels from natural tissue.
Antiviral therapies are notoriously difficult to develop, as viruses can quickly mutate to become resistant to drugs. But what if a new generation of antivirals ignores the fast-mutating proteins on the surface of viruses and instead disrupts their protective layers?
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments include a novel biomarker that may predict the aggressiveness of pancreatic cancer precursors, insights into the structure and function of a breast and ovarian cancer susceptibility gene, a new approach to overcoming treatment resistance in ovarian cancer, distinguishing features of young-onset rectal cancer, a biomarker and potential target for metastatic lung cancer, machine learning models to better predict outcomes of patients with mantle cell lymphoma (MCL), and a promising therapy for patients with relapsed/refractory MCL.
CDx Diagnostics, Inc., developer of the WATS3D AI Platform for the detection and surveillance of Barrett's esophagus (BE) and dysplasia, reported positive data in a recently published study, Benefit of Adjunctive Wide Area Transepithelial Sampling with 3- Dimensional Computer-Assisted Analysis Plus Forceps Biopsy Based on Barrett's Esophagus Segment Length, in the American Society for Gastrointestinal Endoscopy (ASGE) journal GIE (Gastrointestinal Endoscopy).
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Viruses often mutate or hide themselves within cells. But by mimicking the way the immune system naturally deals with invaders, researchers reporting in ACS Infectious Diseases have developed a “peptoid” antiviral therapy that effectively inactivates three viruses in lab tests.
Cholesterol plays many critical roles in biology and medicine. Researchers have revealed for the first time how cholesterol behaves in cells at the atomistic level, information that could have broad implications for future studies of health and disease.
The availability, speed and effectiveness of genomic sequencing increased dramatically during the pandemic, as scientists worldwide rushed to find ways to track and predict the virus’s movement and evolution. It also was critical in the development of effective vaccines. In an essay published today, two NAU biologists argue that building on this momentum is critical in society’s response to future pandemics, but it requires significant collaboration and investment now, before the next pathogen is threatening society.
Researchers have discovered a new way to attack fungal infections. The key is to block fungi from being able to make fatty acids, the major component of fats.
A team of scientists led by the University of Oxford have achieved a significant breakthrough in detecting modifications on protein structures.
Para-cresol is an aromatic compound with a strong horse stable-like odor. It contributes to the off-flavor of some foods, but it is also detectable as a characteristic odorant in whiskey and tobacco, as well as in the urine of various mammals. A research team has now discovered which odorant receptor humans use to perceive para-cresol.
Human cells are constantly communicating, and some cells, particularly in cancer, are master manipulators, using these communications channels to persuade innocent bystander cells to collude and participate in tumor growth.
Ion channels play a crucial role in many cellular processes, including neuronal communication, muscle contraction or cell proliferation. Most multi subunit ion channels exist in two functional states, either closed or open. During gating, one should expect that all subunits undergo conformational changes. The absence of intermediate conduction levels is surprising and asks for an explanation. A team of researchers from the University of Vienna and the Washington University in St. Louis created a smart model system to answer this important question. The study is currently published in Nature Communications.
University of Oregon researchers have developed a system to get that protein to the site of injury and release it gradually over time.
Announcement of contents of the August 2023 issue of Neurosurgical Focus
University of Illinois scientists have identified a protein that plays a critical role in the action of several emerging cancer therapies. The discovery will likely aid efforts to fine-tune the use of immunotherapies against several challenging cancers.
Pilot awards, pre-doctoral fellowship awards and post-doctoral awards totaling $1.5 million were recently awarded to Rutgers Cancer Institute of New Jersey investigators by the New Jersey Commission on Cancer Research (NJCCR).
Research from Ann & Robert H. Lurie Children’s Hospital of Chicago found that direct injection of neonatal mesenchymal stem cells, derived from heart tissue discarded during surgery, reduces intestinal inflammation and promotes wound healing in a mouse model of Crohn’s disease-like ileitis, an illness marked by chronic intestinal inflammation and progressive tissue damage.
A metabolic by-product that is more prevalent during fasting may supercharge immune cells as they fight infection and disease, reports an early stage study by Van Andel Institute scientists and collaborators.
Scientists have found a way to use nanotechnology to create a 3D ‘scaffold’ to grow cells from the retina –paving the way for potential new ways of treating a common cause of blindness.
Systemic sclerosis is the scaring of multiple organs within the body resulting in difficulty in functioning for these organs. The disease can become deadly if the organ scaring isn’t treated properly. Researchers at the University of Michigan Health System have identified a protein in the disease that may be a new target for treatment.
A new study provides evidence for the possibility that mitochondrial dysregulation could be a contributing factor in the development of hypertensive disorders of pregnancy. The study is published in Physiological Genomics. It was chosen as an APSselect article for July.
Opioids remain the most potent and effective pain relievers in medicine, but they’re also among the most addictive drugs that can halt a person’s ability to breathe during an overdose — which can be deadly. Researchers have been racing to develop safer pain reliever drugs that target a specific opioid receptor, called the kappa opioid receptor, that is only found in the central nervous system and not elsewhere in the body, like other opioid receptors.
Niki Patel, MD, a fellowship-trained hematologist-oncologist board certified in internal medicine and medical oncology, has joined the Division of Medical Oncology at Cedars-Sinai Cancer. She is treating patients in Pasadena at Huntington Cancer Center at Huntington Health, an affiliate of Cedars-Sinai.
Support for early career researchers is about to get a major boost, thanks to a new fellowship fund established by leaders at La Jolla Institute for Immunology (LJI) and Japan-based global pharmaceutical corporation, Kyowa Kirin, Inc.
After the successful treatment, a patient shares his story to inspire others.
Susan G. Komen®, the world’s leading breast cancer organization, announced the fourth MBC-focused research grant supported through the Komen Metastatic Breast Cancer Collaborative Research Initiative (MBCCRI), a collaboration between Komen, Duke Cancer Institute and the University of North Carolina Lineberger Comprehensive Cancer Center, which pairs researchers from each of the organizations to work together and address significant gaps in our knowledge about MBC to advance patient care and improve patient outcomes.
In a step forward in the development of genetic medicines, researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body. If translated into the clinic, this approach could expand access and reduce the cost of gene therapies for blood disorders, many of which currently require patients receive chemotherapy and a stem cell transplant. The findings were published today in the journal Science.
According to the National Kidney Foundation, more than 100,000 Americans are waiting for a kidney transplant, and the demand for donated kidneys far exceeds the supply. In fact, only 25,498 kidney transplants were performed in 2022, and kidney disease impacts 37 million people in the U.S. But a new preclinical study, led by scientists at Wake Forest University School of Medicine, shows that a new technology called mitochondrial transplantation holds promise as a potential therapy that could change the kidney transplant landscape.
Immune-checkpoint inhibitors have become the standard of care for patients with advanced melanoma to improve survival, but only some patients respond to this immunotherapy and have long-term benefits. The lack of a long-lasting response, researchers say, is related to failure of antitumor immunologic memory. Treatment options for advanced melanoma are limited for patients who do not respond to this type of therapy.
Chimeric antigen receptor (CAR)-T cells are a powerful, new form of cancer therapy that are being studied to treat blood cancers. Using a new approach, Yale Cancer Center researchers at Yale School of Medicine found a new way to substantially improve the effectiveness of CAR-T cell therapy. The new study was published in Nature Immunology on July 27.
Former Chair of Computational Biology honored with induction into Class of 2023 Fellows.
Investigators at the Icahn School of Medicine at Mount Sinai have designed an innovative RNA-based strategy to activate dendritic cells—which play a key role in immune response—that eradicated tumors and prevented their recurrence in mouse models of melanoma.
Two Tufts researchers have developed and patented an approach that may lead to the ability to recreate tissue in people with loss of smell.
Programmed cell death, a fundamental biological process that facilitates the elimination of old, damaged, infected, and non-functional cells, plays a crucial role in maintaining the balance between health and disease in the human body.
A new study led by researchers at The University of Texas MD Anderson Cancer Center discovered loss of metabolic fitness in chimeric antigen receptor (CAR) natural killer (NK) cells is a critical mechanism of resistance, with infused cells gradually losing the ability to compete with tumor cells for nutrients, leading to tumor relapse.
Zymo Research Corp, a leading provider of life science technologies, has partnered with Opentrons Labworks, Inc., a leader in lab automation, to revolutionize cell-free DNA isolation and analysis.
Researchers have found that dozens of viruses respond to quorum sensing or other chemical signals from bacteria.
In-cell engineering can be a powerful tool for synthesizing functional protein crystals with promising catalytic properties.
Scientists at UT Southwestern Medical Center and Children’s Medical Center Dallas have discovered in mice how high cholesterol causes blood vessels to become inflamed, a necessary prerequisite for atherosclerosis – the “hardening of the arteries” responsible for most heart attacks and strokes. The findings, published in Nature Communications, could lead to new interventions to protect against cardiovascular diseases (CVD), the leading cause of death globally.
Taiwanese IVD (In-Vitro Diagnostic) manufacturer General Biologicals Corporation (GBC) today unveiled two CellBio™ circulating tumor cell (CTC) cancer detection products at the American Association for Clinical Chemistry Annual Scientific Meeting & Clinical Lab Expo, being held July 23-27 in Anaheim, California.
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