Stress is inevitable. But too much of it can be terrible for our health. Chronic stress can increase our risk for heart disease and strokes. It may also help cancer spread. How this works has remained a mystery—a challenge for cancer care.
Scientists at the University of Southampton have discovered that bacteria can pair up their defense systems to create a formidable force, greater than the sum of its parts, to fight off attack from phage viruses.
"Trans masculine people are people born female but do not identify as such, for example they feel male, gender fluid or non-binary. Our examination of their ovarian tissue shows that 33% of them show signs of recent ovulation, despite being on testosterone and no longer menstruating," says Joyce Asseler, PhD candidate at Amsterdam UMC.
Recent developments in cancer research have highlighted the vital role of the immune system, particularly in the notable successes of cancer immunotherapy. Now, a paradigm-shifting study led by researchers at the Icahn School of Medicine at Mount Sinai in New York in collaboration with the University of Helsinki and Massachusetts General Hospital sheds light on how variations in immune genetics influence lung cancer risk, potentially paving the way for enhanced prevention strategies and screening. The findings were described in the February 22 online issue of Science.
Drugs that target a receptor on immune cells called activin receptor 1C may combat tumor-induced immune suppression and help patients’ immune systems fight back against cancer, according to a study by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.
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Scripps Research scientists discovered antibodies that protect against a host of lethal snake venoms.
SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression. New research shows that in Long COVID patients, IFN-y production persists until symptoms improve, highlighting a potential biomarker and a target for therapies.
UT Southwestern Medical Center researchers have identified a compound that selectively eliminates cancer cells while sparing immune cells in a form of cell death known as ferroptosis. The findings, published in Science Translational Medicine, could lead to new treatments for a wide variety of cancer types, the study authors say.
Are you sick and tired of getting sick and tired? A UNLV-led research team is exploring whether the reason we sometimes feel ill in the first place is because our body’s cells suffer from trash that accumulates within them.
Researchers at Umeå University in Sweden, led by Professor Felipe Cava, have identified a new family of enzymes that creates a unique type of cross-linking between the building blocks of bacterial cell walls. This discovery could help develop new antibiotics against infectious diseases.
University of Pittsburgh School of Medicine researchers discovered a molecular mechanism by which excessive dietary protein could increase atherosclerosis risk.
A first-of-its-kind cellular immunotherapy pioneered at Moffitt Cancer Center has received approval from the Food and Drug Administration and is now available for patients with advanced melanoma. Lifileucel is the first tumor-infiltrating lymphocyte therapy, or TIL, approved for solid tumors.
Thanks to advancements in the development of patented synthetic human-like hearts first created at Michigan State, researchers can study human heart development and congenital heart disease on highly accurate models. This is facilitating the development of new therapies and pharmaceutical drugs to treat a variety of heart-related diseases just in time for the observance of American Heart Month in February.
Dr. Nitzan Gonen, a Bar-Ilan University researcher specializing in the process of fetal sex determination, together with research students Aviya Stopel, Cheli Lev and Stav Dahari, has succeeded in creating "laboratory testicles" that may significantly advance understanding of the mechanisms involved in sex determination and provide solutions for male infertility, which affects one in 12 men worldwide.
Neuroscientists from Bonn, New York, and Freiburg discover interactions between so-called "ripples" and nerve cells during human memory processes.
Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have built and demonstrated the potential efficacy of a new chimeric antigen receptor (CAR) T-cell-based immunotherapy specifically designed to treat patients with cutaneous and rare subtypes of melanoma.
Researchers report in the journal Cell that ancient viruses may be to thank for myelin—and, by extension, our large, complex brains.
Com o avanço da idade, as células podem sofrer envelhecimento, um estado no qual elas param de crescer, mas continuam liberando moléculas inflamatórias e tecido degradado.
مدينة روتشستر، ولاية مينيسوتا —مع تقدم السن، يمكن أن تتعرض الخلايا للشَيخُوخَة، وهي حالة تتوقف فيها عن النمو ولكنها تستمر في إطلاق جزيئات التهابية وجزيئات مدمرة للأنسجة. عندما يكون الشخص صغيرًا في السن، يستجيب الجهاز المناعي ويطرح الخلايا الهَرِمة، والتي يشار إليها غالبًا باسم الخلايا الزُومبيّ. ومع ذلك، تبقى خلايا الزُومبيّ باقية وتساهم في العديد من المشاكل والأمراض الصحية المرتبطة بالعمر. سلط الباحثون في مايو كلينك، في دراستين، الضوء على بَيولُوجْيا خلايا الشَيخُوخَة.
Scientists at the UC Davis School of Medicine may have figured out why some people have trouble digesting sorbitol, a sugar alcohol used in sugar-free gum, mints, candy and other products.
A Study by Politecnico di Milano and Istituto Mario Negri has been published in Advanced Materials.
One of the key goals of medical science is to speed up the healing of tissue injuries in a way that would not enable the forming of less functional scar tissue in the affected areas.
Researchers confirm that the established pre-mRNA splicing mechanism that appears in textbooks cannot work in a subset of human short introns: A novel SAP30BP–RBM17 complex-dependent splicing has been uncovered.
Scientists at Cold Spring Harbor Laboratory (CSHL) and the University of California, Davis have reached a new breakthrough in pancreatic cancer research—eight years in the making.
From lab-grown chicken to cricket-derived protein, these innovative alternatives offer hope for a planet struggling with the environmental and ethical impacts of industrial agriculture.
The discovery of a pair of genes that work in perfect harmony to protect male fertility, could provide new insights into some unexplained cases of the most severe form of infertility, research suggests.
Scientists unveil 145 genes vital for genome health, and possible strategies to curb progression of human genomic disorders.
A collaborative effort led by Stuti Sharma, PhD, Assistant Professor in the Department of Biochemistry & Cell Biology at Stony Brook University, resulted in a promising study toward a better understanding of mitochondrial adenosine triphosphate (ATP) synthase.
Researchers from the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium of the National Institutes of Health, The University of Texas MD Anderson Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and others, have unveiled a detailed understanding of immune responses in cancer, marking a significant development in the field. The findings were published in the February 14 online issue of Cell. Utilizing data from more than 1,000 tumors across 10 different cancers, the study is the first to integrate DNA, RNA, and proteomics (the study of proteins), revealing the complex interplay of immune cells in tumors. The data came from the Clinical Proteomic Tumor Analysis Consortium (CPTAC), a program under the National Cancer Institute.
New research from the University of Ottawa proposes using vanoxerine as a safe method for potentially eliminating cancer stem cells in colorectal tumors.
Researchers at Children’s Hospital Los Angeles report in The Journal of Molecular Diagnostics about a new tool that effectively integrates data from four fusion callers and identifies disease-related gene fusions.
Below are some of the latest research and features on this growing population of older adults in the Seniors channel on Newswise.
Labeling cancer cells with genetic barcodes “In ReSisTrace, we label cancer cells uniquely with genetic barcodes and allow them to divide once, so that we get two identical sister cells that share the same barcode.
The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon ageing.
Scientists have developed a new AI tool that maps the function of proteins in a cancerous tumour, enabling clinicians to decide how to target treatment in a more precise way.
Improving the way scientists can see the microscopic structures of the brain can improve our understanding of a host of brain diseases, like Alzheimer’s or multiple sclerosis. Studying these diseases is challenging and has been limited by accuracy of available models.To see the smallest parts of cells, scientists often use a technique called electron microscopy.
A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease amyotrophic lateral sclerosis (ALS).
Space exploration is a complex and risky mission that requires careful preparation and a thorough understanding of the challenges inherent to life in space
Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages.
The company, based on science from the Hackensack Meridian Center for Discovery and Innovation, promises to capture biomarkers for early detection of disease
Investigators from Cedars-Sinai; the University of California, San Francisco (UCSF); Harvard University; and the Weizmann Institute of Science in Israel conducted a study to determine where individual nutrients are absorbed in the small intestine. For the first time, they identified the molecular markers that define five distinct intestinal regions.
Leguminous plants have a mechanism (rhizobial symbiosis) to efficiently acquire nitrogen, which is an essential macronutrient for growth, through the nitrogen-fixing bacteria rhizobia.
Reporters are invited to register for a complimentary press pass to attend #DiscoverBMB in San Antonio or access press materials electronically. Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology will be held March 23–26 in San Antonio.
The research team investigated the four extracellular matrix proteins Brevican, Neurocan, Tenascin-C and Tenascin-R, which occur in the cell environment of nerve cells of the retina.
University at Albany scientist Scott Tenenbaum, founder of UAlbany spinoff company sxRNA Technologies, Inc. (sxRNA Tech), has received $500,000 from the National Institute on Aging, part of the National Institutes of Health, to study how aging brain cells shape the progression of Alzheimer’s disease, and advance RNA technology that could inform new therapeutics to prevent and treat Alzheimer's and related dementias.
New research led by the University of Washington demonstrates a new class of hydrogels that can form not just outside cells, but also inside of them. These hydrogels exhibited similar mechanical properties both inside and outside of cells, providing researchers with a new tool to group proteins together inside of cells.
The latest research and expertise on the flue can be found in the Influenza channel on Newswise.
Activating calcium channels leads to a deadly influx of calcium ions into tumor cells.
BACKGROUNDPeripheral nerve injury can result in significant clinical complications that have uncertain prognoses. Currently, there is a lack of effective pharmacological interventions for nerve damage, despite the existence of several small
‘Lymphatic plexus’ behind the nose drains cerebrospinal fluid from the brain, potentially impacting neurodegenerative conditions.
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