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Article ID: 708209

Speakers Announced for 2019 Experimental Biology Meeting

Federation of American Societies for Experimental Biology (FASEB)

Renowned scientists including Nobel laureates, research pioneers and celebrated educators will convene at the Experimental Biology (EB) 2019 meeting, to be held April 6–9 in Orlando. Bringing together more than 12,000 life scientists in one interdisciplinary community, EB showcases the latest advances in anatomy, biochemistry, molecular biology, investigative pathology, pharmacology and physiology.

19-Feb-2019 9:00 AM EST

Article ID: 708271

Researchers Develop New One-Two Punch Against Melanoma in Mouse Model

Johns Hopkins Medicine

Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins and the Johns Hopkins University School of Medicine report two new forms of an older anti-cancer agent they developed appear to enhance the immune system’s ability to fight melanoma in mice. The agents, dubbed s-DAB-IL-2 and s-DAB-IL-2(V6A), comprise a regulatory protein called human interleukin-2 fused to chemically modified portions of diphtheria toxin.

19-Feb-2019 9:00 AM EST
  • Embargo expired:
    18-Feb-2019 3:00 PM EST

Article ID: 708201

Specialized Lung Cells Appear Very Early in Development

Children's Hospital of Philadelphia

Specialized lung cells appear in the developing fetus much earlier than scientists previously thought. Investigating the fetal signaling pathways active in the biological events by which alveoli form may offer future opportunities to treat lung damage caused by prematurity and other lung injuries.

15-Feb-2019 4:05 PM EST
  • Embargo expired:
    18-Feb-2019 11:00 AM EST

Article ID: 708218

New Insight Into the Balance Between the Tumor-suppressive and Tumor-promoting Effects of Cellular Senescence

Wistar Institute

Researchers at The Wistar Institute have described a novel role of nicotinamide adenine dinucleotide (NAD+) metabolism in the ability of senescent cells to release tumor-promoting molecules.

18-Feb-2019 11:00 AM EST
  • Embargo expired:
    18-Feb-2019 12:05 AM EST

Article ID: 708182

Small cell lung cancer may respond to combination of immunotherapy and DNA damage repair inhibitors

University of Texas M. D. Anderson Cancer Center

Researchers at The University of Texas MD Anderson Cancer Center have discovered that a combination of immune checkpoint blockade and targeted therapies that block normal DNA damage repair (DDR) achieved significant tumor regression in mouse models of small cell lung cancer (SCLC), suggesting a promising new approach for treating patients with this aggressive cancer.

17-Feb-2019 12:05 AM EST

Article ID: 708206

Pesquisadores da Mayo Clinic desenvolvem um sistema mais eficiente para reprogramar as células-tronco

Mayo Clinic

As células-tronco pluripotentes induzidas, o trabalho intenso de muitos projetos médicos regenerativos, começam como células diferenciadas que são reprogramadas para células-tronco pluripotentes por meio da exposição a uma série complexa de coquetéis genéticos. Pesquisadores da Mayo Clinic agora relatam que usando o vetor do vírus do sarampo eles reduziram o processo de multivetor de quatro fatores de reprogramação para um único processo de vetor de “um ciclo”.

15-Feb-2019 11:05 PM EST

Article ID: 708205

تطوير الباحثون في Mayo Clinic لنظام أكثر كفاءة لإعادة برمجة الخلايا الجذعية

Mayo Clinic

تبدأ الخلايا الجذعية متعددة القدرات المستحثة، التي تعد العمود الفقري للعديد من مشروعات الطب التجديدي، كخلايا متباينة يتم إعادة برمجتها إلى خلايا جذعية متعددة القدرات عن طريق التعرض لمجموعة معقدة من مزيج من الجينات. أفاد باحثو Mayo الآن باستخدام ناقل فيروس الحصبة؛ فلقد قاموا بتقليص العمليات المتعددة الناقلات ذات عوامل إعادة البرمجة الأربعة إلى عملية ناقلات فردية "دورة واحدة". يقولون إن العملية آمنة ومستقرة وأسرع ويمكن استخدامها للترجمة السريرية. تظهر النتائج في مجلة Gene Therapy.

15-Feb-2019 10:05 PM EST
Embargo will expire:
21-Feb-2019 11:00 AM EST
Released to reporters:
15-Feb-2019 11:05 AM EST


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Article ID: 708123

Can we repair the brain? The promise of stem cell technologies for treating parkinson's disease

IOS Press

Cell replacement may play an increasing role in alleviating the motor symptoms of Parkinson's disease (PD) in future. Writing in a special supplement to the Journal of Parkinson's Disease, experts describe how newly developed stem cell technologies could be used to treat the disease and discuss the great promise, as well as the significant challenges, of stem cell treatment.

14-Feb-2019 2:05 PM EST
  • Embargo expired:
    14-Feb-2019 11:00 AM EST

Article ID: 707794

New Live-Imaging Technique Reveals Cellular Repair Crew Plugging Leaky Biological Barrier

University of Michigan

Suppose you live in a brick house and notice cracks in the mortar that let in cold air, rain and insect pests. You might call a brick mason to repair those leaks and to restore the barrier that keeps the great outdoors from getting inside.

11-Feb-2019 9:00 AM EST

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