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Released to reporters:
12-Sep-2019 3:05 PM EDT

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Newswise: Major Grant Awarded to Wistar Supports Development of a Novel Therapeutic Approach for Antibiotic-resistant Bacteria

Article ID: 718933

Major Grant Awarded to Wistar Supports Development of a Novel Therapeutic Approach for Antibiotic-resistant Bacteria

Wistar Institute

Wistar has received a grant of approximately $4.6 million from the National Institutes of Health in support of innovative research to tackle antibiotic resistance.

Released:
12-Sep-2019 3:05 PM EDT
Newswise: Texas Biomed Researchers Pinpoint Why HIV Patients Are More Likely to Develop Tuberculosis

Article ID: 718896

Texas Biomed Researchers Pinpoint Why HIV Patients Are More Likely to Develop Tuberculosis

Texas Biomedical Research Institute

Tuberculosis and HIV – two of the world’s deadliest infectious diseases – are far worse when they occur together. Now, Texas Biomedical Research Institute researchers have pinpointed an important mechanism at work in this troubling health problem. And, their discovery could lead to a new mode of treatment for people at risk.

Released:
12-Sep-2019 11:05 AM EDT
Newswise: Failed Cancer Drug Looks Promising For Scleroderma And Other Fibrotic Conditions

Article ID: 718812

Failed Cancer Drug Looks Promising For Scleroderma And Other Fibrotic Conditions

Johns Hopkins Medicine

Sixteen years ago, a research group at Mayo Medical School published results showing that a protein called TRAIL can kill cells that cause liver fibrosis but no one seemed to follow up on these findings. Now, researchers at Johns Hopkins Medicine have improved on this protein and shown that it selectively kills cells that cause the hardening of skin associated with scleroderma, effectively reversing the condition in mice genetically engineered to mimic the disease. A report on these results was published earlier this year in Nature Communications.

Released:
12-Sep-2019 9:00 AM EDT
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Article ID: 718844

Predictors of Response to Guadecitabine Found in Relapsed/Refractory AML Patients

Coriell Institute for Medical Research

Patients with acute myeloid leukemia (AML), a leukemia which arises from bone marrow tissue, often see remission following their initial treatment, but for patients whose cancer returns, there are few options. One such option is guadecitabine, a novel DNA hypomethylating drug which slows problematic changes to a person’s epigenetic profile, but the drug is ineffective in a select number of relapsed or refractory AML patients and there has not been a way to determine who stands to benefit and who does not. However, researchers from the Coriell Institute for Medical Research have found certain biomarkers which can indicate a patient’s likelihood for success. Their findings were published in Clinical Epigenetics in July.

Released:
12-Sep-2019 8:45 AM EDT
Newswise: Lowy Medical Research Institute Scientists Find Cause of Debilitating Eye Disease
  • Embargo expired:
    11-Sep-2019 5:00 PM EDT

Article ID: 718598

Lowy Medical Research Institute Scientists Find Cause of Debilitating Eye Disease

Lowy Medical Research Institute

Scientists at the Lowy Medical Research Institute (LMRI) have discovered one cause of a progressive, debilitating eye disease called macular telangiectasia type 2 (MacTel). The work, using genetic, clinical and biochemical studies has implications for other retinal eye diseases, as well as peripheral neuropathies.

Released:
9-Sep-2019 1:00 PM EDT
Newswise: Scientists Identify Gene as a Master Regulator in Schizophrenia
  • Embargo expired:
    11-Sep-2019 2:00 PM EDT

Article ID: 718728

Scientists Identify Gene as a Master Regulator in Schizophrenia

Children's Hospital of Philadelphia

Using computational tools to investigate gene transcription networks in large collections of brain tissues, a scientific team has identified a gene that acts as a master regulator of schizophrenia during early human brain development.

Released:
10-Sep-2019 10:30 AM EDT
Newswise: Meet the molecule that helps stressed cells decide between life and death

Article ID: 718825

Meet the molecule that helps stressed cells decide between life and death

St. Jude Children's Research Hospital

St. Jude Children’s Research Hospital scientists have identified a molecule that plays a pivotal role in determining the fate of cells under stress, much like a Roman emperor deciding the fate of gladiators in the coliseum.

Released:
11-Sep-2019 1:05 PM EDT
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Article ID: 718813

Trio of Studies Show that Gene Mutation, Tissue Location and Signaling Networks Drive Cancer Incidence and Severity

Beth Israel Deaconess Medical Center

Mutated KRAS genes are commonly found in several cancers and not all KRAS mutations in the same organ tissue cause the same disease severity, according to three new studies from researchers at the Cancer Center at Beth Israel Deaconess Medical Center.

Released:
11-Sep-2019 12:05 PM EDT
  • Embargo expired:
    10-Sep-2019 5:00 PM EDT

Article ID: 718651

Telemedicine Engages Newly Postpartum Women in Cardiovascular Monitoring

Health Sciences at the University of Pittsburgh

America has the highest maternal mortality rate in the developed world. Since cardiovascular disease is the primary cause, researchers have created a blood pressure home-monitoring system to rapidly detect concerning trends in postpartum women before their situation becomes critical.

Released:
9-Sep-2019 11:30 AM EDT

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