Researchers at UC San Diego have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen, particularly in health care settings.
The cowpea mosaic virus has shown great promise as an experimental cancer immunotherapy for treating and preventing recurrence of various cancers. But just how the virus triggers such a potent anti-cancer immune response has remained a mystery. A new study digs deeper and provides answers.
Florida State University College of Medicine Professor Mohamed Kabbaj has been awarded a $3 million grant from the National Institutes of Health to study the effects of acute social isolation and partner separation.
Researchers from Columbia Engineering and Columbia University Irving Medical Center have developed a model of human physiology in the form of a multi-organ chip consisting of engineered human heart, bone, liver, and skin that are linked by vascular flow with circulating immune cells, to allow recapitulation of interdependent organ functions. The researchers have essentially created a plug-and-play multi-organ chip, which is the size of a microscope slide, that can be customized to the patient.
A multi-year study of the role of E. coli gut bacteria in Crohn’s disease finds that intestinal inflammation liberates chemicals that nourish the bacteria’s growth and promotes their ability to cause inflammation.
Tapping into positive emotions and social connections may be key to motivating older adults to exercise. DePaul University psychology professor Joseph Mikels has been awarded a $2.6 million grant from the National Institutes of Health to continue his work on emotion, aging and decision-making throughout the life span.
An artificial intelligence (AI) tool developed by Cedars-Sinai investigators accurately predicted who would develop pancreatic cancer based on what their CT scan images looked like years prior to being diagnosed with the disease. The findings, which may help prevent death through early detection of one of the most challenging cancers to treat, are published in the journal Cancer Biomarkers.
Diagnosing Alzheimer's disease can be a complex and time-consuming process, requiring evaluations ranging from brain scans to cognitive and lab tests to reviews of medical history and symptoms. Simpler and faster ways to diagnose the disease are urgently needed. Researchers at Albert Einstein College of Medicine have been awarded a five-year, $4.2 million National Institutes of Health (NIH) grant to detect behavioral markers for Alzheimer’s that are present early in the course of the disease, before it can be clinically diagnosed. Results could help scientists identify people at risk for Alzheimer’s and related problems, such as falls, and lead to new preventive strategies.
Researchers at Wake Forest University School of Medicine have been awarded a five-year, $4 million grant through the National Institutes of Health (NIH) Helping End Addiction Long-term (HEAL) Initiative to study chronic pain and opioid use disorder.
A new Harvey L. Neiman Health Policy Institute study found that a significant upward trend in CTA, CTP, and MRI utilization, and a simultaneous downtrend in MRA use was observed for ischemic stroke cases while disparities existed in neuroimaging utilization across all demographic groups.
Joslin Diabetes Center, the preeminent institution for diabetes research and care, affiliated with Harvard Medical School and a part of Beth Israel Lahey Health, has again been awarded $8.5 million from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK) in continued support for Joslin’s Diabetes Research Center (DRC) program. The grant, which officially began April 1, 2022, marks the 36th continuous year of NIH investment in Joslin’s DRC.
New research shows that a treatment for retinal vein occlusion yields long-lasting vision gains, with visual acuity remaining significantly above baseline at five years. However, many patients require ongoing treatment.
Study Used Wearable Tech to Foster Activity in High-Risk, Diverse Populations
To help address the rising tide of Alzheimer’s disease nationwide, researchers at Albert Einstein College of Medicine in collaboration with faculty at Pennsylvania State University and other institutions, have received a five-year, $32 million grant from the National Institutes of Health (NIH) to support the ongoing Einstein Aging Study (EAS), which focuses on both normal aging and the special challenges of Alzheimer’s disease, and other dementias. EAS was established at Einstein in 1980 and has been continuously funded by the NIH.
New research from Cornell scientists is exploring how human genetics impacts functions of the gut microbiome, and is expanding awareness of the role human genetics plays in shaping the microbiome.
University of Maryland School of Medicine (UMSOM)’s Institute of Human Virology (IHV) researchers received funding from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID) for $2.7 million to study genetic changes in two genes from the HIV-1 virus that may make it resistant to antiretroviral therapy.
The award entitled, “Integrated Network of Scholars in Global Health Research Training (INSIGHT)” will expand global health research across sub-Saharan Africa, South Asia, Latin America, and the Caribbean by providing one-year mentored research training to U.S. and lower-middle income country scholars.
With the aid of a $3.5 million National Institutes of Health grant (R01HL158850), investigators from Rutgers Cancer Institute of New Jersey – the state’s only National Cancer Institute-designated Comprehensive Cancer Center – along with Holden Cancer Center at the University of Iowa, and the University of Texas MD Anderson Cancer Center, are collaborating on a project to address lung cancer screening disparities among individuals with a history of heavy smoking.
A five-year, $13 million grant to study how certain infectious agents evolve to spread chronic wasting disease (CWD) has been awarded to a UTHealth Houston research team led by Claudio Soto, PhD, from the National Institutes of Health (NIH).
The findings suggest these single-celled organisms have programmed or regulated cell-death mechanisms like those that are known to work in animals and other complex organisms.
Zakrzewski Lab aims to train immune system to make its own CAR T cells
Researchers have developed a new computational tool to select optimal combination therapies for patients with cancer based on the co-occurring alterations in a given tumor.
The National Institutes of Health (NIH) and the National Institute on Aging recently approved funding for a 2022 study by the Institute for Exercise and Environmental Medicine (IEEM), where a research team will look into how body weight – even extra weight gain like the kind recently resulting from the COVID-19 pandemic – may adversely affect breathing in seniors.
The road from discovering a potential drug to getting the therapy into the hands of patients is a long and uncertain one. An NIH program offers researchers a smoother path from basic science to clinical testing and regulatory approval.
The road from discovering a potential drug to getting the therapy into the hands of patients is a long and uncertain one. An NIH program offers researchers a smoother path from basic science to clinical testing and regulatory approval.
Cigarette smoking is overwhelmingly the main cause of lung cancer, yet only a minority of smokers develop the disease. A study led by scientists at Albert Einstein College of Medicine and published online today in Nature Genetics suggests that some smokers may have robust mechanisms that protect them from lung cancer by limiting mutations. The findings could help identify those smokers who face an increased risk for the disease and therefore warrant especially close monitoring.
A study published in Molecular Psychiatry is the first to look at multiple levels of biology within women with postpartum depression (PPD) to see how women with the condition differ from those without it.
People who have difficulty getting to sleep or staying asleep had higher blood sugar levels than people who rarely had sleep issues, new research has found. The findings suggest insomnia could increase people’s risk of type 2 diabetes, and that lifestyle or pharmacological treatments that improve insomnia could help to prevent or treat the condition.
A University of Minnesota-led research team analyzed the fundamental properties and structures of the naturally occurring substances that help human lungs expand and contract, providing insight into how the substances help us breathe.
Imaging at near-atomic resolution of a key immune protein commonly known as STING has revealed a previously unrecognized binding site that appears to be pivotal for launching immune attacks, UT Southwestern scientists report in a new study. The findings, published in Nature, could lead to new ways of manipulating STING to prompt stronger immune responses or stem its action in autoimmune diseases.
Implantable bioelectronics are now often key in assisting or monitoring the heart, brain, and other vital organs, but they often lack a safe, reliable way of transmitting their data to doctors. Now researchers at Columbia Engineering have invented a way to augment implantable bioelectronics with simple, high-speed, low-power wireless data links using the body's naturally present ions.
A new University of California, Irvine-led study indicates base editing may provide long-lasting retinal protection and prevent vision deterioration in patients with inherited retinal degeneration, specifically in Leber congenital amaurosis (LCA) patients.
UTSW scientists identify key molecule produced by male parasitic worms that affects sexual maturity in females and leads to schistosomiasis
The National Institutes of Health is funding a $1.8 million project led by a researcher at the FAMU-FSU College of Engineering that will use artificially grown, simplified mini-organs to create medicine that targets brain cells damaged by stroke. The research team will use stem cells to create miniature organs that resemble human brains.
Funded through a $418,000 R21 grant from the National Institutes of Health’s National Institute on Aging, assistant professor Emily Cope, associate professor Greg Caporaso and professor Egbert Schwartz recently began working together on “Development of in vivo quantitative stable isotope probing to quantify microbiome dynamics in Alzheimer’s disease.”
Dr. Barbara Waszczak, Professor of Pharmacology at Northeastern University's Bouvé College of Health Sciences, is the Principal Investigator and Project Director for the grant.
A team researchers is projected to receive approximately $22 million from the NIH over four years to research long COVID-19. The emerging health condition causes many COVID-19 patients, even those who were not hospitalized, to have continued and new symptoms months after their initial illness.
Searching for ways to extend the survival benefit of targeted therapies, a team led by researchers at the Duke Cancer Institute identified a potential new tactic to disrupt the repair mechanism that cancer cells use after treatment, blunting their ability to regenerate. The approach could present a new treatment strategy.
A three-year, $1.6 million grant to identify patients at risk for a serious secondary neurological complication that can arise after subarachnoid hemorrhage (SAH) has been awarded to UTHealth Houston researcher H. Alex Choi, MD, by the National Institutes of Health (NIH).
Researchers discovered that two distinct classes of fibroblast cells accumulate in pancreatic tumors and play opposing roles to promote and restrain pancreatic cancer growth. Appropriately targeting these cells may offer options to improve treatment outcomes.
New research by National Eye Institute (NEI) investigators shows that while microsaccades seem to boost or diminish the strength of brain signals underlying attention, the eye movements are not drivers of those brain signals.
Capitalizing on the diagonal relationship between phosphorus and carbon, researchers at the University of California San Diego report binding diphosphorus to a single metal ion center through coordination chemistry, something that had historically remained elusive.
Researchers at Washington University School of Medicine have found that many people who tested positive for the coronavirus in the early months of the pandemic also experienced peripheral neuropathy — pain, tingling and numbness in the hands and feet — during and following their bouts with COVID-19.
Florida State University researchers have identified a new pathway in the brain that plays an important role in our response to fear. Scientists have long considered the amygdala, an almond-shaped structure in the center of the brain, to be the “center of fear” and believed it to be largely responsible for how an individual responds to frightening circumstances or perceives threats.
Researchers describe a mechanism in mice that underlies local dopamine release in the brain
Parkinsonism is a term for a group of neurological conditions that cause movement problems including tremors, slowed movement and stiffness, with Parkinson’s disease being one of the better knowns causes. A new study suggests that older people taking statin drugs have a lower chance of developing parkinsonism later compared to people who were not taking statins. The research is published in the March 23, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. Statins are drugs used to lower cholesterol in the blood and protect against atherosclerosis, a buildup of plaque in the arteries that can lead to hardening of the arteries, heart attack and stroke.
The $5.8 million center at Texas Biomed is one of the inaugural Interdisciplinary NexGen TB Research Advancement Centers (IN-TRAC) funded by the U.S. National Institute of Allergy and Infectious Diseases.
The dominant form of heart failure worldwide appears to be caused by a strong, bidirectional interaction between the body’s response to metabolic stress and the immune system, according to a review article written by UT Southwestern researchers and colleagues. The article, published in Nature Cardiovascular Research, argues for more research into this root cause to develop truly effective treatments.
UC San Diego study finds new screening tool flags 95 percent of stage 1 pancreatic cancers.
Consumer interest and awareness in nicotine pouches – products that contain nicotine but have no tobacco and one of the newest industry products — is growing and they are most popular among younger smokers and those trying to quit, according to a Rutgers research study.
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