With an $8 million grant from the National Institutes of Health (NIH), the next stage of the THINKER project — called THINKER-NEXT — will aim to provide a comprehensive view of the risks and benefits of transplanting HCV-infected kidneys into non-infected patients.
Researchers have identified a biomarker in human platelets that tracks the extent of depression.
A potential new route to the diagnosis and treatment of ARDS comes from studying how neutrophils – the white blood cells responsible for detecting and eliminating harmful particles in the body – differentiate what materials to uptake by the material’s surface structure, and favor uptake of particles that exhibit “protein clumping.”
Penn Medicine has been awarded a prestigious seven-year, $14 million grant from the National Institutes of Health (NIH) to promote organ transplantation for patients with end-stage renal disease who are currently on the waitlist for a kidney transplant. The team will launch a clinical trial harnessing synthetic chimeric antigen receptor (CAR) T cells – a form of which was developed at Penn Medicine and became the first personalized cellular therapy for cancer – for use in patients for whom a compatible kidney cannot be found due to pre-existing antibodies against potential donors.
Researchers at Washington University School of Medicine in St. Louis have received two grants from the National Institutes of Health (NIH) totaling more than $5.5 million to develop new treatments for two types of devastating parasitic infections common in sub-Saharan Africa and Central and South America: river blindness and intestinal worm infections.
Researchers identify mechanism that explains how tissues form complex shapes that enable organ function
An alternative statistical method honed and advanced by Cornell researchers can make clinical trials more reliable and trustworthy while also helping to remedy what has been called a “replicability crisis” in the scientific community.
HIV replication in the human body requires that specific viral RNAs be packaged into progeny virus particles. A new study has found how a small difference in the RNA sequence can allow the viral RNA to be packaged for replication, creating potential targets for future HIV treatments.
Small, unique antibody-like proteins known as VNARs — derived from the immune systems of sharks — can prevent the virus that causes COVID-19, its variants, and related coronaviruses from infecting human cells, according to a new study published Dec. 16. The new VNARs will not be immediately available as a treatment in people, but they can help prepare for future coronavirus outbreaks.
UC Davis Health researchers showed that blocking IL-6 and TNF cytokines provides a more effective approach to preventing life-threatening graft-versus-host-disease, an inflammatory condition that develops in patients after their allogeneic hematopoietic stem cell transplantation.
Treating bacterial infections associated with orthopaedic implants has often been a case of too little, too late. The traditional therapy has been a combination of prolonged antibiotics, including rifampin, a 50-year-old drug that has been a staple in the global fight against tuberculosis and other bacterial diseases.
Investigators at Cedars-Sinai have identified growth hormone in the colon that increases as the colon ages—a discovery that can help guide the development of a new anti-aging therapy.
Biomedical sciences researchers at Iowa State University are testing two therapies to gauge their ability to prevent long-term brain damage that results from exposure to nerve agents. The scientists recently received a grant from the National Institutes of Health to test the treatments, which may also have applications for treating severe seizures and head trauma.
The anti-cancer effect of the drug may help those with rare, hereditary cancer syndromes avoid surgeries by shrinking tumors via a daily oral dose.
A new study in mice shows transplanted brown fat can reduce type 2 diabetes risk factors after a heart attack, an encouraging finding for scientists who hope to apply the so-called “good” fat’s beneficial properties to drugs that can help prevent health problems.
Using a stem-cell-derived model, researchers have identified two drug candidates that may slow dry age-related macular degeneration (AMD), a leading cause of blindness for which no treatment exists. The scientists, from the National Eye Institute (NEI), part of the National Institutes of Health, published their findings today in Nature Communications.
Researchers at Washington University School of Medicine in St. Louis have shown, in a small clinical trial, that an immunotherapy harnessing pre-activated natural killer cells can help some children and young adults with recurrent AML and few other treatment options.
The University of Illinois Chicago and Malcolm X College, one of the City Colleges of Chicago, have teamed up for a five-year, $1.2 million grant from the National Institutes of Health to support undergraduate students training in biomedical research during the last two years of their studies.
The University of Texas at El Paso will develop a sustainable public health intervention to suppress human immunodeficiency virus (HIV) in people who use drugs in the El Paso-Ciudad Juárez border region. The initiative will be funded by a $3 million grant from the National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA).
Combining two agents to block a parasitic worm’s life cycle boosted survival from a potentially deadly tropical disease to 85% in animal models, far better than either treatment alone, according to a proof-of-concept study led by UT Southwestern Medical Center pharmacologists.
Scientists have discovered that gene therapy and the diabetes drug metformin may be potential treatments for late-onset retinal degeneration (L-ORD), a rare, blinding eye disease. Researchers from the National Eye Institute (NEI), part of the National Institutes of Health generated a “disease-in-a-dish” model to study the disease. The findings are published in Communications Biology.
Scientists have discovered that gene therapy and the diabetes drug metformin may be potential treatments for late-onset retinal degeneration (L-ORD), a rare, blinding eye disease. Researchers from the National Eye Institute (NEI), part of the National Institutes of Health generated a “disease-in-a-dish” model to study the disease. The findings are published in Communications Biology.
A new study suggests that children, teens and young adults who spend more time outdoors during the summer months and live in areas of the country that expose them to greater amounts of ultraviolet light have a lower risk of developing multiple sclerosis (MS) as children. While rare, MS can develop in children, although most people start to get symptoms of the disease between the ages of 20 and 50. The research is published in the December 8, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Rutgers Robert Wood Johnson Medical School (RWJMS) is projected to receive approximately $30 million, establishing a critical partnership with the larger National Institutes of Health–funded RECOVER Initiative to study long-term and delayed impacts of COVID-19 on children and lead a national collaboration with the potential to recruit from any state to investigate these outcomes.
In a discovery that could one day benefit people suffering from traumatic brain injury, Alzheimer’s disease, and schizophrenia, UT Southwestern researchers have identified the characteristics of more than 100 memory-sensitive neurons that play a central role in how memories are recalled in the brain.
A new Cleveland Clinic-led study has identified sildenafil – an FDA-approved therapy for erectile dysfunction (Viagra) and pulmonary hypertension (Revatio) – as a promising drug candidate to help prevent and treat Alzheimer’s disease.
A trial testing whether multidisciplinary telehealth intervention will help improve racial disparities in outcomes for adult stroke survivors will be launched at The University of Texas Health Science Center at Houston (UTHealth Houston) with a $3.1 million grant from the National Institute on Minority Health and Health Disparities at the National Institutes of Health.
Older women are among the most susceptible to developing UTIs, an infection of the bladder and urethra that causes urinary urgency and pain. UTIs also can cause delirium in older people, resulting in a sharp decline in mental abilities that triggers disoriented thinking.
Researchers will study how pandemic-related stressors influence sexual behavior and risk of sexually transmitted infections among girls and young women in Kenya, where a dramatic increase in infections has been revealed in preliminary data, compared to 12-18 months prior.
Human heart muscle cells cease to multiply after birth, making any heart injury later in life a permanent one, reducing function and leading to heart failure. Now, however, Johns Hopkins Medicine researchers say they have new evidence from mouse experiments that manipulating certain nerve cells or the genes that control them might trigger the formation of new heart muscle cells and restore heart function after heart attacks and other cardiac disorders.
USC study published in the Journal of Experimental Medicine shows that experimental drug protects against injury caused by tiny blood clots in the brain’s white matter, which can accumulate over time and lead to cognitive decline
Researchers at Penn State College of Medicine are seeking volunteers from across the U.S. to participate in a clinical trial examining whether online mindfulness-based stress reduction can reduce stress and average blood sugar levels in those with Type 1 or Type 2 diabetes.
A new study led by University of California, Irvine researchers has confirmed a link between altered DNA repair and increased DNA damage associated with spinocerebellar ataxia type 7 (SCA7), a debilitating, sometimes deadly neurodegenerative condition causing movement disorders. Their work also revealed a potential therapeutic target for the currently incurable and difficult to treat condition.
Mount Sinai researchers have delineated four new subgroups of COVID-19 that can be identified in patients within 24 hours of admission to the intensive care unit (ICU). The finding will help match patients to specific treatments, improving their overall care and outcomes.
Ever since the first barcode appeared on a pack of chewing gum in 1974, the now-ubiquitous system has enabled manufacturers, retailers and consumers to quickly and effectively identify, characterize, locate and track products and materials. In a paper first posted online Nov. 26, 2021, in the journal Cell, researchers at Johns Hopkins Medicine and The Johns Hopkins University demonstrate how they can do the same thing at the molecular level, studying the ways cancer cells “talk” with one another.
Albert Einstein College of Medicine and Montefiore Health System have been awarded a National Institutes of Health (NIH) grant to establish a multidisciplinary research center focused on treatments for people with both chronic pain and opioid use disorder (OUD).
In a baseline scenario, the researchers project a rise in the ART-using population from about 670,000 in 2020 to nearly 910,000 by the end of 2030 if current trends in new HIV infections persist.
The Icahn School of Medicine at Mount Sinai will serve as a hub site for two cohort studies contributing to a nationwide health consortium study by the National Institutes of Health (NIH) on the long-term effects of SARS-CoV-2, the virus that causes COVID-19.
In a collaborative study, Cleveland Clinic researchers sought to understand how COVID-19 infection affects pregnant mothers and their children. They published the results of their clinical study in Cell Reports Medicine.
Researchers discovered that antihistamines are associated with improved responses to immunotherapy. Their work revealed a role for the histamine receptor in suppressing T cell activation to block anti-tumor immune responses.
A new study is showing how value choices are recorded in our brains. Researchers found that persistency allows value signals to be most effectively represented, or “coded,” across different areas of the brain, especially in a critical area within the cerebrum known as the retrosplenial cortex.
Imagine being able to pinpoint the exact moment in utero when brain development changes and leads to genetic disorders such as autism and cerebral palsy. That knowledge could open the door to intervention strategies, potentially lessening or preventing the dysfunction — and the subsequent genetic disorder.
University of Delaware biochemist Jeff Mugridge is trying to figure out how so-called mRNA eraser enzymes work in our cells, why those erasers can sometimes misbehave and lead to cancer, and how science can pave the way for possible solutions to this problem.
Melanoma researchers at Huntsman Cancer Institute published a study that gives a new explanation of what causes moles to change into melanoma. These findings pave the way for more research into how to reduce the risk of melanoma, delay development, and detect melanoma early.
New research shows how genetic variations linked to severe cases of COVID-19 affect our immune cells. The study is one of the first in-depth look at the connections between COVID-19 severity and gene expression in many types of immune cells. This work could guide the development of new COVID-19 therapies to boost immune cell function.
Physicians at Washington University School of Medicine in St. Louis and Massachusetts General Hospital/Harvard Medical School in Boston have received a seven-year, $22 million grant from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) to help lead a multicenter clinical trial evaluating whether a novel immunosuppressant can reduce the risk of organ rejection after a lung transplant.
To grow and spread, cancer cells must evade the immune system. Investigators from Brigham and Women’s Hospital and MIT used the power of nanotechnology to discover a new way that cancer can disarm its would-be cellular attackers by extending out nanoscale tentacles that can reach into an immune cell and pull out its powerpack.
Immune checkpoint inhibitors can boost the immune system’s response to tumor cells, but the medications tend to be ineffective against certain cancers, especially colorectal and pancreatic cancers.
The Bronx is home to more than 27,000 people living with HIV, the majority of whom are Black or Hispanic men. People living with HIV have an increased risk for depression and substance use, which in turn can make adhering to daily antiviral treatments difficult, negatively impacting both quality of life and overall health. Now, the National Institutes of Health (NIH) has awarded researchers at Albert Einstein College of Medicine and Montefiore Health System two five-year grants totaling $7.6 million to study the structural and chemical changes in the brain of people living with HIV, depression, and cannabis use disorder.
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