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Article ID: 704658

Focus on resistance to HIV offers insight into how to fight the virus

Universite de Montreal

Researchers have found that genetic mutations affecting the capsid, the structure surrounding the HIV genome, make it possible for a protein called TRIM5α to trigger the immune system of elite controllers.

Released:
30-Nov-2018 6:00 AM EST
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Article ID: 704595

HIV in Liver Cells Found to Be Inactive, Narrowing Potential Treatment Targets

Johns Hopkins Medicine

In a proof-of-principle study, researchers at Johns Hopkins revealed that certain immune system cells found in the human liver, called liver macrophages, contain only inert HIV and aren’t likely to reproduce infection on their own in HIV-infected people on long-term antiretroviral therapy (ART). ART is a regimen containing combinations of HIV-targeting drugs that prevents the growth of the virus but does not eradicate it.

Released:
29-Nov-2018 10:00 AM EST
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Article ID: 704256

Patients with Rare Natural Ability to Suppress HIV Shed Light on Potential Functional Cure

Johns Hopkins Medicine

Researchers at Johns Hopkins have identified two patients with HIV whose immune cells behave differently than others with the virus and actually appear to help control viral load even years after infection. Moreover, both patients carry large amounts of virus in infected cells, but show no viral load in blood tests. While based on small numbers, the data suggest that long-term viral remission might be possible for more people.

Released:
27-Nov-2018 10:00 AM EST
  • Embargo expired:
    21-Nov-2018 1:00 PM EST

Article ID: 704287

Never-before-seen DNA recombination in the brain linked to Alzheimer’s disease

Sanford Burnham Prebys Medical Discovery Institute

Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified gene recombination in neurons that produces thousands of new gene variants within Alzheimer’s disease brains. The study, published today in Nature, reveals for the first time how the Alzheimer’s-linked gene, APP, is recombined by using the same type of enzyme found in HIV.

Released:
20-Nov-2018 2:00 PM EST
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Article ID: 704306

Mobile health has power to transform HIV/AIDS nursing

University of Washington

The abundance of personal smartphones in southern African countries got University of Washington professor Sarah Gimbel thinking: What if these phones were used by front-line health workers — namely nurses — to collect and analyze data on patients living with HIV or AIDS to improve their care?

Released:
20-Nov-2018 5:05 PM EST

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