Traditional genome editing faced limitations in achieving ultimate precision until now. Prof. Buchholz's team has broken through this barrier by creating what many have sought after: a zinc-finger conditioned recombinase.
Gliomas de alto grau são tumores cancerígenos que se espalham rapidamente no cérebro ou na medula espinhal.
الأورام الدبقية عالية الدرجة هي أورام سرطانية تنتشر بسرعة في الدماغ أو الحبل النخاعي. في دراسة جديدة أجريت تحت إشراف مايو كلينك، وجد الباحثون أن هوامش أورام الدماغ الغزوية للورم الدبقي عالي الدرجة تحتوي على تغيرات جينية وجزيئية مميزة بيولوجيًا تشير إلى السلوك العدواني وتكرار المرض. وتُظهر النتائج تصورات متعمقة للعلاجات المحتملة التي يمكن أن تحوّل مسار المرض.
Los gliomas de alto grado son tumores cancerígenos que se propagan rápidamente en el cerebro o en la médula espinal.
Using a virus-like delivery particle made from DNA, researchers from MIT and the Ragon Institute of MGH, MIT, and Harvard have created a vaccine that can induce a strong antibody response against SARS-CoV-2.
University Hospitals has been selected by the Global Parkinson’s Genetics Program as one of four new study sites for the Black and African American Connections to Parkinson’s Disease (BLAAC PD) study.
Pilot study by Children’s Hospital Los Angeles and City of Hope proposes a promising global, clinically applicable genomic assay for the diagnosis and treatment of this heterogeneous leukemia, reports The Journal of Molecular Diagnostics.
IU School of Medicine investigators and their collaborators in Uganda has revealed that hydroxyurea significantly reduces infections in children with sickle cell anemia, which enhances strong evidence of hydroxyurea’s effectiveness and could ultimately reduce death in children in Africa.
Storb was a Professor in the Department of Molecular Genetics and Cell Biology for more than 29 years.
Legislation introduced in Illinois would eliminate financial barriers to clinically appropriate genetic testing and additional screenings in an effort to detect breast cancers related to a known inherited gene mutation.
The intricate dance of nature often unfolds in mysterious ways, hidden from the naked eye. At the heart of this enigmatic tango lies a vital partnership: the symbiosis between plants and a type of fungi known as arbuscular mycorrhizal (AM) fungi.
Around one million individuals worldwide become infected with HIV, the virus that causes AIDS, each year.
Pesquisadores da Mayo Clinic que estudam a genética de pessoas que recentemente desenvolveram cardiomiopatia dilatada (uma das causas mais comuns de insuficiência cardíaca), descobriram um gene particular para o qual o desenvolvimento de futuros tratamentos de terapia medicamentosa poderá ser direcionado.
Investigadores de Mayo Clinic que estudian la genética de personas que recientemente desarrollaron miocardiopatía dilatada, una de las causas más comunes de insuficiencia cardíaca, descubrieron que deben enfocarse en un gen particular para desarrollar tratamientos farmacológicos en el futuro.
Researchers at the Universities of Basel and Zurich have discovered the genetic material of the pathogen Treponema pallidum in the bones of people who died in Brazil 2,000 years ago.
Rutgers Health researcher develops software that can analyze multigenomic and clinical data to discover biomarkers and predict diseases in individuals.
IntelliGenes analyzes genomic data to discover biomarkers associated with health traits.
A newly published study provides guidance for building accurate mathematical models for gene regulatory networks. The project, which includes an online database, was supported by undergraduate researchers at Iowa State.
Sanjeev S. Ranade, Ph.D., who joined the faculty of Sanford Burnham Prebys this month as an assistant professor in the Development, Aging and Regeneration program, studies how proteins called transcription factors (TFs) specifically control the development and function of cardiac cells — and what happens when things go wrong.
Tumors constantly shed DNA from dying cells, which briefly circulates in the patient’s bloodstream before it is quickly broken down.
Analysis aims to fill knowledge gaps and help guide clinical decisions for a group particularly vulnerable to developing glaucoma
An international team of researchers from McMaster University, University of Alaska Fairbanks and the University of Ottawa has tracked and documented the movements and genetic connections of a female woolly mammoth that roamed the earth more than 14,000 years ago.
The ocean is the world’s largest habitat, yet much of its biodiversity is still unknown. A study published in Frontiers in Science marks a significant breakthrough, reporting the largest and most comprehensive database of marine microbes to date – matched with biological function, location, and habitat type.
An international scientific team made up of more than 40 authors from seven different countries, led by the researcher at the University of Malaga Juan Pascual Anaya, has managed to sequence the first genome of the myxini –also known as ‘hagfish’–, the only large group of vertebrates for which there was no reference genome of any of its species yet.
Identification of genes under recent selection provides insights into the molecular mechanisms of human-related adaptation in Candida pathogens.
The first genome of hagfish – the only vertebrate lineage without a reference genome - has been sequenced by an international team of scientists.
Scientists at St. Jude Children’s Research Hospital refined and enhanced the classification system for a type of pediatric leukemia using genomic and transcriptomic analysis.
Researchers at the Francis Crick Institute, working with University of Oxford, University of York and Oxford Archaeology, have developed a new technique to measure the number of chromosomes in ancient genomes more precisely, using it to identify the first prehistoric person with mosaic Turner syndrome (characterised by one X chromosome instead of two [XX]), who lived about 2500 years ago.
The research, published in Science Translational Medicine, found that messenger RNA (mRNA) could be used to correct a rare liver genetic disease known as argininosuccinic aciduria in a mouse model of the disease.
University of Pittsburgh Schools of Medicine researchers uncovered a fundamental mechanism that controls the body’s response to limited oxygen and regulates blood vessel disease of the lung.
Rice University scientists have developed a noninvasive way to monitor gene expression dynamics in the brain, making it easier to investigate brain development, cognitive function and neurological diseases, according to a study published in Nature Biotechnology.
Researchers at IRB Barcelona discover unexpected patterns in mutation risks across individuals, uncovering 13 distinct genomic patterns.
The genomic analysis of 52 Psilocybe specimens includes 39 species that have never been sequenced.
Researchers from Queen Mary University of London have revealed how sociocultural factors, in addition to geography, play a significant role in shaping the genetic diversity of modern societies.
The research suggests an easy-to-measure brain process may be a target or biomarker in measuring treatment outcomes in clinical trials for patients with Batten disease.
New understanding of a gene that is linked to some forms of dementia and other age-related diseases gives scientists fresh hope that action can be taken against these diseases long before the onset of symptoms.
Thanks to technological advances, scientists have access to vast amounts of data, but in order to put it to work and draw conclusions, they need to be able to process it.
Using a new technology developed at MIT, diagnosing lung cancer could become as easy as inhaling nanoparticle sensors and then taking a urine test that reveals whether a tumor is present.
A new study led by researchers from the University of Helsinki, along with colleagues at the Massachusetts General Hospital and Broad Institute of Harvard and MIT, provides significant breakthroughs in our understanding of the genetics behind gestational diabetes.
Research indicates that the eating disorder anorexia nervosa is associated with being an early riser, unlike many other disorders that tend to be evening-based such as depression, binge eating disorder and schizophrenia.
A research team from Odense University Hospital and the University of Southern Denmark has developed an innovative screening test. With a blood sample from the expectant mother, they can scrutinize all the genes in the fetus.
The egg did come first. Egg-laying arose deep in evolutionary time, long before animals even made their way onto land.
Find the latest research and features on fertility in the Fertility News Source on Newswise.
A groundbreaking study has found that evolution is not as unpredictable as previously thought, which could allow scientists to explore which genes could be useful to tackle real-world issues such as antibiotic resistance, disease and climate change.
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