African American women participating in a clinical study on breast cancer had more side effects and poorer survival rates than did women of European ancestry, according to a an Indiana University study that identified ethnicity through genetics--a first in this type of research.
Researchers use compounds found in a combination plant-based diet to successfully prevent and treat ER-negative breast cancer in mice.
A new study suggests that the ability of a stem cell to differentiate into cardiac muscle (and by extension other cell types) depends on what portions of the genome are available for activation, which is controlled by the location of DNA in a cell’s nucleus.
More than 20 years after scientists revealed that mutations in the BRCA1 gene predispose women to breast cancer, Yale scientists have pinpointed the molecular mechanism that allows those mutations to wreak their havoc.
Mount Sinai researchers discover that insulinomas contain novel molecular pathways and reveal the map to regenerate insulin-producing cells
Scientists have helped provide a way to better understand how to enable drugs to enter the brain and how cancer cells make it past the blood brain barrier.
An existing drug may one day protect premenopausal women from life-altering infertility that commonly follows cancer treatments, according to a new study.
Sunbathers may want to avoid midnight snacks before catching some rays.
Drug zeroes in on mutated nuclear receptors found in cancer, leaves normal proteins alone
Black men who enrolled in patient navigator program at local barbershops were twice as likely to get colorectal cancer screening as those who did not.
Scientists have had limited success at identifying specific inherited genes associated with prostate cancer. Researchers at University of Utah Health studied prostate cancer patients with multiple cancer diagnoses to identify genetic mutations that may influence cancer treatment and cancer risk.
Research from the Stowers Institute provides evidence suggesting that cancer cells might streamline their genomes in order to proliferate more easily. The study, conducted in both human and mouse cells, shows that cancer genomes lose copies of repetitive sequences known as ribosomal DNA. While downsizing might enable these cells to replicate faster, it also seems to render them less able to withstand DNA damage.
Can use of hair products have an impact on breast cancer risk for women? That is a question explored by investigators from Rutgers Cancer Institute of New Jersey, Rutgers School of Public Health and other colleagues who examined use of hair dyes, hair relaxers and cholesterol-based hair products in African-American and Caucasian women.
A new study by UCLA scientists has found that the breakthrough immunotherapy drug pembrolizumab can be more effective in improving survival in people with non-small cell lung cancer (NSCLC) if they have previously received radiation therapy, compared to those without a history of radiation treatment.
A new technology generates cellular images detailed enough to distinguish cancerous from normal tissue. Researchers are working on speeding up the technology so it can be used during surgery, allowing surgeons to know if they have removed all the cancer while they still have time to take out more.
A new study suggests that the use of tomato — a key food of the Mediterranean diet — should be explored to develop supportive strategies against gastric cancer
A research team has engineered a small peptide that binds to a protein found in high-risk prostate cancers and can be imaged using MRI. The system identified aggressive tumors in mouse models of prostate cancer, and is a promising step for reliable early detection and treatment of high-risk, life-threatening prostate cancer.
Uninsured women with breast cancer were nearly 2.6 times more likely to have a late-stage diagnosis than cancer patients who were insured, finds a new study from the Brown School at Washington University in St. Louis.
In experiments with human colon cancer cells and mice, a team led by scientists at the Johns Hopkins Kimmel Cancer Center say they have evidence that cancer arises when a normal part of cells' machinery generally used to repair DNA damage is diverted from its usual task. The findings, if further studies confirm them, could lead to the identification of novel molecular targets for anticancer drugs or tests for cancer recurrence, the investigators say.
Of the 1,000 GI cancer patients seen at his clinic last year, nearly half were under age 50, says John L. Marshall, MD, director of the Ruesch Center for the Cure of Gastrointestinal Cancers at Georgetown Lombardi Comprehensive Cancer Center and chief of hematology and oncology at MedStar Georgetown University Hospital. Many are in their 20s and 30s; one was just 17.
New guidelines recommend that men aged 55 to 69 with no signs of prostate cancer have a conversation with their doctor about the benefits and drawbacks of screening for the disease.
UNC Lineberger Comprehensive Cancer Center researchers report in a new study that anti-tanning bed messages with images showing longer-term health effects, such as skin cancer or wrinkles, produced greater negative emotional reactions and higher ratings of effectiveness in a survey of female college students than text-only messages.
Researchers at Penn State have developed nanoprobes to rapidly isolate rare markers in blood for potential development of precision cancer diagnosis and personalized anticancer treatments.
A new study from the University of Michigan Comprehensive Cancer Center examines the complex interaction between patients’ desires for contralateral prophylactic mastectomy and surgeons’ responsibility to minimize harm.
A patient’s confidence in their ability to schedule, plan for and properly conduct their part in colorectal screening methods is a key factor that predicts whether they intend to be tested, according to new research from Penn State College of Medicine.
A study of racial disparities in health-related quality of life of colorectal cancer patients revealed among several findings, that Hispanics and blacks had a higher burden of poor health-related quality-of-life (HR-QoL) than white patients and that poor HR-QoL resulted in shorter median survival. Yet Hispanics had an average survival time of 85.4 months as compared to blacks at 47.8 months and whites at 43.2 months.
Genetic mutations that cause cancer also weaken cancer cells, allowing researchers to develop drugs that will selectively kill them. This is called “synthetic lethality” because the drug is only lethal to mutated (synthetic) cells. Researchers at UC San Diego School of Medicine and Jacobs School of Engineering developed a method to search for synthetic-lethal gene combinations. The technique, published March 20 in Nature Methods, uncovered 120 new opportunities for cancer drug development.
In a rigorous study of tumor tissue collected from 125 patients with aggressive brain cancers, researchers at Johns Hopkins say they have found no evidence of cytomegalovirus (CMV) infection and conclude that a link between the two diseases, as claimed by earlier reports, likely does not exist.
More than three decades after surviving breast cancer, Susanne Calabrette faced a second scare. In June 2016, an MRI for an unrelated condition revealed she had pancreatic cysts, giving her a chance for a pre-emptive strike against this killer cancer.
Researchers have developed a non-invasive imaging technique that accurately detects skin cancer without surgical biopsy. Multiphoton microscopy of mitochondria accurately identified melanomas and basal cell carcinomas by detecting abnormal clusters of mitochondria in both types of skin cancer.
The cellular skeleton protein actin can bind cells together, and also play a number of roles in cancer’s invasion into new tissues in the body.
“Every cancer diagnosis should come with a referral to genetic counseling,” says cancer expert Dr. Antonio Giordano, President of the Sbarro Health Research Organization at Temple University.
Using immature stem cells to create a miniature model of the gut in the laboratory, researchers at Washington University School of Medicine in St. Louis and the University of Pittsburgh have determined how infection-causing enteroviruses enter the intestine.
Researchers at Washington University School of Medicine in St. Louis have developed an online “knowledgebase” intended for the gathering and organization of cancer genomic information so that clinicians have improved chances of identifying important mutations in a patient’s tumor and potentially connecting genetic errors with drugs known to target them. The online resource, called CIViC, is described Jan. 30 in Nature Genetics.
An important step in planning tumor surgery includes assessing the tumor stiffness to aid in surgical planning. Because tumors within the skull cannot be examined non-invasively, researchers used Magnetic Resonance Elastography (MRE) to assess pituitary tumor stiffness. MRE reliably identified tumors that were soft enough for removal with a minimally-invasive suction technique versus harder tumors requiring more invasive surgery.
Researchers have found that sunlight, through a mechanism separate than vitamin D production, energizes T cells that play a central role in human immunity. The findings suggest how the skin, the body’s largest organ, stays alert to the many microbes that can nest there.
Pop culture icons can influence our fashion choices, dietary habits and brand preferences, but can celebrities also influence our medical decisions?
Between 2008 and 2014, more than 53 million people in 88 countries stopped smoking due to tobacco control measures, which means that more than 22 million smoking-related deaths have been averted, say researchers at the Georgetown Lombardi Comprehensive Cancer Center. These conclusions update their 2013 landmark study that found tobacco control measures undertaken by 41 countries between 2007-2010 had prevented 7.4 smoking-related million deaths.
A personalized cancer vaccine markedly improved outcomes for patients suffering from acute myeloid leukemia (AML), a potentially lethal blood cancer, in a clinical trial led by investigators at Beth Israel Deaconess Medical Center (BIDMC). The product of a long-term collaboration among investigators at the Cancer Center at BIDMC and Dana-Farber Cancer Institute, the vaccine stimulated powerful immune responses against AML cells and resulted in protection from relapse in a majority of patients, the team of researchers reported today in Science Translational Medicine.
Previous studies identified the Hippo pathway kinases LATS1/2 as a tumor suppressor, but new research led by University of California San Diego School of Medicine scientists reveals a surprising role for these enzymes in subduing cancer immunity. The findings could have a clinical role in improving efficiency of immunotherapy drugs.
Breakthrough UNLV study shows major differences between the types of cancer and mortality rates of U.S.-born blacks versus those who emigrate from the Caribbean.
Researchers at University of California San Diego School of Medicine, Ludwig Institute for Cancer Research and The Scripps Research Institute, with colleagues in Los Angeles and Japan, report that depriving deadly brain cancer cells of cholesterol, which they import from neighboring healthy cells, specifically kills tumor cells and caused tumor regression and prolonged survival in mouse models.
Researchers have discovered that an enzyme called uracil-DNA glycosylase (UNG) protects the ends of B cell chromosomes to facilitate the proliferation of these antibody-producing cells in response to infection. The study “UNG protects B cells from AID-induced telomere loss,” which will be published online October 3 ahead of issue in The Journal of Experimental Medicine, also suggests that targeting this enzyme may help treat certain types of non-Hodgkin’s lymphoma.
Approximately 20 percent of all human cancers have mutations in a gene called KRAS. KRAS-mutant cancers are among the most difficult to treat, with poor survival and resistance to chemotherapy. Researchers at University of California San Diego School of Medicine and Moores Cancer Center used microRNAs to systematically inhibit thousands of other genes to find combinations that are specifically lethal to cancer cells driven by a KRAS mutation.
Researchers have recently shown that magnetic bacteria are a promising vehicle for more efficiently delivering tumor-fighting drugs.
On Friday, Aug. 23, the University of Alabama at Birmingham Comprehensive Cancer Center celebrated the public grand opening of the renovated Lurleen B. Wallace Tumor Institute (WTI).
As a woman in her mid-forties who didn’t smoke, Elizabeth Lacasia never expected to be diagnosed with lung cancer. But in 2006, after she developed a persistent and serious cough, a chest X-ray and CT scan revealed several tumors in her lower left lung.
Researchers at the University of Chicago Medicine Comprehensive Cancer Center (UCCCC) have identified a gene that contributes to the development of acute myeloid leukemia (AML). This pivotal finding follows 40 years of University of Chicago research that has slowly unraveled the genetic basis of leukemia.
Researchers at the University of Kansas Cancer Center's Cancer Control and Population Health program address the enormous health disparities common among American Indians and other populations at risk.
A thorough understanding of cancer treatments and the emotional aspects surrounding cancer are important in diagnosing depression in cancer patients.
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