Engaging in repetitive and ritualistic behaviors is part of typical child development. However, behaviors that develop into obsessive and compulsive symptoms (OCS) may represent a red flag for serious psychiatric conditions.
A molecule derived from a type of primrose could prove to be a potent inhibitor of metastatic growth for a rare and aggressive cancer.
Until now, it was unclear how this DNA packing affected development in early embryos. In a paper published this week in Science, researchers from the Perelman School of Medicine at the University of Pennsylvania found that in mouse embryos--only eight days after fertilization--compacted regions along the genome increase at protein-coding genes. Days later in the cell differentiation phase, these domains open to allow certain genes to be read and made into their corresponding proteins.
When researchers unlock the mysteries of Castleman disease, they may single out 2018 as one of the years in which they laid the foundation to help them turn the key, and the University of Pennsylvania has been the epicenter.
An implantable neuroprosthetic device may one day provide a new approach to restoring more natural facial movement in patients with one-sided facial paralysis (hemifacial palsy), suggests a study in the January issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
A growing body of evidence supports the effectiveness of botulinum toxin injections in reducing the frequency of chronic migraine headaches, concludes an updated review and analysis in the January issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
An analysis of nationwide data shows patients with symptoms are most likely to return to the hospital within a week of their thyroid surgery, suggesting avenues for better care.
Researchers at Children’s Hospital of Philadelphia (CHOP) evaluated a digital medicine tool designed as an investigational treatment for children with autism spectrum disorder (ASD) and co-occurring attention/deficit-hyperactivity disorder (ADHD).
Scientists have used a combination of mathematical modeling, electrophysiology, and computer simulations to explain how cells communicate effectively in highly constricted spaces such as the olfactory cilia. The findings will inform future studies of cellular signaling in the olfactory system and other confined spaces of the nervous system.
Wolters Kluwer, Health and the American Journal of Nursing (AJN) announced the 2018 winners of its annual AJN Book of the Year Awards honoring exceptional texts for advancing healthcare quality. The list of winners appears in the January 2019 issue of AJN, the “leading voice of nursing since 1900.” AJN is published in the Lippincott portfolio by Wolters Kluwer.
At least for brief periods, overlapping surgery is safe for patients undergoing outpatient or "same-day" orthopaedic surgery procedures, reports a study in the December 19, 2018 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
A community-based, pilot study shows a high-tech app is as effective as low-tech picture card intervention at improving social and communication skills in children with autism.
The Monell Center and Thomas Jefferson University announce the funding of five collaborative pilot grants for projects that combine Monell’s research on the senses of taste and smell with Jefferson’s complementary strengths in the basic and clinical neurosciences.
Findings published in JNCCN-Journal of the National Comprehensive Cancer Network examine the differences between patient- and clinician-reported outcomes; recommend a greater focus on the cumulative effect of multiple low-level toxicities.
Brain tumor patients will now have access to Penn Medicine’s world-renowned cancer expertise through the launch of a new telemedicine second opinion program for brain tumors.
The overwhelming draw of DTC genetic kits is their appeal to discover more about one’s ancestry and heritage, as well as health and wellness. When I first wrote on this topic, I sought details about my risk for heart disease, given my family history, but as I learned from speaking with several Penn Medicine geneticists, DTC kits aren’t set up for this area yet. However, it is possible to glean the genetic basis for seemingly off-beat behaviors and traits, such as toe-length ratio or sweet-versus-salty taste preference.
Researcher shows the two most common means of resistance to BRAF and MEK inhibitors are actually connected processes and can be targeted by other therapies.
A new treatment for patients with a form of congenital retinal blindness has shown success in improving vision, according to results published today in led by researchers at the Scheie Eye Institute in the Perelman School of Medicine at the University of Pennsylvania.
A new study from the University of Pennsylvania School of Nursing’s Center for Health Outcomes and Policy Research (CHOPR) describes the quality of end of life care in nearly 500 U.S. hospitals, utilizing nearly 13,000 bedside nurses as informants of quality. The study has been published online first. It will also be in a future issue of the Journal of the American Geriatrics Society.
Researchers find an effective way to treat an underdiagnosed condition that can cause heart attack and heart-attack-like symptoms.
Researchers find an effective way to treat an underdiagnosed condition that can cause heart attack and heart-attack-like symptoms.
Researchers find an effective way to treat an underdiagnosed condition that can cause heart attack and heart-attack-like symptoms.
Researchers find an effective way to treat an underdiagnosed condition that can cause heart attack and heart-attack-like symptoms.
Pediatric oncologist and researcher Yael Mossé, MD, Director of the Neuroblastoma Development Therapeutics Program at Children’s Hospital of Philadelphia, has been named the inaugural holder of the Patricia Brophy Endowed Chair in Neuroblastoma Research.
Children with elevated levels of callous traits—such as a lack of remorse and disregard for other people’s feelings—show widespread differences in brain structure compared with children with lower levels of the traits, according to a new study published in Biological Psychiatry. The differences, which included large- and small-scale structural alterations, support the idea of callous traits as a neurodevelopmental condition.
Isaac H. Clothier Jr. Professor of Biology Amy Cheng Vollmer was recently a guest on Key Conversations, a podcast from the Phi Beta Kappa (PBK) Society that features dialogues with PBK Visiting Scholars.
Saint Joseph’s University is one of the first higher education institutions to offer an Autism Break Room in an NCAA Division I athletic arena
The Perelman School of Medicine at the University of Pennsylvania and Arcadia University are launching a Master of Science in Genetic Counseling program at Penn in 2019.
A study finds that palbociclib, in combination with endocrine therapy, improves progression free survival
This week, SHRO partners with the Italian Movie Award International Film Festival to support Italian-American work in cinema, particularly in recognition for accomplishments with the use of Virtual Reality (VR) in applications in medicine
More and more, through sequencing done for medical reasons or done by direct-to-consumer companies, people learn they have variants of disease genes with uncertain significance to their health. With a new assay, researchers have a way to determine the potential impact of these cardiomyopathy variants on the health of patients and their family members.
Advocates, patients, providers, and other experts examine disparities and explore solution at the NCCN Patient Advocacy Summit on Equity in Cancer Care
A team of surgeons from the Perelman School of Medicine at the University of Pennsylvania are the first in the world to use a surgical robot to assist with a bilateral free flap breast reconstruction, allowing patients to recover and be discharged more quickly and without the use of addictive narcotic painkillers.
Children’s Hospital of Philadelphia celebrates a pivotal moment in medicine: approval by the European Commission of LUXTURNA® (voretigene neparvovec), the first and only gene therapy for patients with an inherited retinal disease, last month. This also makes LUXTURNA the first gene therapy for a genetic disease that has received regulatory approval in both the U.S. and European Union.
Children’s Hospital of Philadelphia celebrates a pivotal moment in medicine: approval by the European Commission of LUXTURNA® (voretigene neparvovec), the first and only gene therapy for patients with an inherited retinal disease, last month. This also makes LUXTURNA the first gene therapy for a genetic disease that has received regulatory approval in both the U.S. and European Union.
Researchers at The Wistar Institute have developed novel synthetic DNA-encoded monoclonal antibodies (DMAbs) directed against PCSK9, a protein key to regulating cholesterol levels in the bloodstream.
Over the years, the Centers for Disease Control (CDC) and its partners have made major progress towards reducing lead exposure in the United States. But more work remains in preventing lead poisoning in US children and adults, according to a special supplement to the Journal of Public Health Management and Practice. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Investigations of lead poisoning cases in New York City (NYC) have found high levels of lead in certain spices purchased abroad, reports a study in the Journal of Public Health Management and Practice, part of a special supplement devoted to Lead Poisoning Prevention. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Physician-scientists from Children’s Hospital of Philadelphia presented updated efficacy and safety data on Kymriah (tisagenlecleucel) --the first-ever FDA-approved personalized CAR T-cell gene immunotherapy for aggressive blood cancers, at the American Society of Hematology annual meeting, as well as first-of-its-kind research on overcoming CAR T-cell resistance.
The Basser Center for BRCA at Penn Medicine’s Abramson Cancer Center, the world’s first comprehensive center aimed at advancing research, treatment, and prevention of BRCA-related cancers, has announced Maria Jasin, PhD, as the recipient of the sixth annual Basser Global Prize. Jasin is a member of the Developmental Biology Program at Memorial Sloan Kettering Cancer Center and a professor at the Weill Graduate School of Medical Sciences at Cornell University.
NCCN Oncology Research Program Awarded $2 Million from Lilly to Study Mechanisms of Resistance to CDK4 & 6 Inhibitors in Breast Cancer Treatment
A new study from the University of Pennsylvania School of Nursing (Penn Nursing) suggests that alcohol consumption may attenuate long-term weight loss in adults with Type 2 diabetes.
In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah® (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL).
Chronic myelomonocytic leukemia (CMML) is a rare disease with overlapping features of two categories of bone marrow and blood cell disorders that poses challenges in clinical management. Joint recommendations on diagnosis and treatment of CMML from two European specialty societies were published today in HemaSphere, the official journal of the European Hematology Association (EHA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Hospitalization rates among homeless adults have increased sharply in recent years, with a very different set of causes from those in non-homeless individuals, reports a study in the January issue of Medical Care. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Scoring models used to predict 30-day readmission risk in the general hospital population may not accurately predict readmissions for patients in the neurocritical care unit, reports a study in the Journal of Neuroscience Nursing, official journal of the American Association of Neuroscience Nurses. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Breast reconstruction using a "free flap" from the patient's abdomen is a safe procedure with a high success rate in older women opting for reconstruction after mastectomy, reports a study in the December issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
Nasal surgery to relieve obstructed breathing can reduce or eliminate chronic headaches in selected patients, reports a paper in the December issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
The U.S. Food and Drug Administration (FDA) has approved the first ever inhibitor drug specifically approved for treating patients with relapsed or refractory acute myeloid leukemia (AML) with a mutation in the Fms-like tyrosine kinase 3 (FLT3) gene.
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