A recent study from the lab of the University of Kentucky’s Sanders-Brown Center on Aging Director Linda Van Eldik, Ph.D., has been published in PLOS ONE. The work centers around the idea that various anti-inflammatory drugs could be effective treatments for Alzheimer’s disease (AD). This study focused on a protein known as p38.
An estimated 1,200 Americans, on average, are diagnosed with Lyme disease each day. Some of those patients continue to experience negative effects, even after treatment. Lyme disease researcher Brandon Jutras, associate professor in the College of Agriculture and Life Sciences and affiliated faculty of the Fralin Life Sciences Institute, recently received a $2.
If the human cell is a nightclub, then the nucleus is a VIP lounge fiercely maintained by the nuclear pore complex. By modeling a dynamic simulation of the NPC, Beckman physicists have theorized as to why some proteins enter the nucleus more readily than others.
Musical rhythms can help children with speech and language processing difficulties in finding their voice by improving their capacity to repeat sentences they just heard, according to a study led by a Western Sydney University researcher and co-authored by Vanderbilt University Medical Center.
Researchers from the University of Notre Dame, in a study recently published in Nature, found that removing invasive vegetation at water access points in and around several Senegalese villages reduced rates of schistosomiasis by almost a third. As a bonus, the removed vegetation can also be used for compost and livestock feed.
What makes the vital layer of protective cells around the brain and spinal cord — the blood-brain barrier — more or less permeable has been one of the more mystifying questions in neuroscience.
In a pre-clinical, proof-of-concept study from Johns Hopkins Medicine, researchers found that epigallocatechin gallate (EGCG), a green tea compound with powerful antioxidant properties, could be promising for both treating and preventing uterine fibroids. Results of the study, first posted online May 25 in Scientific Reports, add to growing evidence that EGCG may reduce fibroid cell growth.
On July 6, 2023, the U.S. Food and Drug Administration (FDA) granted full approval to lecanemab, marketed as Leqembi, for the treatment of Alzheimer’s disease. The University of Kentucky’s Sanders-Brown Center on Aging has been working with this drug and others like it for more than a decade.
New research from Cedars-Sinai Cancer investigators could warrant reconsideration of current screening guidelines to include a poorly recognized cause of Lynch syndrome, the most common cause of hereditary colorectal and endometrial cancers.
UT Southwestern Medical Center researchers have identified a gene called Lipe that appears to be pivotal to retinal health, with mutations spurring immune activation and retinal degeneration. This is important because the retina is responsible for detecting the light that is transformed into vision. The findings, published in Communications Biology, provide clues about the mechanisms behind a variety of disorders affecting the retina, including macular degeneration and diabetic retinopathy.
A new national study, led by researchers at Tufts Medical Center in Boston, has found whole genome sequencing (WGS) to be nearly twice as effective as a targeted gene sequencing test at identifying abnormalities responsible for genetic disorders in newborns and infants.
A $40.5 million grant from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH), will fund the Asian Cohort for Alzheimer’s Disease (ACAD) study at Penn Medicine and 15 other academic research centers across the United States and Canada.
Two drugs commonly used to treat inflammatory diseases such as rheumatoid arthritis and psoriasis did not shorten recovery time for patients hospitalized with severe COVID-19 but did reduce the likelihood of death when compared with standard care alone, according to a national study led by Washington University School of Medicine in St. Louis.
University of Virginia School of Medicine researchers have discovered how the cells that let us hear can repair themselves after being damaged. That important insight could benefit efforts to develop new and better ways to treat and prevent hearing loss.
A Ludwig Cancer Research study has discovered that the presence of relatively high numbers of immune cells known as monocytes in tumors is linked to better outcomes in esophageal cancer patients treated with a combination of chemotherapy and immunotherapy, or immunochemotherapy.
Now that the emergency phase of the COVID-19 pandemic has ended, scientists are looking at ways to surveil indoor environments in real time for viruses. By combining recent advances in aerosol sampling technology and an ultrasensitive biosensing technique, researchers at Washington University in St. Louis have created a real-time monitor that can detect any of the SARS-CoV-2 virus variants in a room in about 5 minutes.
Scientists at St. Jude Children’s Research Hospital and colleagues in Latin America found that early identification of clinical deterioration saves lives, especially in hospitals with the greatest need.
A novel molecular pathway to explain how a mutation in the gene ACTA2 can cause individuals in their 30s – with normal cholesterol levels and no other risk factors — to develop coronary artery disease has been identified, according to researchers with UTHealth Houston.
The society is concerned that new NIH subaward policy, if adopted, will harm the global scientific enterprise by disrupting collaboration and heighten administrative burden on scientists.
A modeled implementation of a nationwide produce prescription program—which would provide free or discounted fruits and vegetables to eligible Americans living with diabetes —projected extensive reductions in national rates of cardiovascular disease and associated healthcare costs.
U.S. Black women have a disproportionately higher burden of both preeclamptic pregnancy and stroke compared with white women, but virtually all existing evidence on the association between the two medical conditions has come from studies of white women.
Plant and animal stem cells both rely on the cytoskeleton to divide properly, but a new study finds that they use them in opposite ways—while animal cells pull on the cytoskeleton, plant cells push it away. Harnessing that action could help scientists engineer more resilient plants.
Researchers at Johns Hopkins Medicine, in collaboration with researchers at the National Institutes of Health, report that two new studies in mice with a humanized immune system and human cell lines have identified an enzyme that plays a critical role in the late stages of HIV replication.
ASBMB applauds NIH's proposed changes to the NRSA grant application including removal of grades, inclusion of applicant special circumstance statement and reviewer bias training
Nearly 700,000 people in the United States die from heart disease every year, and one-third of those deaths result from complications in the first weeks or months following a traumatic heart-related event. To help prevent those deaths, researchers at Northwestern and George Washington (GW) universities have developed a new device to monitor and treat heart disease and dysfunction in the days, weeks or months following such events.
With $7 million in funding from the National Institutes of Health, researchers from Wake Forest University School of Medicine and Wake Forest University will study whether a combination of resistance training plus bone-strengthening exercises and/or osteoporosis medication use can help older adults safely lose weight without sacrificing bone mass.
Scientists at St. Jude Children’s Research Hospital found that altering amounts of the nutrient glutamine in the tumor microenvironment could enhance or impair the immune system’s anti-cancer response.
Distinct, though neighboring, areas of the brain are activated when processing music and language, with specific sub-regions engaged for simple melodies versus complex melodies, and for simple versus complex sentences, according to research from UTHealth Houston.
In a study led by Johns Hopkins Medicine, in collaboration with Yale School of Medicine, researchers have identified a biomarker found via a simple urine test that can be used to diagnose acute tubulointerstitial nephritis (AIN), a medical condition that causes inflammation of the kidneys and can lead to acute kidney injury (AKI) — a sudden loss of kidney function. Experts say a kidney biopsy is often required to diagnose AIN because there are no disease-specific signs or symptoms.
Gene therapy that alters hemoglobin genes may be an answer to curing sickle cell disease and beta thalassemia. Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard found base editing increased fetal hemoglobin production in a new treatment.
A soft robotic glove is lending a “hand” and providing hope to piano players who have suffered a disabling stroke. Combining flexible tactile sensors, soft actuators and AI, this robotic glove is the first to “feel” the difference between correct and incorrect versions of the same song and to combine these features into a single hand exoskeleton. Unlike prior exoskeletons, this new technology provides precise force and guidance in recovering the fine finger movements required for piano playing and other complex tasks.
A blood-based four-protein panel (4MP), when combined with a lung cancer risk model (PLCOm2012), can better identify those at high risk of dying from lung cancer than the current U.S. Preventive Services Task Force (USPSTF) criteria.
When it comes to e-cigarette warning labels, respondents in focus groups organized by Cornell researchers were clear: Give it to me straight.
A study of more than 22,000 people with multiple sclerosis has discovered the first genetic variant associated with faster disease progression, which can rob patients of their mobility and independence over time.
Johns Hopkins Medicine scientists say they have developed a nanoparticle — an extremely tiny biodegradable container — that has the potential to improve the delivery of messenger ribonucleic acid (mRNA)-based vaccines for infectious diseases such as COVID-19, and vaccines for treating non-infectious diseases including cancer.
A new collective named the Great Lakes Clinical Center (GLCC) for the ARDS, Pneumonia and Sepsis (APS) Phenotyping Consortium will be intensely focused on examining the various mechanisms underpinning these conditions to better understand their impact on disease development, trajectory and outcomes.
Scleroderma is an autoimmune disease characterized by thickening and scarring of the skin and vital organs, and the narrowing of the blood vessels which lead to poor circulation.
People who have just one or two drinks per day are not protected against endocrine conditions such as obesity and type 2 diabetes, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
For many patients with hypertension—an elevated blood pressure that can lead to stroke or heart attack—medication keeps the condition at bay. But what happens when medication that physicians usually prescribe doesn’t work? Known as apparent resistant hypertension (aRH), this form of high blood pressure requires more medication and medical management.
In a study that followed more than 2,000 community-dwelling older adults over eight years, researchers at Johns Hopkins Medicine say they have significant new evidence of a link between decreased sense of smell and risk of developing late-life depression.
A laboratory at the Hackensack Meridian Center for Discovery and Innovation (CDI) has been issued a major grant to repurpose drugs to combat non-tuberculous mycobacteria (NTM), an emerging family of germs naturally found in soil and water and which can be deadly to those with compromised immune systems and pre-existing lung diseases.
Loss of two key “protector” proteins initiates epigenetic changes that transform healthy lung cells into cancerous ones, according to new research from Van Andel Institute scientists.
As men age, some of their cells lose the very thing that makes them biological males—the Y chromosome—and this loss hampers the body’s ability to fight cancer, according to new research from Cedars-Sinai Cancer.
Irvine, Calif., June 21, 2023 — The process by which aged, or senescent, pigment-making cells in the skin cause significant growth of hair inside skin moles, called nevi, has been identified by a research team led by the University of California, Irvine. The discovery may offer a road map for an entirely new generation of molecular therapies for androgenetic alopecia, a common form of hair loss in both women and men.
Researchers at The University of Texas MD Anderson Cancer Center have uncovered a gene on the Y chromosome that is upregulated in KRAS-mutated colorectal cancer (CRC), increasing tumor cell invasiveness and reducing anti-tumor immunity in male patients.
Adults who live in walkable neighborhoods are more likely to socialize and have a stronger sense of community, report researchers at the UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science.
Cedars-Sinai investigators have identified several steps in a cellular process responsible for triggering one of the body’s important inflammatory responses. Their findings, published in the peer-reviewed journal Science Immunology, open up possibilities for modulating the type of inflammation associated with several infections and inflammatory diseases.
Scientists at City of Hope have developed universal donor stem cells that could one day provide lifesaving therapy to children with lethal brain conditions, such as Canavan disease, as well as to people with other degenerative diseases, such as Alzheimer’s and multiple sclerosis.
The University of California, Irvine has received a five-year, $10 million grant from the National Institutes of Health to lead a multi-institutional study of specific brain cell vulnerabilities to abnormal tau protein deposits in regions affected in the early stages of Alzheimer’s disease.
UC San Diego scientists discover shattered chromosomal fragments are tethered together during cell division before being rearranged; destroying the tether may help prevent cancerous mutations.
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