Every day, one person in Switzerland is diagnosed with multiple sclerosis. MS is an autoimmune disease in which the body’s own immune system attacks the myelin sheath of the nerve cells in the brain and spinal cord.
For the first time, scientists have used CRISPR technology to insert genes that allow immune cells to focus their attack on cancer cells, potentially leaving normal cells unharmed and increasing the effectiveness of immunotherapy.
A new study being presented at this year’s ACAAI Annual Scientific Meeting shows a treatment using the CRISPR genome editing technology succeeded in alleviating swelling and reducing the frequency of attacks.
Tailoring the analysis of whole genome sequencing to individual patients could double the diagnostic rates of rare diseases, finds a new study led by UCL researchers.
The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented in-person and online at ASN Kidney Week 2022 November 3–November 6.
Cleveland Clinic’s Lerner Research Institute was awarded a five-year $12 million grant by the National Cancer Institute, part of the National Institutes of Health, to define how cytokines - proteins produced during immune response - regulate inflammation and interact with cells and molecules surrounding tumors.
Vasa Therapeutics, Inc., a preclinical stage company developing first-in-class treatments for cardiovascular indications with limited or no available therapies, today announced two upcoming poster presentations showing data on the company's lead clinical candidate, VS-041, a selective matrix metalloprotease (MMP) inhibitor for treatment of heart failure with preserved ejection fraction (HFpEF) and the discovery of novel calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ) inhibitors for treatment of β-blocker resistant arrythmias, at the American Heart Association (AHA) Scientific Sessions November 5 – 7 in Chicago, IL.
Un nuevo estudio dirigido por investigadores de Cedars-Sinai encontró que el uso de pruebas de aliento para identificar perfiles de gases intestinales puede conducir a terapias más personalizadas para personas diagnosticadas con síndrome del intestino irritable (SII). El trastorno gastrointestinal más común afecta del 10% al 15% de la población mundial.
The environment could be playing a critical role in the expression of polycystic ovary syndrome (PCOS) in women living in Alabama, as compared to women in California, according to a new study published in the Journal of Clinical Endocrinology & Metabolism.
As more patients with cancer have their tumors genomically profiled, and more therapies targeting genomic alterations enter clinical trials, the task of connecting patients to trials for which they are eligible can be especially challenging. A computer platform developed at Dana-Farber Cancer Institute makes the matching process both easier and faster, its designers report in a new study.
An important new clue for preventing and treating brain tumors known as gliomas has been identified in research led by the Lunenfeld-Tannenbaum Research Institute (LTRI) at Mount Sinai Hospital in Toronto and Mayo Clinic Comprehensive Cancer Center and Mayo Clinic Center for Individualized Medicine. The study, published in the journal Science, provides a rare window into the biological changes behind glioma development.
Following rapid growth during the COVID-19 pandemic, telehealth visits are expected to remain an important part of endocrine care, according to a new Endocrine Society policy perspective published in The Journal of Clinical Endocrinology & Metabolism.
Mayo Clinic researchers have discovered that people with major depressive disorder and a history of attempted suicide have distinct biomarkers that correlate with their response to antidepressant therapy. The new findings, published in Frontiers Pharmacology, are key to individualized treatment strategies and early identification of patients who are at the highest risk for suicide.
Cedars-Sinai Guerin Children’s pediatric specialists will share their expertise and recent research findings at the American Academy of Pediatrics Annual Meeting, taking place Oct. 7-11 in Anaheim, California.
Researchers at the University of Michigan Rogel Cancer Center have developed a computational platform that can predict new and specific metabolic targets in ovarian cancer, suggesting opportunities to develop personalized therapies for patients that are informed by the genetic makeup of their tumors. The study appeared in Nature Metabolism.
Cleveland Clinic received a $7.9 million five-year grant from the National Cancer Institute at the National Institutes of Health to form one of three national centers as part of the newly established Radiation Oncology-Biology Integration Network (ROBIN).
The National Institute on Deafness and Other Communication Disorders (NIDCD) has awarded Xue Zhong Liu, M.D., Ph.D., Marian and Walter Hotchkiss Endowed Chair in Otolaryngology at the University of Miami Miller School of Medicine, a five-year, $3.5 million R01 research grant to develop a precision medicine approach to treat hearing loss (HL) in Usher syndrome (USH).
In February, UCI launched the Institute for Precision Health, a campus-wide, interdisciplinary endeavor that merges UCI’s powerhouse health sciences, engineering, machine learning, artificial intelligence, clinical genomics and data science capabilities. The objective is to identify, create and deliver the most effective health and wellness strategy for each individual person and, in doing so, confront the linked challenges of health equity and the high cost of care.
Gay men are more than twice as likely to develop inflammatory bowel disease (IBD) than heterosexual men when both populations engage in high-risk sexual activity, according to new research from the Digestive Health Research Institute at Case Western Reserve University and University Hospitals Cleveland Medical Center (UH).
Scientists are using in vitro skeletal muscle engineering to gain a better understanding of the complex genetic and environmental factors underlying diabetes, putting lab-grown, healthy skeletal muscle tissues in a state resembling diabetes or growing skeletal muscle from diabetic patients' muscle stem cells. In Biophysics Reviews, researchers describe how skeletal muscle engineering has advanced significantly during the past few decades and recent developments that make it easier to explore diabetes in humans and have led to more personalized medicine.
Millions of children are diagnosed each year with attention-deficit/hyperactivity disorder, or ADHD. When untreated, or undertreated, children with ADHD face challenges focusing, managing time, and practicing self-control, and these difficulties can persist into adulthood.
The highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses across multiple tumor types in the Phase I/II LIBRETTO-001 trial.
Analyzing genetic ancestry data from a large genomic repository – the UCLA ATLAS Precision Health Biobank – researchers have found a highly diverse patient population that’s consistent with the global diversity of Los Angeles – one of the most ethnically diverse cities in the world and an ideal location to pursue personalized, precision medicine for underrepresented populations.
Stuart and Molly Sloan have pledged $78 million to support Fred Hutchinson Cancer Center. It is the largest single gift in Fred Hutch’s 47-year history.“Miracles begin in the lab, and nowhere else is that truer than at Fred Hutch,” said Stuart Sloan. “I’ve been involved with this organization for years, and during that time, I have had the opportunity to personally interact with the scientists and leaders who are making this progress possible.
Los investigadores del Centro para Medicina Personalizada en Mayo Clinic descubrieron en el genoma humano firmas decisivas que podrían explicar por qué la COVID-19 es tan grave en algunas personas y leve en otras.
Researchers from Children’s Hospital of Philadelphia (CHOP) used advanced three-dimensional mapping techniques at a microscopic level to identify a multitude of genetic variants and corresponding target gene pairings in the pancreas that are implicated in type 2 diabetes. In addition to these discoveries, the resulting datasets will serve as a key resource for researchers all over the world to delve deeper into the genetic origins of type 2 diabetes and further explore the roles of different types of cells in the development of the disease.
Magnus Medical received clearance from the U.S. FDA for the SAINT™ Neuromodulation System for the treatment of major depressive disorder in adults who have failed to achieve satisfactory improvement from prior antidepressant medications.
Ochsner Health, through its Precision Medicine Program, is the first in the nation to incorporate Epic’s Orders and Results Anywhere integration with its Genomics module.
اكتشف الباحثون في مركز مايو كلينك لنهج الطب الشخصي التوقيعات الجينومية البشرية الرئيسية التي قد تساعد في تفسير سبب كون فيروس كورونا المستجد (كوفيد-19) شديدًا لدى بعض الأشخاص ومعتدلًا لدى آخرين.
Pesquisadores do Centro de Medicina Individualizada da Mayo Clinic descobriram assinaturas genômicas importantes que podem explicar por que a COVID-19 é grave para algumas pessoas e leve para outras.
Cancer Council SA-funded researcher Associate Professor Stephanie Reuter Lange from UniSA hopes that a simple computer program can help personalise treatment for cancer patients.
In possible violation of the No Surprises Act, health insurance company calculations of Qualified Payment Amounts (QPA) for anesthesiology, emergency medicine and radiology services (and possibly other specialty services) likely include rates from primary care provider (PCP) contracts. A new study conducted by Avalere Health and commissioned by three national physician organizations examined a subpopulation of PCPs and determined that contracting practices may directly impact the QPA.
In February, UCI launched the Institute for Precision Health, a campus-wide, interdisciplinary endeavor that merges UCI’s powerhouse health sciences, engineering, machine learning, artificial intelligence, clinical genomics and data science capabilities. The objective is to identify, create and deliver the most effective health and wellness strategy for each individual person and, in doing so, confront the linked challenges of health equity and the high cost of care.
Researchers from the Mayo Clinic Comprehensive Cancer Center and the Mayo Clinic Center for Individualized Medicine are studying a rare genetic condition called Familial Adenomatous Polyposis (FAP) looking for potential ways to prevent colorectal cancer in the general population at an earlier more treatable stage. The researchers’ findings are published in GUT.
The targeted therapy pralsetinib was well-tolerated and demonstrated high response rates in patients with RET gene fusions regardless of tumor type, according to results from the Phase I/II ARROW trial.
Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai have launched a new human genome sequencing research project called the Mount Sinai Million Health Discoveries Program with the Regeneron Genetics Center (RGC), part of the industry-leading, New York-based biotechnology company Regeneron.
Um acúmulo de produtos químicos, poluentes, micróbios e partículas ambientais pode estar vivendo dentro de cada um de nós, adquiridos do ar que respiramos, dos alimentos que comemos, dos produtos que tocamos e da água que bebemos.