Researchers have discovered that a particular molecular signaling pathway plays an important role in producing osteoarthritis (OA) pain. Using a mouse model of painful osteoarthritis, they show that blocking this signaling pathway eliminates pain and results in a return to normal limb use.
NYU researchers, including Jin Kim Montclare, professor of chemical and biomolecular engineering, along with investigators from the NYU Grossman School of Medicine have found both the molecular vehicle and therapeutic payload for delivering pharmacologic treatment to affected joints, which could halt post-traumatic osteoarthritis (PTOA) onset and progression.
The latest research news from the Health Disparities Channel.
The American College of Rheumatology (ACR) welcomes members of the press to write about rheumatology research presented at the Winter Rheumatology Symposium in Snowmass Village, CO on January 22 -28, 2022.
Treatment options for rheumatoid arthritis have often relied on trial and error. Now Mayo Clinic researchers are exploring the use of artificial intelligence (AI) and pharmacogenomics to predict how patients will respond to treatments, and to personalize care. Findings were published in Arthritis Care & Research.
For Medicare beneficiaries with knee osteoarthritis, the use of hyaluronic acid (HA) injections has increased in recent years, despite clinical guidelines recommending against the use of this treatment, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
Cells from a cheek swab revealed biomarkers for rheumatoid arthritis that could lead to a way to diagnose and begin treatment before the disease develops, according to a study published in Scientific Reports.
Two complementary studies show that defibrotide can successfully suppress the formation and progression of neutrophil extracellular traps, or NETs, which are web-like networks of toxic proteins that play a role in forming blood clots and promoting inflammation in several disease, including COVID-19. Researchers say findings may set the stage for defibrotide clinical trials in potentially several diseases.
Mayo Clinic researchers have linked the T cell dysfunction seen in rheumatoid arthritis with a metabolic deficiency in a new Nature Immunology publication.
People taking TNF inhibitors, a kind of immunosuppressive drug used to treat rheumatoid arthritis and other autoimmune conditions, produced a weaker and shorter-lived antibody response after two doses of Pfizer's COVID-19 vaccine, according to a study from Washington University School of Medicine in St. Louis. A third vaccine dose drove antibody levels back up, indicating that this additional dose may provide protection as the virus's delta variant continues to spread.
Exercise increases the body’s own cannabis-like substances, which in turn helps reduce inflammation and could potentially help treat certain conditions such as arthritis, cancer and heart disease.
Despite clear directives outlined in the updated guidelines published by the American College of Rheumatology/National Psoriasis Foundation (ACR/NPF) in 2018, there is limited data regarding medication use in real-world clinical practice and patient medication preferences for the treatment of psoriatic arthritis (PsA).
A new study by researchers at Hospital for Special Surgery (HSS) in New York City demonstrates over half of patients with rheumatic diseases who contracted COVID-19 during the pandemic and completed a COVID-19 survey, experienced so-called “long-haul” COVID, or prolonged symptoms of the infection, including loss of taste or smell, muscle aches and difficulty concentrating, for one month or longer.
Crowdsourcing has become an increasingly popular way to develop machine learning algorithms to address many clinical problems in a variety of illnesses. Today at the American College of Rheumatology (ACR) annual meeting, a multicenter team led by an investigator from Hospital for Special Surgery (HSS) presented the results from the RA2-DREAM Challenge, a crowdsourced effort focused on developing better methods to quantify joint damage in people with rheumatoid arthritis (RA).
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that people with chronic inflammatory diseases, such as rheumatoid arthritis (RA), who take immunosuppressive therapy appear to have an impaired immunity response to SARS-CoV-2, the coronavirus that causes COVID-19, vaccines. Patients currently on glucocorticoids or B-cell depleting therapy appear to have an even more severely impeded vaccine response.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that proactive therapeutic drug monitoring, a newer treatment strategy where a patient’s drug serum levels are regularly assessed to adjust the dose and intervals, controlled disease more effectively than standard therapy with infliximab, a tumor necrosis factor (TNF) inhibitor.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, found that an innovative new artificial neural network can detect radiographic sacroiliitis in patients with suspected axial spondyloarthritis, a progressive disease that is more common in young adults.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that statins are associated with reduced rates of cardiovascular disease (CVD) and mortality in people with rheumatoid arthritis, but only modestly increase risk of type-2 diabetes, suggesting that statins’ benefits outweigh the risks in these patients.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that allopurinol and febuxostat may effectively lower urate levels when used in a treat-to-target approach. Importantly, both urate-lowering therapies were very effective with 90% of patients reaching target urate levels. Additionally, both appeared safe, with no evidence of increased cardiovascular toxicity.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, found that racial and ethnic disparities for disease activity persist in people with rheumatoid arthritis. Black and Hispanic patients often had higher disease activity and lower self-reported functional status when compared to white patients.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows significant decreases in infections among people with psoriatic arthritis over the years 2012-2017.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, found that patients started on early, aggressive treatment with a combination of biologic and conventional disease modifying antirheumatic drugs (DMARDs) achieved clinically inactive disease in children with polyarticular juvenile idiopathic arthritis (JIA) more frequently compared to other treatment plans 24 months after starting treatment.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that in Alabama, one in 10 racial or ethnic minority patients with a rheumatic disease in a large rheumatology clinic said they were unlikely to get vaccinated against COVID-19.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, found that while hospitalized children with juvenile lupus have fewer adverse kidney outcomes overall, significant racial gaps for developing these complications persist and do not seem to be narrowing (Abstract #0956).
After an anterior cruciate ligament reconstruction surgery, it's common to experience quadriceps weakness, which was thought to be caused primarily by muscle atrophy, or shrinkage.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows a significant lack of fairness among telemedicine and electronic patient portals used by rheumatology clinic patients based on their race, age, sex and English language proficiency.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows patients using rituximab were able to produce antibodies against COVID-19 after receiving a third vaccine dose, even if there was no development of the antibody after the first two.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that people with difficult-to-treat rheumatoid arthritis who do not have success with JAK inhibitor can achieve success either cycling to other JAKi or switching to a biologic drug.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that pregnant women with Takayasu’s arteritis appear to have a high prevalence of serious maternal and fetal adverse outcomes
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, found that a virtual exercise program can be safe for people with musculoskeletal conditions, improved their health outcomes, and helped them feel more socially connected.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows the majority of rheumatoid arthritis patients on an ultra-low dose of rituximab maintained low disease activity for up to 4 years, and rarely needed to switch to other biologic drugs.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that higher doses, longer duration of use, chronic kidney disease and Asian race could all be risk factors for retinopathy in people using hydroxychloroquine for rheumatoid arthritis.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows a relationship between genotype, bone marrow failure and survival in patients with the rare autoinflammatory disease VEXAS syndrome, which was only identified in 2020.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that the COVID-19 vaccine was not associated with severe disease flares in patients with rheumatic diseases.
The American Medical Society for Sports Medicine (AMSSM) has released a position statement on Principles for the Responsible Use of Regenerative Medicine in Sports Medicine.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that biologics were the most common initial treatment prescribed to treat systemic juvenile idiopathic arthritis patients in one major registry.
NYU Langone rheumatologists are presenting their discoveries at the annual American College of Rheumatology conference, November 1 to November 9. The conference will be held virtually.
The Osteoarthritis Action Alliance (OAAA) recently evaluated numerous evidence-based (medically proven) interventions to identify which met established criteria for being known as "Arthritis-Appropriate Evidence-Based Interventions" (AAEBIs). Programs that meet these criteria must be shown to improve arthritis symptoms, such as pain or limitations in function, and demonstrate that they have a sufficient level of support for program oversight and organized, wide-scale community delivery.
Patients with a rare form of scleroderma that causes more skin thickening have a greater chance of dying from related heart, lung and kidney problems, a new study found. This occurs despite the patient population taking drugs used to treat most people with scleroderma. Researchers say it is an opportunity for more targeted drug development.
Systemic lupus erythematosus (SLE), commonly referred to as simply “lupus”, is an autoimmune disorder where the body’s immune system attacks healthy tissue.
Ankylosing spondylitis is a painful and inflammatory form of axial spondyloarthritis (SpA) which affects 1-2% of Canadians and causes inflammation in the spine, joints, eyes, gut and skin. In a new paper recently published in the journal Science Translational Medicine, researchers at the Schroeder Arthritis Institute at UHN have made a discovery that could lead to new treatments for SpA.
The partnership makes it easier for veterans to take specific, practical actions to manage their osteoarthritis, by providing tools and resources to help prevent joint injuries and reduce the pain and disability associated with the disease.
明尼苏达州罗切斯特—家庭成员Barbara Domaille、Deborah Neville、Pamela Neville和Rylie Ronnenberg分享了许多她们所珍视的事物，其中只有一项是她们希望自己不曾分享的：即因关节异常，而导致疼痛难忍、髋关节总是发出“咔咔”的噼啪声响。
Barbara, Deborah, Pamela y Rylie pertenecen a la misma familia y comparten entre ellas muchas cosas preciadas, pero hay una que desearían no tener en común: se trata de una anomalía en la articulación de la cadera que les provoca dolor y emite ruidos como de chasquido o crujido.
membros da mesma família, Barbara Domaille, Deborah Neville, Pamela Neville e Rylie Ronnenberg compartilham muitas coisas que valorizam e apenas uma que gostariam de não compartilhar: uma anormalidade nas articulações que causava dor, estalos e crepitações em seus quadris.
The American College of Rheumatology (ACR) is providing complimentary registration to journalists wishing to write about studies presented at ACR Convergence 2021, the ACR’s annual meeting taking place Nov. 1 – 10.
这项发表在《基因组医学》（Genome Medicine）上的研究发现，通过关注胃肠道中数万亿的细菌、病毒和真菌，即肠道微生物组，可以预测类风湿性关节炎患者的未来预后。研究结果表明，肠道微生物与类风湿性关节炎患者的预后有关。
لقد وجدت الدراسة، المنشورة في مجلة طب الجينوم، أن التنبؤ بمآل مرض التهاب المفاصل الروماتويدي للمريض قد يكون ممكنًا من خلال التركيز على تريليونات البكتيريا والفيروسات والفطريات التي تعيش في السبيل المَعدي المَعوي، والمعروفة باسم الحَيُّوم الدقيق للأمعاء
O estudo, publicado na Genome Medicine, descobriu que a previsão do futuro prognóstico de artrite reumatoide de um paciente poderia ser possível ao direcionar o foco para os trilhões de bactérias, vírus e fungos que habitam o trato gastrointestinal, conhecido como microbioma intestinal.
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