A tension-activated repair patch used in animal trials plugs holes in discs in the spine like car tire patches and could prevent further disease progression
A new NIH award to Wayne State University aims to understand the early events around critical cell death that cause motor deficits, and ultimately, provide understanding for the development of much-needed therapies for prevention of motor deficits from congenital BH4 deficiency and CP.
St. Jude scientists mapped the gene regulatory networks responsible for progressive differentiation states of tumor-infiltrating T cells, using a technology known as single-cell CRISPR screening to knock out or genetically perturb multiple genes potentially involved.
A study showed that patient pain scores were a good predictor for opioid use, but younger patients and those who hadn’t used opioids before were less likely to take them
The Department of Immunology and Immunotherapy and the Icahn Genomics Institute (IGI) at the Icahn School of Medicine at Mount Sinai have been awarded a $5 million grant from the National Cancer Institute (NCI) of the National Institutes of Health to establish a state-of-the-art center dedicated to the discovery and development of cutting-edge targets for cancer therapy.
Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.
A five-year, $5 million grant has been awarded by the National Cancer Institute (NCI) to the UTHealth Houston Institute for Implementation Science to support research and training in implementation science, with a focus on improving cancer control efforts in Mexico and Latin America.
A UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science study reveals that online shopping for tobacco products increased the months following the California flavored tobacco ban and identified potential loopholes in tobacco control policies on e-commerce sales.
A widespread Medicare program that aims to improve health care and lower costs by providing financial incentives to doctors and hospitals resulted in no improvements in mental health care, according to a study by researchers at Washington University School of Medicine in St. Louis and the Yale School of Public Health.
Firearm deaths, injuries among young people exert massive physical, mental health burden on survivors and families. Financial costs also high; survivor health spending up by $35,000 in the year following injury, according to the analysis. Deaths and injuries likely to grow in coming years.
The United States has the highest maternal mortality rate of any industrialized nation, a trend that has been accelerating for 20 years. But nearly two out of three maternal deaths are preventable, with cardiovascular disease (CVD) being the leading cause of death, said Kathryn Lindley, MD, holder of the Samuel S. Riven, MD, Directorship in Cardiology.
A new study from researchers at Wake Forest University School of Medicine shows that frailty is associated with higher rates of death and major morbidity after surgery. The findings appear online today in JAMA Network Open.
ASU bioengineer Benjamin Bartelle studies the innate immune system, which serves as the body’s first line of defense for many disease processes.
A team led by a University of Illinois chemistry professor recently created copper molecules that can transfer electrons at least an order of magnitude faster than previously reported. Finding faster, more efficient ways to transfer electrons between synthetically made molecules could lead to more efficient energy conversion technology, like solar panels.
Building upon the expertise in dementia research and care across Penn Medicine, the health system has been awarded a $5 million grant from the Delaware Community Foundation to support the Penn Institute on Aging’s (IOA) work to develop the next generation of therapies for Alzheimer’s disease and related dementias (ADRD).
UC San Diego engineers have developed modular nanoparticles that can be easily customized to target different biological entities such as tumors, viruses or toxins. The surface of the nanoparticles is engineered to host any biological molecules of choice, making it possible to tailor the nanoparticles for a wide array of applications, ranging from targeted drug delivery to neutralizing biological agents.
A research team from the Monell Chemical Senses Center demonstrated, using a novel quantitative analysis, that the neuronal response to odors undergoes some modifications in the nose. Such early processing of olfactory signals is a result of interactions between olfactory receptor neurons and the neighboring trigeminal neurons.
Cancer center scientists have identified a combination of biological effects that likely make some people with HIV vulnerable to cancer
Research from Osaka University demonstrates a nanopore-based technique that can detect different variants of SARS-CoV-2, the virus that causes COVID-19. The method was very effective in detecting the Omicron variant of the virus in the saliva of people with COVID-19.
Researchers at Wake Forest University School of Medicine have received a five-year, $9 million grant from the National Institute on Aging, part of the National Institutes of Health, to create a national consortium that will study the use, interpretation and implementation of biomarkers to diagnose Alzheimer's disease.
Layered lithium cobalt oxide, a key component of lithium-ion batteries, has been synthesized at temperatures as low as 300°C and durations as short as 30 minutes.
Navigating the labyrinthine vasculature of the brain with standard surgical instruments can be incredibly challenging, even for the steadiest of hands. But with some robotic assistance, brain surgeons could potentially operate with far greater ease.
Researchers have developed soft yet durable 3D-printed materials that glow in response to mechanical stress, such as compression, stretching or twisting. The materials derive their luminescence from single-celled algae known as dinoflagellates, which are embedded within the materials. The work was inspired by the bioluminescent waves caused by dinoflagellates during red tide events at San Diego’s beaches.
LA JOLLA, CA—Scientists from La Jolla Institute for Immunology (LJI) and The University of Southampton, UK, have uncovered a group of immune cells that may drive severe asthma. These cells, called cytotoxic CD4+ tissue-resident memory T cells, gather in the lungs and appear to possess the molecular weaponry to cause the most harm in men who developed asthma later in life.
A broad-spectrum antiviral drug candidate, 2-thiouridine, that targets positive-strand RNA viruses has been identified and characterized.
A UC Davis study shows the first-in-human imaging of the body’s CD8 T cell immune response to COVID-19 infection in recovering patients.
Scientists at Tufts University School of Medicine have developed a genome-scale metabolic model or “subway map” of key metabolic activities of the bacterium that causes Lyme disease.
UC San Diego engineers have developed a recipe to make a certain class of ceramics tougher and more resistant to cracking. The newfound toughness of these ceramics paves the way for their use in extreme applications, such as spacecraft and other hypersonic vehicles.
Iowa State researchers are developing mathematical models to simulate soybean aphid population dynamics over a growing season with a wide array of stressors, including droughts and floods. The project received a USDA grant earlier this year and is in collaboration with entomologists at Ohio State University.
Researchers from Iowa State University and the University of California, Santa Barbara will work together to fundamentally change the capabilities of light-based 3D printing.
Wake Forest University School of Medicine has received a two-year, $445,000 grant from the National Institute on Minority Health and Health Disparities, part of the National Institutes of Health.
UC San Diego engineers have developed an experimental vaccine that could prevent the spread of metastatic cancers to the lungs. Its success lies in targeting a protein known to play a central role in cancer growth and spread, rather than targeting the primary tumor itself.
Dendritic cells are key orchestrators of the immune response, but most vaccination strategies don’t effectively target them. NIBIB-funded researchers have developed biodegradable nanoparticles that are designed to deliver mRNA cargo to dendritic cells in the spleen.
Most people think of dementia as something that affects a person’s brain. But a new study shows just how much damage it does to a person’s wallet and bank account too – as well as the higher demands it places on their family members -- compared with people of the same age in similar health but without dementia.
Worries that surgery patients would have a tougher recovery if their doctors had to abide by a five-day limit on opioid pain medication prescriptions didn’t play out as expected, a new study finds. Instead, patient-reported pain levels and satisfaction didn’t change at all for Michigan adults who had their appendix or gallbladder removed, a hernia repaired, a hysterectomy or other common operations after the state’s largest insurer put the limit in place, the study shows.
Police officers often respond to incidents that do not involve crime or immediate threats to public safety but instead deal with community members facing unmet mental health needs. In response to this, many cities are experimenting with co-deploying police officers alongside health professionals or deploying teams entirely composed of civilian health professionals.
An international team of scientists has identified nearly a dozen genes that contribute to calcium buildup in our coronary arteries that can lead to life-threatening coronary artery disease, a condition responsible for up to one in four deaths in the United States. Doctors may be able to target these genes with existing medications – or possibly even nutritional supplements – to slow or halt the disease’s progression.
In a new article published today in Science Translational Medicine, a team of Moffitt Cancer Center researchers, in collaboration with NFlection Therapeutics and researchers at Stanford University, reports the identification of a new drug, NFX-179, that can be applied to the skin and was shown to prevent the development of cutaneous squamous cell carcinoma in pre-clinical models.
A new study of the microbial ecosystem in sourdough finds that using different types of flour fosters distinct bacterial communities, and that these differences contribute to the variation of sourdough aromas and flavors.
UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science researchers report in a new study that exposures to two of the most popular herbicides were associated with worse brain function among adolescents.
UC San Diego engineers developed electronic “stickers” that measure the force exerted by one object upon another. The force stickers are wireless, run without batteries and fit in tight spaces, making them versatile for a wide range of applications, from surgical robots to smart implants and inventory tracking.
Models built on machine learning in health care can be victims of their own success, according to researchers at the Icahn School of Medicine and the University of Michigan.
To improve the quality of care and reduce healthcare expenditures, heart failure patients in the U.S. are increasingly being treated in community-based programs such as managed long-term care. Although early identification of patients’ risks of negative outcomes, including hospitalizations or emergency department visits, has been shown to prevent these adverse outcomes in settings including hospitals and nursing homes, it has not been studied in managed long-term care.
A groundbreaking study presented today by University of North Carolina (UNC) School of Medicine researchers at the XXIV FIGO World Congress of Gynecology and Obstetrics could revolutionize pregnancy care, especially in areas with limited resources.
Liquid biopsies are blood tests that can serially measure circulating tumor DNA (cell-free DNA that is shed into the bloodstream by dying cancer cells). When used in patients with advanced non-small cell lung cancer undergoing immunotherapy, they may identify patients who could benefit from treatment with additional drugs, according to a phase 2 clinical trial in the U.S. and Canada. The trial is led by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy, BC Cancer and the Canadian Cancer trials Group (CCTG).
In 2019, St. Jude lentiviral gene therapy restored the immune system in multiple infants of X-linked severe combined immunodeficiency disorder (SCID-X1) or “bubble boy disease” at the DNA level. These children can now produce functional immune systems.
Borrowing from neuroscience, researchers at the University of Pittsburgh will engineer neural networks for robots, giving them the ability to learn and improve their ability to navigate different terrains.
In a study co-led by investigators at Dana-Farber Cancer Institute, researchers developed a low-cost, ultrasensitive blood test to detect minute levels of a cancer biomarker that is highly specific to multiple common cancers.
A technology being studied to curb climate change – one that could be put in place in one or two decades if work on the technology began now – would affect food productivity in parts of planet Earth in dramatically different ways, benefiting some areas, and adversely affecting others, according to projections prepared by a Rutgers-led team of scientists.
Researchers at Wake Forest University School of Medicine have received a five-year $10 million grant from the National Institute on Drug Abuse, part of the National Institutes of Health (NIH), to create a broad research program that will work to reduce opioid-related harms and improve quality of life in patients on long-term opioid therapy.
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